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1. 发明授权

US4361032A Apparatus for measuring surface tension 失效
标题翻译：用于测量表面张力的装置
公开(公告)号：US4361032A
公开(公告)日：1982-11-30
申请号：US186696
申请日：1980-09-12
申请人： Werner Lessnig , Gunter Metz , Willi Spiegel , Manfred Faust , Gunter Junkers
发明人： Werner Lessnig , Gunter Metz , Willi Spiegel , Manfred Faust , Gunter Junkers
IPC分类号： G01N13/02
CPC分类号： G01N13/02 , G01N2013/0241
摘要： An apparatus for automatically determining the surface tension by the stalagmometer principle using a pipette containing a test volume, having a drop face at its lower end and is provided with three light barriers. The three light barriers are connected to an evaluation circuit which counts the number of whole drops and also determines the fractions of whole drops pertaining to the test volume.
摘要翻译：一种用于通过使用含有测试体积的移液管通过测压仪原理来自动确定表面张力的装置，在其下端具有滴面并设置有三个光栅。三个光栅连接到评估电路，该评估电路对整个液滴的数量进行计数，并且还确定与测试体积有关的整个液滴的分数。

2. 发明授权

US4096965A Storage device for sample containers 失效
标题翻译：样品容器的储存装置
公开(公告)号：US4096965A
公开(公告)日：1978-06-27
申请号：US724199
申请日：1976-09-17
申请人： Werner Lessnig , Gunter Metz , Willi Spiegel , Jurgen Fleischer
发明人： Werner Lessnig , Gunter Metz , Willi Spiegel , Jurgen Fleischer
IPC分类号： G01N35/02 , B01L3/14 , B01L9/06 , A47B73/00 , B65D53/00
CPC分类号： B01L3/50825 , B01L9/06
摘要： A device for the storage of sample containers comprises a holder for receiving the sample containers and a covering, whereby a common covering is provided for all the sample containers which seals them individually and simultaneously.
摘要翻译：用于储存样品容器的装置包括用于接收样品容器和覆盖物的保持器，由此为所有样品容器提供共同的覆盖物，所述样品容器单独并同时密封。

3. 发明授权

US4980498A Method of producing 2-(2-hydroxyethoxy)-ethanol ester of flufenamic acid 失效
标题翻译：制备氟芬那酸的2-（2-羟基乙氧基） - 乙醇酯的方法
公开(公告)号：US4980498A
公开(公告)日：1990-12-25
申请号：US331125
申请日：1989-03-31
申请人： Gunter Metz
发明人： Gunter Metz
IPC分类号： C07B61/00 , C07C20060101 , C07C227/18 , C07C229/00 , C07C229/56 , C07C229/58
CPC分类号： C07C227/18
摘要： By using a new method 2-(2-hydroxyethoxy)-ethanol ester is produced from flufenamic acid as a result of direct esterification with diol with an excess of 8-15 mol diol per mol flufenamic acid without concurrent removal of water.
摘要翻译：通过使用新的方法，2-（2-羟基乙氧基） - 乙醇酯是由氟芬那酸生产的，因为与二醇与过量的8-15mol二醇/ mol氟芬那酸直接酯化而不同时除去水。

4. 发明授权

US4960793A Diethylene glycol monoester derivatives, compositions and therapeutic use 失效
标题翻译：二甘醇单酯衍生物，组合物和治疗用途
公开(公告)号：US4960793A
公开(公告)日：1990-10-02
申请号：US331124
申请日：1989-03-31
申请人： Gunter Metz , Kurt Rauchle , Manfred Erdmann
发明人： Gunter Metz , Kurt Rauchle , Manfred Erdmann
IPC分类号： A61K31/215 , A61K31/415 , A61P29/00 , C07C69/003 , C07C69/612 , C07C69/65 , C07C69/738 , C07C227/18 , C07C229/36 , C07C229/42 , C07D231/12
CPC分类号： C07D231/12 , C07C229/42
摘要： Novel diethylene glycol monoester of antirheumatically effective acids, e.g., lonazolac and diclofenac and others are disclosed which have inflammation inhibitory properties superior to the corresponding acid base forms. They may be produced through direct esterification without elimination of water and are suitable in the fight against diseases of the rheumatic complex.
摘要翻译：公开了具有优于相应的酸碱形式的抗炎性有效酸的新型二乙二醇单酯，例如，咪唑烷和双氯芬酸等。它们可以通过直接酯化而不消除水而生产，并且适用于抗风湿复合物的疾病。

