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1. 发明授权

US08975447B2 Process for asymetric methylallylation in the presence of a 2,2′-substituted 1,1′-BI-2-naphthol catalyst 有权
标题翻译：在2,2'-取代的1,1'-二-2-萘酚催化剂的存在下进行不对称甲基化反应的方法
公开(公告)号：US08975447B2
公开(公告)日：2015-03-10
申请号：US14003248
申请日：2012-03-06
申请人： Wenjie Li , Zhi-Hui Lu , Chris Hugh Senanayake , Yongda Zhang
发明人： Wenjie Li , Zhi-Hui Lu , Chris Hugh Senanayake , Yongda Zhang
IPC分类号： C07C33/48 , C07C39/38 , C07C29/38 , C07C29/40 , C07C39/14 , C07C37/055 , C07C41/48 , C07C29/143 , C07C37/62
CPC分类号： C07C39/14 , C07B2200/07 , C07C29/143 , C07C29/38 , C07C37/055 , C07C37/62 , C07C39/38 , C07C41/48 , C07C43/313 , C07C33/483
摘要： Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X1, X2, R3 and R4 are as defined herein. Compounds made by the process of the invention can be used to prepare pharmaceutically active compounds such as 11-β-hydroxysteroid hydrogenase type 1 (11-β-HSD1) inhibitors including 1,3-disubstituted oxazinan-2-ones.
摘要翻译：公开了用于进行不对称甲基化反应的方法和催化剂。用于本发明的催化剂具有式（Ⅳ）：其中X 1，X 2，R 3和R 4如本文所定义。通过本发明的方法制备的化合物可用于制备药物活性化合物，例如11-＆bgr-羟基类固醇氢化酶1型（11-＆amp; bgr-HSD1）抑制剂，包括1,3-二取代的恶嗪烷-2-酮。

2. 发明申请

US20140171692A1 PROCESS FOR ASYMETRIC METHYLALLYLATION IN THE PRESENCE OF A 2,2'-SUBSTITUTED 1,1'-BI -2-NAPHTHOL CATALYST 有权
标题翻译：在2,2'-取代的1,1'-二-2-萘基催化剂存在下进行异亚甲基化的方法
公开(公告)号：US20140171692A1
公开(公告)日：2014-06-19
申请号：US14003248
申请日：2012-03-06
申请人： Wenjie Li , Zhi-Hui Lu , Chris Hugh Senanayake , Yongda Zhang
发明人： Wenjie Li , Zhi-Hui Lu , Chris Hugh Senanayake , Yongda Zhang
IPC分类号： C07C39/14 , C07C37/62 , C07C29/143
CPC分类号： C07C39/14 , C07B2200/07 , C07C29/143 , C07C29/38 , C07C37/055 , C07C37/62 , C07C39/38 , C07C41/48 , C07C43/313 , C07C33/483
摘要： Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X1, X2, R3 and R4 are as defined herein. Compounds made by the process of the invention can be used to prepare pharmaceutically active compounds such as 11-β-hydroxysteroid hydrogenase type 1 (11-β-HSD1) inhibitors including 1,3-disubstituted oxazinan-2-ones.
摘要翻译：公开了用于进行不对称甲基化反应的方法和催化剂。用于本发明的催化剂具有式（Ⅳ）：其中X 1，X 2，R 3和R 4如本文所定义。通过本发明的方法制备的化合物可用于制备药物活性化合物，例如11-＆bgr-羟基类固醇氢化酶1型（11-＆amp; bgr-HSD1）抑制剂，包括1,3-二取代的恶嗪烷-2-酮。

