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1. 发明申请

US20120204082A1 DATA BUS SYSTEM, ITS ENCODER/DECODER AND ENCODING/DECODING METHOD 有权
标题翻译：数据总线系统，其编码器/解码器和编码/解码方法
公开(公告)号：US20120204082A1
公开(公告)日：2012-08-09
申请号：US13446565
申请日：2012-04-13
申请人： Wen Bo Shen , Chao-Jun Liu , Yi Ge , Qiang Liu
发明人： Wen Bo Shen , Chao-Jun Liu , Yi Ge , Qiang Liu
IPC分类号： H03M13/00 , G06F11/08
CPC分类号： G06F11/10
摘要： The present application relates to a data bus system, its encoder/decoder and encoding/decoding method. The data bus encoder comprises: a bus-invert encoder for generating encoded data and invert-indication information by performing bus-invert encoding on data according to a predetermined bus-invert encoding scheme; a virtual bit-group generator for converting the invert-indication information into a virtual bit-group according to a predetermined code mapping; and an error-checking-and-correction encoder for generating an error-checking-and-correction code for a virtual word according to a predetermined error-checking-and-correction encoding scheme, wherein the number of error-checking bits is more than the number of error-correction bits at least by one in the predetermined error-checking-and-correction encoding scheme, and the virtual word includes the data to be output, the virtual bit-group corresponding to the data, and at least one padding bit of a fixed value, which is configured as required by the error-checking-and-correction encoding scheme.
摘要翻译：本申请涉及数据总线系统，其编码器/解码器和编码/解码方法。数据总线编码器包括：总线反转编码器，用于通过根据预定的总线反转编码方案对数据执行总线反转编码来产生编码数据和反转指示信息; 虚拟位组生成器，用于根据预定的代码映射将反转指示信息转换为虚拟位组; 以及用于根据预定的错误检查和校正编码方案为虚拟字生成错误校验码的纠错编码器，其中错误校验位的数目大于在预定的错误校验和校正编码方案中至少一个纠错位的数量，虚拟字包括要输出的数据，对应于数据的虚拟位组，以及至少一个填充位，其被配置为由错误校验和校正编码方案所要求的。

2. 发明授权

US08181101B2 Data bus system, its encoder/decoder and encoding/decoding method 有权
标题翻译：数据总线系统，其编码器/解码器和编码/解码方法
公开(公告)号：US08181101B2
公开(公告)日：2012-05-15
申请号：US12363128
申请日：2009-01-30
申请人： Wen Bo Shen , Chao-Jun Liu , Yi Ge , Qiang Liu
发明人： Wen Bo Shen , Chao-Jun Liu , Yi Ge , Qiang Liu
IPC分类号： H03L1/00
CPC分类号： G06F11/10
摘要： The present application relates to a data bus system, its encoder/decoder and encoding/decoding method. The data bus encoder comprises: a bus-invert encoder for generating encoded data and invert-indication information by performing bus-invert encoding on data according to a predetermined bus-invert encoding scheme; a virtual bit-group generator for converting the invert-indication information into a virtual bit-group according to a predetermined code mapping; and an error-checking-and-correction encoder for generating an error-checking-and-correction code for a virtual word according to a predetermined error-checking-and-correction encoding scheme, wherein the number of error-checking bits is more than the number of error-correction bits at least by one in the predetermined error-checking-and-correction encoding scheme, the mapping is such that the Hamming distance between any possible value of the virtual bit-group and a reference virtual bit-group which cannot be converted into under the mapping is a fixed value, and not greater than the number of error-correction bits of the error-checking-and-correction encoding scheme, and the virtual word includes the data to be output, the virtual bit-group corresponding to the data, and at least one padding bit of a fixed value, which is configured as required by the error-checking-and-correction encoding scheme.
摘要翻译：本申请涉及数据总线系统，其编码器/解码器和编码/解码方法。数据总线编码器包括：总线反转编码器，用于通过根据预定的总线反转编码方案对数据执行总线反转编码来产生编码数据和反转指示信息; 虚拟位组生成器，用于根据预定的代码映射将反转指示信息转换为虚拟位组; 以及用于根据预定的错误检查和校正编码方案为虚拟字生成错误校验码的纠错编码器，其中错误校验位的数目大于在预定的错误校验和校正编码方案中至少一个纠错位的数量，映射使得虚拟位组的任何可能值和参考虚拟位组之间的汉明距离，其中不能转换成映射为固定值，并且不大于错误校验和校正编码方案的纠错位数，虚拟字包括要输出的数据，虚拟位 - 对应于数据的组，以及被配置为由错误校验和校正编码方案所要求的固定值的至少一个填充位。

