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    • 3. 发明申请
    • Cobalamin conjugates for anti-tumor therapy
    • 钴胺素共轭物用于抗肿瘤治疗
    • US20050054607A1
    • 2005-03-10
    • US10659501
    • 2003-09-10
    • Ned WeinshenkerFrederick WestBarbara AraneoWeiping Li
    • Ned WeinshenkerFrederick WestBarbara AraneoWeiping Li
    • A01N43/04A61K20060101A61K31/70A61K31/714A61K47/48
    • A61K47/551
    • The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a first spacer or the cleavable linker via the 5′-OH of the cobalamin ribose ring. The drug is bound to a second spacer of the cleavable linker via an existing or added functional group on the drug. After administration, the conjugate forms a complex with transcobalamin (any of its isoforms). The complex then binds to a receptor on a cell membrane and is taken up into the cell. Once in the cell, an intracellular enzyme cleaves the conjugate thereby releasing the drug. Depending upon the structure of the conjugate, a particular class or type of intracellular enzyme affects the cleavage. Due to the high demand for cobalamin in growing cells, tumor cells typically take up a higher percentage of the conjugate than do normal non-growing cells. The conjugate of the invention advantageously provides a reduced systemic toxicity and enhanced efficacy as compared to a corresponding free drug.
    • 本发明提供了一种适用于治疗肿瘤相关疾病的钴胺素药物缀合物。 钴胺素通过可裂解连接体和一个或多个任选的间隔物间接共价结合抗肿瘤药物。 钴胺素通过钴胺核糖环的5'-OH共价结合到第一间隔物或可切割的接头。 药物通过药物上现有或添加的官能团与可切割接头的第二间隔物结合。 给药后,缀合物与转钴胺素(其任何同种型)形成复合物。 然后,该复合物与细胞膜上的受体结合,并被吸收到细胞中。 一旦在细胞中,细胞内酶切割缀合物从而释放药物。 根据缀合物的结构,细胞内酶的特定类别或类型影响切割。 由于对生长细胞中钴胺素的高需求,肿瘤细胞通常占有比正常非生长细胞更高的缀合物百分比。 与相应的游离药物相比,本发明的缀合物有利地提供降低的全身毒性和增强的功效。
    • 5. 发明授权
    • Controlled delivery of therapeutic agents by insertable medical devices
    • 通过可插入的医疗设备控制治疗剂的输送
    • US06899731B2
    • 2005-05-31
    • US09750779
    • 2001-01-02
    • Weiping LiHai-Quan MaoKam W. Leong
    • Weiping LiHai-Quan MaoKam W. Leong
    • A61L29/16A61L31/16A61F2/06A61K48/00
    • A61L31/16A61L29/16A61L2300/258A61L2300/416A61L2300/602A61L2300/608A61L2300/802
    • A medical device and method for transportation and release of a therapeutic agent into a mammalian body are disclosed. The medical device is coated with alternating layers of a negatively charged therapeutic agent and a cationic polyelectrolyte, following a controlled adsorption technique. The method is simple, with minimal perturbation to the therapeutic agent and uses clinically acceptable biopolymers such as human serum albumin. The amount of the therapeutic agent that can be delivered by this technique is optimized by the number of the layers of the therapeutic agent adsorbed on the surface of medical device. There is a washing step between alternate layers of the therapeutic agent and cationic polyelectrolyte carrier, so that the amount of the therapeutic agent on the insertable medical device represents the portion that is stably entrapped and adsorbed on to the medical device. The insertable medical device and method according to this invention are capable of reproducibly delivering therapeutic agent to a site in a mammalian body, and allow for a highly reproducible and controllable release kinetics of the therapeutic agent.
