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1. 发明授权

US5218009A Mono- and di-acylphosphine oxides 失效
标题翻译：单酰基和二酰基氧化膦
公开(公告)号：US5218009A
公开(公告)日：1993-06-08
申请号：US751048
申请日：1991-08-28
申请人： Werner Rutsch , Kurt Dietliker , Roger G. Hall
发明人： Werner Rutsch , Kurt Dietliker , Roger G. Hall
IPC分类号： C07F9/32 , C07F9/53 , C07F9/6568 , C08F2/50 , G03F7/029
CPC分类号： C07F9/5337 , C07F9/3252 , C07F9/65685 , C08F2/50 , G03F7/029
摘要： Compounds of the formula I ##STR1## in which at least one of the radicals R.sub.1, R.sub.2 and R.sub.3 is a substituted alkyl radical or cycloalkyl radical, or R.sub.1 and R.sub.2 together with the phosphorus atom form a monocyclic or tricyclic ring, are effective photoinitiators for the photopolymerization of ethylenically unsaturated compounds.
摘要翻译：其中基团R 1，R 2和R 3中的至少一个是取代的烷基或环烷基，或者R 1和R 2与磷原子一起形成单环或三环的式I的化合物是有效的光引发剂用于烯属不饱和化合物的光聚合。

2. 发明授权

US5013863A Substituted propane-phosphinic acid compounds 失效
标题翻译：取代的丙烷 - 次膦酸化合物
公开(公告)号：US5013863A
公开(公告)日：1991-05-07
申请号：US378887
申请日：1989-07-12
申请人： Eric K. Baylis , Helmut Bittiger , Wolfgang Froostl , Roger G. Hall , Ludwig Maier , Stuart J. Mickel , Hans-Rudolf Olpe
发明人： Eric K. Baylis , Helmut Bittiger , Wolfgang Froostl , Roger G. Hall , Ludwig Maier , Stuart J. Mickel , Hans-Rudolf Olpe
IPC分类号： A61K31/66 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P39/02 , A61P43/00 , C07F9/30 , C07F9/48
CPC分类号： C07F9/48 , C07F9/301 , Y02P20/55
摘要： Compounds of the formula I ##STR1## wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen or, in the case of R.sup.1 and R.sup.2, is hydroxy, and the remaining one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen, and their salts have GABA.sub.B -antagonistic properties and can be used as GABA.sub.B -antagonists. They are obtained when in a compound of formula II ##STR2## in which R, R.sup.1, R.sup.2 and R.sup.3 have their previous significances, Z represents --NH.sub.2 and R.sup.4 denotes a hydroxy-protective group R.sup.5 or, when R.sup.1 and R.sup.3 denote hydrogen and R.sup.2 denotes hydrogen or alkyl, denotes an alkali metal or ammonium ion R.sup.6, or Z represents a protected or latent amino group Z.sup.0 and R.sup.4 deontes hydrogen or a hydroxy-protective group R.sup.5, any group R.sup.5 or R.sup.6 is replaced by hydrogen, and/or any group Z.sup.0 is converted into --NH.sub.2.

3. 发明授权

US5414133A Protected phosphine oxides 失效
标题翻译：受保护的氧化膦
公开(公告)号：US5414133A
公开(公告)日：1995-05-09
申请号：US179403
申请日：1994-01-10
申请人： Roger G. Hall , Peter Riebli
发明人： Roger G. Hall , Peter Riebli
IPC分类号： C07F9/46 , C07F9/53
CPC分类号： C07F9/5337 , C07F9/46 , C07F9/5304 , Y02P20/55
摘要： Protected phosphine oxides of formula X are useful intermediates for the preparation of tertiary phosphine oxides and acylphosphine oxide photoinitiators. ##STR1##
摘要翻译：式X的受保护的膦氧化物是制备叔氧化膦和酰基氧化膦光引发剂的有用中间体。 X