3. 发明申请

US20090193319A1 DATA BUS SYSTEM, ITS ENCODER/DECODER AND ENCODING/DECODING METHOD 有权
标题翻译：数据总线系统，其编码器/解码器和编码/解码方法
公开(公告)号：US20090193319A1
公开(公告)日：2009-07-30
申请号：US12363128
申请日：2009-01-30
申请人： Wen Bo Shen , Chao-Jun Liu , Yi Ge , Qiang Liu
发明人： Wen Bo Shen , Chao-Jun Liu , Yi Ge , Qiang Liu
IPC分类号： H03M13/13 , G06F11/10
CPC分类号： G06F11/10
摘要： The present application relates to a data bus system, its encoder/decoder and encoding/decoding method. The data bus encoder comprises: a bus-invert encoder for generating encoded data and invert-indication information by performing bus-invert encoding on data according to a predetermined bus-invert encoding scheme; a virtual bit-group generator for converting the invert-indication information into a virtual bit-group according to a predetermined code mapping; and an error-checking-and-correction encoder for generating an error-checking-and-correction code for a virtual word according to a predetermined error-checking-and-correction encoding scheme, wherein the number of error-checking bits is more than the number of error-correction bits at least by one in the predetermined error-checking-and-correction encoding scheme, the mapping is such that the Hamming distance between any possible value of the virtual bit-group and a reference virtual bit-group which cannot be converted into under the mapping is a fixed value, and not greater than the number of error-correction bits of the error-checking-and-correction encoding scheme, and the virtual word includes the data to be output, the virtual bit-group corresponding to the data, and at least one padding bit of a fixed value, which is configured as required by the error-checking-and-correction encoding scheme.
摘要翻译：本申请涉及数据总线系统，其编码器/解码器和编码/解码方法。数据总线编码器包括：总线反转编码器，用于通过根据预定的总线反转编码方案对数据执行总线反转编码来产生编码数据和反转指示信息; 虚拟位组生成器，用于根据预定的代码映射将反转指示信息转换为虚拟位组; 以及用于根据预定的错误检查和校正编码方案为虚拟字生成错误校验码的纠错编码器，其中错误校验位的数目大于在预定的错误校验和校正编码方案中至少一个纠错位的数量，映射使得虚拟位组的任何可能值和参考虚拟位组之间的汉明距离，其中不能转换成映射为固定值，并且不大于错误校验和校正编码方案的纠错位数，虚拟字包括要输出的数据，虚拟位 - 对应于数据的组，以及被配置为由错误校验和校正编码方案所要求的固定值的至少一个填充位。