    • 公开了用于将哺乳动物体内的治疗剂输送和释放的医疗装置和方法。 在受控吸附技术之后,医疗装置涂覆有带负电的治疗剂和阳离子聚电解质的交替层。 该方法简单,对治疗剂的扰动最小,并且使用临床可接受的生物聚合物例如人血清白蛋白。 通过该技术可以递送的治疗剂的量通过吸收在医疗装置表面上的治疗剂的层数来优化。 在治疗剂和阳离子聚电解质载体的交替层之间存在洗涤步骤,使得可插入医疗装置上的治疗剂的量表示稳定地截留并吸附到医疗装置上的部分。 根据本发明的可插入医疗装置和方法能够将治疗剂可再现地递送到哺乳动物体内的部位,并且允许治疗剂的高度可重现和可控的释放动力学。
    • 6. 发明授权
    • Encoding and decoding apparatus and method for analog and digital signals
    • 用于模拟和数字信号的编码和解码装置和方法
    • US5940542A
    • 1999-08-17
    • US743631
    • 1996-11-04
    • Weiping LiQinghong CaoChun WangKenneth K. Tzeng
    • Weiping LiQinghong CaoChun WangKenneth K. Tzeng
    • G06T9/00G06K9/36H04L23/02H04L27/06
    • G06T9/008
    • A method and apparatus is disclosed for encoding and decoding an input signal representative of video or audio information. A form of the method includes the following steps: processing the input signal to produce a sequence of vectors representative of the input signal; implementing a lattice vector quantization procedure on individual vectors of the sequence to identify a lattice point of a lattice that is closest to the individual vector and to obtain an index value representative of a labelling of the identified lattice point, the lattice vector quantization procedure including a multi-level allocation of groups of reserved indices, and selection of the index value for the individual vector within a group of reserved indices. The index signals representative of the index values are stored and/or transmitted, and then recovered for decoding. The decoding is operative to obtain a recovered sequence of vectors, and the sequence of vectors can be processed to produce an output signal.
    • 公开了一种用于对表示视频或音频信息的输入信号进行编码和解码的方法和装置。 该方法的一种形式包括以下步骤:处理输入信号以产生表示输入信号的向量序列; 对所述序列的各个向量实施格子矢量量化过程,以识别最接近所述个体矢量的格子的格点,并获得表示所识别的格点的标记的索引值,所述格子矢量量化过程包括 保留索引组的多级分配,以及一组保留索引内各个向量的索引值的选择。 表示索引值的索引信号被存储和/或发送,然后被恢复用于解码。 解码操作以获得恢复的向量序列,并且可以处理向量序列以产生输出信号。
    • 9. 发明授权
    • Modular LED lighting systems and flexible or rigid strip lighting devices
    • 模块化LED照明系统和柔性或刚性条带照明装置
    • US08262250B2
    • 2012-09-11
    • US12499306
    • 2009-07-08
    • Qing Charles LiWeiping LiQingyue ZuoYihang Pan
    • Qing Charles LiWeiping LiQingyue ZuoYihang Pan
    • F21S4/00
    • F21V23/06F21S4/24F21S4/28F21V17/007F21V21/005F21Y2103/10F21Y2115/10H05K1/189H05K2201/10106H05K2201/10189
    • The present invention relates to lighting strips and more particularly to modular lighting systems comprising lighting devices, for example, lighting strips, physically and electrically connectable with one another by way of a plug and socket integrally formed at opposing ends of the lighting strips. The lighting strip devices can be made of flexible material to allow for applying the lighting devices along flat as well as contoured surfaces. The lighting strips can also be rigid. More particularly, embodiments of the invention include modular lighting strips comprising: a non-conductive substrate strip comprising an electrical circuit; a plurality of light sources operably connected to the electrical circuit; a plug integrally formed at an end of the substrate strip; and a socket integrally formed at an opposing end of the substrate strip; wherein the plug and socket provide for removable, friction-fit, latch or latchless, and electrical interconnection of two or more circuits. Also included in the invention are connector assemblies comprising the inventive socket and plugs integral to PCBs for use in the field of electronics. One or more lighting strip can be combined to form lighting systems, which are useful in many functional and decorative lighting applications. The lighting systems are useful for any residential or commercial application where modular, discrete, low-profile, and/or flexible lighting is desired. The lighting strips of the invention can be used in particular for back lighting, accent lighting, aisle or path lighting, contour lighting, elegant interior decoration, holiday decorations, or landscape lighting.
    • 技术领域本发明涉及照明条,更具体地涉及包括照明装置(例如,照明条)的模块化照明系统,所述照明装置通过一体地形成在照明条的相对端处的插头和插座彼此物理上和电气可连接。 照明条装置可以由柔性材料制成,以便沿着平坦和轮廓的表面施加照明装置。 照明条也可以是刚性的。 更具体地,本发明的实施例包括模块化照明条,其包括:包括电路的非导电衬底条; 多个光源,可操作地连接到所述电路; 一体地形成在所述基板条的端部的插塞; 以及一体地形成在所述基板条的相对端部的插座; 其中所述插头和插座提供两个或更多个电路的可移除,摩擦配合,闩锁或闩锁和电互连。 本发明还包括连接器组件,其包括本发明的插座和与电子器件领域中使用的PCB集成的插头。 一个或多个照明条可以组合以形成在许多功能和装饰照明应用中有用的照明系统。 照明系统对于需要模块化,分立,低调和/或柔性照明的住宅或商业应用是有用的。 本发明的照明条特别可用于背光照明,重点照明,通道照明,道路照明,轮廓照明,优雅的室内装饰,假日装饰或景观照明。