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1. 发明授权

US08377277B2 System and method for performing microfluidic manipulation 失效
标题翻译：用于执行微流体操作的系统和方法
公开(公告)号：US08377277B2
公开(公告)日：2013-02-19
申请号：US12255962
申请日：2008-10-22
申请人： Jun Xie , Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout
发明人： Jun Xie , Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout
IPC分类号： B01D57/02
CPC分类号： G01N27/44791
摘要： Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis comprises a loading channel, a separation channel, and an injection channel. The loading channel is in fluid communication with a first and second sample port. The separation channel is connected to the loading channel to form a first intersection, and an injection channel connected to the separation channel to form a second intersection and in fluid communication with a first reservoir, and wherein the separation channel is in fluid communication with a second reservoir. The electrophoresis system further comprises two electrodes coupled to the first sample port and the first reservoir, and the first sample port and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the first reservoir and form a sample plug in the separation channel, and to further move the sample plug into the separation channel towards the second reservoir.
摘要翻译：电泳系统和方法包括电泳装置，其中电泳包括加载通道，分离通道和注射通道。装载通道与第一和第二采样端口流体连通。分离通道连接到装载通道以形成第一交叉点，以及连接到分离通道以形成第二交叉并与第一储存器流体连通的注入通道，并且其中分离通道与第二交换流体连通水库电泳系统还包括分别耦合到第一样品端口和第一储存器的两个电极以及适于将样品移动到装载通道中以朝向第一储存器形成样品塞的第一样品端口和第二储存器在分离通道中，并且进一步将样品塞进入分离通道朝向第二储存器。

2. 发明申请

US20100096267A1 SYSTEM AND METHOD FOR PERFORMING MICROFLUIDIC MANIPULATION 失效
标题翻译：用于执行微流控制的系统和方法
公开(公告)号：US20100096267A1
公开(公告)日：2010-04-22
申请号：US12255962
申请日：2008-10-22
申请人： Jun Xie , Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout
发明人： Jun Xie , Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout
IPC分类号： G01N27/26
CPC分类号： G01N27/44791
摘要： Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis comprises a loading channel, a separation channel, and an injection channel. The loading channel is in fluid communication with a first and second sample port. The separation channel is connected to the loading channel to form a first intersection, and an injection channel connected to the separation channel to form a second intersection and in fluid communication with a first reservoir, and wherein the separation channel is in fluid communication with a second reservoir. The electrophoresis system further comprises two electrodes coupled to the first sample port and the first reservoir, and the first sample port and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the first reservoir and form a sample plug in the separation channel, and to further move the sample plug into the separation channel towards the second reservoir.
摘要翻译：电泳系统和方法包括电泳装置，其中电泳包括加载通道，分离通道和注射通道。装载通道与第一和第二采样端口流体连通。分离通道连接到装载通道以形成第一交叉点，以及连接到分离通道以形成第二交叉并与第一储存器流体连通的注入通道，并且其中分离通道与第二交换流体连通水库电泳系统还包括分别耦合到第一样品端口和第一储存器的两个电极以及适于将样品移动到装载通道中以朝向第一储存器形成样品塞的第一样品端口和第二储存器在分离通道中，并且进一步将样品塞进入分离通道朝向第二储存器。

3. 发明授权

US07740748B2 Electrophoresis system and method 失效
标题翻译：电泳系统及方法
公开(公告)号：US07740748B2
公开(公告)日：2010-06-22
申请号：US12258657
申请日：2008-10-27
申请人： Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout , Jun Xie
发明人： Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout , Jun Xie
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , B01L3/502715 , G01N27/44743
摘要： Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis device comprises a loading channel, an injection channel, and a separation channel. The loading channel is in fluid communication with a first and second sample port. The injection channel is connected to the loading channel to form a first intersection. The separation channel is connected to the injection channel to form a second intersection and in fluid communication with a first and second reservoir, and wherein the injection channel is in fluid communication with a third reservoir. The electrophoresis system further comprises electrodes coupled to the first sample port and the third reservoir, and the first reservoir and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the third reservoir and form a sample plug in the second intersection, and to further move the sample plug into the separation channel towards the second reservoir.
摘要翻译：电泳系统和方法包括电泳装置，其中电泳装置包括装载通道，注射通道和分离通道。装载通道与第一和第二采样端口流体连通。注入通道连接到装载通道以形成第一交叉。分离通道连接到注入通道以形成第二交叉并且与第一和第二储存器流体连通，并且其中注入通道与第三储存器流体连通。电泳系统还包括分别耦合到第一样品端口和第三储存器的电极，以及分别适于将样品移动到装载通道中的第一储存器和第二储存器，以朝向第三储存器形成样品塞并且将样品塞进一步朝向第二储存器移动到分离通道中。

