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    • 3. 发明授权
    • Peroxides, their preparation process and use
    • 过氧化物,其制备过程和用途
    • US06384287B1
    • 2002-05-07
    • US09762671
    • 2001-02-12
    • Anna Gerdine Van De Bovenkamp-BouwmanBernhard De VriesJohn MeijerEjaz Ahmed SyedAndreas Herman Hogt
    • Anna Gerdine Van De Bovenkamp-BouwmanBernhard De VriesJohn MeijerEjaz Ahmed SyedAndreas Herman Hogt
    • C07C40900
    • C08F4/36C07C409/22C07C2601/14C08F283/01C08F4/28
    • The present invention relates to a new class of peroxides and to a process for the preparation of these peroxides having the general formula (I), wherein n=1 or 2, R1, R2, R4, R5, and R6 are independently selected from the group comprising hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, C6-C20 aryl, C7-C20 aralkyl, and C7-C20 alkaryl, or R1 and R2 form a C3-C12 cycloalkyl group, which groups may include linear or branched alkyl moieties; and each of R1, R2, R4, R5, and R6 may optionally be substituted with one or more groups selected from hydroxy, alkoxy, linear or branched alkyl, aryloxy, halogen, ester, carboxy, nitrile, and amido, and R1 and R2 may form a ring, and R3 is independently selected from the group comprising C1-C20, alkyl; C3-C20 cycloalkyl, C6-C20 aryl, C7-C20, aralkyl, and C7-C20 alkaryl, which groups may include linear or branched alkyl moieties; and R3 may optionally be substituted with one or more groups selected from hydroxy, alkoxy, linear or branched alkyl, aryloxy, halogen, ester, carboxy, nitrile, and amido, and any pair of the optionally substituted R3, R4, R5, and R6 may form a ring, comprising the reaction of the corresponding ketone.
    • 本发明涉及一类新型过氧化物,以及制备具有通式(I)的这些过氧化物的方法,其中n = 1或2,R 1,R 2,R 4,R 5和R 6独立地选自 包括氢,C 1 -C 20烷基,C 3 -C 20环烷基,C 6 -C 20芳基,C 7 -C 20芳烷基和C 7 -C 20烷芳基,或R 1和R 2形成C 3 -C 12环烷基,所述基团可包括直链或支链烷基 部分; R 1,R 2,R 4,R 5和R 6可以任选被一个或多个选自羟基,烷氧基,直链或支链烷基,芳氧基,卤素,酯,羧基,腈和酰氨基的基团取代,并且R 1和R 2 可以形成环,R 3独立地选自C 1 -C 20烷基, C 3 -C 20环烷基,C 6 -C 20芳基,C 7 -C 20,芳烷基和C 7 -C 20烷芳基,这些基团可以包括直链或支链烷基部分; 并且R 3可以任选被一个或多个选自羟基,烷氧基,直链或支链烷基,芳氧基,卤素,酯,羧基,腈和酰氨基的基团取代,以及任意一对任选取代的R 3,R 4,R 5和R 6 可形成环,包括相应酮的反应。
    • 4. 发明授权
    • Pacemaker system with diurnal pattern controlled overdrive for
prevention of tachycardia
    • 起搏器系统具有昼夜模式控制超速度,用于预防心动过速
    • US6161041A
    • 2000-12-12
    • US179043
    • 1998-10-26
    • Gustaaf A. P. StoopBernhard De Vries
    • Gustaaf A. P. StoopBernhard De Vries
    • A61N1/362A61N1/365
    • A61N1/3622
    • There is provided a cardiac pacemaker system with a ventricular tachycardia prevention feature, whereby the pacemaker monitors ventricular activity during each patient awakening period to determine when VT is likely. In a preferred embodiment, QRS and T wave templates are generated cyclically during awakening, and compared to normal templates to obtain a measure of variability, indicative of refractory dispersion and thus of probable VT. Ventricular extra-systoles are also monitored and analyzed during the awakening period to see how closely they occur to the ventricular vulnerable period. When the monitored data indicates VT probability during awakening, the pacemaker responds by overdriving the heart with an intervention pacing rate which is continually adjusted as a function of the currently obtained data.
    • 提供了具有室性心动过速预防功能的心脏起搏器系统,由此起搏器在每个病人觉醒期间监测心室活动,以确定VT何时可能。 在优选实施例中,QRS和T波模板在唤醒过程中循环生成,并与正常模板进行比较,以获得变异性的量度,指示难溶性分散,从而指示可能的VT。 在觉醒期间还监测和分析心室外肌肉,以了解心室容易发生的时间。 当监视的数据在唤醒期间指示VT概率时,心脏起搏器通过以干预起搏速率的过动作用来响应心脏,该介入起搏速率作为当前获得的数据的函数而不断调整。