4. 发明授权

US5064819A Substituted propane-phosphinic acid compounds 失效
标题翻译：取代的丙酸 - 磷酸化合物
公开(公告)号：US5064819A
公开(公告)日：1991-11-12
申请号：US502399
申请日：1990-03-30
申请人： Eric K. Baylis , Helmut Bittiger , Wolfgang Frostl , Roger G. Hall , Ludwig Maier , Stuart J. Mickel , Hans-Rudolf Olpe
发明人： Eric K. Baylis , Helmut Bittiger , Wolfgang Frostl , Roger G. Hall , Ludwig Maier , Stuart J. Mickel , Hans-Rudolf Olpe
IPC分类号： A61K31/66 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P39/02 , A61P43/00 , C07F9/30 , C07F9/48
CPC分类号： C07F9/48 , C07F9/301 , Y02P20/55
摘要： Compounds of the formula I ##STR1## wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen or, in the case of R.sup.1 and R.sup.2, is hydroxy, and the remaining one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen, or wherein R denotes methyl, R.sub.1 denotes hydrogen or hydroxy, R.sub.2 denotes an aromatic radical and R.sub.3 represents hydrogen, and their salts have GABA.sub.B -antagonistic properties and can be used as GABA.sub.B -antagonists. They are obtained when in a compound of formula II ##STR2## in which R, R.sup.1, R.sup.2 and R.sup.3 have their previous significances, Z represents --NH.sub.2 and R.sup.4 denotes a hydroxy-protective group R.sup.5 or, when R.sup.1 and R.sup.3 denote hydrogen and R.sup.2 denotes hydrogen or alkyl, denotes an alkali metal or ammonium ion R.sup.6, or Z represents a protected or latent amino group Z.sup.0 and R.sup.4 denotes hydrogen or a hydroxy-protective group R.sup.5, any group R.sup.5 or R.sup.6 is replaced by hydrogen, and/or any group Z.sup.0 is converted into --NH.sub.2.

5. 发明授权

US4656298A Substituted propane-phosphonous acid compounds 失效
标题翻译：取代的丙烷 - 膦酸化合物
公开(公告)号：US4656298A
公开(公告)日：1987-04-07
申请号：US787300
申请日：1985-10-15
申请人： John G. Dingwall , Josef Ehrenfreund , Roger G. Hall , James Jack
发明人： John G. Dingwall , Josef Ehrenfreund , Roger G. Hall , James Jack
IPC分类号： C07F9/38 , A61K31/66 , A61P21/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P25/28 , C07F9/32 , C07F9/40 , C07F9/48 , C07F7/08 , A61K31/13 , A61K31/185
CPC分类号： C07F9/48 , C07F9/3211 , C07F9/4816
摘要： The compounds of the formula ##STR1## in which one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1-8 -alkyl, C.sub.3-6 -cycloalkyl, phenyl optionally substituted by halogeno, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy and/or trifluoromethyl, or C.sub.7-10 -phenylalkyl optionally substituted in the phenyl moiety by halogeno, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy and/or trifluormethyl, and the other two are hydrogen, or salts thereof.These compounds have valuable pharmaceutical properties.
摘要翻译：其中R 1，R 2和R 3中的一个代表氢，C 1-8 - 烷基，C 3-6 - 环烷基，任选被卤素取代的苯基，C 1-4 - 烷基，C 1-4 - 烷氧基和/或三氟甲基，或在苯基部分任选被卤代，C 1-4 - 烷基，C 1-4 - 烷氧基和/或三氟甲基取代的C 7-10 - 苯基烷基，另外两个是氢或其盐。这些化合物具有有价值的药物性质。

