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1. 发明授权

US08936932B2 Magnetic and/or electric label assisted detection system and method 有权
标题翻译：磁性和/或电子标签辅助检测系统和方法
公开(公告)号：US08936932B2
公开(公告)日：2015-01-20
申请号：US12444698
申请日：2007-10-05
申请人： Wendy Uyen Dittmer , Menno Willem Jose Prins
发明人： Wendy Uyen Dittmer , Menno Willem Jose Prins
IPC分类号： C12M3/00 , G01N33/543 , G01N27/74 , G01N35/00
CPC分类号： G01N33/54326 , G01N27/745 , G01N35/0098
摘要： A detection system (100) is described for detecting analytes in a fluid sample. The detection system (100) comprises a transporting means (6) for transporting magnetic and/or electric labels (5) after interaction between the sample fluid and the reagents towards a detection receptacle (1). The detection receptacle (1) is initially substantially magnetic and/or electric label (5) free. By transporting the magnetic and/or electric labels (5) after reaction, interference between unreacted reagents and magnetic and/or electric label-assisted detection can be reduced.
摘要翻译：描述了用于检测流体样品中的分析物的检测系统（100）。检测系统（100）包括用于在样品流体和试剂相互作用后朝向检测容器（1）传送磁性和/或电气标签（5）的传送装置（6）。检测容器（1）最初基本上是磁性和/或电子标签（5）。通过在反应后传送磁性和/或电子标签（5），可以减少未反应试剂与磁性和/或电标签辅助检测之间的干扰。

2. 发明授权

US08217647B2 Measuring agglutination parameters 有权
标题翻译：测量凝集参数
公开(公告)号：US08217647B2
公开(公告)日：2012-07-10
申请号：US12518895
申请日：2007-12-18
申请人： Wendy Uyen Dittmer , Peggy De Kievit , Jeroen Hans Nieuwenhuis , Menno Willem Jose Prins , Leonardus Josephus Van Ijzendoorn , Xander Jozef Antoine Janssen
发明人： Wendy Uyen Dittmer , Peggy De Kievit , Jeroen Hans Nieuwenhuis , Menno Willem Jose Prins , Leonardus Josephus Van Ijzendoorn , Xander Jozef Antoine Janssen
IPC分类号： G01R33/00 , G01N33/553
CPC分类号： G01N15/0266 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01N2015/0092 , G01R33/093 , G01R33/1269 , Y10S436/806
摘要： A method and system for measuring agglutination in a target-induced agglutination assay with one or more magnetic particles is performed in a reaction chamber. After the magnetic particles, which are capable of binding to a target are provided in the assay, an agglutination process is performed resulting in agglutinated particles. Further an alternating current magnetic field (HAC) is applied to the assay. The method further includes measuring an effect of the HAC on the one or more magnetic particles unattached to any surface. The measured effect is indicative of one or more agglutination parameters.
摘要翻译：在反应室中进行用于测定靶诱导的凝集测定中的一种或多种磁性颗粒的凝集的方法和系统。在测定中提供能够结合到靶的磁性颗粒之后，进行凝集过程，导致凝集的颗粒。此外，将交流磁场（HAC）应用于测定。该方法还包括测量HAC对未附着到任何表面的一个或多个磁性颗粒的影响。测量的效果表示一个或多个凝集参数。

3. 发明申请

US20100289483A1 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：US20100289483A1
公开(公告)日：2010-11-18
申请号：US12669218
申请日：2008-07-16
申请人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
发明人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/74
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，并且第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

4. 发明申请

US20080268481A1 Sensitive Magnetic Catch Assay By Building a Strong Binding Couple 审中-公开
标题翻译：通过建立强绑定夫妇的敏感磁性捕捉测定
公开(公告)号：US20080268481A1
公开(公告)日：2008-10-30
申请号：US12094791
申请日：2006-11-21
申请人： Menno Willem Jose Prins , Wendy Uyen Dittmer
发明人： Menno Willem Jose Prins , Wendy Uyen Dittmer
IPC分类号： G01N33/53 , B01J19/00 , G01N33/553
CPC分类号： G01N33/54373
摘要： The invention relates to a sensor device for detecting a target in a sample suspected of comprising the target, which device is suitable for use in an assay such as a sandwich assay. The invention further relates to a method for detecting a target in a sample. The device comprises a sensor surface, which is functionalised with one moiety of a strong binding couple, which moiety preferably shows little or no cross reactivity with the target molecule.
摘要翻译：本发明涉及一种用于检测疑似包含靶的样品中的靶的传感器装置，该装置适用于诸如夹心测定法的测定。本发明还涉及一种用于检测样品中靶标的方法。该装置包括传感器表面，其被强结合对的一个部分功能化，该部分优选显示与靶分子很少或不具有交叉反应性。

