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1. 发明授权

US08811145B2 Detection method and apparatus for multiple-input multiple-output single carrier block transmission system 有权
标题翻译：多输入多输出单载波传输系统的检测方法和装置
公开(公告)号：US08811145B2
公开(公告)日：2014-08-19
申请号：US13544640
申请日：2012-07-09
申请人： Wenjin Wang , Shaoqing Chen , Xiqi Gao , Long Qin , Dongming Wang
发明人： Wenjin Wang , Shaoqing Chen , Xiqi Gao , Long Qin , Dongming Wang
IPC分类号： H04J11/00
CPC分类号： H04B7/0413 , H04L25/03019
摘要： The present invention discloses a detection method, a receiver, and an apparatus in a multiple-input multiple-output single-carrier block transmission system. Through sorted QR decomposition (Sorted QR Decomposition, SQRD) decomposition based on a minimum mean squared error (Minimum Mean Squared Error, MMSE) criterion, an matrix inverse operation in minimum mean squared error equalization is avoided, and complexity is significantly reduced. In addition, through layer-by-layer soft interference cancellation detection after the SQRD decomposition and further iterative processing, better detection performance may be obtained. Especially, inter-stream interference suppression may be performed in first iteration. Compared with a conventional parallel iterative soft interference cancellation detection algorithm, with the same number of times of iteration, especially under the limit that a receiver can only support a small number of times of iteration, the inter-stream interference suppression has more evident advantages, and an advantage in the aspect of cost performance is very obvious.
摘要翻译：本发明公开了一种多输入多输出单载波块传输系统中的检测方法，接收机和装置。通过基于最小均方误差（Minimum Mean Squared Error，MMSE）标准的QR码分解（QRD分解，SQRD）分解，避免了最小均方误差均衡中的矩阵逆运算，复杂度显着降低。另外，通过SQRD分解和进一步迭代处理后的逐层软干扰消除检测，可以获得更好的检测性能。特别地，可以在第一次迭代中执行流间干扰抑制。与传统的并行迭代软干扰消除检测算法相比，具有相同的迭代次数，特别是在接收机只能支持少量迭代的限制下，流间干扰抑制具有更明显的优点，而在性能方面的优势非常明显。

2. 发明申请

US20120327757A1 DETECTION METHOD AND APPARATUS FOR MULTIPLE-INPUT MULTIPLE-OUTPUT SINGLE-CARRIER BLOCK TRANSMISSION SYSTEM 有权
标题翻译：多输入多输出单载波传输系统的检测方法及装置
公开(公告)号：US20120327757A1
公开(公告)日：2012-12-27
申请号：US13544640
申请日：2012-07-09
申请人： Wenjin WANG , Shaoqing Chen , Xiqi Gao , Long Qin , Dongming Wang
发明人： Wenjin WANG , Shaoqing Chen , Xiqi Gao , Long Qin , Dongming Wang
IPC分类号： H04B15/00 , H04J11/00 , H04L27/01
CPC分类号： H04B7/0413 , H04L25/03019
摘要： The present invention discloses a detection method, a receiver, and an apparatus in a multiple-input multiple-output single-carrier block transmission system. Through sorted QR decomposition (Sorted QR Decomposition, SQRD) decomposition based on a minimum mean squared error (Minimum Mean Squared Error, MMSE) criterion, an matrix inverse operation in minimum mean squared error equalization is avoided, and complexity is significantly reduced. In addition, through layer-by-layer soft interference cancellation detection after the SQRD decomposition and further iterative processing, better detection performance may be obtained. Especially, inter-stream interference suppression may be performed in first iteration. Compared with a conventional parallel iterative soft interference cancellation detection algorithm, with the same number of times of iteration, especially under the limit that a receiver can only support a small number of limes of iteration, the inter-stream interference suppression has more evident advantages, and an advantage in the aspect of cost performance is very obvious.
摘要翻译：本发明公开了一种多输入多输出单载波块传输系统中的检测方法，接收机和装置。通过基于最小均方误差（Minimum Mean Squared Error，MMSE）标准的QR码分解（QRD分解，SQRD）分解，避免了最小均方误差均衡中的矩阵逆运算，复杂度显着降低。另外，通过SQRD分解和进一步迭代处理后的逐层软干扰消除检测，可以获得更好的检测性能。特别地，可以在第一次迭代中执行流间干扰抑制。与传统的并行迭代软干扰消除检测算法相比，具有相同的迭代次数，特别是在接收机只能支持少量迭代的限制下，流间干扰抑制具有更明显的优点，而在性能方面的优势非常明显。