4. 发明申请

US20100101951A1 ELECTROPHORESIS SYSTEM AND METHOD 失效
标题翻译：电泳系统和方法
公开(公告)号：US20100101951A1
公开(公告)日：2010-04-29
申请号：US12258657
申请日：2008-10-27
申请人： Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout , Jun Xie
发明人： Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout , Jun Xie
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , B01L3/502715 , G01N27/44743
摘要： Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis device comprises a loading channel, an injection channel, and a separation channel. The loading channel is in fluid communication with a first and second sample port. The injection channel is connected to the loading channel to form a first intersection. The separation channel is connected to the injection channel to form a second intersection and in fluid communication with a first and second reservoir, and wherein the injection channel is in fluid communication with a third reservoir. The electrophoresis system further comprises electrodes coupled to the first sample port and the third reservoir, and the first reservoir and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the third reservoir and form a sample plug in the second intersection, and to further move the sample plug into the separation channel towards the second reservoir.
摘要翻译：电泳系统和方法包括电泳装置，其中电泳装置包括装载通道，注射通道和分离通道。装载通道与第一和第二采样端口流体连通。注入通道连接到装载通道以形成第一交叉。分离通道连接到注入通道以形成第二交叉并且与第一和第二储存器流体连通，并且其中注入通道与第三储存器流体连通。电泳系统还包括分别耦合到第一样品端口和第三储存器的电极，以及分别适于将样品移动到装载通道中的第一储存器和第二储存器，以朝向第三储存器形成样品塞并且将样品塞进一步朝向第二储存器移动到分离通道中。

5. 发明授权

US08622223B2 Membrane assemblies and methods of making and using the same 失效
标题翻译：膜组件及其制造和使用方法
公开(公告)号：US08622223B2
公开(公告)日：2014-01-07
申请号：US12337164
申请日：2008-12-17
申请人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
发明人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
IPC分类号： B01D71/02 , B01D69/12 , B01D63/08
CPC分类号： C23C26/00 , B01D67/0065 , C23C28/00 , C23C28/04 , C25D11/02 , C25D11/045 , C25D11/32 , Y10T428/249953 , Y10T428/249967 , Y10T428/249969
摘要： A method of making a membrane assembly is provided. The method comprises forming an inorganic membrane layer disposed on a substrate, and forming a plurality of macropores in the substrate at least in part using anodization. Further, a membrane assembly is provided. The membrane assembly comprises a filtering membrane that is coupled to an anodized substrate comprising a plurality of macropores.
摘要翻译：提供制造膜组件的方法。该方法包括形成设置在基板上的无机膜层，并且至少部分地使用阳极氧化在基板中形成多个大孔。此外，提供了膜组件。膜组件包括过滤膜，其与包括多个大孔的阳极化底物耦合。

6. 发明申请

US20100159572A1 DEVICE AND ASSOCIATED METHOD 审中-公开
标题翻译：装置和相关方法
公开(公告)号：US20100159572A1
公开(公告)日：2010-06-24
申请号：US12340789
申请日：2008-12-22
申请人： Rui Chen , Anping Zhang , Anup Sood , Anthony John Murray
发明人： Rui Chen , Anping Zhang , Anup Sood , Anthony John Murray
IPC分类号： C12M1/34 , B01J19/00 , B05D3/02
CPC分类号： B01J19/0046 , B01J2219/00536 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , G01N33/54353 , G01N33/552
摘要： A microfluidic device for detecting one or more molecules of interest comprising: a non-conductive substrate; wherein the non-conductive substrate is provided with a plurality of thermally active elements is provided. A method for selectively functionalizing a plurality of thermally active elements is also provided.
摘要翻译：一种用于检测一个或多个感兴趣分子的微流体装置，包括：非导电衬底; 其中所述非导电基板设置有多个热活性元件。还提供了一种用于选择性地功能化多个热活性元件的方法。