5. 发明授权

US08520211B2 Carrier for optical detection in small sample volumes 有权
标题翻译：小样本量的光学检测载体
公开(公告)号：US08520211B2
公开(公告)日：2013-08-27
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： A carrier and an apparatus for optical detection of a sample in a sample chamber includes en optical structure for refracting an input light beam into the adjacent sample chamber and for collecting an output light beam from light that originates in the sample chamber from the input light beam. The optical structure includes grooves in the surface of the carrier in which the Input light beam is transmitted Over a short distance through a sample. The optical structure can also be used for a wetting detection.
摘要翻译：用于样品室中的样品的光学检测的载体和设备包括用于将输入光束折射到相邻样品室中的光学结构，并且用于从输入光束收集来自样品室的光的输出光束。光学结构包括在载体的表面中的凹槽，其中输入光束在短距离内透射通过样品。光学结构也可用于润湿检测。

6. 发明申请

US20110026030A1 CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 有权
标题翻译：用于小样品中光学检测的载体
公开(公告)号：US20110026030A1
公开(公告)日：2011-02-03
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (L1) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.
摘要翻译：本发明涉及一种用于在样品室（2）中的样品（1）中进行光学检测的载体（11）和装置（100）。载体（11）包括用于将输入光束（L1）折射到相邻的样品室（2）中并用于从源于样品室（2）的光收集输出光束（L2）的光学结构（50）从输入光束。优选地，光学结构（50）包括在载体（11）的表面（12）中的凹槽，其中输入光束通过样品在短距离上传播。光学结构（50）也可用于润湿检测。

7. 发明申请

US20100194386A1 MAGNETIC SENSOR DEVICE 审中-公开
标题翻译：磁传感器装置
公开(公告)号：US20100194386A1
公开(公告)日：2010-08-05
申请号：US12669211
申请日：2008-07-14
申请人： Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
发明人： Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
IPC分类号： G01R33/12
CPC分类号： G01N33/54333 , G01N27/745
摘要： The present invention provides a sensor device (20) and a method for determining the presence and/or amount of target moieties (22) in a sample fluid (27), the target moieties (22) being labeled with magnetic or magnetizable objects (23). The sensor device (20) comprises a magnetic field generating means adapted for applying a retention field for retaining the labeled target moieties (22, 23) to the sensor surface (24) during fluid manipulations. Through this the binding between the labeled target moieties (22, 23) and the sensor surface (24) and/or the magnetic particles (23) and the target moieties (22) is substantially not disturbed during these fluid manipulations. This leads to a reliable and accurate sensor device (20).
摘要翻译：本发明提供一种传感器装置（20）和用于确定样品流体（27）中目标部分（22）的存在和/或数量的方法，目标部分（22）用磁性或可磁化物体（23）标记）。传感器装置（20）包括磁场产生装置，其适于在流体操纵期间施加用于将标记的目标部分（22,23）保持到传感器表面（24）的保持场。通过这一点，标记的目标部分（22,23）和传感器表面（24）和/或磁性颗粒（23）和目标部分（22）之间的结合在这些流体操纵过程中基本上不受干扰。这导致可靠且准确的传感器装置（20）。

8. 发明申请

US20100045267A1 MAGNETIC AND/OR ELECTRIC LABEL ASSISTED DETECTION SYSTEM AND METHOD 有权
标题翻译：磁性和/或电子标签辅助检测系统及方法
公开(公告)号：US20100045267A1
公开(公告)日：2010-02-25
申请号：US12444698
申请日：2007-10-05
申请人： Wendy Uyen Dittmer , Menno Willem Jose Prins
发明人： Wendy Uyen Dittmer , Menno Willem Jose Prins
IPC分类号： G01N27/74 , G01R33/12
CPC分类号： G01N33/54326 , G01N27/745 , G01N35/0098
摘要： A detection system (100) is described for detecting analytes in a fluid sample. The detection system (100) comprises a transporting means (6) for transporting magnetic and/or electric labels (5) after interaction between the sample fluid and the reagents towards a detection receptacle (1). The detection receptacle (1) is initially substantially magnetic and/or electric label (5) free. By transporting the magnetic and/or electric labels (5) after reaction, interference between unreacted reagents and magnetic and/or electric label-assisted detection can be reduced.
摘要翻译：描述了用于检测流体样品中的分析物的检测系统（100）。检测系统（100）包括用于在样品流体和试剂相互作用后朝向检测容器（1）传送磁性和/或电气标签（5）的传送装置（6）。检测容器（1）最初基本上是磁性和/或电子标签（5）。通过在反应后传送磁性和/或电子标签（5），可以减少未反应试剂与磁性和/或电标签辅助检测之间的干扰。