3. 发明申请

US20090170920A1 SUBSTITUTED HYDANTOINS 失效
标题翻译：取代的HYDANTOINS
公开(公告)号：US20090170920A1
公开(公告)日：2009-07-02
申请号：US12331538
申请日：2008-12-10
申请人： Shaoqing Chen , Nicholas J.S. Huby , Norman Kong , Jonh Anthony Moliterni , Omar Jose Morales
发明人： Shaoqing Chen , Nicholas J.S. Huby , Norman Kong , Jonh Anthony Moliterni , Omar Jose Morales
IPC分类号： A61K31/4166 , C07D403/06 , A61P35/00
CPC分类号： C07D233/74 , C07D233/78 , C07D417/14
摘要： The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
摘要翻译：本发明涉及其制备方法的化合物及其使用方法。该化合物可用于治疗以MEK多动症为特征的疾病。因此，该化合物可用于治疗诸如癌症，认知和CNS疾病以及炎性/自身免疫性疾病的疾病。

4. 发明申请

US20090048452A1 SUBSTITUTED HYDANTOINS 失效
标题翻译：取代的HYDANTOINS
公开(公告)号：US20090048452A1
公开(公告)日：2009-02-19
申请号：US12186648
申请日：2008-08-06
申请人： Shaoqing Chen , Nicholas J.S. Huby , Norman Kong , John Anthony Moliterni , Omar Jose Morales
发明人： Shaoqing Chen , Nicholas J.S. Huby , Norman Kong , John Anthony Moliterni , Omar Jose Morales
IPC分类号： C07D403/06 , C07D409/14
CPC分类号： C07D403/06
摘要： This invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof,wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit the enzymes MEK 1 and MEK2, protein kinases that are components of the MAP kinase signal transduction pathway and as such the compounds will have anti-hyperproliferative cellular activity.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中本申请中描述了R1，R2，R3，R4，R5和R6。这些化合物抑制作为MAP激酶信号转导途径成分的蛋白激酶MEK1和MEK2，因此这些化合物将具有抗过度增殖的细胞活性。

5. 发明申请

US20050113407A1 Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors 失效
标题翻译：谷氨酰胺果糖-γ-磷酸酰胺转移酶（GFAT）抑制剂
公开(公告)号：US20050113407A1
公开(公告)日：2005-05-26
申请号：US10961906
申请日：2004-10-12
申请人： David Bolin , Shaoqing Chen , Steven Mischke , Yimin Qian
发明人： David Bolin , Shaoqing Chen , Steven Mischke , Yimin Qian
IPC分类号： A61K31/47 , A61K31/4709 , C07D217/12 , C07D217/22 , C07D217/26 , C07D401/04 , C07D401/14
CPC分类号： C07D217/26 , C07D401/04
摘要： Compounds of formula (I) are provided, wherein R1 and R2 are as designated in the specification. The compounds have utility for the treatment of type 2 diabetes mellitus.
摘要翻译：提供式（I）化合物，其中R 1和R 2如本说明书中所指出。该化合物可用于治疗2型糖尿病。