3. 发明授权

US08487094B2 Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 有权
标题翻译：合成11β-羟基类固醇脱氢酶抑制剂1型
公开(公告)号：US08487094B2
公开(公告)日：2013-07-16
申请号：US13054959
申请日：2009-07-23
申请人： Keith R. Fandrick , Joe Ju Gao , Wenjie Li , Zhi-Hui Lu , Yongda Zhang
发明人： Keith R. Fandrick , Joe Ju Gao , Wenjie Li , Zhi-Hui Lu , Yongda Zhang
IPC分类号： C07D265/10 , C07D413/06
CPC分类号： C07D265/10 , C07D413/06 , C07D413/10
摘要： Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).
摘要翻译：公开了11beta-HSD1抑制剂和相应的中间体的合成，其有希望用于治疗各种疾病状态，包括糖尿病，代谢综合征，肥胖症，葡萄糖不耐症，胰岛素抵抗，高血糖症，高血压，高血压相关心血管疾病，高脂血症，有害的葡萄糖 - 皮质激素对神经元功能的影响（例如认知障碍，痴呆和/或抑郁），眼内压升高，各种形式的骨疾病（如骨质疏松症），结核病，麻风病（汉森氏病），牛皮癣和伤口受损愈合（例如，在葡萄糖耐量异常和/或2型糖尿病患者中）。

4. 发明申请

US20110269957A1 SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 有权
标题翻译： 11BETA-羟基脱氢酶脱氢酶抑制剂的合成
公开(公告)号：US20110269957A1
公开(公告)日：2011-11-03
申请号：US13054959
申请日：2009-07-23
申请人： Keith R. Fandrick , Joe Ju Gao , Wenjie Li , Zhi-Hui Lu , Yongda Zhang
发明人： Keith R. Fandrick , Joe Ju Gao , Wenjie Li , Zhi-Hui Lu , Yongda Zhang
IPC分类号： C07D413/10 , C07D265/10
CPC分类号： C07D265/10 , C07D413/06 , C07D413/10
摘要： Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).
摘要翻译：公开了11和b-HSD1抑制剂和相应的中间体的合成，其有希望用于治疗各种疾病状态，包括糖尿病，代谢综合征，肥胖症，葡萄糖不耐症，胰岛素抵抗，高血糖症，高血压，高血压相关心血管疾病，高脂血症，有害的葡萄糖 - 皮质激素对神经元功能的影响（例如认知障碍，痴呆和/或抑郁），眼内压升高，各种形式的骨病（例如骨质疏松症），结核病，麻风病（汉森氏病），牛皮癣和受损伤口愈合（例如，在葡萄糖耐量异常和/或2型糖尿病患者中）。

5. 发明授权

US12098815B2 Headlamp light-sensing detection device, and headlamp 有权
公开(公告)号：US12098815B2
公开(公告)日：2024-09-24
申请号：US18309574
申请日：2023-04-28
申请人： Wenjie Li
发明人： Wenjie Li
IPC分类号： B60Q1/00 , F21S41/143 , F21S41/27 , F21S41/65 , F21V23/04 , F21V31/00
CPC分类号： F21S41/27 , F21S41/143 , F21S41/65 , F21V23/0464 , F21V31/005
摘要： Disclosed are a headlamp light-sensing detection device and a headlamp. The headlamp light-sensing detection device includes a condensing lens, a lens hood and a light-sensing element. The condensing lens is arranged in front of the light-sensing element, to converge external light to the light-sensing element. The lens hood is arranged between the light-sensing element and the condensing lens, and may be configured to shield the light which is projected to the light-sensing element by a high beam light source and a low beam light source, so as to reduce optical crosstalk, such that external ambient light is received accurately, thereby achieving a desirable light-sensing detection effect. The light-sensing element may provide photoelectric parameters according to the brightness of sensed light, and then an MCU chip collects the photoelectric parameters and provides a corresponding control signal.

6. 发明授权

US10277047B2 Multi-function car-mounted charger 有权
公开(公告)号：US10277047B2
公开(公告)日：2019-04-30
申请号：US15415470
申请日：2017-01-25
申请人： Wenjie Li
发明人： Wenjie Li
IPC分类号： H02J7/00 , B60Q3/88 , B60Q3/59 , B60Q3/74 , B60Q3/82 , B60Q3/35 , B60Q1/52 , B60Q3/275 , B60R16/02 , B60R16/03 , B60Q1/26 , B60Q1/24
摘要： A multi-function car-mounted charger comprises a main housing, a lighting housing, a power input portion, a main circuit, a rechargeable battery, a magnet, a power output portion and a lighting portion; the power input portion, the main circuit, the rechargeable battery, the magnet, and the power output portion are disposed in the main housing; the lighting portion is disposed in the lighting housing; the power input portion, the rechargeable battery, the power output portion, and the lighting portion are electrically connected with the main circuit respectively; the power input portion comprises a first electrode and a second electrode, both of which are electrically connected with the main circuit respectively; and the first electrode is provided with a cone body. The car-mounted charger is diverse in function and may be attracted onto a car shell through the magnet.

