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1. 发明申请

US20060275881A1 Methods for the production of tyrosine, cinnamic acid and para-hydroxycinnamic acid 失效
公开(公告)号：US20060275881A1
公开(公告)日：2006-12-07
申请号：US11486826
申请日：2006-07-14
申请人： Wei Qi , Sima Sariaslani , Xiao-Song Tang
发明人： Wei Qi , Sima Sariaslani , Xiao-Song Tang
IPC分类号： C12P7/40 , C12N9/06 , C12N1/21 , C12N1/16 , C12N1/18
CPC分类号： C12N9/88 , C12P7/40 , C12P7/42 , C12P13/225
摘要： Genes encoding phenylalanine ammonia-lyase (PAL), tyrosine ammonia lyase (TAL) and phenylalanine hydroxylase (PAH) have been introduced into a host organism for the production of Para-hydroxycinnamic acid (PHCA). The introduction of these genes results in the redirection of carbon flow in the host, optimizing the flow of carbon from glucose to PHCA. The intermediates, tyrosine and cinnamic acid are also produced.

2. 发明授权

US06368837B1 Bioproduction of para-hydroxycinnamic acid 有权
标题翻译：生物生产对羟基肉桂酸
公开(公告)号：US06368837B1
公开(公告)日：2002-04-09
申请号：US09627216
申请日：2000-07-27
申请人： Anthony A. Gatenby , Sima Sariaslani , Xiao-Song Tang , Wei Wei Qi , Todd Vannelli
发明人： Anthony A. Gatenby , Sima Sariaslani , Xiao-Song Tang , Wei Wei Qi , Todd Vannelli
IPC分类号： C12P742
CPC分类号： C12N9/0042 , C12N9/0077 , C12N9/88 , C12N15/8243 , C12P7/42
摘要： The present invention provides several methods for biological production of para-hydroxycinnamic acid (PHCA). The invention is also directed to the discovery of new fungi and bacteria that possess the ability to convert cinnamate to PHCA. The invention relates to developing of a new biocatalyst for conversion of glucose to PHCA by incorporation of the wild type PAL from the yeast Rhodotorula glutinis into E. coli underlining the ability of the wildtype PAL to convert tyrosine to PHCA. The invention is also directed to developing a new biocatalyst for conversion of glucose to PHCA by incorporation of the wildtype PAL from the yeast Rhodotorula glutinis plus the plant cytochrome P-450 and the cytochrome P-450 reductase into E. coli. In yet another embodiment, the present invention provides for the developing of a new biocatalyst through mutagenesis of the wild type yeast PAL which possesses enhanced tyrosine ammonia-lyase (TAL) activity.
摘要翻译：本发明提供了几种生物制备对羟基肉桂酸（PHCA）的方法。本发明还涉及具有将肉桂酸转化为PHCA的能力的新真菌和细菌的发现。本发明涉及通过将来自酵母红酵母的野生型PAL掺入到大肠杆菌中的葡萄糖转化为PHCA的新的生物催化剂的开发，其强调野生型PAL将酪氨酸转化为PHCA的能力。本发明还涉及开发新的生物催化剂，用于通过将来自酵母红酵母（Rhodotorula glutinis）加植物细胞色素P-450和细胞色素P-450还原酶的野生型PAL掺入大肠杆菌将葡萄糖转化为PHCA。在另一个实施方案中，本发明提供了通过具有增强的酪氨酸氨裂解酶（TAL）活性的野生型酵母PAL的诱变来开发新的生物催化剂。

3. 发明授权

US07195898B2 Method for the production of p-hydroxybenzoate in species of pseudomonas and agrobacterium 失效
标题翻译：在假单胞菌和农杆菌物种中生产对羟基苯甲酸酯的方法
公开(公告)号：US07195898B2
公开(公告)日：2007-03-27
申请号：US11484129
申请日：2006-07-11
申请人： Arie Ben-Bassat , Monica Cattermole , Anthony A. Gatenby , Katharine J. Gibson , M. Isabel Ramos-Gonzalez , Juan Ramos , Sima Sariaslani
发明人： Arie Ben-Bassat , Monica Cattermole , Anthony A. Gatenby , Katharine J. Gibson , M. Isabel Ramos-Gonzalez , Juan Ramos , Sima Sariaslani
IPC分类号： C12P17/14 , C12P7/00 , C12N15/00 , C12N9/00
CPC分类号： C12P7/62 , C12N15/52 , C12P7/42
摘要： Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from Pseudomonas mendocina KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.
摘要翻译：用pcu基因转化的细菌菌株可用于生产对羟基苯甲酸酯（PHBA）。申请人提供了使用来自假单胞菌KR-1的对甲酚（pcu）和tmoX基因序列，由这些序列编码的蛋白质，含有此类序列的重组质粒和含有此类质粒或整合序列的细菌宿主细胞。还公开了使用这些材料制备PHBA的方法。