6. 发明授权

US5340837A Benzophenonehydrazones 失效
标题翻译：二苯甲酮腙
公开(公告)号：US5340837A
公开(公告)日：1994-08-23
申请号：US83245
申请日：1993-06-25
申请人： Roger G. Hall , Alfons Pascual , Odd Kristiansen
发明人： Roger G. Hall , Alfons Pascual , Odd Kristiansen
IPC分类号： A01N33/26 , A01N35/02 , A01N41/04 , A01N41/06 , A01N43/30 , A01N47/02 , A01N47/12 , A01N47/40 , C07C251/86 , C07C251/88 , C07C255/61 , C07C255/66 , C07C307/06 , C07C309/65 , C07C309/66 , C07C311/05 , C07C311/51 , C07D317/46 , C07D307/87
CPC分类号： A01N43/30 , A01N35/02 , A01N41/04 , A01N41/06 , A01N47/02 , A01N47/12 , A01N47/40 , C07C251/86 , C07C307/06 , C07C309/65 , C07C309/66 , C07C311/51 , C07D317/46
摘要： Compounds of the formula ##STR1## wherein each of o and p, independently of the other, is 0, 1, 2, 3, 4 or 5, the radicals R.sub.1 being the same or different when o is greater than 1 and the radicals R.sub.2 being the same or different when p is greater than 1;each of R.sub.1 and R.sub.2, independently of the other, is C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, halogen, --NO.sub.2, --OH, C.sub.1 -C.sub.4 alkoxy, halo-C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, halo-C.sub.1 -C.sub.4 alkylthio, --O--S(.dbd.O)--R.sub.6, --O--S(.dbd.O).sub.2 --R.sub.6, phenoxy or --N(R.sub.11)SO.sub.2 R.sub.12 and/or two substituents R.sub.1 and/or two substituents R.sub.2 are, independently of one another, together --Y--Z--Y--;R.sub.3 is hydrogen, C.sub.1 -C.sub.4 alkyl or halo-C.sub.1 -C.sub.4 alkyl;R.sub.4 is hydrogen, C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, unsubstituted phenyl or naphthyl or mono- or di-substituted phenyl or naphthyl;R.sub.5 is --S--R.sub.7, --S(.dbd.O)--R.sub.7, --S(.dbd.O).sub.2 --R.sub.7, --NO.sub.2, --CN, --C(.dbd.O)--R.sub.8 or --C(.dbd.O)--OR.sub.8 ;R.sub.6 is C.sub.1 -C.sub.8 alkyl, or halo-C.sub.1 -C.sub.8 alkyl or phenyl;X is N or C(R.sub.9);each Y, independently of the other, is O or S; andZ is methylene, eth-1,2-ylene, halomethylene or haloeth-1,2-ylene;and the tautomers and salts thereof can be used as pesticidal compositions and can be prepared in a manner known per se.
摘要翻译：式（I）的化合物其中o和p各自独立地为0,1,2,3,4或5，当o大于1时，基团R 1相同或不同，并且当p大于1时，基团R2相同或不同; R 1和R 2各自独立地为C 1 -C 4烷基，卤代C 1 -C 4烷基，卤素，-NO 2，-OH，C 1 -C 4烷氧基，卤代C 1 -C 4烷氧基，C 1 -C 4烷硫基，卤代C 1 -C 4烷硫基， -OS（= O）-R6，-OS（= O）2 -R6，苯氧基或-N（R11）SO2R12和/或两个取代基R1和/或两个取代基R2彼此独立地是-YZY- ; R3是氢，C1-C4烷基或卤代-C1-C4烷基; R4是氢，C1-C4烷基，卤代C1-C4烷基，未取代的苯基或萘基或单或二取代的苯基或萘基; R5是-S-R7，-S（= O）-R7，-S（= O）2-R7，-NO2，-CN，-C（= O）-R8或-C（= O） R 6是C 1 -C 8烷基或卤代C 1 -C 8烷基或苯基; X为N或C（R9）; 每个Y独立于O或S; 并且Z是亚甲基，乙-1,2-亚烯基，卤代亚甲基或卤代乙烯基1,2-亚烯基; 并且其互变异构体和盐可以用作农药组合物，并且可以以本身已知的方式制备。

