专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4070373A Tricyclic aminoalkyl derivatives 失效
标题翻译：三环氨基烷基衍生物
公开(公告)号：US4070373A
公开(公告)日：1978-01-24
申请号：US291426
申请日：1972-09-22
申请人： Werner Winter , Max Thiel , Kurt Stach, deceased , by Werner Plattner, administrator , Wolfgang Schaumann , Karl Dietmann
发明人： Werner Winter , Max Thiel , Kurt Stach, deceased , by Werner Plattner, administrator , Wolfgang Schaumann , Karl Dietmann
IPC分类号： C07D311/90 , C07D313/12 , C07D337/12 , C07D337/16
CPC分类号： C07D337/16 , C07D311/90 , C07D313/12 , C07D337/12 , C07C2103/18
摘要： Novel tricyclic aminoalkyl derivatives are disclosed which are characterized by valuable pharmacological activities and namely by cardiac and circulatory activities. The tricyclic aminoalkyl derivatives are compounds of the formula: ##STR1## wherein X is an oxygen or a sulfur atom, a saturated or unsaturated, straight chain or branched alkylene group containing up to 3 carbon atoms, an oxymethylene, thiamethylene or thiaethylene group or a valency bond, R.sub.1 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen or hydroxyl, R.sub.3 is hydrogen or together with R.sub.2 represents a further valency bond, R.sub.4 and R.sub.5 which may be the same or different are each hydrogen or lower alkyl, A is alkylene which is substituted by an optionally acylated hydroxyl group, Y is an oxygen or sulfur atom or an optionally alkylated imino group and Z is aryl, aralkyl, cycloalkyl or cycloalkyl-alkyl which may be substituted by halogen, hydroxyl, nitro, amino, alkoxy, aralkoxy, alkyl, trifluoromethyl, alkylamino or alkylsulfonyl group, and the acid addition salts thereof with pharmacologically acceptable acids.
摘要翻译：公开了新颖的三环氨基烷基衍生物，其特征在于有价值的药理活性，即通过心脏和循环活性。三环氨基烷基衍生物是下式的化合物：其中X是氧或硫原子，含有至多3个碳原子的饱和或不饱和的直链或支链亚烷基，亚甲基，亚亚甲基或亚硫代亚乙基或化合键，R 1是氢，卤素，烷基，烷氧基或三氟甲基，R 2是氢或羟基，R 3是氢或与R 2一起代表另外的价键，可以相同或不同的R 4和R 5各自是氢或低级烷基 A是被任意酰化的羟基取代的亚烷基，Y是氧或硫原子或任选烷基化的亚氨基，Z是可以被卤素，羟基，硝基取代的芳基，芳烷基，环烷基或环烷基 - 烷基，氨基，烷氧基，芳烷氧基，烷基，三氟甲基，烷基氨基或烷基磺酰基，及其与药理学上可接受的酸的酸加成盐。

2. 发明授权

US4229464A Aminopropanol substituted indole compounds and compositions for the treatment of cardiac and circulatory diseases 失效
标题翻译：氨基丙醇取代的吲哚化合物和用于治疗心脏和循环系统疾病的组合物
公开(公告)号：US4229464A
公开(公告)日：1980-10-21
申请号：US943512
申请日：1978-09-18
申请人： Wolfgang Kampe , Kurt Stach, deceased , by Werner Plattner, administrator , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
发明人： Wolfgang Kampe , Kurt Stach, deceased , by Werner Plattner, administrator , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
IPC分类号： C07D209/43 , A61K31/40 , A61K31/403 , A61K31/404 , A61P25/02 , C07D209/08 , C07D209/12 , C07D209/32 , C07D209/42 , C07D209/18 , C07D209/20
CPC分类号： C07D209/42 , C07D209/08 , C07D209/12 , Y10S514/927
摘要： New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：新的式（I）的氨基丙醇化合物其中R是低级烷基，环烷基或烷硫基烷基，R1是氢或低级烷基，羟烷基，新戊酰氧基烷基，烷氧基烷基，烷氧基羰基，羧基或-CONR3R4，其中R3和R4可以是 R 2为低级烷基，羟基烷基，烷氧基烷基或新戊酰氧基烷基，或当R为烷硫基烷基或R 1为新戊酰氧基烷基时，R 2也可为氢及其药理学上可接受的盐; 在治疗或预防心脏和循环系统疾病方面非常有效。