7. 发明申请

US20100300882A1 DEVICES AND METHODS FOR IN-LINE SAMPLE PREPARATION OF MATERIALS 审中-公开
标题翻译：用于材料的在线样品制备的装置和方法
公开(公告)号：US20100300882A1
公开(公告)日：2010-12-02
申请号：US12471519
申请日：2009-05-26
申请人： Anping Zhang , Anthony John Murray , Rui Chen , Wei Yuan
发明人： Anping Zhang , Anthony John Murray , Rui Chen , Wei Yuan
IPC分类号： C25B7/00 , B01D61/42 , C07K1/26
CPC分类号： C07K1/34 , B01D63/087 , B01D2325/028 , B01L3/502753 , B01L2200/0631 , B01L2300/0681 , C07K1/16
摘要： A microfluidic device for in-line sample preparation of one or more materials. The microfludic device comprises an in-line tangential flow component. The in-line tangential flow component comprises a first channel through which the sample flows; and one or more additional channels. The first channel and the one ore more channels are separated by a membrane; and wherein a differential is present between the first channel and additional channel that is separated by the membrane.
摘要翻译：用于在线样品制备一种或多种材料的微流体装置。微流体装置包括直线切向流分量。在线切向流分量包括样品流过的第一通道; 和一个或多个附加信道。第一个通道和一个以上的通道被隔膜隔开; 并且其中在所述第一通道和由所述隔膜分离的附加通道之间存在差速器。

8. 发明申请

US20100129795A1 AGENTS AND METHODS FOR SPECTROMETRIC ANALYSIS 审中-公开
标题翻译：用于光谱分析的试剂和方法
公开(公告)号：US20100129795A1
公开(公告)日：2010-05-27
申请号：US12275753
申请日：2008-11-21
申请人： Andrew David Pris , Tracy Lynn Paxon , Anthony John Murray
发明人： Andrew David Pris , Tracy Lynn Paxon , Anthony John Murray
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N33/54306
摘要： Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or vapor phase detection methods.
摘要翻译：本文公开了用于以单一或多路复用的方式确定样品中靶或多个靶的存在或浓度的试剂，方法和试剂盒。通常，这些方法可以分析在液相中产生或消耗的小分子，这些分子可以使用气相或气相检测方法进行分析。

9. 发明授权

US10046995B2 Wastewater treatment plant online monitoring and control 有权
公开(公告)号：US10046995B2
公开(公告)日：2018-08-14
申请号：US14234955
申请日：2012-07-25
申请人： Aditya Kumar , Anthony John Murray , Ruijie Shi , Zhaoyang Wan , Mustafa Tekin Dokucu , Vijaysai Prasad
发明人： Aditya Kumar , Anthony John Murray , Ruijie Shi , Zhaoyang Wan , Mustafa Tekin Dokucu , Vijaysai Prasad
IPC分类号： C02F3/00 , C02F3/12 , C02F3/28 , C02F3/30 , C02F1/66 , G01N33/18 , G01N21/00 , G01N33/00 , G01N31/00
摘要： A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer.

10. 发明申请

US20160202254A1 NANOSTRUCTURED DEVICES FOR DETECTING AND ANALYZING BIOMOLECULES 有权
标题翻译：用于检测和分析生物分子的纳米结构设备
公开(公告)号：US20160202254A1
公开(公告)日：2016-07-14
申请号：US11947834
申请日：2007-11-30
申请人： An-Ping Zhang , Anthony John Murray , Rui Chen
发明人： An-Ping Zhang , Anthony John Murray , Rui Chen
IPC分类号： G01N33/543 , G01N27/414
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y40/00 , G01N27/327 , G01N27/4145 , G01N27/4146 , G01N33/545
摘要： A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.
摘要翻译：一种生物传感FET器件，包括多个纳米结构SOI沟道，其适于在具有高离子强度的溶液中操作并且提供灵敏度和检测。通常，生物传感装置包括下面的基底层，绝缘体和半导体层，以及半导体层中的多个通道，其在通道中包括多个整体或部分形成的纳米孔。

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