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1. 发明申请

US20070254880A1 Heteroaryl Piperidine Glycine Transporter Inhibitors 有权
标题翻译：杂芳基哌啶甘氨酸转运蛋白抑制剂
公开(公告)号：US20070254880A1
公开(公告)日：2007-11-01
申请号：US10593950
申请日：2005-03-23
申请人： Wesley Blackaby , Mark Duggan , David Hallett , George Hartman , Andrew Jennings , William Leister , Richard Lewis , Craig Lindsley , Elizabeth Naylor , Leslie Street , Yi Wang , David Wisnoski , Scott Wolkenberg , Zhijian Zhao
发明人： Wesley Blackaby , Mark Duggan , David Hallett , George Hartman , Andrew Jennings , William Leister , Richard Lewis , Craig Lindsley , Elizabeth Naylor , Leslie Street , Yi Wang , David Wisnoski , Scott Wolkenberg , Zhijian Zhao
IPC分类号： A61K31/445 , A61K31/5375 , C07D211/06 , C07D413/02
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
摘要： The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
摘要翻译：本发明涉及抑制甘氨酸转运蛋白GlyT1的吡啶基，哒嗪基，嘧啶基和吡嗪基哌啶化合物，其可用于治疗与甘氨酸能或谷氨酸能神经传递功能障碍相关的神经和精神疾病以及其中涉及甘氨酸转运蛋白GlyT1的疾病。

2. 发明申请

US20060276655A1 Cyclohexanesulfonyl derivatives as GlyT1 inhibitors to treat schizophrenia 有权
标题翻译：环己磺酰基衍生物作为治疗精神分裂症的GlyT1抑制剂
公开(公告)号：US20060276655A1
公开(公告)日：2006-12-07
申请号：US11446735
申请日：2006-06-05
申请人： Wesley Blackaby , Jose Castro Pineiro , Richard Lewis , Elizabeth Naylor , Leslie Street
发明人： Wesley Blackaby , Jose Castro Pineiro , Richard Lewis , Elizabeth Naylor , Leslie Street
IPC分类号： C07C317/50 , C07D213/46
CPC分类号： C07D213/82 , C07C233/70 , C07C233/76 , C07C317/30 , C07C2601/02 , C07C2601/14 , C07D231/12 , C07D231/18 , C07D239/28 , C07D249/04 , C07D285/125 , C07D295/108 , C07D295/135 , C07D307/68 , C07D333/38 , C07D471/04 , C07D495/04
摘要： The present invention provides compounds of formula I: wherein R1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R3 is an alkyl, cycloalkyl, cycloalkylalkyl, amino or heterocyclyl group; R4 and R5 are hydrogen or alkyl or form a cycloalkyl ring; A is O or N; and m is zero or one; as inhibitors of GlyT1 and thus as useful for treating or preventing diseases such as schizophrenia; with the provision of pharmaceutical compositions, first and second medical uses and methods of treatment.
摘要翻译：本发明提供式I化合物：其中R 1是烷基，苯基，杂环基，环烷基，烷氧基，酯，氨基或酰胺基; R 2是苯基，杂环基，烷基，环烷基或环烷基烷基; R 3是烷基，环烷基，环烷基烷基，氨基或杂环基; R 4和R 5是氢或烷基或形成环烷基环; A是O或N; m为零或一; 作为GlyT1的抑制剂，因此可用于治疗或预防精神分裂症等疾病; 提供药物组合物，第一和第二医疗用途和治疗方法。

3. 发明申请

US20080090796A1 Piperidine And Azetidine Derivatives As Glyt1 Inhibitors 有权
标题翻译：哌啶和氮杂环丁烷衍生物作为Glyt1抑制剂
公开(公告)号：US20080090796A1
公开(公告)日：2008-04-17
申请号：US11792111
申请日：2005-12-21
申请人： Wesley Blackaby , Stephen Fletcher , Andrew Jennings , Richard Lewis , Elizabeth Naylor , Leslie Joseph , Joanne Thomson
发明人： Wesley Blackaby , Stephen Fletcher , Andrew Jennings , Richard Lewis , Elizabeth Naylor , Leslie Joseph , Joanne Thomson
IPC分类号： A61K31/165 , A61K31/397 , A61K31/4178 , A61K31/4192 , A61K31/454 , A61K31/4545 , A61P25/18 , C07C233/64 , C07D211/96 , C07D249/04 , C07D401/12 , C07D401/14 , C07D403/12
CPC分类号： C07D401/14 , C07D401/12 , C07D403/12 , C07D409/14
摘要： The present invention provides compounds of formula (I), wherein both p's are one or two, R1 is generally heteroaryl or cycloalkyl, R2 is C3-6cycloalkyl or phenyl and R3 is heteroaryl, and pharmaceutically acceptable salts thereof, as GlyT1 inhibitors for treating schizophrenia, pharmaceutical compositions comprising the same and methods for their preparation.
摘要翻译：本发明提供了式（I）化合物，其中两个p是一个或两个，R 1通常是杂芳基或环烷基，R 2是C 3〜 6个环烷基或苯基，R 3是杂芳基及其药学上可接受的盐，作为用于治疗精神分裂症的GlyT1抑制剂，包含其的药物组合物及其制备方法。

