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1. 发明授权

US08124088B2 Methods of treatment using anti-IL-22RA antibodies 有权
标题翻译：使用抗IL-22RA抗体的治疗方法
公开(公告)号：US08124088B2
公开(公告)日：2012-02-28
申请号：US12423699
申请日：2009-04-14
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断，抑制，降低，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。

2. 发明授权

US07537761B2 Anti-IL-22RA antibodies and binding partners and methods of using in inflammation 有权
标题翻译：抗IL-22RA抗体和结合配偶体以及在炎症中使用的方法
公开(公告)号：US07537761B2
公开(公告)日：2009-05-26
申请号：US11256499
申请日：2005-10-21
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断，抑制，减少，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。

3. 发明授权

US07871616B2 Anti-IL-22RA antibodies and binding partners and methods of using in inflammation 有权
标题翻译：抗IL-22RA抗体和结合配偶体以及在炎症中使用的方法
公开(公告)号：US07871616B2
公开(公告)日：2011-01-18
申请号：US12540084
申请日：2009-08-12
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断，抑制，降低，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。

4. 发明申请

US20090220519A1 ANTI-IL-22RA ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 有权
标题翻译：抗IL-22RA抗体和结合合作伙伴及其在炎症中的使用方法
公开(公告)号：US20090220519A1
公开(公告)日：2009-09-03
申请号：US12423699
申请日：2009-04-14
申请人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人： Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号： A61K39/395 , A61P29/00 , A61P31/00
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断，抑制，降低，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。

5. 发明授权

US07262025B2 Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter 失效
标题翻译：具有巨细胞病毒增强子和骨髓增生肉瘤病毒启动子的杂交载体
公开(公告)号：US07262025B2
公开(公告)日：2007-08-28
申请号：US10465156
申请日：2003-06-18
申请人： Margaret Dow Moore
发明人： Margaret Dow Moore
IPC分类号： C12N5/10 , C12N15/85 , C12N15/63 , C12N15/64 , C12P21/00 , C07K14/745
CPC分类号： C12N9/6429 , C12N15/85 , C12N15/86 , C12N2740/13043 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2840/203 , C12Y304/21005
摘要： An expression vector capable of expressing high levels of heterologous proteins having a cytomegalovirus (CMV) enhancer 5′ upstream from a myeloproliferative sarcoma virus (MPSV) promoter.
摘要翻译：能够表达来自骨髓增生性肉瘤病毒（MPSV）启动子上游的具有巨细胞病毒（CMV）增强子5'的高水平异源蛋白质的表达载体。

6. 发明申请

US20080220478A1 TRIMERIZING POLYPEPTIDES 失效
标题翻译：调整多糖
公开(公告)号：US20080220478A1
公开(公告)日：2008-09-11
申请号：US11530672
申请日：2006-09-11
申请人： Margaret Dow Moore , Brian A. Fox
发明人： Margaret Dow Moore , Brian A. Fox
IPC分类号： C12P21/02
CPC分类号： C12N15/62 , A61K38/00 , C07K14/005 , C07K14/705 , C07K2319/03 , C07K2319/81 , C12N2740/10022 , C12N2740/13022
摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.
摘要翻译：本发明涉及一种三聚蛋白的制备方法，其包括用编码包含ZymoZipper（ZZ）结构域和异源蛋白质的融合蛋白的表达载体转化或转染的宿主细胞。在一个实施方案中，异源蛋白质是膜蛋白，融合蛋白中包含的异源蛋白质的部分是该蛋白质的细胞外结构域，并且所得的融合蛋白质是可溶的。在本发明的另一个实施方案中，ZZ结构域衍生自病毒包膜蛋白的跨膜（TM）亚基或其它含有病毒基因组的七重复重复基因。该方法可用于产生同型和异三聚体蛋白质。本发明还包括本方法中使用的DNA分子，表达载体和宿主细胞以及通过本发明方法产生的融合蛋白。

7. 发明授权

US07241593B2 Materials and methods for preparing dimeric growth factors 失效
标题翻译：制备二聚生长因子的材料和方法
公开(公告)号：US07241593B2
公开(公告)日：2007-07-10
申请号：US10365095
申请日：2003-02-11
申请人： Brian A. Fox , Margaret Dow Moore , Kristine M. Swiderek , Carl W. Birks
发明人： Brian A. Fox , Margaret Dow Moore , Kristine M. Swiderek , Carl W. Birks
IPC分类号： C12P21/04 , C07K14/49
CPC分类号： C07K14/49 , A61K38/00 , C07K2319/00 , C07K2319/50 , C07K2319/735 , C12N2710/14043
摘要： Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365–370, inclusive. The linker polypeptide consists of from 11–40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
摘要翻译：公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽，接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质，以及用于制备蛋白质的材料和方法。第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO：2或SEQ ID NO：4所示的氨基酸残基序列组成，其中x是 246至258（含），y为365-370的整数，包括端值。接头多肽由11-40个氨基酸残基组成。蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。

