会员体验
专利管家（专利管理）
工作空间（专利管理）
风险监控（情报监控）
数据分析（专利分析）
侵权分析（诉讼无效）
联系我们
交流群
官方交流：
QQ群： 891211   
微信请扫码    >>>
现在联系顾问~
下载
著录项
PDF全文
热词
    • 1. 发明申请
      US20080051346A1 Compounds and methods for modulating cell-adhesion mediated drug resistance 审中-公开
    • Compounds and methods for modulating cell-adhesion mediated drug resistance
    • 用于调节细胞粘附介导的耐药性的化合物和方法
    • US20080051346A1
    • 2008-02-28
    • US11731947
    • 2007-03-30
    • William Dalton , Jason Damiano , Anne Cress
    • William Dalton , Jason Damiano , Anne Cress
    • A61K38/08 , A61K38/00 , A61P35/00
    • A61K38/08 , C07K14/4747 , C07K14/7055 , A61K2300/00
    • Peptides and methods of their use for inhibiting drug and radiation-therapy resistance in cancerous cells in which efficacy of chemotherapy and/or radiotherapy of a patient is enhanced by administration of an effective amount of a peptide that inhibits cell adhesion mediated drug resistance (CAM-DR). Preferably, the peptide comprises D-amino acids having the sequence: kmviywkag(RZ-3) or is a variant or modified version thereof. The peptide is preferably administered to the patient prior to chemotherapy and/or radiation therapy. Inhibition of cell adhesion mediated drug resistance (CAM-DR) by RZ-3 in multiple myeloma cells is disclosed.
    • 肽及其用于抑制癌细胞中的药物和放射治疗抗性的方法，其中通过施用有效量的抑制细胞粘附介导的药物抗性的肽（CAM-1）来增强患者的化学疗法和/或放射疗法的功效， DR）。 优选地，肽包含具有以下序列的D-氨基酸：
      kmviywkag （RZ-3） ENTRY> 或是其变体或修改版本。 肽在化疗和/或放射治疗之前优选施用于患者。 公开了通过RZ-3在多发性骨髓瘤细胞中抑制细胞粘附介导的药物抗性（CAM-DR）。
      基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
        • 3. 发明申请
          US20080108552A1 HYD1 Peptides as Anti-Cancer Agents 失效
        • HYD1 Peptides as Anti-Cancer Agents
        • HYD1肽作为抗癌剂
        • US20080108552A1
        • 2008-05-08
        • US11852177
        • 2007-09-07
        • Lori Hazlehurst , William Dalton , Anne Cress , Kit Lam
        • Lori Hazlehurst , William Dalton , Anne Cress , Kit Lam
        • A61K38/00 , A61P35/00 , C07H21/02 , C07K7/06 , C12N15/00 , C12N5/00
        • G01N33/5011 , C07K7/06
        • The present invention concerns fragments and variants of the HYD1 peptide; polynucleotides encoding the peptides; host cells genetically modified with the polynucleotides; vectors comprising the polynucleotides; compositions containing these peptides, polynucleotides, vectors, or host cells; and methods of using the peptides, polynucleotides, vectors, and host cells as inhibitors of aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as myeloma. The present invention further includes a method of increasing the efficacy of chemotherapy and radiation therapy, comprising administering an agent that binds β1 integrin to a patient in need thereof. In one embodiment, the β1 integrin binding agent is the HYD1 peptide, or a functional fragment or variant thereof. In another aspect, the invention pertains to a composition (an adhesion trap) comprising a substrate (also referred to as a surface or support) with a HYD1 peptide, or fragment or variant thereof, immobilized to the substrate, and a method of removing circulating tumor cells (CTC) from blood by contacting a subject's blood with the immobilized peptide. Another aspect of the invention concerns a method of identifying modulators of peptide binding. Another aspect of the invention concerns a method for detecting CTC.
        • 本发明涉及HYD1肽的片段和变体; 编码肽的多核苷酸; 用多核苷酸遗传修饰的宿主细胞; 包含多核苷酸的载体; 含有这些肽，多核苷酸，载体或宿主细胞的组合物; 以及使用肽，多核苷酸，载体和宿主细胞作为体外或体内异常细胞生长的抑制剂的方法，例如用作治疗癌症如骨髓瘤的抗癌剂。 本发明进一步包括增加化学疗法和放射治疗功效的方法，其包括向有需要的患者施用结合β1整联蛋白的药剂。 在一个实施方案中，β1整联蛋白结合剂是HYD1肽或其功能片段或变体。 另一方面，本发明涉及一种组合物（粘附陷阱），其包含固定在基底上的HYD1肽或其片段或变体的底物（也称为表面或载体），以及除去循环的方法 通过使受试者的血液与固定的肽接触，从血液中获得肿瘤细胞（CTC）。 本发明的另一方面涉及鉴定肽结合调节剂的方法。 本发明的另一方面涉及一种检测CTC的方法。
        • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
        • 6. 发明授权
          US5022013A Underwater release apparatus, underwater release system and method 失效
        • Underwater release apparatus, underwater release system and method
        • 水下释放装置，水下释放系统及方法
        • US5022013A
        • 1991-06-04
        • US489457
        • 1990-03-06
        • William Dalton , Al Billings
        • William Dalton , Al Billings