4. 发明授权

US08418047B2 Data bus system, its encoder/decoder and encoding/decoding method 有权
标题翻译：数据总线系统，其编码器/解码器和编码/解码方式
公开(公告)号：US08418047B2
公开(公告)日：2013-04-09
申请号：US13446565
申请日：2012-04-13
申请人： Wen Bo Shen , Chao-Jun Liu , Yi Gee , Qiang Liu
发明人： Wen Bo Shen , Chao-Jun Liu , Yi Gee , Qiang Liu
IPC分类号： H04L1/00
CPC分类号： G06F11/10
摘要： The present application relates to a data bus system, its encoder/decoder and encoding/decoding method. The data bus encoder comprises: a bus-invert encoder for generating encoded data and invert-indication information by performing bus-invert encoding on data according to a predetermined bus-invert encoding scheme; a virtual bit-group generator for converting the invert-indication information into a virtual bit-group according to a predetermined code mapping; and an error-checking-and-correction encoder for generating an error-checking-and-correction code for a virtual word according to a predetermined error-checking-and-correction encoding scheme, wherein the number of error-checking bits is more than the number of error-correction bits at least by one in the predetermined error-checking-and-correction encoding scheme, and the virtual word includes the data to be output, the virtual bit-group corresponding to the data, and at least one padding bit of a fixed value, which is configured as required by the error-checking-and-correction encoding scheme.
摘要翻译：本申请涉及数据总线系统，其编码器/解码器和编码/解码方法。数据总线编码器包括：总线反转编码器，用于通过根据预定的总线反转编码方案对数据执行总线反转编码来产生编码数据和反转指示信息; 虚拟位组生成器，用于根据预定的代码映射将反转指示信息转换为虚拟位组; 以及用于根据预定的错误检查和校正编码方案为虚拟字生成错误校验码的纠错编码器，其中错误校验位的数目大于在预定的错误校验和校正编码方案中至少一个纠错位的数量，虚拟字包括要输出的数据，对应于数据的虚拟位组，以及至少一个填充位，其被配置为由错误校验和校正编码方案所要求的。

5. 发明授权

US11845981B2 Delayed pyrophosphorolysis activated polymerization 有权
公开(公告)号：US11845981B2
公开(公告)日：2023-12-19
申请号：US17586596
申请日：2022-01-27
申请人： Shaofeng Ding , Qiang Liu
发明人： Shaofeng Ding , Qiang Liu
IPC分类号： C12Q1/6853 , C12Q1/686 , C12Q1/6858
CPC分类号： C12Q1/6853 , C12Q1/686 , C12Q2525/186 , C12Q2565/301
摘要： A minimal-copy-ratio of templates is a problem in detecting early stage cancer where minimal copies of somatic cancer-specific mutations are targeted in the presence of large copies of wildtype genome DNA, commonly a 1/10,000 or even less minimal-copy-ratios between the mutant target and wildtype control templates. To overcome this problem, delayed pyrophosphorolysis activated polymerization (delayed-PAP) was developed which can delay product accumulation of the wildtype control to a much later time or cycle, such as by 15 cycles or by 30,000 folds. In the multiplex format, delayed-PAP is particularly useful to amplify not only the wildtype control but also mutant target templates accurately and consistently in the minimal-copy-ratio situation.

6. 发明申请

US20200150047A1 Pyrophosphorolysis activated fluorescence to measure PAP amplification of nucleic acid 审中-公开
公开(公告)号：US20200150047A1
公开(公告)日：2020-05-14
申请号：US16658029
申请日：2019-10-19
申请人： Shaofeng Ding , Qiang Liu
发明人： Shaofeng Ding , Qiang Liu
IPC分类号： G01N21/76 , C12Q1/6844
摘要： A new fluorescence detection method called pyrophosphorolysis activated fluorescence was developed to measure PAP amplification of nucleic acid. A fluorophore-quencher dual-attached blocked primer was used for PAP which has a fluorophore attached to a nucleotide in the internal region or at the 5′ end and a quencher attached to a blocked nucleotide at the 3′ end. Multiple fluorophore-quencher dual-labeled blocked primers were also used for multiplex PAP, which are attached with different fluorophores to distinguish multiple templates in a reaction.

7. 发明授权

US10619197B2 Lyophilized integrated composition for storage and manipulation of pyrophosphorolysis activated polymerization 有权
公开(公告)号：US10619197B2
公开(公告)日：2020-04-14
申请号：US15825114
申请日：2017-11-29
申请人： Shaofeng Ding , Qiang Liu
发明人： Shaofeng Ding , Qiang Liu
IPC分类号： C12Q1/68 , C12Q1/6848 , C12Q1/6844
CPC分类号： C12Q1/6848 , C12Q1/6844 , C12Q1/6844 , C12Q2527/125
摘要： The invention provides a method for lyophilizing integrated composition of pyrophosphorolysis activated polymerization (PAP) in an aqueous solution. It also provides lyophilized integrated PAP composition. Except for nucleic acid template, the integrated composition contains all components. For manipulation, simply add nucleic acid template in an aqueous solution to start amplification. In addition to the easy manipulation, the lyophilized integrated composition can be stored for prolonged period at ambiguous temperature.