3. 发明授权

US4087520A Lowering blood pressure with new L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptides 失效
标题翻译：用新的L-3-（3,4-二羟基苯基）-2-甲基 - 丙氨酸肽降低血压
公开(公告)号：US4087520A
公开(公告)日：1978-05-02
申请号：US665341
申请日：1976-03-09
申请人： Franz Braun , Kurt Stach, deceased , by Werner Plattner, executor , Max Thiel , Gisbert Sponer , Karl Dietmann
发明人： Franz Braun , Kurt Stach, deceased , by Werner Plattner, executor , Max Thiel , Gisbert Sponer , Karl Dietmann
IPC分类号： C07K1/113 , A61K38/00 , A61K38/05 , C07C67/00 , C07C231/00 , C07C231/02 , C07K5/06 , C07K5/065 , C07K5/083 , A61K37/00 , C07C103/52
CPC分类号： C07K5/0806 , C07K5/06026 , C07K5/06078 , A61K38/00 , Y10S530/80
摘要： An L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptide of the formula ##STR1## wherein A is an alkylene radical which can be substituted by a hydroxyl group or by a phenyl radical which optionally carries at least one hydroxyl group, andR is a hydrogen atom or a lower alkyl radical or a glycyl or alanyl radical,Or a pharmacologically compatible salt thereof. These compounds are outstanding in lowering blood pressure.
摘要翻译：其中A是可被羟基取代的亚烷基或可任选地携带至少一个的苯基的L-3-（3,4-二羟基苯基）-2-甲基 - 丙氨酸肽羟基，R为氢原子或低级烷基或甘氨酰或丙氨酰基，或其药理学兼容的盐。这些化合物在降低血压方面表现突出。

4. 发明授权

US4076829A Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases 失效
标题翻译：用于治疗心脏和循环系统疾病的氨基丙醇化合物和组合物
公开(公告)号：US4076829A
公开(公告)日：1978-02-28
申请号：US626512
申请日：1975-10-28
申请人： Wolfgang Kampe , Kurt Stach , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
发明人： Wolfgang Kampe , Kurt Stach , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
IPC分类号： C07D209/43 , A61K31/40 , A61K31/403 , A61K31/404 , A61P25/02 , C07D209/08 , C07D209/12 , C07D209/32 , C07D209/42 , C07D209/14
CPC分类号： C07D209/42 , C07D209/08 , C07D209/12 , Y10S514/927
摘要： New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen andThe pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：式（I）的新的氨基丙醇化合物其中R是低级烷基，环烷基或烷硫基烷基，R1是氢或低级烷基，羟基烷基，新戊酰氧基烷基，烷氧基烷基，烷氧基羰基，羧基或-CONR3R4，其中R3和R4可以是相同或不同，代表氢或低级烷基，R2是低级烷基，羟基烷基，烷氧基烷基或新戊酰氧基烷基，或当R是烷硫基烷基或R1是新戊酰氧基烷基时，R2也可以是氢，并且其药学上可接受的盐; 在治疗或预防心脏病和循环系统疾病方面具有突出优势。

5. 发明授权

US4152446A Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases 失效
标题翻译：用于治疗心脏和循环系统疾病的氨基丙醇化合物和组合物
公开(公告)号：US4152446A
公开(公告)日：1979-05-01
申请号：US805558
申请日：1977-06-10
申请人： Wolfgang Kampe , Kurt Stach , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
发明人： Wolfgang Kampe , Kurt Stach , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
IPC分类号： C07D209/08 , C07D209/12 , C07D209/42 , A61K31/40 , C07D209/04
CPC分类号： C07D209/42 , C07D209/08 , C07D209/12
摘要： New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof;Are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：新的式（I）的氨基丙醇化合物其中R是低级烷基，环烷基或烷硫基烷基，R1是氢或低级烷基，羟烷基，新戊酰氧基烷基，烷氧基烷基，烷氧基羰基，羧基或-CONR3R4，其中R3和R4可以是 R 2为低级烷基，羟基烷基，烷氧基烷基或新戊酰氧基烷基，或当R为烷硫基烷基或R 1为新戊酰氧基烷基时，R 2也可为氢及其药理学上可接受的盐; 在治疗或预防心脏病和循环系统疾病方面具有突出优势。