4. 发明申请

US20060235021A1 Phenylpyridazine derivatives as ligands for gaba receptors 审中-公开
标题翻译：苯基哒嗪衍生物作为gaba受体的配体
公开(公告)号：US20060235021A1
公开(公告)日：2006-10-19
申请号：US10524173
申请日：2003-08-04
申请人： Wesley Blackaby , Peter Blurton , Frank Burkamp , Stephen Fletcher , Andrew Jennings , Richard Lewis , Angus Macleod , Leslie Street , Steve Thomas , Monique Van Niel , Kevin Wilson
发明人： Wesley Blackaby , Peter Blurton , Frank Burkamp , Stephen Fletcher , Andrew Jennings , Richard Lewis , Angus Macleod , Leslie Street , Steve Thomas , Monique Van Niel , Kevin Wilson
IPC分类号： A61K31/501 , C07D403/02 , A61K31/50
CPC分类号： C07D231/12 , C07D233/56 , C07D237/08 , C07D237/14 , C07D237/20 , C07D237/24 , C07D249/08 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D417/14
摘要： A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
摘要翻译：一类式（I）的4-苯基哒嗪衍生物，作为GABA A A受体的选择性配体，特别是对α2和/或α3和α5亚基具有高亲和力，因此具有益处在治疗和/或预防中枢神经系统的不利条件，包括焦虑，抽搐和认知障碍。

5. 发明授权

US09392430B2 Bonding of receiver to camera based mobile device having connectivity 有权
标题翻译：将接收机绑定到具有连接性的基于摄像机的移动设备
公开(公告)号：US09392430B2
公开(公告)日：2016-07-12
申请号：US13093215
申请日：2011-04-25
申请人： Richard Lewis
发明人： Richard Lewis
IPC分类号： H04B7/00 , H04W4/20
CPC分类号： H04W4/21 , G08C2201/20 , G08C2201/93
摘要： A mobile device is bonded to a controllable device by reading a code on the controllable device, banding the mobile device to the controllable device by use of the code, and transmitting a remote control signal from the mobile device to control a controllable function of the bonded controllable device so that only the bonded controllable device responds to the remote control signal by performing the controllable function.
摘要翻译：移动设备通过读取可控设备上的代码而被绑定到可控设备，通过使用代码将移动设备绑定到可控设备，以及从移动设备发送遥控信号，以控制绑定的可控功能可控制装置，使得只有结合的可控制装置通过执行可控功能来响应遥控信号。

6. 发明授权

US08442226B2 Decryption key management 有权
标题翻译：解密密钥管理
公开(公告)号：US08442226B2
公开(公告)日：2013-05-14
申请号：US12355323
申请日：2009-01-16
申请人： Raymond C. Hauge , Richard Lewis
发明人： Raymond C. Hauge , Richard Lewis
IPC分类号： H04L29/06
CPC分类号： H04N7/1675 , G06F21/10 , G06F2221/2107 , H04L9/0662 , H04L9/0869 , H04L63/0428 , H04L2209/12 , H04L2209/605 , H04L2463/062 , H04N21/235 , H04N21/2362 , H04N21/23895 , H04N21/435 , H04N21/43853 , H04N21/47211
摘要： An encrypted program received in an MPEG transport stream is decrypted by receiving an address in the MPEG transport stream, reading a key from a memory in accordance with the received address, and decrypting the encrypted program based on the key.
摘要翻译：在MPEG传输流中接收的加密程序通过接收MPEG传输流中的地址，根据接收的地址从存储器读取密钥，并根据密钥对加密的程序进行解密来解密。