4. 发明授权

US07083953B2 Method for the production of p-Hydrozybenzoate in species of Pseudomonas and Agrobacterium 失效
标题翻译：在假单胞菌和农杆菌物种中生产对羟基苯甲酸酯的方法
公开(公告)号：US07083953B2
公开(公告)日：2006-08-01
申请号：US10464952
申请日：2003-06-19
申请人： Arie Ben-Bassat , Monica Cattermole , Anthony A. Gatenby , Katharine J. Gibson , M. Isabel Ramos-Gonzalez , Juan L. Ramos , Sima Sariaslani
发明人： Arie Ben-Bassat , Monica Cattermole , Anthony A. Gatenby , Katharine J. Gibson , M. Isabel Ramos-Gonzalez , Juan L. Ramos , Sima Sariaslani
IPC分类号： C12P17/14 , C12P7/00 , C12N15/00 , C12N5/00 , C12N9/00
CPC分类号： C12P7/62 , C12N15/52 , C12P7/42
摘要： Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from Pseudomonas mendocina KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.
摘要翻译：用pcu基因转化的细菌菌株可用于生产对羟基苯甲酸酯（PHBA）。申请人提供了使用来自假单胞菌KR-1的对甲酚（pcu）和tmoX基因序列，由这些序列编码的蛋白质，含有此类序列的重组质粒和含有此类质粒或整合序列的细菌宿主细胞。还公开了使用这些材料制备PHBA的方法。

5. 发明申请

US20060246559A1 Method for the production of p-hydroxybenzoate in species of Pseudomonas and agrobacterium 失效
标题翻译：在假单胞菌和农杆菌物种中生产对羟基苯甲酸酯的方法
公开(公告)号：US20060246559A1
公开(公告)日：2006-11-02
申请号：US11484129
申请日：2006-07-11
申请人： Arie Ben-Bassat , Monica Cattermole , Anthony Gatenby , Katharine Gibson , M. Ramos-Gonzalez , Juan Ramos , Sima Sariaslani
发明人： Arie Ben-Bassat , Monica Cattermole , Anthony Gatenby , Katharine Gibson , M. Ramos-Gonzalez , Juan Ramos , Sima Sariaslani
IPC分类号： C12P7/62 , C12P7/40
CPC分类号： C12P7/62 , C12N15/52 , C12P7/42
摘要： Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from Pseudomonas mendocina KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.
摘要翻译：用pcu基因转化的细菌菌株可用于生产对羟基苯甲酸酯（PHBA）。申请人提供了使用来自假单胞菌KR-1的对甲酚（pcu）和tmoX基因序列，由这些序列编码的蛋白质，含有此类序列的重组质粒和含有此类质粒或整合序列的细菌宿主细胞。还公开了使用这些材料制备PHBA的方法。

6. 发明授权

US06586229B1 Method for the production of &rgr;-Hydroxybenzoate in species of pseudomonas and agrobacterium 失效
标题翻译：在假单胞菌和农杆菌物种中生产对羟基苯甲酸酯的方法
公开(公告)号：US06586229B1
公开(公告)日：2003-07-01
申请号：US09585174
申请日：2000-06-01
申请人： Arie Ben-Bassat , Monica Cattermole , Anthony A. Gatenby , Katharine J. Gibson , M. Isabel Ramos-Gonzalez , Juan Ramos , Sima Sariaslani
发明人： Arie Ben-Bassat , Monica Cattermole , Anthony A. Gatenby , Katharine J. Gibson , M. Isabel Ramos-Gonzalez , Juan Ramos , Sima Sariaslani
IPC分类号： C12N120
CPC分类号： C12P7/62 , C12N15/52 , C12P7/42
摘要： Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from Pseudomonas mendocina KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.
摘要翻译：用pcu基因转化的细菌菌株可用于生产对羟基苯甲酸酯（PHBA）。申请人提供了使用来自假单胞菌KR-1的对甲酚（pcu）和tmoX基因序列，由这些序列编码的蛋白质，含有此类序列的重组质粒和含有此类质粒或整合序列的细菌宿主细胞。还公开了使用这些材料制备PHBA的方法。

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