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1. 发明授权

US07271397B2 Combined chemical/biological agent detection system and method utilizing mass spectrometry 有权
标题翻译：组合化学/生物试剂检测系统和利用质谱法的方法
公开(公告)号：US07271397B2
公开(公告)日：2007-09-18
申请号：US10515300
申请日：2003-07-17
申请人： Wayne A. Bryden , Robert J. Cotter , Scott A. Ecelberger
发明人： Wayne A. Bryden , Robert J. Cotter , Scott A. Ecelberger
IPC分类号： H01J49/44
CPC分类号： H01J49/147 , H01J49/107
摘要： A mass spectrometer is provided herein and is configured to have two ionization sources, in which a first ionization source, such as MALDI, ESI and the like, which is capable of providing in addition to ions a set of normally intractable desorbed neutrals that are ionized by a second EI source coupled with the first source.
摘要翻译：本文提供了一种质谱仪，并且被配置为具有两个电离源，其中第一电离源如MALDI，ESI等能够提供除离子之外的一组正常难溶的解吸的中性粒子，其被离子化通过与第一源耦合的第二EI源。

2. 发明授权

US06841773B2 Portable time-of-flight mass spectrometer system 有权
标题翻译：便携式飞行时间质谱仪系统
公开(公告)号：US06841773B2
公开(公告)日：2005-01-11
申请号：US10069894
申请日：2001-05-23
申请人： Michael P. McLoughlin , William R. Allmon , Charles W. Anderson , Micah A. Carlson , Nicholas H. Evancich , Wayne A. Bryden , Scott A. Ecelberger , James T. Velky , Daniel J. DeCicco , Timothy J. Cornish
发明人： Michael P. McLoughlin , William R. Allmon , Charles W. Anderson , Micah A. Carlson , Nicholas H. Evancich , Wayne A. Bryden , Scott A. Ecelberger , James T. Velky , Daniel J. DeCicco , Timothy J. Cornish
IPC分类号： G01N27/62 , G01N1/00 , G01N1/02 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16 , H01J49/24 , H01J49/40
CPC分类号： H01J49/0409 , H01J49/0022 , H01J49/40 , Y10T436/24
摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.
摘要翻译：一种现场便携式质谱仪系统，包括样品收集器和样品转运器。样品转运器与样品收集器接口以在其上接收样品沉积物。该系统还包括飞行时间（TOF）质谱仪。飞行时间质谱仪具有可密封的开口，其接收在质谱仪的提取区域中通过样品转运器传送的样品。该系统还包括控制单元，其处理由质谱仪输出的时间序列用于接收的样本，并识别样品中包含的一种或多种试剂。

3. 发明授权

US06806465B2 Sample collection preparation methods for time-of flight miniature mass spectrometer 失效
标题翻译：飞行时间微型质谱仪的样品收集准备方法
公开(公告)号：US06806465B2
公开(公告)日：2004-10-19
申请号：US10031041
申请日：2002-01-15
申请人： Charles W. Anderson , Peter F. Scholl , Ronald G. Chappell , Wayne A. Bryden , Harvey W. Ko , Scott A. Ecelberger
发明人： Charles W. Anderson , Peter F. Scholl , Ronald G. Chappell , Wayne A. Bryden , Harvey W. Ko , Scott A. Ecelberger
IPC分类号： H01J4940
CPC分类号： H01J49/0445 , H01J49/0022 , H01J49/40
摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.
摘要翻译：一种现场便携式质谱仪系统，包括样品收集器和样品转运器。样品转运器与样品收集器接口以在其上接收样品沉积物。该系统还包括飞行时间（TOF）质谱仪。飞行时间质谱仪具有可密封的开口，其接收在质谱仪的提取区域中通过样品转运器传送的样品。该系统还包括控制单元，其处理由质谱仪输出的时间序列用于接收的样本，并识别样品中包含的一种或多种试剂。