7. 发明授权

US08401189B2 Opportunistic use of keys during encryption/decryption 有权
标题翻译：在加密/解密过程中机会使用密钥
公开(公告)号：US08401189B2
公开(公告)日：2013-03-19
申请号：US12355260
申请日：2009-01-16
申请人： Raymond C. Hauge , Richard Lewis
发明人： Raymond C. Hauge , Richard Lewis
IPC分类号： H04L29/06
CPC分类号： H04N7/1675 , G06F21/10 , G06F2221/2107 , H04L9/0662 , H04L9/0869 , H04L63/0428 , H04L2209/12 , H04L2209/605 , H04L2463/062 , H04N21/235 , H04N21/2362 , H04N21/23895 , H04N21/435 , H04N21/43853 , H04N21/47211
摘要： An encrypted program received in an MPEG transport stream is decrypted by receiving a message in the MPEG transport stream, wherein the message contains a key, decrypting the encrypted program based on the key, and replacing the message in the MPEG transport stream with a null packet.
摘要翻译：通过接收MPEG传输流中的消息来解密在MPEG传输流中接收的加密程序，其中消息包含密钥，基于密钥对加密程序进行解密，并用空分组替换MPEG传输流中的消息。

8. 发明申请

US20120214207A1 METHODS AND SYSTEMS FOR FAST PCR HEATING 有权
标题翻译：快速PCR加热的方法和系统
公开(公告)号：US20120214207A1
公开(公告)日：2012-08-23
申请号：US13329183
申请日：2011-12-16
申请人： Ian Gunter , Richard Lewis
发明人： Ian Gunter , Richard Lewis
IPC分类号： C12M1/40 , C12P19/34
CPC分类号： C12P19/34 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2300/0829 , B01L2300/1811 , B01L2300/1822 , B01L2300/1827
摘要： A microplate for polymerase chain reaction (PCR) comprises a substrate having a metallic material for heating PCR samples, and a barrier layer disposed adjacent to the substrate. In some cases, the barrier layer is formed of a first polymeric material. The microplate includes one or more wells for containing PCR samples. The one or more wells are formed of a second polymeric material sealed to the barrier layer. In some cases, the substrate can provide a PCR ramp rate of at least about 5° C./second.
摘要翻译：用于聚合酶链反应（PCR）的微孔板包括具有用于加热PCR样品的金属材料的底物和与基底相邻设置的阻挡层。在一些情况下，阻挡层由第一聚合物材料形成。微孔板包括一个或多个用于含有PCR样品的孔。一个或多个孔由密封到阻挡层的第二聚合材料形成。在一些情况下，底物可以提供至少约5℃/秒的PCR斜率。

9. 发明授权

US07969474B2 Camera, encoder, and modulator in same enclosure 有权
标题翻译：摄像机，编码器和调制器在同一个机箱中
公开(公告)号：US07969474B2
公开(公告)日：2011-06-28
申请号：US11710360
申请日：2007-02-23
申请人： Richard Lewis
发明人： Richard Lewis
IPC分类号： H04N5/228 , H04N9/64
CPC分类号： H04N5/225 , H04N21/4223
摘要： An RF signal source having a camera that provides a camera output, an encoder that encodes the camera output in a compressed digital format, and a modulator that digitally encodes and modulates the compressed camera output and that provides the digitally encoded, modulated, and compressed camera output as an RF output of the RF signal source. The camera, the encoder, and the modulator may be contained in an enclosure. Additionally or alternatively, the encoder, the modulator, and at least part of the camera may be formed on a semiconductor substrate.
摘要翻译：具有提供相机输出的相机的RF信号源，以压缩数字格式编码相机输出的编码器以及对压缩的相机输出进行数字编码和调制并且提供数字编码的调制和压缩的相机的调制器作为RF信号源的RF输出输出。相机，编码器和调制器可以包含在外壳中。附加地或替代地，编码器，调制器和照相机的至少一部分可以形成在半导体衬底上。

10. 发明申请

US20110063346A1 PRINTER INK DELIVERY SYSTEMS 有权
标题翻译：打印机墨水输送系统
公开(公告)号：US20110063346A1
公开(公告)日：2011-03-17
申请号：US12992332
申请日：2008-05-14
申请人： Richard Lewis , Francesc Ros Cerro , Marcos Arminana Terrasa , Gloria Hernandez Ballester
发明人： Richard Lewis , Francesc Ros Cerro , Marcos Arminana Terrasa , Gloria Hernandez Ballester
IPC分类号： B41J2/195 , B41J2/175
CPC分类号： B41J2/175 , B41J2/17509 , B41J2/17566 , B41J2/17596
摘要： An ink delivery system for a printer. In one embodiment, the system includes an ink supply that contains ink to be delivered to a printhead of the printer and an ink buffer having a capacity that is smaller than a capacity of the ink supply, the ink buffer being configured to be repeatedly filled with ink from the ink supply and to deliver that ink to the printhead.
摘要翻译：一种用于打印机的墨水输送系统。在一个实施例中，该系统包括一个墨水供应装置，该墨水供应装置包括要传送到打印机的打印头的墨水和一个具有小于墨水容量的墨水容量的墨水缓冲器，该墨水缓冲器被配置为重复填充墨水从墨水供应并将墨水输送到打印头。

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