8. 发明申请

US20190271035A1 Multiplex pyrophosphorolysis activated polymerization to amplify multiple almost-sequence-identical templates in a single reaction 审中-公开
公开(公告)号：US20190271035A1
公开(公告)日：2019-09-05
申请号：US16408442
申请日：2019-05-09
申请人： Shaofeng Ding , Qiang Liu
发明人： Shaofeng Ding , Tony Zhou Lee , Qiang Liu
IPC分类号： C12Q1/6853 , C12Q1/6848 , C12Q1/6858
摘要： Multiplex pyrophosphorolysis activated polymerization uses multiple pairs of blocked primers to amplify multiple potential templates in a single reaction, including those almost-sequence-identical templates located in one locus. To identify and differentiate the multiple amplified products, individual molecules are sequenced in parallel. Thus multiplex PAP amplification is combined with parallel sequencing for ultrahigh-sensitive, ultrahigh-selective and ultrahigh-throughput detection of early cancer.

9. 发明申请

US20180073067A1 Lyophilized integrated composition for storage and manipulation of pyrophosphorolysis activated polymerization 审中-公开
公开(公告)号：US20180073067A1
公开(公告)日：2018-03-15
申请号：US15825114
申请日：2017-11-29
申请人： Shaofeng Ding , Qiang Liu
发明人： Shaofeng Ding , Qiang Liu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6848 , C12Q1/6844 , C12Q2527/125
摘要： The invention provides a method for lyophilizing integrated composition of pyrophosphorolysis activated polymerization (PAP) in an aqueous solution. It also provides lyophilized integrated PAP composition. Except for nucleic acid template, the integrated composition contains all components. For manipulation, simply add nucleic acid template in an aqueous solution to start amplification. In addition to the easy manipulation, the lyophilized integrated composition can be stored for prolonged period at ambiguous temperature.

10. 发明授权

US09470205B2 Wind turbine blades with layered, multi-component spars, and associated systems and methods 有权
标题翻译：具有分层，多组分翼梁的风力涡轮机叶片以及相关的系统和方法
公开(公告)号：US09470205B2
公开(公告)日：2016-10-18
申请号：US13802590
申请日：2013-03-13
申请人： Qiang Liu , Myles L. Baker
发明人： Qiang Liu , Myles L. Baker
IPC分类号： F03D1/06 , F03D1/00 , B29C70/52 , B29L31/08 , B29C65/48 , B29C65/00
CPC分类号： F03D1/0675 , B29C65/48 , B29C66/1248 , B29C66/43 , B29C66/721 , B29C70/52 , B29L2031/085 , F03D13/10 , F05B2240/302 , Y02E10/721 , Y02E10/728 , Y02P70/523 , Y10T29/49337
摘要： Wind turbine blades with layered, multi-component spars, and associated systems and methods are disclosed. A wind turbine blade system in accordance with a particular embodiment includes a first blade segment having a first spar element that includes first planks having a first thickness and a first plank composition, and a second blade segment having a second spar element that includes second planks having a second thickness and a second plank composition different than the first plank composition. The second blade segment is joined to the first blade segment at a joint, and, in particular embodiments, an overall product of thickness and elastic modulus of the first planks is approximately equal to an overall product of thickness and elastic modulus for the second planks.
摘要翻译：公开了具有分层，多组分翼梁以及相关系统和方法的风力涡轮机叶片。根据特定实施例的风力涡轮机叶片系统包括具有第一翼梁元件的第一叶片段，所述第一翼梁元件包括具有第一厚度的第一木板和第一木板组合物，以及具有第二翼梁元件的第二叶片段，所述第二翼梁元件包括第二木板，第二厚度和与第一板组合物不同的第二板组合物。第二刀片段在接头处连接到第一刀片段，并且在具体实施例中，第一板的厚度和弹性模量的总体乘积近似等于第二板的厚度和弹性模量的总积。

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