4. 发明授权

US06943344B2 Microchannel plate detector assembly for a time-of-flight mass spectrometer 有权
标题翻译：用于飞行时间质谱仪的微通道板检测器组件
公开(公告)号：US06943344B2
公开(公告)日：2005-09-13
申请号：US10030397
申请日：2001-05-23
申请人： Timothy J. Cornish , Scott A. Ecelberger
发明人： Timothy J. Cornish , Scott A. Ecelberger
IPC分类号： H01J49/02 , H01J49/40 , B01D59/44 , H01J49/00
CPC分类号： H01J43/246 , H01J49/025 , H01J49/40
摘要： A method is provided for reducing signal ringing in a microchannel plate detector assembly having a cylindrical mount with a center tube extending through at least a portion of the assembly, in a mass spectrometer including the steps of providing the microchannel plate detector assembly with a pin anode extending from the cylindrical mount and located in proximity to the center tube; holding a front portion of the assembly at ground potential; setting a middle portion of the assembly between the front portion and a rear portion to a first voltage potential for accelerating ions; holding the rear portion of the assembly to a second voltage potential; holding the pin anode at a third voltage potential; and accelerating electrons emitted from the middle portion of the assembly toward the pin anode. The third voltage potential is established by an amplifier of an oscilloscope connected to the detector assembly.
摘要翻译：提供了一种用于减小微通道板检测器组件中的信号振铃的方法，所述微通道板检测器组件具有圆柱形安装件，所述圆柱形安装件具有延伸穿过所述组件的至少一部分的中心管，质谱仪包括以下步骤：为所述微通道板检测器组件提供引脚阳极从圆柱形支架延伸并位于中心管附近; 将组件的前部部分保持在地电位; 将组件的前部和后部之间的中间部分设置为用于加速离子的第一电压电位; 将组件的后部保持在第二电压电位; 将引脚阳极保持在第三电压电位; 并且将从组件的中间部分发射的电子加速到针状阳极。第三电压电位由连接到检测器组件的示波器的放大器建立。

5. 发明授权

US5998995A Microelectromechanical (MEMS)-based magnetostrictive magnetometer 失效
标题翻译：基于微机电（MEMS）的磁致伸缩磁力计
公开(公告)号：US5998995A
公开(公告)日：1999-12-07
申请号：US944625
申请日：1997-10-03
申请人： Robert Osiander , Scott A. Ecelberger , Robert B. Givens , Dennis K. Wickenden , John C. Murphy , Thomas J. Kistenmacher
发明人： Robert Osiander , Scott A. Ecelberger , Robert B. Givens , Dennis K. Wickenden , John C. Murphy , Thomas J. Kistenmacher
IPC分类号： G01R33/02
CPC分类号： G01R33/0286 , G01R33/02
摘要： A microelectromechanical-based magnetostrictive magnetometer that uses, as an active element, a commercial (001) silicon microcantilever coated with an amorphous thin film of the giant magnetostrictive alloy Terfenol-D and a compact optical beam deflection transduction scheme. A set of Helmholtz coils is used to create an ac magnetic excitation field for driving the mechanical resonance of the coated microcantilever. When the coated microcantilever is placed in a dc magnetic field, the dc field will change the amplitude at the mechanical resonance of the coated microcantilever thereby causing a deflection that can be measured. The magnetometer has been demonstrated with a sensitivity near 1 .mu.T.
摘要翻译：使用涂覆有巨磁致伸缩合金Terfenol-D的非晶薄膜的商业（001）硅微悬臂梁作为有源元件的微机电型磁致伸缩磁力计和紧凑的光束偏转换能方案。一组亥姆霍兹线圈用于产生用于驱动涂覆的微型悬臂梁的机械共振的交流磁激励场。当涂覆的微悬臂梁放置在直流磁场中时，直流场将改变涂覆的微型悬臂梁的机械谐振处的振幅，从而引起可测量的偏转。磁力计已被证明灵敏度接近1亩。

