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1. 发明授权

EP1062192B1 PREPARATION OF CYCLOALKYLACETYLENE COMPOUNDS 有权
标题翻译：用于生产环丙基乙炔
公开(公告)号：EP1062192B1
公开(公告)日：2004-09-15
申请号：EP99911381.4
申请日：1999-03-12
申请人： Wiley Organics Inc.
发明人： STICKLEY, Kurt, R. , WILEY, David, B.
IPC分类号： C07C1/30 , C07C13/04
CPC分类号： C07F3/02 , C07C1/30 , C07C2601/02 , C07C13/04
摘要： The process of the invention reacts an alkynyl halide with a mixture that includes a dialkylaminomagnesium halide or a bis(dialkylamino)magnesium compound to produce a cycloalkylacetylene compound. Preferably, the dialkylaminomagnesium halide compound is of the general formula: R2NMgX (where R is a linear, branched, or cyclic alkyl substituent or R2N represents a heterocyclic alkyl amine and X is Cl, Br, or I) and the bis(dialkylamino)magnesium compound is of the general formula: (R2N)2Mg (where R is a linear, branched, or cyclic alkyl substituent or R2N represents a heterocyclic alkylamine). In a preferred method of the invention, the reaction is conducted at moderate temperatures for a period of about 12 to 24 hours. The reaction mixture preferably includes tetrahydrofuran (THF), or a hydrocarbon, or a hydrocarbon-ether mixture. The preferred compounds produced by this process are cycloalkylacetylene compounds having 5 to 20 carbons, such as cyclopropylacetylene and cyclobutylacetylene.

2. 发明公开

EP1062192A1 PREPARATION OF CYCLOALKYLACETYLENE COMPOUNDS 有权
标题翻译：环烷基乙炔化合物的制备
公开(公告)号：EP1062192A1
公开(公告)日：2000-12-27
申请号：EP99911381.4
申请日：1999-03-12
申请人： Wiley Organics Inc.
发明人： STICKLEY, Kurt, R. , WILEY, David, B.
IPC分类号： C07C1/30 , C07C13/04
CPC分类号： C07F3/02 , C07C1/30 , C07C2601/02 , C07C13/04
摘要： The process of the invention reacts an alkynyl halide with a mixture that includes a dialkylaminomagnesium halide or a bis(dialkylamino)magnesium compound to produce a cycloalkylacetylene compound. Preferably, the dialkylaminomagnesium halide compound is of the general formula: R2NMgX (where R is a linear, branched, or cyclic alkyl substituent or R2N represents a heterocyclic alkyl amine and X is Cl, Br, or I) and the bis(dialkylamino)magnesium compound is of the general formula: (R2N)2Mg (where R is a linear, branched, or cyclic alkyl substituent or R2N represents a heterocyclic alkylamine). In a preferred method of the invention, the reaction is conducted at moderate temperatures for a period of about 12 to 24 hours. The reaction mixture preferably includes tetrahydrofuran (THF), or a hydrocarbon, or a hydrocarbon-ether mixture. The preferred compounds produced by this process are cycloalkylacetylene compounds having 5 to 20 carbons, such as cyclopropylacetylene and cyclobutylacetylene.
摘要翻译：本发明的方法使炔基卤与包含二烷基氨基镁卤化物或双（二烷基氨基）镁化合物的混合物反应以产生环烷基乙炔化合物。优选地，二烷基氨基卤化镁化合物具有以下通式：R2NMgX（其中R为直链，支链或环状烷基取代基或R2N表示杂环烷基胺且X为Cl，Br或I）和双（二烷基氨基）镁化合物具有通式：（R2N）2Mg（其中R是直链，支链或环状烷基取代基或R2N表示杂环烷基胺）。在本发明的优选方法中，反应在中等温度下进行约12至24小时。反应混合物优选包括四氢呋喃（THF）或烃或烃 - 醚混合物。通过该方法生产的优选化合物是具有5至20个碳的环烷基乙炔化合物，例如环丙基乙炔和环丁基乙炔。

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