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1. 发明申请

US20110184439A1 Biological Matrix for Cardiac Repair 审中-公开
标题翻译：心脏修复生物矩阵
公开(公告)号：US20110184439A1
公开(公告)日：2011-07-28
申请号：US12991809
申请日：2009-05-08
申请人： William D. Anderson , Stephen F. Badylak , Thomas W. Gilbert , John M. Wainwright
发明人： William D. Anderson , Stephen F. Badylak , Thomas W. Gilbert , John M. Wainwright
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867
摘要： Provided herein is a device to occlude a hole in a wall of an organ or tissue. In another embodiment, a device is provided which comprises an extracellular matrix-derived material and an adhesive to occlude a hole in a wall of an organ or tissue. Provided are devices prepared from extracellular matrix-derived cell-growth scaffolding to repair defects in walls of organs or tissues. Also provided are methods for preparing the device as well as for using the device.
摘要翻译：本文提供了一种用于封闭器官或组织的壁中的孔的装置。在另一个实施方案中，提供了一种装置，其包括细胞外基质衍生的材料和用于封闭器官或组织的壁中的孔的粘合剂。提供的是从细胞外基质衍生的细胞生长支架制备的装置来修复器官或组织的壁中的缺陷。还提供了用于准备装置以及使用装置的方法。

2. 发明授权

US08927003B2 Extracellular matrix based gastroesophageal junction reinforcement device 有权
标题翻译：基于细胞外基质的胃食管结合加强装置
公开(公告)号：US08927003B2
公开(公告)日：2015-01-06
申请号：US13108074
申请日：2011-05-16
申请人： Stephen F. Badylak , Thomas W. Gilbert , Alejandro Nieponice
发明人： Stephen F. Badylak , Thomas W. Gilbert , Alejandro Nieponice
IPC分类号： A61L27/36 , A61K35/38 , A61L27/38
CPC分类号： A61L27/3679 , A61F2/04 , A61F2002/044 , A61K35/38 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3882 , A61L2430/22
摘要： Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
摘要翻译：提供用于植入患有至少部分食管的患者的医疗装置。医疗装置将食道或其余部分与胃连接以形成胃食管连接处，其在分配负荷并减少吻合部位的张力的同时促进愈合并促进新的宿主组织生长。医疗装置包括细胞外基质成形为更接近天然胃食管结合物的几何形状的构象，而不是将胃直接附着于缩短的食道。在本文中还描述了用于制造医疗装置的模具和装置的使用方法。

3. 发明申请

US20110288654A1 EXTRACELLULAR MATRIX BASED GASTROESOPHAGEAL JUNCTION REINFORCEMENT DEVICE 有权
标题翻译：基于细胞基质的胃肠道结节加强装置
公开(公告)号：US20110288654A1
公开(公告)日：2011-11-24
申请号：US13108074
申请日：2011-05-16
申请人： Stephen F. Badylak , Thomas W. Gilbert , Alejandro Nieponice
发明人： Stephen F. Badylak , Thomas W. Gilbert , Alejandro Nieponice
IPC分类号： A61F2/04
CPC分类号： A61L27/3679 , A61F2/04 , A61F2002/044 , A61K35/38 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3882 , A61L2430/22
摘要： Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
摘要翻译：提供用于植入患有至少部分食管的患者的医疗装置。医疗装置将食道或其余部分与胃连接以形成胃食管连接处，其在分配负荷并减少吻合部位的张力的同时促进愈合并促进新的宿主组织生长。医疗装置包括细胞外基质成形为更接近天然胃食管结合物的几何形状的构象，而不是将胃直接附着于缩短的食道。在本文中还描述了用于制造医疗装置的模具和装置的使用方法。

4. 发明授权

US08535719B2 Biohybrid elastomeric scaffolds and methods of use thereof 有权
标题翻译：生物混合弹性体支架及其使用方法
公开(公告)号：US08535719B2
公开(公告)日：2013-09-17
申请号：US11825540
申请日：2007-07-06
申请人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
发明人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
IPC分类号： A61K9/70
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3804 , A61L27/58
摘要： Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
摘要翻译：本文提供了包含合成聚合物组分和生物聚合物组分的生物混合弹性体支架。支架可以制造成具有许多不同的形式，其非限制性实例包括非织造纤维网或多孔复合材料。还提供了在伤口愈合和组织再生中使用生物混合弹性体支架的方法。

5. 发明申请

US20080268019A1 Biohybrid elastomeric scaffolds and methods of use thereof 有权
标题翻译：生物混合弹性体支架及其使用方法
公开(公告)号：US20080268019A1
公开(公告)日：2008-10-30
申请号：US11825540
申请日：2007-07-06
申请人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
发明人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
IPC分类号： A61L27/54 , A61L27/58 , A61P17/02 , A61P43/00
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3804 , A61L27/58
摘要： Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
摘要翻译：本文提供了包含合成聚合物组分和生物聚合物组分的生物混合弹性体支架。支架可以制造成具有许多不同的形式，其非限制性实例包括非织造纤维网或多孔复合材料。还提供了在伤口愈合和组织再生中使用生物混合弹性体支架的方法。

6. 发明授权

US06176704B1 Children's learning toy 失效
标题翻译：儿童学习玩具
公开(公告)号：US06176704B1
公开(公告)日：2001-01-23
申请号：US09379250
申请日：1999-08-23
申请人： Thomas W. Gilbert
发明人： Thomas W. Gilbert
IPC分类号： G09B1700
CPC分类号： G09B17/02 , G09B17/00
摘要： A learning toy based upon the concept of design or pattern formation is disclosed. The toy is comprised of a tray having a transparent bottom and a plurality of blocks which are arrangeable in the tray to form a design or pattern. Each block is painted with a primary color on four of its surfaces while the fifth surface of the block is painted with two of the primary colors with the boundary therebetween being on a diagonal across the surface of the block and the sixth surface of the block is painted with the other two primary colors with the boundary therebetween being on a diagonal across the surface of the block. When the blocks are arranged in the tray to form a design or pattern, a juxtaposition of dark and light colors is created on the top surface of the blocks and an “opposite” design or pattern is formed on the bottom surfaces of the blocks which can be viewed through the transparent bottom surface of the tray.
摘要翻译：公开了一种基于设计或图案形成概念的学习玩具。该玩具由具有透明底部的托盘和可布置在托盘中以形成设计或图案的多个块组成。每个块在其四个表面上涂上原色，而块的第五表面涂有两种原色，其间的边界在块的表面上在对角线上，块的第六表面是用其他两种原色涂漆，其间的边界在块的表面上在对角线上。当块被布置在托盘中以形成设计或图案时，在块的顶表面上产生暗色和浅色的并置，并且在块的底表面上形成“相对”的设计或图案，其可以通过托盘的透明底面观察。

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