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    • 5. 发明授权
    • Protein tyrosine kinase inhibitors
    • 蛋白酪氨酸激酶抑制剂
    • US07629347B2
    • 2009-12-08
    • US10531107
    • 2003-10-09
    • Wayne R. DanterGeorge MaNatalie LazarowychStephen HouldsworthMartyn BrownGhenadie RusuJianhua Zhong
    • Wayne R. DanterGeorge MaNatalie LazarowychStephen HouldsworthMartyn BrownGhenadie RusuJianhua Zhong
    • C07D401/14A61K31/506
    • C07D401/14A61K31/506
    • The present invention relates to uses of the compounds of Formula I as well as pharmaceutically acceptable salts and stereoisomers thereof in methods to treat a variety of tumors in mammals involving abnormal tyrosine kinase signaling, the compounds represented as: wherein R1 and R2 are independently selected from the group consisting of H; alkyl; alkenyl; alkynyl; halogen; aryl; heteroaryl containing N, O, or S; the aryl and heteroaryl may be further substituted with halogen, an alkyl, alkenyl, and alkynyl; NZ1Z2, wherein Z1 and Z2 are independently selected from the group consisting of H and alkyl; and (CO)Y wherein Y is selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, heteroaryl containing N, O, or S, and the aryl and heteroaryl may be further substituted with halogen, alkyl, alkenyl, and alkynyl; with the proviso that when R1 is hydrogen, R2 is a group other than hydrogen.
    • 本发明涉及式I化合物及其药学上可接受的盐和立体异构体在治疗涉及异常酪氨酸激酶信号传导的哺乳动物中的各种肿瘤的方法中的用途,所述化合物表示为:其中R1和R2独立地选自 由H组成的组; 烷基; 烯基; 炔基; 卤素; 芳基; 含有N,O或S的杂芳基; 芳基和杂芳基可以进一步被卤素,烷基,烯基和炔基取代; NZ1Z2,其中Z1和Z2独立地选自H和烷基; 和(CO)Y,其中Y选自H,烷基,烯基,炔基,芳基,含有N,O或S的杂芳基,芳基和杂芳基可以进一步被卤素,烷基,烯基和 炔基; 条件是当R 1是氢时,R 2是不同于氢的基团。