6. 发明授权

US06844544B2 Mass spectrometer for simultaneous detection of reflected and direct ions 有权
标题翻译：用于同时检测反射和直接离子的质谱仪
公开(公告)号：US06844544B2
公开(公告)日：2005-01-18
申请号：US10480243
申请日：2002-09-20
申请人： Timothy J. Cornish , Scott A. Ecelberger
发明人： Timothy J. Cornish , Scott A. Ecelberger
IPC分类号： G01N27/62 , B01D59/44 , H01J49/00 , H01J49/06 , H01J49/40
CPC分类号： H01J49/025 , H01J49/405
摘要： Techniques for simultaneously detecting direct and reflected ions in a time-of-flight tube (120) and a source (110) for generating an ion beam of ions of a sample and introducing the ion beam into a first portion of the flight tube. A reflector (126) reflects ions from the ion beam in a second portion of the flight tube. A plate (140) substantially perpendicular to an axis of the ion beam is located between the first portion of the flight tube and the second portion of the flight tube. The plate has a hole through which some ions in the ion beam may pass from the first portion to the second portion of the flight tube. Each of two opposite faces of the plate includes a set of one or more ion detectors (140). The technique allows rapid, reliable detection of complex agents in a small number of samples.
摘要翻译：用于同时检测飞行时间管（120）和源（110）中的直接和反射离子的技术，用于产生样品的离子离子束并将离子束引入飞行管的第一部分。反射器（126）在飞行管的第二部分中从离子束反射离子。基本上垂直于离子束的轴线的板（140）位于飞行管的第一部分和飞行管的第二部分之间。该板具有一个孔，离子束中的一些离子可以从该孔穿过飞行管的第一部分到第二部分。板的两个相对面中的每一个包括一组一个或多个离子检测器（140）。该技术允许在少量样品中快速，可靠地检测复合物。

7. 发明授权

US06580070B2 Time-of-flight mass spectrometer array instrument 有权
标题翻译：飞行时间质谱仪阵列仪
公开(公告)号：US06580070B2
公开(公告)日：2003-06-17
申请号：US10030395
申请日：2002-01-08
申请人： Timothy J. Cornish , Scott A. Ecelberger
发明人： Timothy J. Cornish , Scott A. Ecelberger
IPC分类号： H01J4900
CPC分类号： H01J49/009 , H01J49/40
摘要： A time-of-flight mass spectrometer (TOF-MS) array instrument is provided. Each TOF-MS of the array instrument includes (1) a gridless, focusing ionization extraction device allowing for the use of very high extraction energies in a maintenance-free design, (2) a fiberglass-clad flexible circuit-board reflector using rolled flexible circuit-board material, and (3) a low-noise, center-hole microchannel plate detector assembly that significantly reduces the noise (or “ringing”) inherent in the coaxial design. The miniature TOF-MS array allows for the bundling of a plurality of mass analyzers, e.g., a plurality of TOF-MSs, into a single array working in parallel fashion to greatly enhance the throughput of each TOF-MS in the array by multiplexing the data collection process. A preferred embodiment of the TOF-MS array instrument incorporates 16 TOF-MS units that are arranged in mirror-image clusters of eight units.
摘要翻译：提供飞行时间质谱仪（TOF-MS）阵列仪。阵列仪器的每个TOF-MS包括（1）无栅格聚焦电离提取装置，允许在免维护设计中使用非常高的提取能量，（2）使用滚动柔性的玻璃纤维包覆柔性电路板反射器电路板材料，以及（3）低噪声中心孔微通道板检测器组件，其显着地减少了同轴设计中固有的噪声（或“振铃”）。微型TOF-MS阵列允许将多个质量分析器（例如，多个TOF-MS）捆绑成并行工作的单个阵列，以通过多路复用来大大增强阵列中每个TOF-MS的吞吐量数据收集过程。 TOF-MS阵列仪器的优选实施例包括布置在八个单元的镜像簇中的16个TOF-MS单元。

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