        • B63B22/06 , H04B13/02
        • H04B13/02 , B63B22/06
        • An improved underwater release apparatus, underwater release system and method of controlled release of an underwater object employing the underwater release apparatus. The underwater release apparatus comprises a housing release means mounted on a housing, a securing means for holding the housing at a defined position, the housing release means comprising a pair of load-balanced clamping jaws mounted for movement between a clamping position and a load releasing position, a coupling means attached to a water balanced shaft means slideably mounted on a nonexplosive drive means for driving the shaft between an engaged position and a disengaged position and for releasing the housing from the mooring. The housing release apparatus may be employed in an underwater release system including a transmitter adapted to transmit command signals to a receiver mounted in a housing attached to a mooring means adapted to secure the housing at a defined depth in the water and a buoy means to provide positive flotation for the housing for positioning at a defined depth and for retrieval upon release from the mooring by upon the command from the transmitter and released by the housing release means.
        • 一种改进的水下释放装置，水下释放系统和使用该水下释放装置的水下物体的控制释放方法。 水下释放装置包括安装在壳体上的壳体释放装置，用于将壳体保持在限定位置的固定装置，壳体释放装置包括一对负载平衡的夹爪，其安装成在夹紧位置和负载释放之间移动 位置，附接到水平衡轴的联接装置，其可滑动地安装在非易失性驱动装置上，用于在接合位置和脱离位置之间驱动轴并且用于将系统从系泊释放。 壳体释放装置可以用在水下释放系统中，包括发射器，其适于将指令信号发送到安装在附接到系泊装置的壳体中的接收器，该系泊装置适于将壳体固定在水中的限定深度，以及浮标装置， 用于定位在限定深度处的壳体的正浮选，并且在从发射器发出并由壳体释放装置释放时从系泊释放时进行检索。
        • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
        • 9. 发明申请
          US20060187670A1 Light bar providing illumination from inside a vehicle 审中-公开
        • Light bar providing illumination from inside a vehicle
        • 灯条从车内提供照明
        • US20060187670A1
        • 2006-08-24
        • US11399932
        • 2006-04-07
        • William Dalton , Steven Neufeglise
        • William Dalton , Steven Neufeglise
        • B60Q1/26
        • B60Q1/268 , B60Q1/28 , B60Q3/252 , B60Q3/51 , B60Q3/74 , B60Q3/78 , B60Q3/80 , B60Q3/88 , Y10S362/80
        • A light bar contains one or more rows of light-emitting diodes (LED's) in a housing which extends across substantially the entire width of a windshield of a vehicle and is narrow in width to minimize interference with visibility through the windshield. The housing has an interior forming a channel with a throat; the throat acting as a hood which directs the illumination out of the windshield and minimizes stray light. The LED's are arranged in banks generally symmetrically arrayed about the center of the length of the housing. Two of the banks, preferably equidistant from the center, are tilted in opposite directions to each other so as to project light toward the right side and left side of the vehicle. The LED's may be illuminated continuously or in selected sequence, as established by the user with a switch on the housing. Attached to the housing in a separate compartment is another bank of LED's which may direct light inside the vehicle for use as a dome or map light. A mechanism is provided for displacing and tilting the housing and may use pivotal arms attached to the end of the housing or adjustable Z-shaped hangers attached preferably to clamps such as visor clips already on the vehicle.
        • 灯条在壳体中包含一排或多排发光二极管（LED），其延伸跨越车辆的挡风玻璃的基本上整个宽度，并且宽度窄，以最小化对通过挡风玻璃的可见性的干扰。 壳体具有形成具有喉部的通道的内部; 喉咙作为引擎罩，将照明引导到挡风玻璃上，并最大限度地减少杂散光。 LED围绕容器的长度的中心大致对称排列。 优选地与中心相等的两个堤岸中的两个堤坝彼此相反地倾斜，以便朝向车辆的右侧和左侧突出。 LED可以按照用户在壳体上的开关建立的连续或按照选定顺序照亮。 在另一个隔间内连接到外壳的另一个LED组，可以将车内的光引导为穹顶或地图光。 提供了用于移动和倾斜壳体的机构，并且可以使用附接到壳体的端部的枢转臂或者优选地连接到诸如已经在车辆上的护目镜夹具的可调节的Z形衣架。
        • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
      每页展示10个专利
      每页展示10个专利
      每页展示20个专利
      每页展示50个专利
      每页展示100个专利

      IPRDB

      最新中国发明专利 最新美国发明专利 技术领域 专利库 专利分类库 国际专利分类库

      热门服务

      会员版试用 API 数据接口 找代理 知嘟嘟专利交易 排行榜 大学排行榜 专利百科

      关于我们

      平台介绍 战略合作 网站地图

      友情链接

      知嘟嘟专利交易 国家知识产权局 中国商标网

      联系方式


      ©2019-2023 上海吉码数字技术有限公司 版权所有，并保留所有权利 沪ICP备20016256号-6 沪公网安备31011702005475号