7. 发明授权

US08676253B2 Method and device for ranking frequencies 有权
标题翻译：多模多苗多待通信终端，以及用于仲裁接收冲突的仲裁方法和装置
公开(公告)号：US08676253B2
公开(公告)日：2014-03-18
申请号：US13574563
申请日：2011-05-24
申请人： Wenjie Li
发明人： Wenjie Li
IPC分类号： H04W88/02
CPC分类号： H04W88/06 , H04W8/183 , H04W68/00 , H04W76/40
摘要： An arbitration method and device for arbitrating receiving conflict in a multi-mode multi-SIM multi-standby communication terminal is provided. The method includes: determining if there are at least two cards to receive messages in a time cycle while all of the cards are in standby states, the time cycle being a radio frame of one card; identifying types of messages to be received by the at least two cards after determining there are at least two cards to receive messages in the time cycle, and the types of messages comprising paging message and broadcast message; determining if a receiving conflict occurs; and arbitrating based on the types of receiving conflicts and obtaining arbitration results after determining there is a receiving conflict. The arbitration results include: receiving a paging message preferentially; receiving the paging message with the longest paging period; and receiving the broadcast message with the highest priority.
摘要翻译：提供了一种仲裁方法和装置，用于仲裁多模多SIM多待通信终端中的接收冲突。该方法包括：当所有卡处于待机状态时，确定是否存在至少两个卡以在时间周期中接收消息，该时间周期是一个卡的无线电帧; 在确定在该时间周期中存在至少两个接收消息的卡以及包括寻呼消息和广播消息的消息的类型之后，识别由至少两张卡接收的消息的类型; 确定是否发生接收冲突; 并根据接收冲突的类型进行仲裁，并在确定接收冲突后获得仲裁结果。仲裁结果包括：优先接收寻呼消息; 以最长的寻呼周期接收寻呼消息; 并接收具有最高优先级的广播消息。

8. 发明授权

US07700262B2 Top coat material and use thereof in lithography processes 失效
标题翻译：面漆材料及其在光刻工艺中的应用
公开(公告)号：US07700262B2
公开(公告)日：2010-04-20
申请号：US12044004
申请日：2008-03-07
申请人： Wenjie Li , Margaret C. Lawson , Pushkara Rao Varanasi
发明人： Wenjie Li , Margaret C. Lawson , Pushkara Rao Varanasi
IPC分类号： G03F7/00 , G03F7/004
CPC分类号： G03F7/11 , G03F7/0046 , G03F7/2041 , Y10T428/3154
摘要： A top coat material for applying on top of a photoresist material is disclosed. The top coat material includes a polymer, which includes at least one fluorosulfonamide monomer unit having one of the following two structures: wherein: M is a polymerizable backbone moiety; Z is a linking moiety selected from the group consisting of —C(O)O—, —C(O)—, —OC(O)—, and —O—C(O)—C(O)—O—; R1 is selected from the group consisting of an alkylene, an arylene, a semi- or perfluorinated alkylene, and a semi- or perfluorinated arylene; p and q are 0 or 1; R2 is selected from the group consisting of hydrogen, fluorine, an alkyl group of 1 to 6 carbons, and a semi- or perfluorinated alkyl group of 1 to 6 carbons; n is an integer from 1 to 6; and R3 is selected from the group consisting of hydrogen, an alkyl, an aryl, a semi- or perfluorinated alkyl, and a semi- or perfluorinated aryl. The top coat material may be used in lithography processes, wherein the top coat material is applied on a photoresist layer. The top coat material is preferably soluble in aqueous alkaline developer. The top coat material is also preferably insoluble in water, and is therefore particularly useful in immersion lithography techniques using water as the imaging medium.
摘要翻译：公开了一种用于涂覆在光致抗蚀剂材料上的顶涂层材料。面漆材料包括聚合物，其包括至少一种具有以下两种结构之一的氟磺酰胺单体单元：其中：M是可聚合主链部分; Z是选自-C（O）O-，-C（O） - ， - OC（O） - 和-O-C（O）-C（O）-O-的连接部分; R1选自亚烷基，亚芳基，半或全氟亚烷基，以及半或全氟化亚芳基; p和q为0或1; R2选自氢，氟，1至6个碳的烷基和1至6个碳的半或全氟化烷基; n是1至6的整数; 并且R 3选自氢，烷基，芳基，半或全氟烷基和半或全氟芳基。面漆材料可以用在光刻工艺中，其中将顶涂层材料施加在光致抗蚀剂层上。顶涂层材料优选可溶于含水碱性显影剂。面漆材料也优选不溶于水，因此特别适用于使用水作为成像介质的浸渍光刻技术。