6. 发明授权

US4016262A Therapeutic compositions and methods employing N(6)-disubstituted adenosine compounds 失效
标题翻译：使用N（6） - 二取代腺苷化合物的治疗组合物和方法
公开(公告)号：US4016262A
公开(公告)日：1977-04-05
申请号：US582529
申请日：1975-05-30
申请人： Erich Fauland , Wolfgang Kampe , Kurt Stach, deceased , by Werner Plattner, executor , Harald Stork , Karl Dietmann
发明人： Erich Fauland , Wolfgang Kampe , Kurt Stach, deceased , by Werner Plattner, executor , Harald Stork , Karl Dietmann
IPC分类号： C07H19/16 , A61K31/70
CPC分类号： C07H19/16
摘要： N(6)-disubstituted adenosine compounds of the formula: ##STR1## wherein R.sub.1 is alkenyl, cycloalkenyl or cycloalkenyl-alkyl; andR.sub.2 is alkenyl, cycloalkenyl, straight or branched-chain alkyl, cycloalkyl, bicycloalkyl, alkyl-cycloalkyl, or alkyl-bicycloalkyl;And the pharmacologically compatible salts thereof; exhibit outstanding anti-lipolytic, anti-hyperlipaemic and anti-hypercholesterolaemic action.
摘要翻译：具有下式的N（6） - 二取代的腺苷化合物：其中R 1是烯基，环烯基或环烯基 - 烷基; R 2为烯基，环烯基，直链或支链烷基，环烷基，二环烷基，烷基 - 环烷基或烷基 - 双环烷基; 及其药理学兼容性; 展示超耐药，抗高血压和抗高胆固醇血管作用。

7. 发明授权

US4224438A Adenosine-5'-carboxylic acid amides 失效
标题翻译：腺苷-5'-羧酸酰胺
公开(公告)号：US4224438A
公开(公告)日：1980-09-23
申请号：US161338
申请日：1971-07-09
申请人： Erich Fauland , Wolfgang Kampe , Max Thiel , Karl Dietmann , Wolfgang Juhran
发明人： Erich Fauland , Wolfgang Kampe , Max Thiel , Karl Dietmann , Wolfgang Juhran
IPC分类号： C07H19/16 , A61K31/70 , C07H19/18
CPC分类号： C07H19/16
摘要： Adenosine-5'-carboxylic acid derivatives of the general formula: ##STR1## wherein Z is two hydrogen atoms or a divalent lower alkylidene radical, ##STR2## R is an aliphatic or arylaliphatic radical, and R.sub.1 and R.sub.2 are independently a hydrogen, hydroxyl, amino, lower alkyl, lower alkenyl, optionally N-alkylated lower aminoalkyl, cycloalkyl, hydroxyalkyl or piperidinyl radical, orR.sub.1 and R.sub.2 taken together are a divalent ethylene radical containing 4-7 carbon atoms optionally interrupted by an oxygen or sulfur atom or by an imino, alkylimino or arylimino radical or a pharmacologically compatible salt thereof.The esters surprisingly can be prepared by esterifying the acid in the presence of sulfuric acid without hydrolyzing the sugar group. While the esters have some activity, they can be used to make the amides which are characterized by marked coronary activity.
摘要翻译：具有以下通式的腺苷-5'-羧酸衍生物：其中Z为两个氢原子或二价低级亚烷基，其中R 1和R 2独立为氢，羟基，氨基，低级烷基，低级烯基，任选N-烷基化的低级氨基烷基，环烷基，羟基烷基或哌啶基，或者R 1和R 2一起是含有4-7个碳原子的任选被氧或硫中断的二价亚乙基或亚氨基，亚氨基亚氨基或芳基亚氨基或其药理学上相容的盐。这些酯令人惊奇地可以通过在硫酸存在下酯化酸而不水解糖基来制备。虽然酯具有一些活性，但它们可用于制备以标记的冠状动脉为特征的酰胺。