6. 发明申请

US20090318408A1 HALO-SUBSTITUTED PYRIMIDODIAZEPINES 失效
标题翻译： HALO取代的吡咯烷酮
公开(公告)号：US20090318408A1
公开(公告)日：2009-12-24
申请号：US12485108
申请日：2009-06-16
申请人： Jianping Cai , Shaoqing Chen , Xin-Jie Chu , Kin-Chun Luk , Steven Gregory Mischke , Hongmao Sun , Peter Michael Wovkulich
发明人： Jianping Cai , Shaoqing Chen , Xin-Jie Chu , Kin-Chun Luk , Steven Gregory Mischke , Hongmao Sun , Peter Michael Wovkulich
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides PLK1 inhibitor compounds of formula I: useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.
摘要翻译：本发明提供式I的PLK1抑制剂化合物：可用于治疗或控制细胞增殖性疾病，特别是肿瘤疾病。含有这些化合物的这些化合物和制剂可用于治疗或控制实体瘤，例如乳腺癌，结肠癌，肺癌和前列腺肿瘤以及其它肿瘤疾病如非霍奇金淋巴瘤。还提供了可用于合成式I化合物的中间体化合物。

7. 发明授权

US07557221B2 Substituted hydantoins 失效
标题翻译：取代乙内酰脲
公开(公告)号：US07557221B2
公开(公告)日：2009-07-07
申请号：US12186648
申请日：2008-08-06
申请人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , John Anthony Moliterni , Omar Jose Morales
发明人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , John Anthony Moliterni , Omar Jose Morales
IPC分类号： A61K31/4184 , C07D403/06
CPC分类号： C07D403/06
摘要： This invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit the enzymes MEK 1 and MEK2, protein kinases that are components of the MAP kinase signal transduction pathway and as such the compounds will have anti-hyperproliferative cellular activity.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中本申请中描述了R1，R2，R3，R4，R5和R6。这些化合物抑制作为MAP激酶信号转导途径成分的蛋白激酶MEK1和MEK2，因此这些化合物将具有抗过度增殖的细胞活性。

8. 发明申请

US20080234255A1 SUBSTITUTED PYRIMIDODIAZEPINES 失效
标题翻译：取代的吡咯烷酮
公开(公告)号：US20080234255A1
公开(公告)日：2008-09-25
申请号：US12051000
申请日：2008-03-19
申请人： Shaoqing Chen
发明人： Shaoqing Chen
IPC分类号： A61K31/551 , C07D487/04 , C07C69/608
CPC分类号： C07D487/04 , C07D471/18 , C07D487/18
摘要： The present invention provides PLK1 inhibitor compounds of formula I: Useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas.
摘要翻译：本发明提供式I的PLK1抑制剂化合物：可用于治疗或控制细胞增殖性疾病，特别是肿瘤疾病。含有这些化合物的这些化合物和制剂可用于治疗或控制实体瘤，例如乳腺癌，结肠癌，肺癌和前列腺肿瘤以及其它肿瘤疾病如非霍奇金淋巴瘤。

9. 发明申请

US20060084804A1 Quinazoline thiazolinones 失效
公开(公告)号：US20060084804A1
公开(公告)日：2006-04-20
申请号：US11244028
申请日：2005-10-05
申请人： Li Chen , Shaoqing Chen , Jin-Jun Liu
发明人： Li Chen , Shaoqing Chen , Jin-Jun Liu
IPC分类号： C07D417/02
CPC分类号： C07D417/14 , C07D417/06
摘要： Quinazoline thiazolinone derivatives which demonstrate CDK1 antiproliferative activity and are useful as anti-cancer agents.

10. 发明申请

US20060063805A1 Thiazolinone 4-monosubstituted quinolines 失效
标题翻译：噻唑啉酮4-单取代喹啉
公开(公告)号：US20060063805A1
公开(公告)日：2006-03-23
申请号：US11214153
申请日：2005-08-29
申请人： Li Chen , Shaoqing Chen , Jianping Lou , Achyutharao Sidduri
发明人： Li Chen , Shaoqing Chen , Jianping Lou , Achyutharao Sidduri
IPC分类号： A61K31/4709 , C07D417/02
CPC分类号： C07D417/06 , C07D417/14
摘要： Thiazolinone monosubstituted quinoline derivatives where the quinoline ring is mono-substituted at the 4 positions which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents.
摘要翻译：噻唑啉酮单取代喹啉衍生物，其中喹啉环在4位被单取代，该衍生物表现出CDK1抗增殖活性并且可用作抗癌剂。

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