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1. 发明申请

US20070031402A1 Immunoconjugate formulations 有权
标题翻译：免疫缀合物制剂
公开(公告)号：US20070031402A1
公开(公告)日：2007-02-08
申请号：US11498139
申请日：2006-08-03
申请人： Wei Zhang , Michael Fleming , Godfrey Amphlett , Hung-wei Chih , Elizabeth Bartlett
发明人： Wei Zhang , Michael Fleming , Godfrey Amphlett , Hung-wei Chih , Elizabeth Bartlett
IPC分类号： A61K39/395
CPC分类号： A61K47/48561 , A61K9/0019 , A61K47/10 , A61K47/26 , A61K47/40 , A61K47/6803 , A61K47/6849 , A61K47/6863
摘要： The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.
摘要翻译：本发明提供了基本上不含颗粒的免疫偶联物制剂，所述免疫偶联物制剂包含：免疫偶联物和一种或多种选自以下的赋形剂：蔗糖，聚山梨醇酯20，聚山梨醇酯80，环糊精，右旋糖，甘油，聚乙二醇，甘露醇，氯化钠和氨基酸，其中所述制剂是pH为4.5至7.6的缓冲水溶液。本发明还提供了基本上不含聚集体的免疫缀合物制剂，免疫缀合物制剂包含：免疫偶联物和一种或多种选自组氨酸，蔗糖，甘氨酸和氯化钠的赋形剂，其中所述制剂是缓冲水溶液 pH为4.5至7.6。本发明还提供基本上不含颗粒和聚集体的免疫偶联物制剂。

2. 发明授权

US09114179B2 Immunoconjugate formulations 有权
标题翻译：免疫缀合物制剂
公开(公告)号：US09114179B2
公开(公告)日：2015-08-25
申请号：US11498139
申请日：2006-08-03
申请人： Wei Zhang , Michael S. Fleming , Godfrey Amphlett , Hung-wei Chih , Elizabeth Bartlett
发明人： Wei Zhang , Michael S. Fleming , Godfrey Amphlett , Hung-wei Chih , Elizabeth Bartlett
IPC分类号： A61K39/395 , A61K47/48 , A61K9/00 , A61K47/10 , A61K47/26 , A61K47/40
CPC分类号： A61K47/48561 , A61K9/0019 , A61K47/10 , A61K47/26 , A61K47/40 , A61K47/6803 , A61K47/6849 , A61K47/6863
摘要： The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.
摘要翻译：本发明提供了基本上不含颗粒的免疫偶联物制剂，所述免疫偶联物制剂包含：免疫偶联物和一种或多种选自以下的赋形剂：蔗糖，聚山梨醇酯20，聚山梨醇酯80，环糊精，右旋糖，甘油，聚乙二醇，甘露醇，氯化钠和氨基酸，其中所述制剂是pH为4.5至7.6的缓冲水溶液。本发明还提供了基本上不含聚集体的免疫缀合物制剂，免疫缀合物制剂包含：免疫偶联物和一种或多种选自组氨酸，蔗糖，甘氨酸和氯化钠的赋形剂，其中所述制剂是缓冲水溶液 pH为4.5至7.6。本发明还提供基本上不含颗粒和聚集体的免疫偶联物制剂。

3. 发明申请

US20070009540A1 Drug conjugate composition 有权
公开(公告)号：US20070009540A1
公开(公告)日：2007-01-11
申请号：US11521120
申请日：2006-09-14
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
IPC分类号： A61K39/395 , C07K16/46 , C07D491/04
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

4. 发明申请

US20070009541A1 Drug conjugate composition 有权
公开(公告)号：US20070009541A1
公开(公告)日：2007-01-11
申请号：US11521129
申请日：2006-09-14
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
IPC分类号： A61K39/395 , C07K16/46 , C07D491/04
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

5. 发明授权

US07494649B2 Drug conjugate composition 有权
标题翻译：药物缀合物组成
公开(公告)号：US07494649B2
公开(公告)日：2009-02-24
申请号：US11521120
申请日：2006-09-14
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
IPC分类号： A61K39/00 , A61K39/395 , A61K39/44
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.
摘要翻译：本发明提供一种液体组合物和冻干组合物，其包含治疗有效量的包含与美登木素生物素化学偶联的抗体的缀合物。本发明进一步提供了一种杀死人体细胞的方法，包括对人体施用组合物使得抗体结合细胞表面，并且美登木素生物碱的细胞毒性被激活，由此细胞被杀死。

6. 发明申请

US20070009539A1 Drug conjugate composition 有权
标题翻译：药物缀合物组成
公开(公告)号：US20070009539A1
公开(公告)日：2007-01-11
申请号：US11520878
申请日：2006-09-14
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming , Hung-Wei Chih
IPC分类号： A61K39/395 , C07K16/46 , C07D491/04
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.
摘要翻译：本发明提供一种液体组合物和冻干组合物，其包含治疗有效量的包含与美登木素生物素化学偶联的抗体的缀合物。本发明进一步提供了一种杀死人体细胞的方法，包括对人体施用组合物使得抗体结合细胞表面，并且美登木素生物碱的细胞毒性被激活，由此细胞被杀死。

7. 发明授权

US07374762B2 Drug conjugate composition 有权
标题翻译：药物缀合物组成
公开(公告)号：US07374762B2
公开(公告)日：2008-05-20
申请号：US10846129
申请日：2004-05-14
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming
IPC分类号： A61K39/00 , A61K39/395 , A61K39/44
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.
摘要翻译：本发明提供一种液体组合物和冻干组合物，其包含治疗有效量的包含与美登木素生物素化学偶联的抗体的缀合物。本发明进一步提供了一种杀死人体细胞的方法，包括对人体施用组合物使得抗体结合细胞表面，并且美登木素生物碱的细胞毒性被激活，由此细胞被杀死。

8. 发明授权

US07501120B2 Drug conjugate composition 有权
公开(公告)号：US07501120B2
公开(公告)日：2009-03-10
申请号：US11521129
申请日：2006-09-14
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming
IPC分类号： A61K39/00 , A61K39/395 , A61K39/44
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

9. 发明授权

US08012485B2 Drug conjugate composition 有权
标题翻译：药物缀合物组成
公开(公告)号：US08012485B2
公开(公告)日：2011-09-06
申请号：US12366830
申请日：2009-02-06
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming
IPC分类号： A61K39/395 , A61K39/44 , C07K19/00 , C07K16/28 , C07K16/30
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human the reconstituted composition such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.
摘要翻译：本发明提供一种冻干组合物，其包含治疗有效量的包含化学偶联于美登木素生物碱的抗体的缀合物。本发明还提供了一种杀死人类细胞的方法，包括向人体施用复原组合物，使得抗体结合细胞表面，并且美登木素生物碱的细胞毒性被激活，由此细胞被杀死。

10. 发明授权

US07514080B2 Drug conjugate composition 有权
公开(公告)号：US07514080B2
公开(公告)日：2009-04-07
申请号：US11520878
申请日：2006-09-14
申请人： Godfrey Amphlett , Wei Zhang , Michael Fleming
发明人： Godfrey Amphlett , Wei Zhang , Michael Fleming
IPC分类号： A61K39/00 , A61K39/395 , A61K39/44
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

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