7. 发明授权

US5190933A Substituted propane-phosphinic acid compounds 失效
标题翻译：取代的丙烷 - 次膦酸化合物
公开(公告)号：US5190933A
公开(公告)日：1993-03-02
申请号：US845871
申请日：1992-03-03
申请人： Eric K. Baylis , Ludwig Maier , Stuart J. Mickel , Hans-Rudolf Olpe , Helmut Bittiger , Wolfgang Frostl , Roger G. Hall
发明人： Eric K. Baylis , Ludwig Maier , Stuart J. Mickel , Hans-Rudolf Olpe , Helmut Bittiger , Wolfgang Frostl , Roger G. Hall
IPC分类号： C07F9/30 , C07F9/48
CPC分类号： C07F9/48 , C07F9/301 , Y02P20/55
摘要： Compounds of the formula I ##STR1## wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen or, in the case of R.sup.1 and R.sup.2, is hydroxy, and the remaining one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen, or wherein R denotes methyl, R.sub.1 denotes hydrogen or hydroxy, R.sub.2 denotes an aromatic radical and R.sub.3 represents hydrogen, and their salts have GABA.sub.B -antagonistic properties and can be used as GABA.sub.B -antagonists. They are obtained when in a compound of formula II ##STR2## in which R, R.sup.1, R.sup.2 and R.sup.3 have their previous significances, Z represents --NH.sub.2 and R.sup.4 denotes a hydroxy-protective group R.sup.5 or, when R.sup.1 and R.sup.3 denote hydrogen and R.sup.2 denotes hydrogen or alkyl, denotes an alkali metal or ammonium ion R.sup.6, or Z represents a protected or latent amino group Z.sup.o and R.sup.4 denotes hydrogen or a hydroxy-protective group R.sup.5, any group R.sup.5 or R.sup.6 is replaced by hydrogen, and/or any group Z.sup.o is converted into --NH.sub.2.
摘要翻译：式I的化合物（I）其中R表示具有2个或更多个碳原子的脂族，脂环族，脂环族 - 脂族或芳脂族基团，其中R1，R2和R3中的一个表示氢或脂族，脂环族，芳脂族或芳族基团，R 1，R 2和R 3中的另一个为氢，或在R 1和R 2的情况下为羟基，其余的R 1，R 2和R 3为氢，或其中R为甲基，R 1为氢或羟基，R 2表示芳族基团，R 3表示氢，并且它们的盐具有GABAB拮抗性质，可用作GABAB-拮抗剂。当其中R，R 1，R 2和R 3具有其先前含义的式II化合物（II）时，它们是得到的，Z表示-NH 2，R4表示羟基保护基R5，或者当R1和R3表示氢和R2表示氢或烷基，表示碱金属或铵离子R6，或Z表示保护或潜在氨基Zo，R4表示氢或羟基保护基R5，任何基团R5或R6被氢代替，以及 /或任何基团Zo被转化为-NH 2。

8. 发明授权

US5004826A Substituted propane-phosphonous acid compounds 失效
标题翻译：取代的丙烷 - 膦酸化合物
公开(公告)号：US5004826A
公开(公告)日：1991-04-02
申请号：US444466
申请日：1989-12-01
申请人： John G. Dingwall , Josef Ehrenfreund , Roger G. Hall , James Jack
发明人： John G. Dingwall , Josef Ehrenfreund , Roger G. Hall , James Jack
IPC分类号： C07F9/38 , A61K31/66 , A61P21/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P25/28 , C07F9/32 , C07F9/40 , C07F9/48
CPC分类号： C07F9/48 , C07F9/3211 , C07F9/4816
摘要： The compounds of the formula ##STR1## in which one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1-8 -alkyl, C.sub.3-6 -cycloalkyl, phenyl optionally substituted by halogeno, C.sub. 1-4 -alkyl, C.sub. -4 -alkoxy and/or trifluoromethyl, or C.sub.7-10 -phenylalkyl optionally substituted in the phenyl moiety by halogeno, C.sub.1-4 -alkyl C.sub.1-4 -alkoxy and/or trifluormethyl, and the other two are hydrogen, or salts thereof.These compounds have valuable pharmaceutical properties.