9. 发明申请

US20080166568A1 TOP COAT MATERIAL AND USE THEREOF IN LITHOGRAPHY PROCESSES 失效
公开(公告)号：US20080166568A1
公开(公告)日：2008-07-10
申请号：US12044004
申请日：2008-03-07
申请人： Wenjie Li , Margaret C. Lawson , Pushkara Rao Varanasi
发明人： Wenjie Li , Margaret C. Lawson , Pushkara Rao Varanasi
IPC分类号： B32B27/28
CPC分类号： G03F7/11 , G03F7/0046 , G03F7/2041 , Y10T428/3154
摘要： A top coat material for applying on top of a photoresist material is disclosed. The top coat material includes a polymer, which includes at least one fluorosulfonamide monomer unit having one of the following two structures: wherein: M is a polymerizable backbone moiety; Z is a linking moiety selected from the group consisting of —C(O)O—, —C(O)—, —OC(O)—, and —O—C(O)—C(O)—O—; R1 is selected from the group consisting of an alkylene, an arylene, a semi- or perfluorinated alkylene, and a semi- or perfluorinated arylene; p and q are 0 or 1; R2 is selected from the group consisting of hydrogen, fluorine, an alkyl group of 1 to 6 carbons, and a semi- or perfluorinated alkyl group of 1 to 6 carbons; n is an integer from 1 to 6; and R3 is selected from the group consisting of hydrogen, an alkyl, an aryl, a semi- or perfluorinated alkyl, and a semi- or perfluorinated aryl. The top coat material may be used in lithography processes, wherein the top coat material is applied on a photoresist layer. The top coat material is preferably soluble in aqueous alkaline developer. The top coat material is also preferably insoluble in water, and is therefore particularly useful in immersion lithography techniques using water as the imaging medium.

10. 发明授权

US07365202B2 Polymorphs of an androgen receptor modulator 失效
标题翻译：雄激素受体调节剂的多态性
公开(公告)号：US07365202B2
公开(公告)日：2008-04-29
申请号：US11633152
申请日：2006-12-04
申请人： Lushi Tan , Robert S. Meissner , Wenjie Li , James J. Perkins , Aaron S. Cote , Joyce Stellabott , Yuan-Hon Kiang
发明人： Lushi Tan , Robert S. Meissner , Wenjie Li , James J. Perkins , Aaron S. Cote , Joyce Stellabott , Yuan-Hon Kiang
IPC分类号： C07D221/18
CPC分类号： C07J73/005 , C07D471/04
摘要： Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.
摘要翻译：结构式I的化合物是以组织选择性方式的雄激素受体（AR）的调节剂。这些化合物可用于增强弱化肌张力和治疗由雄激素缺乏引起的疾病或可由雄激素给药改善的疾病，包括骨质疏松症，骨质减少，糖皮质激素诱导的骨质疏松症，牙周病，骨折，骨重建后的骨损伤手术，肌营养不良，虚弱，老化的皮肤，男性性腺机能减退，女性绝经后症状，动脉粥样硬化，高胆固醇血症，高脂血症，肥胖，再生障碍性贫血和其他造血障碍，炎性关节炎和关节修复，艾滋病毒消耗，前列腺癌，良性前列腺增生），腹部肥胖，代谢综合征，II型糖尿病，癌症恶病质，阿尔茨海默氏病，肌营养不良症，认知衰退，性功能障碍，睡眠呼吸暂停，抑郁症，卵巢早衰以及自身免疫性疾病，单独或与其它活性剂组合。

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