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1. 发明授权

US06273856B1 Apparatus and methods for METS measurement by accelerometer and minute ventilation sensors 有权
标题翻译：通过加速度计和分钟通气传感器进行METS测量的装置和方法
公开(公告)号：US06273856B1
公开(公告)日：2001-08-14
申请号：US09421017
申请日：1999-10-19
申请人： Weimin Sun , Bruce R. Jones , Donald L. Hopper , Wyatt K. Stahl
发明人： Weimin Sun , Bruce R. Jones , Donald L. Hopper , Wyatt K. Stahl
IPC分类号： A61B500
CPC分类号： A61N1/36585
摘要： Exertion levels of a patient are measured by monitoring signals from adaptive-rate sensors such as an accelerometer and or a minute ventilation sensor; sensor data is collected for conversion into metabolic equivalent measurements. The data obtained can be used to evaluate patient physical activity levels and can be used to assess the patient's condition and change pacing therapy or other treatments accordingly. An automatic adjustment of the adaptive-rate pacing therapy may be based on the activity levels detected by the metabolic equivalent measurements made by the pacemaker.
摘要翻译：通过监测来自自适应速率传感器（例如加速度计和/或分钟通气传感器）的信号来测量患者的消耗水平; 收集传感器数据以转化为代谢等效测量。获得的数据可用于评估患者的身体活动水平，并可用于相应地评估患者的状况和改变起搏治疗或其他治疗。自适应起搏治疗的自动调整可以基于由起搏器进行的代谢等效测量检测到的活动水平。

2. 发明授权

US08494632B2 Self-calibrating rate-adaptive pacemaker 失效
公开(公告)号：US08494632B2
公开(公告)日：2013-07-23
申请号：US13230563
申请日：2011-09-12
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
IPC分类号： A61N1/18
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

3. 发明授权

US08019418B2 Self-calibrating rate-adaptive pacemaker 有权
标题翻译：自校准速率自适应起搏器
公开(公告)号：US08019418B2
公开(公告)日：2011-09-13
申请号：US12507414
申请日：2009-07-22
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
IPC分类号： A61N1/18
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.
摘要翻译：一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。

4. 发明申请

US20090287270A1 SELF-CALIBRATING RATE-ADAPTIVE PACEMAKER 有权
标题翻译：自校准率自适应贴片机
公开(公告)号：US20090287270A1
公开(公告)日：2009-11-19
申请号：US12507414
申请日：2009-07-22
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.
摘要翻译：一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。

5. 发明授权

US06459929B1 Implantable cardiac rhythm management device for assessing status of CHF patients 有权
标题翻译：用于评估CHF患者状态的植入式心律管理装置
公开(公告)号：US06459929B1
公开(公告)日：2002-10-01
申请号：US09547519
申请日：2000-04-12
申请人： Donald L. Hopper , Jeffrey E. Stahmann , Bruce R. Jones , James P. Nelson
发明人： Donald L. Hopper , Jeffrey E. Stahmann , Bruce R. Jones , James P. Nelson
IPC分类号： A61B50205
CPC分类号： A61N1/36585 , A61N1/3627
摘要： A method and apparatus for providing congestive heart failure therapy status. An electronic device, preferably a cardiac rhythm management device, capable of measuring transthoracic impedance and for sensing a level of physical activity is implanted in a patient. The transthoracic impedance signal is processed to obtain an estimate of the subject's minute ventilation, respiratory rate, tidal volume, inspiratory rate and expiratory rate. From accelerometer measured activity, an estimate is obtained of oxygen uptake, carbon dioxide production and work rate. Ratios of tidal volume to respiratory rate, tidal volume to inspiratory time, tidal volume to expiratory time, heart rate to minute ventilation, respiratory rate to minute ventilation, tidal volume to minute ventilation, minute ventilation to oxygen uptake, minute ventilation to carbon dioxide production, minute ventilation to work rate, heart rate to work rate, oxygen uptake to heart rate and other ratios are meaningful status indicators for assessing the efficacy of particular therapy regimens to CHF patients.
摘要翻译：一种用于提供充血性心力衰竭治疗状态的方法和装置。将能够测量经胸阻抗并感测身体活动水平的电子设备，优选心脏节律管理装置植入患者体内。处理经胸阻抗信号，以获得受试者的分钟通气量，呼吸频率，潮气量，吸气率和呼气率的估计。从加速度计测量的活动，得到氧气摄取，二氧化碳生产和工作率的估计。潮气量对呼吸频率，潮气量吸气时间，潮气量与呼气时间，心率与分钟通气量的比例，呼吸频率到每分钟通气量，潮气量到分钟通气量，分钟通气至吸氧量，分钟通气至二氧化碳生成，分钟通气到工作率，心率到工作率，氧摄取对心率和其他比例是评估特定治疗方案对CHF患者的疗效的有意义的状态指标。

