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1. 发明申请

US20060281131A1 Novel anti-feline albumin antibodies and methods of detecting early renal disease 失效
标题翻译：新型抗猫白蛋白抗体及早期肾病检测方法
公开(公告)号：US20060281131A1
公开(公告)日：2006-12-14
申请号：US10550563
申请日：2004-03-25
申请人： Wayne Jensen , Shirley Hunter , Karen Sverlow , Thomas McDonald , Annika Weber , Janet Andrews
发明人： Wayne Jensen , Shirley Hunter , Karen Sverlow , Thomas McDonald , Annika Weber , Janet Andrews
IPC分类号： G01N33/53 , C12N5/06
CPC分类号： G01N33/6893 , C07K16/18 , G01N33/6827 , G01N2333/765 , G01N2800/347 , G01N2800/52
摘要： The present invention provides isolated monoclonal antibodies that selectively bind albumin from animals. Also provided are methods using such antibodies for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested; (b) contacting the sample with an antibody having a greater avidity for feline albumin than for other proteins or components in the sample; (c) detecting the complex formed by the antibody and albumin; and (d) determining the amount of albumin in the sample from the amount of antibody-albumin complex detected. An amount of albumin in the range of from 10 μg/ml to about 300 μg/ml indicates the presence of early renal disease.
摘要翻译：本发明提供了从动物中选择性结合白蛋白的分离的单克隆抗体。还提供了使用这种抗体检测动物早期肾脏疾病的方法。该方法包括以下步骤：（a）从待测动物获得样品; （b）使样品与样品中其它蛋白质或组分具有比猫眼白蛋白更高亲合力的抗体接触; （c）检测由抗体和白蛋白形成的复合物; 和（d）从检测到的抗体 - 白蛋白复合物的量确定样品中白蛋白的量。 10μg/ ml至约300μg/ ml范围内的白蛋白量表明存在早期肾脏疾病。

2. 发明申请

US20070154920A1 Novel Ectoparasite Saliva Proteins 失效
标题翻译：新型外寄生唾液蛋白
公开(公告)号：US20070154920A1
公开(公告)日：2007-07-05
申请号：US11611011
申请日：2006-12-14
申请人： Glenn Frank , Shirley Hunter , Lynda Wallenfels
发明人： Glenn Frank , Shirley Hunter , Lynda Wallenfels
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/24 , C12N5/06
CPC分类号： C07K14/4359 , A61K38/17 , C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , Y10S530/855 , Y10S530/858 , Y10S530/868
摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection apparatus capable of collecting ectoparasite saliva proteins substantially free of contaminating material. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.
摘要翻译：本发明涉及一种用于分离外寄生唾液蛋白质的新产品和方法，以及用于在动物中检测和/或治疗过敏性皮炎的新产品和方法。本发明包括能够收集基本上不含污染物质的外寄生唾液蛋白质的唾液蛋白质收集装置。本发明还涉及外寄生物唾液蛋白质，具有编码这种蛋白质的序列的核酸分子和针对这种蛋白质产生的抗体。本发明还包括获得这种蛋白质和使用这些蛋白质鉴定易感或具有过敏性皮炎的动物的方法。本发明还包括包含这些蛋白质的治疗组合物及其用于治疗易感或具有过敏性皮炎的动物的用途。

3. 发明申请

US20080045693A1 Novel flea saliva protein 审中-公开
标题翻译：新型跳蚤唾液蛋白
公开(公告)号：US20080045693A1
公开(公告)日：2008-02-21
申请号：US11694771
申请日：2007-03-30
申请人： Shirley Hunter , Gek-Kee Sim , Eric Weber
发明人： Shirley Hunter , Gek-Kee Sim , Eric Weber
IPC分类号： C07K14/00 , C07K7/00
CPC分类号： C07K14/43563 , C07K14/4359
摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.
摘要翻译：本发明涉及一种用于分离异位唾液蛋白的新产品和方法，以及用于在动物中检测和/或治疗过敏性皮炎的新产品和方法。本发明还涉及外寄生物唾液蛋白质，具有编码这种蛋白质的序列的核酸分子和针对这种蛋白质产生的抗体。本发明还包括获得这种蛋白质和使用这些蛋白质鉴定易感或具有过敏性皮炎的动物的方法。本发明还包括包含这些蛋白质的治疗组合物及其用于治疗易感或具有过敏性皮炎的动物的用途。

4. 发明申请

US20080038205A1 NOVEL DERMATOPHAGOIDES PROTEINS 审中-公开
标题翻译：新颖的抗真菌蛋白
公开(公告)号：US20080038205A1
公开(公告)日：2008-02-14
申请号：US11836317
申请日：2007-08-09
申请人： Catherine McCall , Shirley Hunter , Eric Weber
发明人： Catherine McCall , Shirley Hunter , Eric Weber
IPC分类号： A61K38/16 , C07K14/195
CPC分类号： C07K16/18 , A61K38/00 , A61K39/00 , C07K14/43531
摘要： The present invention relates to high molecular weight Dermatophagoides proteins, nucleic acid molecules encoding such proteins, and therapeutic and diagnostic reagents derived from such proteins.
摘要翻译：本发明涉及高分子量Dermatophagoides蛋白质，编码这种蛋白质的核酸分子，以及衍生自这些蛋白质的治疗和诊断试剂。

5. 发明申请

US20070041965A1 Novel dermatophagoides nucleic acid molecules, proteins and uses thereof 有权
标题翻译：新型皮肤癣菌核酸分子，蛋白质及其用途
公开(公告)号：US20070041965A1
公开(公告)日：2007-02-22
申请号：US11506444
申请日：2006-08-18
申请人： Catherine McCall , Shirley Hunter , Eric Weber
发明人： Catherine McCall , Shirley Hunter , Eric Weber
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/18 , C07K16/42
CPC分类号： C07K16/18 , C07K14/43531 , Y10S530/857
摘要： The present invention relates to high molecular weight Dermatophagoides proteins, nucleic acid molecules encoding such proteins, and therapeutic and diagnostic reagents derived from such proteins.
摘要翻译：本发明涉及高分子量Dermatophagoides蛋白质，编码这种蛋白质的核酸分子，以及衍生自这些蛋白质的治疗和诊断试剂。

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