8. 发明授权

US4120963A Certain pyrido[3,4-b]indole-1-ones 失效
标题翻译：某些吡啶并[8,3-b {9吲哚-1-酮
公开(公告)号：US4120963A
公开(公告)日：1978-10-17
申请号：US798736
申请日：1977-05-19
申请人： Wolfgang Kampe , Martin Senn , Max Thiel , Wolfgang Bartsch , Karl Dietmann
发明人： Wolfgang Kampe , Martin Senn , Max Thiel , Wolfgang Bartsch , Karl Dietmann
IPC分类号： A61K31/435 , A61P25/02 , C07D471/04 , C07D471/14 , A61K31/44
CPC分类号： C07D471/04
摘要： New aminopropanol compounds of the formula ##STR1## wherein A is alkylene;B is sulfur or a valency bond;R is a straight-chained or branched lower alkyl; and the pharmacologically compatible salts thereof; are outstandingly effective adrenergic .beta.-receptor inhibitors and useful in the treatment or prophylaxis of circulatory diseases.
摘要翻译：新的式（I）的氨基丙醇化合物，其中A是亚烷基; B是硫或价键; R是直链或支链的低级烷基; 和其药理学上相容的盐; 是非常有效的肾上腺素能β受体抑制剂，可用于治疗或预防循环系统疾病。

9. 发明授权

US4503067A Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions 失效
标题翻译：（4） - 氧丙醇胺化合物和治疗组合物
公开(公告)号：US4503067A
公开(公告)日：1985-03-05
申请号：US479921
申请日：1983-04-04
申请人： Fritz Wiedemann , Wolfgang Kampe , Max Thiel , Gisbert Sponer , Egon Roesch , Karl Dietmann
发明人： Fritz Wiedemann , Wolfgang Kampe , Max Thiel , Gisbert Sponer , Egon Roesch , Karl Dietmann
IPC分类号： A61K31/40 , A61K31/403 , A61P9/08 , A61P25/02 , C07D209/88 , C07D317/64 , C07D401/12 , C07D405/12 , C07D209/82
CPC分类号： C07D209/88 , C07D317/64
摘要： Carbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl or aroyl;R.sub.2 is hydrogen, lower alkyl or arylalkyl;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen or lower alkyl, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--;X is a valency bond, --CH.sub.2 --, oxygen or sulfur;Ar is mono- or bicyclic aryl or pyridyl;R.sub.5 and R.sub.6 are individually selected from hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, aralkyloxy, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl;R.sub.5 and R.sub.6 together can represent methylenedioxy;and the salts thereof with physiologically acceptable acids are outstandingly effective in the treatment and prophylaxis of circulatory and cardiac diseases, e.g., hypertension and angina pectoris.
摘要翻译：式（I）的羧基 - （4） - 氧丙醇胺化合物，其中R 1是氢，低级烷酰基或芳酰基; R2是氢，低级烷基或芳基烷基; R3是氢或低级烷基; R4是氢或低级烷基，或者当X是氧时，R4与R5一起可以代表-CH2-O-; X是价键，-CH 2 - ，氧或硫; Ar是单环或双环芳基或吡啶基; R5和R6分别选自氢，卤素，羟基，低级烷基，氨基羰基，低级烷氧基，芳烷氧基，低级烷硫基，低级烷基亚磺酰基或低级烷基磺酰基; R5和R6一起可以代表亚甲二氧基; 并且其与生理上可接受的酸的盐在治疗和预防循环和心脏疾病例如高血压和心绞痛方面是显着的。

10. 发明授权

US3998810A N-substituted 1-amino-3-phenoxy-propan-2-ol compounds and therapeutic compositions containing them 失效
标题翻译： N-取代的1-氨基-3-苯氧基丙-2-醇化合物和含有它们的治疗组合物
公开(公告)号：US3998810A
公开(公告)日：1976-12-21
申请号：US487423
申请日：1974-07-10
申请人： Fritz Wiedemann , Max Thiel , Kurt Stach , Karl Dietmann , Gisbert Sponer
发明人： Fritz Wiedemann , Max Thiel , Kurt Stach , Karl Dietmann , Gisbert Sponer
IPC分类号： A61K31/135 , A61K31/00 , A61K31/395 , A61K31/54 , A61K31/5415 , A61P9/00 , C07C67/00 , C07C213/00 , C07C217/30 , C07D209/82 , C07D209/86 , C07D223/24 , C07D223/28 , C07D279/24 , C07D279/28
CPC分类号： C07D209/86
摘要： New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;B is straight or branched chain alkylene or hydroxyalkylene of from 2 to 5 carbon atoms; andR.sub.3 is hydrogen or alkyl of up to 3 carbon atoms;And the physiologically compatible salts thereof; possess valuable cardiac and circulatory activity.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式