6. 发明授权

US06275727B1 Implantable cardiac rhythm management device for assessing status of CHF patients 有权
标题翻译：用于评估CHF患者状态的植入式心律管理装置
公开(公告)号：US06275727B1
公开(公告)日：2001-08-14
申请号：US09434009
申请日：1999-11-04
申请人： Donald L. Hopper , Jeffrey E. Stahmann , Bruce R. Jones , James P. Nelson
发明人： Donald L. Hopper , Jeffrey E. Stahmann , Bruce R. Jones , James P. Nelson
IPC分类号： A61B504
CPC分类号： A61N1/36585 , A61N1/3627
摘要： A method and apparatus for providing congestive heart failure therapy status. An electronic device, preferably a cardiac rhythm management device, capable of measuring transthoracic impedance and for sensing a level of physical activity is implanted in a patient. The transthoracic impedance signal is processed to obtain an estimate of the subject's minute ventilation, respiratory rate and tidal volume. From accelerometer measured activity, an estimate is obtained of oxygen uptake and carbon dioxide production. Ratios of tidal volume to respiratory rate, tidal volume to inspiratory time, minute ventilation to carbon dioxide production and oxygen uptake to heart rate are meaningftil status indicators for assessing the efficacy of particular therapy regimens to CHF patients.
摘要翻译：一种用于提供充血性心力衰竭治疗状态的方法和装置。将能够测量经胸阻抗并感测身体活动水平的电子设备，优选心脏节律管理装置植入患者体内。经胸廓阻抗信号被处理以获得受试者的分钟通气量，呼吸频率和潮气量的估计值。从加速度计测量的活动，得到氧气摄取和二氧化碳生产的估计。潮气量与呼吸频率的比值，潮气量吸气时间，二氧化碳产生的分钟通气量和对心率的氧吸收是评估特定治疗方案对CHF患者的疗效的意义状态指标。

7. 发明授权

US07079897B2 Self-calibrating rate-adaptive pacemaker 失效
公开(公告)号：US07079897B2
公开(公告)日：2006-07-18
申请号：US10839875
申请日：2004-05-06
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
IPC分类号： A61N1/18
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

8. 发明授权

US06839593B1 Rate-adaptive therapy with automatic limiting of maximum pacing rate 有权
标题翻译：速率自适应治疗，自动限制最大起搏率
公开(公告)号：US06839593B1
公开(公告)日：2005-01-04
申请号：US09657404
申请日：2000-09-08
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
IPC分类号： A61N1/18 , A61N1/365
CPC分类号： A61N1/365
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker in which maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. In accordance with the invention, the rate response curve is defined such that an exertion level corresponding to the patient's maximum exercise capacity would be mapped to a physiologically favorable maximum rate that is independent from a specified maximum sensor indicated rate.
摘要翻译：用于自动调整速率自适应心脏起搏器的操作参数的系统和方法，其中以周期性间隔测量由患者达到的最大消耗水平并被存储。然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。根据本发明，速率响应曲线被定义为使得与患者的最大运动能力相对应的运动水平将被映射到独立于指定的最大传感器指示速率的生理上有利的最大速率。

9. 发明申请

US20120004696A1 SELF-CALIBRATING RATE-ADAPTIVE PACEMAKER 失效
标题翻译：自校准率自适应贴片机
公开(公告)号：US20120004696A1
公开(公告)日：2012-01-05
申请号：US13230563
申请日：2011-09-12
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald Hopper
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.
摘要翻译：一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。

10. 发明授权

US07493163B2 Rate-adaptive therapy with sensor cross-checking 有权
标题翻译：速率自适应治疗与传感器交叉检查
公开(公告)号：US07493163B2
公开(公告)日：2009-02-17
申请号：US11461632
申请日：2006-08-01
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： A method and system for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker in which maximum exertion levels attained by the patient are measured at periodic intervals and stored in order to compute or update a maximum exercise capacity. The slope of the rate-response curve is then adjusted to map an exertion level corresponding to the updated maximum exercise capacity to a maximum allowable pacing rate. In accordance with the invention, a maximum exercise capacity is determined by cross-checking periodic maximum exertion level sensor values with a motion-level sensor value.
摘要翻译：一种用于自动调整速率自适应心脏起搏器的操作参数的方法和系统，其中以周期性间隔测量由患者获得的最大消耗水平并存储以便计算或更新最大运动能力。然后调整速率 - 响应曲线的斜率以将对应于更新的最大运动能力的运动水平映射到最大允许起搏速率。根据本发明，通过用运动水平传感器值交叉检查周期性最大消耗水平传感器值来确定最大运动能力。

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