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1. 发明授权

US06726718B1 Medical articles prepared for cell adhesion 有权
标题翻译：制备用于细胞粘附的医疗用品
公开(公告)号：US06726718B1
公开(公告)日：2004-04-27
申请号：US09459451
申请日：1999-12-13
申请人： Wenda C. Carlyle , Avrom M. Brendzel
发明人： Wenda C. Carlyle , Avrom M. Brendzel
IPC分类号： A61F224
CPC分类号： A61L27/10 , A61L27/227 , A61L27/303 , A61L27/507 , A61L29/048 , A61L31/047
摘要： A prosthesis is formed from a biocompatible material having one or more associated cell adhesion stimulating proteins. The biocompatible material can be a ceramic material or a carbon coated material. The cell adhesion stimulating protein can be a structural protein or a polypeptide growth factor, such as vascular endothelial growth factor. Viable cells can be adhered in vivo or in vitro to the biocompatible material with the cell adhesion stimulating protein.
摘要翻译：假体由具有一种或多种相关联的细胞粘附刺激蛋白的生物相容性材料形成。生物相容性材料可以是陶瓷材料或碳涂层材料。细胞粘附刺激蛋白可以是结构蛋白或多肽生长因子，如血管内皮生长因子。活细胞可以体内或体外附着到具有细胞粘附刺激蛋白的生物相容性材料上。

2. 发明授权

US06391053B1 Prosthetic heart valve with increased valve lumen 失效
标题翻译：假性心脏瓣膜增加瓣膜内腔
公开(公告)号：US06391053B1
公开(公告)日：2002-05-21
申请号：US08664235
申请日：1996-06-07
申请人： Avrom M. Brendzel , James R. Ringdal , Guy P. Vanney
发明人： Avrom M. Brendzel , James R. Ringdal , Guy P. Vanney
IPC分类号： A61F224
CPC分类号： A61F2/2403 , A61F2/2409
摘要： A heart valve prosthesis having a valve housing providing a lumen therethrough. The valve housing has a first annulus on one end and a second annulus on the other end spaced apart from the first annulus. A suture cuff is used for attaching the valve housing to heart tissue of a patient. The cuff is attached between the first annulus and the second annulus. The cuff is positioned such that prosthesis is attached in a supra-annular position relative to a tissue annulus of the heart. The design allows for an increased valve lumen.
摘要翻译：一种心脏瓣膜假体，其具有提供通过其中的腔的阀壳体。阀壳体在一端具有第一环形空间，而第二环形空间在与第一环空间间隔开的另一端上。缝合袖口用于将阀壳体附接到患者的心脏组织。袖带连接在第一环和第二环之间。袖带被定位成使得假体相对于心脏的组织环连接在超环形位置。该设计允许增加阀腔。

3. 发明授权

US07632309B1 Pyrolytic carbon and metal/metalloid carbide composites 有权
标题翻译：热解碳和金属/准金属复合材料
公开(公告)号：US07632309B1
公开(公告)日：2009-12-15
申请号：US09460140
申请日：1999-12-13
申请人： Avrom M. Brendzel , Richard Rodriguez , Michelle Lund Toy
发明人： Avrom M. Brendzel , Richard Rodriguez , Michelle Lund Toy
IPC分类号： A61F2/24
CPC分类号： A61F2/0077 , A61F2/24 , A61F2310/00011 , A61F2310/00173 , A61F2310/00179 , A61F2310/00574 , A61F2310/0073 , A61F2310/00736 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/0079 , A61L27/303 , A61L27/306
摘要： Medical devices can be formed from improved composite materials that include a composition that has at least about 50 percent by volume pyrolytic carbon and a second composition having at least about 50 percent by volume metal/metalloid carbide. The composite material can optionally include a substrate. Some embodiments of the composite material have the pyrolytic carbon material at exposed surfaces.
摘要翻译：医疗装置可以由改进的复合材料形成，所述复合材料包括具有至少约50体积％热解碳的组合物和具有至少约50体积％的金属/准金属碳化物的第二组合物。复合材料可任选地包括基底。复合材料的一些实施方案在暴露的表面具有热解碳材料。

4. 发明授权

US06395025B1 Mechanical heart valve prosthesis 有权
标题翻译：机械心脏瓣膜假体
公开(公告)号：US06395025B1
公开(公告)日：2002-05-28
申请号：US09224149
申请日：1998-12-31
申请人： Paul J. Fordenbacher , Avrom M. Brendzel , A. Tanya Shipkowitz , Stephen A. Petersen
发明人： Paul J. Fordenbacher , Avrom M. Brendzel , A. Tanya Shipkowitz , Stephen A. Petersen
IPC分类号： A61F206
CPC分类号： A61F2/2403
摘要： Mechanical heart valve prostheses are disclosed that inherently reduce the probability of thrombus formation by minimizing blood flow disturbance, high shear stress, and stagnation. The pivot configuration includes a recess, preferably in the housing, that has a profile which promotes smooth blood flow.
摘要翻译：公开了机械心脏瓣膜假体，其通过最小化血流紊乱，高剪切应力和停滞来固有地降低血栓形成的可能性。枢轴构造包括优选在壳体中的凹部，其具有促进平滑血流的轮廓。