8. 发明授权

US07122351B2 Dimerized PDGF-D and materials and methods for producing it 失效
标题翻译：二聚PDGF-D及其制备方法
公开(公告)号：US07122351B2
公开(公告)日：2006-10-17
申请号：US10274638
申请日：2002-10-18
申请人： Margaret Dow Moore , Brian A. Fox
发明人： Margaret Dow Moore , Brian A. Fox
IPC分类号： C12N5/10 , C12N15/16 , C12N15/63
CPC分类号： C07K14/49 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： Proteins consisting of two PDGF-D polypeptide chains, polynucleotides encoding the polypeptides, and materials and methods for making the proteins are disclosed. Each of the polypeptide chains consists of, from amino terminus to carboxyl terminus, the following operably linked segments: P1-P2-h-CH2-CH3; P1-P2-CH2-CH3; h-CH2-CH3-P2-P1; or CH2-CH3-P2-P1. Within these polypeptide chains, P1 is a first polypeptide segment as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365–370, inclusive; P2 is a second polypeptide segment consisting of from 4 to 20 amino acid residues; h is an immunoglobulin hinge region or portion thereof; and CH2 and CH3 are CH2 and CH3 domains of an immunoglobulin heavy chain, respectively. Within the protein, the two polypeptide chains are joined by one or more disulfide bonds, each of the chains is optionally glycosylated, and the protein binds to and activates cell-surface PDGF receptors.
摘要翻译：公开了由两个PDGF-D多肽链组成的蛋白质，编码多肽的多核苷酸，以及用于制备蛋白质的材料和方法。每个多肽链由氨基末端至羧基末端组成以下可操作连接的片段：P1-P2-h-C H-2-C 3 H 3; P1-P2-C H-2-C H 3; H-C H-2-C 3-P2-P1; 或C H 2 -C 3 -PO-P-2。在这些多肽链中，P1是从氨基酸x至氨基酸y的SEQ ID NO：2或SEQ ID NO：4所示的第一个多肽区段，其中x是246至258的整数，包括端值，y是整数为365-370，含 P2是由4至20个氨基酸残基组成的第二多肽区段; h是免疫球蛋白铰链区域或其部分; 和C H 2和C H 3是免疫球蛋白重链的C H 2 H 2和C 3 H 3结构域，分别。在蛋白质内，两条多肽链通过一个或多个二硫键连接，每个链任选被糖基化，并且蛋白质结合并激活细胞表面PDGF受体。

9. 发明授权

US07655439B2 Trimerizing polypeptides 失效
标题翻译：三聚多肽
公开(公告)号：US07655439B2
公开(公告)日：2010-02-02
申请号：US11530672
申请日：2006-09-11
申请人： Margaret Dow Moore , Brian A. Fox
发明人： Margaret Dow Moore , Brian A. Fox
IPC分类号： C12P21/06
CPC分类号： C12N15/62 , A61K38/00 , C07K14/005 , C07K14/705 , C07K2319/03 , C07K2319/81 , C12N2740/10022 , C12N2740/13022
摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.
摘要翻译：本发明涉及一种三聚蛋白的制备方法，其包括用编码包含ZymoZipper（ZZ）结构域和异源蛋白质的融合蛋白的表达载体转化或转染的宿主细胞。在一个实施方案中，异源蛋白质是膜蛋白，融合蛋白中包含的异源蛋白质的部分是该蛋白质的细胞外结构域，并且所得的融合蛋白质是可溶的。在本发明的另一个实施方案中，ZZ结构域衍生自病毒包膜蛋白的跨膜（TM）亚基或其它含有病毒基因组的七重复重复基因。该方法可用于产生同型和异三聚体蛋白质。本发明还包括本方法中使用的DNA分子，表达载体和宿主细胞以及通过本发明方法产生的融合蛋白。

10. 发明授权

US08084230B2 Trimerizing polypeptides 有权
标题翻译：三聚多肽
公开(公告)号：US08084230B2
公开(公告)日：2011-12-27
申请号：US12686896
申请日：2010-01-13
申请人： Margaret Dow Moore , Brian A. Fox
发明人： Margaret Dow Moore , Brian A. Fox
IPC分类号： C12P21/06
CPC分类号： C12N15/62 , A61K38/00 , C07K14/005 , C07K14/705 , C07K2319/03 , C07K2319/81 , C12N2740/10022 , C12N2740/13022
摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.
摘要翻译：本发明涉及一种三聚蛋白的制备方法，其包括用编码包含ZymoZipper（ZZ）结构域和异源蛋白质的融合蛋白的表达载体转化或转染的宿主细胞。在一个实施方案中，异源蛋白质是膜蛋白，融合蛋白中包含的异源蛋白质的部分是该蛋白质的细胞外结构域，并且所得的融合蛋白质是可溶的。在本发明的另一个实施方案中，ZZ结构域衍生自病毒包膜蛋白的跨膜（TM）亚基或其它含有病毒基因组的七重复重复基因。该方法可用于产生同型和异三聚体蛋白质。本发明还包括本方法中使用的DNA分子，表达载体和宿主细胞以及通过本发明方法产生的融合蛋白。

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