9. 发明授权

US5567840A Substituted aminoalkylphosphinic acids 失效
标题翻译：取代的氨基烷基次膦酸
公开(公告)号：US5567840A
公开(公告)日：1996-10-22
申请号：US461090
申请日：1995-06-05
申请人： Roger G. Hall , Ludwig Maier , Wolfgang Frostl
发明人： Roger G. Hall , Ludwig Maier , Wolfgang Frostl
IPC分类号： C07F9/30
CPC分类号： C07F9/301
摘要： P-substituted aminoalkylphosphinic acids of the formula ##STR1## wherein R denotes an optionally fluorinated methyl group, R.sub.1 denotes hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or a fluorinated methyl group and R.sub.2 and R.sub.3 denote hydrogen or R.sub.2 denotes hydroxy, lower alkoxy or halogen and R.sub.3 is hydrogen or R.sub.2 and R.sub.3 together represent an oxo group, and their pharmaceutically acceptable salts are active as GABA.sub.B -agonists and can be used in the treatment of spinal spasticity, multiple sclerosis and cerebral palsy, trigeminus neuralgia, drug withdrawal syndromes and/or conditions of pain. They can be manufactured by methods known per se and suitable such methods are described.
摘要翻译：式（I）的P取代氨基烷基次膦酸其中R表示任意氟化的甲基，R 1表示氢，低级烷基，低级烷氧基，羟基，卤素或氟化甲基，R 2和R 3表示氢或R 2表示羟基，低级烷氧基或卤素，R 3是氢或R 2和R 3一起代表氧基，其药学上可接受的盐作为GABAB-激动剂是有活性的，可用于治疗脊柱痉挛，多发性硬化和脑性麻痹，三叉神经痛神经痛戒毒综合征和/或疼痛状况。它们可以通过本身已知的方法制造，并且描述合适的这种方法。

10. 发明授权

US5300679A Substituted propane-phosphinic acid compounds 失效
标题翻译：取代的丙烷 - 次膦酸化合物
公开(公告)号：US5300679A
公开(公告)日：1994-04-05
申请号：US968101
申请日：1992-10-29
申请人： Eric K. Baylis , Helmut Bittiger , Wolfgang Frostl , Roger G. Hall , Ludwig Maier , Stuart J. Mickel , Hans-Rudolf Olpe
发明人： Eric K. Baylis , Helmut Bittiger , Wolfgang Frostl , Roger G. Hall , Ludwig Maier , Stuart J. Mickel , Hans-Rudolf Olpe
IPC分类号： C07F9/30 , C07F9/48 , A61K31/13 , A61K31/185
CPC分类号： C07F9/301 , C07F9/48 , Y02P20/55
摘要： Compounds of the formula I ##STR1## wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen or, in the case of R.sup.1 and R.sup.2, is hydroxy, and the remaining one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen, or wherein R denotes methyl, R.sub.1 denotes hydrogen or hydroxy, R.sub.2 denotes an aromatic radical and R.sub.3 represents hydrogen, and their salts have GABA.sub.B -antagonistic properties and can be used as GABA.sub.B -antagonists. They are obtained when in a compound of formula II ##STR2## in which R, R.sup.1, R.sup.2 and R.sup.3 have their previous significances, Z represents --NH.sub.2 and R.sup.4 denotes a hydroxy-protective group R.sup.5 or, when R.sup.1 and R.sup.3 denote hydrogen and R.sup.2 denotes hydrogen or alkyl, denotes an alkali metal or ammonium ion R.sup.6, or Z represents a protected or latent amino group Z.sup.o and R.sup.4 denotes hydrogen or a hydroxy-protective group R.sup.5, any group R.sup.5 or R.sup.6 is replaced by hydrogen, and/or any group Z.sup.o is converted into --NH.sub.2.
摘要翻译：式I的化合物（I）其中R表示具有2个或更多个碳原子的脂族，脂环族，脂环族 - 脂族或芳脂族基团，其中R1，R2和R3中的一个表示氢或脂族，脂环族，芳脂族或芳族基团，R 1，R 2和R 3中的另一个为氢，或在R 1和R 2的情况下为羟基，其余的R 1，R 2和R 3为氢，或其中R为甲基，R 1为氢或羟基，R 2表示芳族基团，R 3表示氢，并且它们的盐具有GABAB拮抗性质，可用作GABAB-拮抗剂。当其中R，R 1，R 2和R 3具有其先前含义的式II化合物（II）时，它们是得到的，Z表示-NH 2，R4表示羟基保护基R5，或者当R1和R3表示氢和R2表示氢或烷基，表示碱金属或铵离子R6，或Z表示保护或潜在氨基Zo，R4表示氢或羟基保护基R5，任何基团R5或R6被氢代替，以及 /或任何基团Zo被转化为-NH 2。

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