5. 发明授权

US4505914A Pharmaceutical for the treatment of sleep disorders 失效
标题翻译：用于治疗睡眠障碍的药物
公开(公告)号：US4505914A
公开(公告)日：1985-03-19
申请号：US518394
申请日：1983-07-29
申请人： Gunter Metz , Kurt Rauchle
发明人： Gunter Metz , Kurt Rauchle
IPC分类号： A61K31/495 , A61K31/515 , A61P25/20
CPC分类号： A61K31/515
摘要： At least one barbiturate or one of its pharmaceutically acceptable salts is combined with cinnarizine or flunarizine or one of their pharmaceutically acceptable salts to provide a hypnotic requiring lower dosages of barbiturates to produce the same effect as the barbiturate alone.
摘要翻译：将至少一种巴比妥酸盐或其药学上可接受的盐之一与肉桂酸或氟桂利嗪或其药学上可接受的盐之一组合以提供催眠剂，其需要较低剂量的巴比妥酸盐以产生与单独的巴比妥酸盐相同的效果。

6. 发明授权

US3984413A Phenoxyalkanecarboxylic acid esters of hydroxyalkyltheophyllines and method for their manufacture 失效
标题翻译：羟烷基茶碱的苯氧基羧酸酯及其制备方法
公开(公告)号：US3984413A
公开(公告)日：1976-10-05
申请号：US444666
申请日：1974-02-21
申请人： Gunter Metz , Manfred Specker
发明人： Gunter Metz , Manfred Specker
IPC分类号： C07D473/08
CPC分类号： C07D473/08 , Y10S514/929
摘要： Phenoxyalkanecarboxylic acids are esterified with 7-(2-hydroxyethyl) theophylline or 7-(2,3-dihydroxypropyl) theophylline. The resulting esters have excellent antilipemic and anticholesterolemic properties as well as pronounced peripheral and vasodilative effect.
摘要翻译：苯氧基羧酸与7-（2-羟乙基）茶碱或7-（2,3-二羟丙基）茶碱酯化。所得酯具有优异的抗血脂和抗胆固醇性质以及显着的外周血管扩张作用。

7. 发明授权

US4593044A Injectable solution for the treatment of inflammations 失效
标题翻译：注射用于治疗炎症的溶液
公开(公告)号：US4593044A
公开(公告)日：1986-06-03
申请号：US636333
申请日：1984-07-31
申请人： Gunter Metz
发明人： Gunter Metz
IPC分类号： A61K31/205 , A61K9/08 , A61P29/00 , C07C59/64 , C07C59/84 , A61K31/19 , A61K31/13 , A61K31/195
CPC分类号： C07C59/84 , C07C59/64
摘要： The invention relates to the use of naproxen lysinate, ketoprofen lysinate and/or diclofenac lysinate in the form of an injectable solution in the treatment of inflammations and rheumatic disorders, and to injectable solutions containing the anti-inflammatory active compound naproxen, ketoprofen or diclofenac in the form of its lysinate.
摘要翻译：本发明涉及萘普生裂解物，酮洛芬裂解物和/或双氯芬酸裂解物在注射用溶液形式中的用途，用于治疗炎症和风湿性疾病，以及含有抗炎活性化合物萘普生，酮洛芬或双氯芬酸的可注射溶液在其裂解物的形式。