5. 发明授权

US06358278B1 Heart valve prosthesis with rotatable cuff 有权
标题翻译：具有可旋转袖口的心脏瓣膜假体
公开(公告)号：US06358278B1
公开(公告)日：2002-03-19
申请号：US09406275
申请日：1999-09-24
申请人： Avrom M. Brendzel , William R. Kramlinger , Michael J. Girard , Jonas A. Runquist
发明人： Avrom M. Brendzel , William R. Kramlinger , Michael J. Girard , Jonas A. Runquist
IPC分类号： A61F224
CPC分类号： A61F2/2409
摘要： A prosthetic heart valve includes an orifice ring adapted to carry blood therethrough. An annular recess is formed in an outer surface of the orifice ring and has first and second axially spaced walls. A sewing cuff is adapted to be coupled to a native tissue annulus of a heart and includes an inner annular cuff portion adapted to conform to the first and second recess walls in the orifice ring. A cuff retaining ring extends around the inner annular fabric portion such that the inner annular cuff portion is positioned between the cuff retaining ring and the annular recess. The cuff retaining ring is further adapted to exert a substantially axially directed force directed against the annular cuff portion and first and second axially spaced walls of the annular recess, which is substantially greater than a radial force directed substantially inwardly by the cuff retaining ring against an annulus of the recess located between the first and second walls, whereby a controllable torque to rotate the cuff relative to the orifice ring is developed substantially due to friction between the first and second recess walls cuff portion and the annular recess.
摘要翻译：假体心脏瓣膜包括适于携带血液的孔口环。环形凹部形成在孔环的外表面中并具有第一和第二轴向隔开的壁。缝合箍适于联接到心脏的天然组织环，并且包括适于与孔环中的第一和第二凹陷壁一致的内环形箍部分。袖带保持环围绕内部环形织物部分延伸，使得内部环形箍部分位于袖带保持环和环形凹部之间。套箍保持环还适于施加指向环形箍部分和环形凹部的第一和第二轴向隔开的壁的基本上轴向的力，其基本上大于由套箍保持环基本向内指向的径向力位于第一和第二壁之间的凹部的环形空间，由此基本上由于第一和第二凹部壁箍部分和环形凹部之间的摩擦而使袖带相对于孔环旋转的可控转矩变大。

6. 发明授权

US06719790B2 Prosthetic heart valve with increased valve lumen 有权
标题翻译：假性心脏瓣膜增加瓣膜内腔
公开(公告)号：US06719790B2
公开(公告)日：2004-04-13
申请号：US10152503
申请日：2002-05-21
申请人： Avrom M. Brendzel , James R. Ringdal , Guy P. Vanney
发明人： Avrom M. Brendzel , James R. Ringdal , Guy P. Vanney
IPC分类号： A61F224
CPC分类号： A61F2/2403 , A61F2/2409
摘要： A heart valve prosthesis having a valve housing providing a lumen therethrough. The valve housing has a first annulus on one end and a second annulus on the other end spaced apart from the first annulus. A suture cuff is used for attaching the valve housing to heart tissue of a patient. The cuff is attached between the first annulus and the second annulus. The cuff is positioned such that prosthesis is attached in a supra-annular position relative to a tissue annulus of the heart. The design allows for an increased valve lumen.
摘要翻译：一种心脏瓣膜假体，其具有提供通过其中的腔的阀壳体。阀壳体在一端具有第一环形空间，而第二环形空间在与第一环空间间隔开的另一端上。缝合袖口用于将阀壳体附接到患者的心脏组织。袖带连接在第一环和第二环之间。袖带被定位成使得假体相对于心脏的组织环连接在超环形位置。该设计允许增加阀腔。

7. 发明授权

US6007577A Prosthetic heart valve with increased valve lumen 失效
公开(公告)号：US6007577A
公开(公告)日：1999-12-28
申请号：US937521
申请日：1997-09-25
申请人： Guy P. Vanney , Avrom M. Brendzel , James R. Ringdal
发明人： Guy P. Vanney , Avrom M. Brendzel , James R. Ringdal
IPC分类号： A61F2/24
CPC分类号： A61F2/2403 , A61F2/2409
摘要： A heart valve prosthesis having a valve housing providing a lumen therethrough. The valve housing has a first annulus on one end and a second annulus on the other end spaced apart from the first annulus. A suture cuff is used for attaching the valve housing to heart tissue of a patient. The cuff is attached between the first annulus and the second annulus. The cuff is positioned such that prosthesis is attached in a supra-annular position relative to a tissue annulus of the heart. The design allows for an increased valve lumen.

8. 发明授权

US06761736B1 Medical article with a diamond-like carbon coated polymer 有权
标题翻译：具有类金刚石碳涂层聚合物的医疗用品
公开(公告)号：US06761736B1
公开(公告)日：2004-07-13
申请号：US09437167
申请日：1999-11-10
申请人： Yi-Ren Woo , Avrom M. Brendzel , Chad Qingshen Cai , Stephen A. Peterson
发明人： Yi-Ren Woo , Avrom M. Brendzel , Chad Qingshen Cai , Stephen A. Peterson
IPC分类号： A61F224
CPC分类号： A61L33/025 , Y10S977/89
摘要： Implantable vascular devices and implantable cardiovascular devices suitable for contacting a patient's blood or bodily fluids include a polymer substrate that is at least partly coated with a diamond-like carbon coating. The diamond-like carbon coated polymer substrate can be flexible or rigid. Preferred medical devices include heart valve prostheses with leaflets or orifice rings formed from diamond-like carbon coated polymer materials. Preferred approaches for the deposition of the diamond-like carbon coating are performed at low pressures and include ion beam assisted deposition.
摘要翻译：适于接触患者血液或体液的植入式血管装置和可植入的心血管装置包括至少部分地涂覆有类金刚石碳涂层的聚合物基底。类金刚石碳涂覆的聚合物基材可以是柔性的或刚性的。优选的医疗装置包括具有由类金刚石碳涂覆的聚合物材料形成的小叶或孔环的心脏瓣膜假体。用于沉积类金刚石碳涂层的优选方法在低压下进行并且包括离子束辅助沉积。

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