9. 发明申请

US20100033158A1 MEASURING AGGLUTINATION PARAMETERS 有权
标题翻译：测量参数
公开(公告)号：US20100033158A1
公开(公告)日：2010-02-11
申请号：US12518895
申请日：2007-12-18
申请人： Wendy Uyen Dittmer , Peggy De Kievit , Jeroen Hans Nieuwenhuis , Menno Willem Jose Prins , Leonardus Josephus Van IJjzendoorn , Xander Jozef Antoine Janssen
发明人： Wendy Uyen Dittmer , Peggy De Kievit , Jeroen Hans Nieuwenhuis , Menno Willem Jose Prins , Leonardus Josephus Van IJjzendoorn , Xander Jozef Antoine Janssen
IPC分类号： G01N27/00 , G01R33/12
CPC分类号： G01N15/0266 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01N2015/0092 , G01R33/093 , G01R33/1269 , Y10S436/806
摘要： A method and system are described for measuring agglutination in a target-induced agglutination assay with one or more magnetic particles performed in a reaction chamber. After the magnetic particles (3, 15), which are capable of binding to a target (5) are provided in the assay, an agglutination process resulting in agglutinated particles (100) comprising at least one magnetic particle is performed. The method then further comprises applying an alternating current magnetic field (HAC) to the assay and—measuring an effect of the HAC on the one or more magnetic particles (3,15) unattached to any surface. The measured effect is indicative of one or more agglutination parameters.
摘要翻译：描述了用于在反应室中进行的一种或多种磁性颗粒测量靶诱导的凝集测定中的凝集的方法和系统。在测定中提供能够结合靶（5）的磁性颗粒（3,15）之后，进行产生包含至少一个磁性颗粒的凝集颗粒（100）的凝集过程。该方法然后还包括对测定应用交流磁场（HAC）并测量HAC对未附着于任何表面的一个或多个磁性颗粒（3,15）的影响。测量的效果表示一个或多个凝集参数。

10. 发明授权

US08981772B2 Rotating magnetic field for improved detection in cluster assays 有权
标题翻译：旋转磁场用于集群测定中的改进检测
公开(公告)号：US08981772B2
公开(公告)日：2015-03-17
申请号：US13060804
申请日：2009-09-04
申请人： Andrea Ranzoni , Menno Willem Jose Prins , Mikhail Mikhaylovich Ovsyanko
发明人： Andrea Ranzoni , Menno Willem Jose Prins , Mikhail Mikhaylovich Ovsyanko
IPC分类号： G01R33/02 , G01N33/553 , G01N33/543 , G01N27/74
CPC分类号： G01N33/54333 , G01N27/745
摘要： In a method of performing a cluster assay, a suspension (14) of superparamagnetic particles in a fluid to be analyzed is provided, wherein the superparamagnetic particles are coated with a bioactive agent. The particles are then allowed to form clusters due to an analyte present within the fluid. Subsequently, clusters of superparamagnetic particles are selectively actuated by applying a rotating magnetic field, wherein the amplitude of the magnetic field varies over time. Finally, the selectively actuated clusters are detected. An apparatus for performing a cluster assay comprises means for accommodating a sample (12) and means for applying a rotating magnetic field (11), the magnetic field being adapted for selectively actuating clusters of superparamagnetic particles. The apparatus further comprises means for detecting the selectively actuated clusters.
摘要翻译：在进行聚集测定的方法中，提供了待分析流体中超顺磁性颗粒的悬浮液（14），其中超顺磁性颗粒用生物活性剂涂覆。然后由于存在于流体内的分析物，使颗粒形成簇。随后，通过施加旋转磁场来选择性地致动超顺磁性颗粒簇，其中磁场的振幅随时间而变化。最后，检测到选择性地致动的簇。用于进行聚集测定的装置包括用于容纳样品（12）的装置和用于施加旋转磁场（11）的装置，所述磁场适于选择性地致动超顺磁颗粒簇。该装置还包括用于检测选择性地致动的簇的装置。

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