8. 发明授权

US4294851A Aminobenzoic acid derivatives 失效
标题翻译：氨基苯甲酸衍生物
公开(公告)号：US4294851A
公开(公告)日：1981-10-13
申请号：US919747
申请日：1978-06-27
申请人： Gunter Metz , Manfred Specker
发明人： Gunter Metz , Manfred Specker
IPC分类号： C07D207/09 , C07D213/40 , C07D213/80 , C07D239/90 , C07D295/13 , C07D295/192 , A61K31/17 , A61K31/165 , C07C101/00 , C07C103/78
CPC分类号： C07D213/40 , C07D207/09 , C07D213/80 , C07D239/90 , C07D295/13 , C07D295/192 , Y10S514/821
摘要： The object of the present invention are novel aminobenzoic acid derivatives having the general formula: ##STR1## wherein R.sub.1 is hydrogen, chlorine, hydroxy, acetoxy or C.sub.1 -C.sub.3 -alkoxy;R.sub.2 is hydrogen, chlorine or sulfamoyl;R.sub.5 is hydrogen or combined with R.sub.6 a C.sub.2 -C.sub.3 -alkylene;Y is the group ##STR2## or in ortho-position together with the hydrogen atom on the nitrogen and with R.sub.5 the group ##STR3## wherein R.sub.3 is hydrogen or methyl;R.sub.4 is hydrogen, C.sub.1 -C.sub.3 -alkyl, or with Z substituted phenoxy; andZ is hydrogen, halogen or trifluoromethyl;X is C.sub.1 -C.sub.3 -alkylene forming, if necessary, under substitution with R.sub.6 a 5- or 6-link aliphatic or aromatic ring system;R.sub.6 is C.sub.1 -C.sub.4 -alkyl or in combination with X a C.sub.3 -C.sub.4 -cycloalkylene or cycloarylene;R.sub.7 is hydrogen, C.sub.1 -C.sub.3 -alkyl, formyl, the group Y, or together with R.sub.6 a C.sub.4 -C.sub.5 -cycloalkylene, or together with X and R.sub.6 pyridylmethyl;R.sub.8 is hydrogen or, if necessary, halogen- or phenyl-substituted C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkenyl; andn has the value 0 or 1,and if n=1, their salts with pharmaceutically compatible acid radicals.Said compounds show antilipemic activity.The present invention relates furthermore to the preparation of said compounds and of drugs containing such compounds.
摘要翻译：本发明的目的是具有以下通式的新的氨基苯甲酸衍生物：其中R 1是氢，氯，羟基，乙酰氧基或C 1 -C 3 - 烷氧基; R2是氢，氯或氨磺酰; R5是氢或R6与C2-C3-亚烷基结合; Y是基团或与氮原子上的氢原子一起在邻位置，R5是基团，其中R3是氢或甲基; R4是氢，C1-C3-烷基或与Z取代的苯氧基; Z是氢，卤素或三氟甲基; 如果需要，X是C 1 -C 3 - 亚烷基，用R 6取代为5-或6-连接的脂族或芳族环系; R6是C1-C4-烷基或与X一个C3-C4-亚环烷基或环亚芳基组合; R 7为氢，C 1 -C 3 - 烷基，甲酰基，Y基团，或与R6一起为C4-C5-亚环烷基，或与X和R6吡啶基甲基一起; R8是氢或必要时卤素或苯基取代的C 1 -C 4 - 烷基或C 1 -C 4 - 烯基; 并且n具有0或1的值，并且如果n = 1，则其与药学上相容的酸基的盐。所述化合物显示抗血脂活性。本发明还涉及所述化合物和含有这些化合物的药物的制备。

9. 发明授权

US4146637A Anti-inflammatory N-acyl substituted benzamides 失效
标题翻译：抗炎剂N-取代的苯甲酸
公开(公告)号：US4146637A
公开(公告)日：1979-03-27
申请号：US799166
申请日：1977-05-23
申请人： Gunter Metz , Manfred Specker
发明人： Gunter Metz , Manfred Specker
IPC分类号： C07D213/82 , A61K31/165 , A61K31/17 , C07C101/00 , C07C103/78
CPC分类号： C07D213/82
摘要： There are disclosed N-acyl substituted benzamides of the general formula: ##STR1## wherein: X is carbon or nitrogen;R.sub.1 is hydrogen, alkyl, halogen, trifluoromethyl, alkoxy, phenoxy or acetoxy;Y is the radical --O--, --NH-- or --S--;Z is an alkylene group containing 1 to 5 carbon atoms, or an alkenylene group containing 1 to 5 carbon atoms, either of which group may be unsubstituted or substituted by an alkyl, alkenyl, phenyl, cycloalkyl, acetyl, amino or halogenphenoxy group;R.sub.2 is hydrogen, an alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 1 to 4 carbon atoms in which either the alkyl or the alkenyl group may be unsubstituted or substituted with a halogen, phenyl or halogenphenyl substituent; andThe value of n, m, and p may each be 0 or 1, and in the case of p=1, pharmaceutically acceptable salts thereof.Also disclosed is a method for making such compounds and pharmaceutical compositions containing such compounds.

10. 发明授权

US4073918A Phenoxyalkylcarboxylic acid amides of substituted thiazolidinecarboxylic acids and their utilization in medicaments 失效
标题翻译：取代噻唑烷羧酸的苯氧基烷基羧酸酰胺及其在药物中的应用
公开(公告)号：US4073918A
公开(公告)日：1978-02-14
申请号：US616890
申请日：1975-09-25
申请人： Gunter Metz , Manfred Specker
发明人： Gunter Metz , Manfred Specker
IPC分类号： C07D277/06 , C07D277/60 , A61K31/425
CPC分类号： C07D277/60 , C07D277/06
摘要： Phenoxyalkylcarboxylic acid amides and their preparation is described. These compounds are useful as antihypercholesteremic agents.
摘要翻译：描述了苯氧基烷基羧酸酰胺及其制备方法。这些化合物可用作抗胆固醇血症药。

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