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1. 发明授权

US08734735B2 Tissue cassette for automated handling and embedding of tissue samples 有权
标题翻译：用于自动处理和包埋组织样品的组织盒
公开(公告)号：US08734735B2
公开(公告)日：2014-05-27
申请号：US13047044
申请日：2011-03-14
申请人： Warren P. Williamson, IV , Thomas J. Ward , Stephen P. Whitlatch
发明人： Warren P. Williamson, IV , Thomas J. Ward , Stephen P. Whitlatch
IPC分类号： A61B10/00
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

2. 发明授权

US07776274B2 Cassette and embedding assembly for handling and holding tissue samples during processing, embedding and microtome procedures, staging devices therefore, and methods therefor 有权
标题翻译：因此，在处理，嵌入和切片机程序期间处理和保持组织样本的盒式和嵌入组件，因此分级装置及其方法
公开(公告)号：US07776274B2
公开(公告)日：2010-08-17
申请号：US11072119
申请日：2005-03-04
申请人： Warren P. Williamson, IV , Craig B. Berky , Stephen P. Whitlatch , Thomas J. Ward
发明人： Warren P. Williamson, IV , Craig B. Berky , Stephen P. Whitlatch , Thomas J. Ward
IPC分类号： B01L9/00
CPC分类号： G01N1/36 , B01L3/508 , B01L9/52 , B01L2300/043 , G01N2001/315 , G01N2001/366 , Y10T436/25
摘要： The disclosure relates to a cassette, frame and mold for holding a tissue sample during an embedding and mircotoming process, and related methods. The cassette is sectionable in a microtome and includes a body with a bottom wall and a plurality of side walls. First and second side walls are generally V-shaped to present an apex of the “V” to the microtome blade. A lid of the cassette is stiffer than the bottom wall of the cassette to assist with positioning the tissue sample. The side walls of the cassette are perforated so as to significantly reduce the amount of cassette material that must be cut by the microtome blade. In one embodiment, to additionally reduce blade wear the ribs on one side wall are offset lengthwise relative to the ribs on an opposite side wall. An upper flange of the cassette includes depressions configured to register with detents in the frame.
摘要翻译：本公开涉及一种用于在嵌入和微型切割过程期间保持组织样本的盒，框架和模具及相关方法。盒子可在切片机中切片，并且包括具有底壁和多个侧壁的主体。第一侧壁和第二侧壁通常为V形以呈现与切片机叶片“V”的顶点。盒的盖比盒的底壁更硬，以帮助定位组织样品。盒的侧壁是穿孔的，以便显着减少必须由切片机刀片切割的盒材料的量。在一个实施例中，为了额外地减少刀片磨损，一个侧壁上的肋相对于相对侧壁上的肋纵向偏移。盒的上凸缘包括配置成与框架中的棘爪对准的凹陷。

3. 发明授权

US07179424B2 Cassette for handling and holding tissue samples during processing, embedding and microtome procedures, and methods therefor 有权
标题翻译：用于在处理，嵌入和切片机程序期间处理和保持组织样品的盒，及其方法
公开(公告)号：US07179424B2
公开(公告)日：2007-02-20
申请号：US10963315
申请日：2004-10-12
申请人： Warren P. Williamson, IV , Thomas J. Ward , Stephen P. Whitlatch
发明人： Warren P. Williamson, IV , Thomas J. Ward , Stephen P. Whitlatch
IPC分类号： B01L3/00
CPC分类号： B01L3/545 , B01L2300/02 , G01N1/31 , G01N2001/315
摘要： A cassette for holding a tissue sample includes a body having a bottom wall and a plurality of side walls extending upwardly with respect to the bottom wall to define an interior space for receiving the tissue sample. A lid is configured to be received in the interior space, and the cassette is sectionable in a microtome. Sensing elements are associated with the body or lid and configured to allow an automated sensing system to determine at least one characteristic of the cassette. A flange extends along upper portions of at least two of the side walls and includes a plurality of holes. Other features are included to more effectively and efficiently manufacture and use the cassette.
摘要翻译：用于保持组织样本的盒包括具有底壁和相对于底壁向上延伸的多个侧壁的主体，以限定用于接收组织样本的内部空间。盖被配置为容纳在内部空间中，并且盒可在切片机中分段。感测元件与主体或盖相关联并且被配置为允许自动感测系统确定盒的至少一个特性。凸缘沿至少两个侧壁的上部延伸并且包括多个孔。包括其他功能，以更有效和高效地制造和使用磁带。

4. 发明授权

US08877146B2 Cassette for handling and holding tissue samples during processing, embedding and microtome procedures, and methods therefor 有权
标题翻译：用于在处理，嵌入和切片机程序期间处理和保持组织样品的盒，及其方法
公开(公告)号：US08877146B2
公开(公告)日：2014-11-04
申请号：US11618987
申请日：2007-01-02
申请人： Warren P. Williamson, IV , Thomas J. Ward , Stephen P. Whitlatch
发明人： Warren P. Williamson, IV , Thomas J. Ward , Stephen P. Whitlatch
IPC分类号： B01L9/00 , B01L3/00 , G01N1/31
CPC分类号： B01L3/545 , B01L2300/02 , G01N1/31 , G01N2001/315
摘要： A cassette for holding a tissue sample includes a body having a bottom wall and a plurality of side walls extending upwardly with respect to the bottom wall to define an interior space for receiving the tissue sample. A lid is configured to be received in the interior space, and the cassette is sectionable in a microtome. Sensing elements are associated with the body or lid and configured to allow an automated sensing system to determine at least one characteristic of the cassette. A flange extends along upper portions of at least two of the side walls and includes a plurality of holes. Other features are included to more effectively and efficiently manufacture and use the cassette.
摘要翻译：用于保持组织样本的盒包括具有底壁和相对于底壁向上延伸的多个侧壁的主体，以限定用于接收组织样本的内部空间。盖被配置为容纳在内部空间中，并且盒可在切片机中分段。感测元件与主体或盖相关联并且被配置为允许自动感测系统确定盒的至少一个特性。凸缘沿至少两个侧壁的上部延伸并且包括多个孔。包括其他功能，以更有效和高效地制造和使用磁带。

5. 发明授权

US08609431B2 Cassette and embedding assembly for handling and holding tissue samples during processing, embedding and microtome procedures, staging devices therefor, and methods therefor 有权
标题翻译：在处理，嵌入和切片机程序期间处理和保持组织样品的盒式和嵌入组件，其分级装置及其方法
公开(公告)号：US08609431B2
公开(公告)日：2013-12-17
申请号：US12836102
申请日：2010-07-14
申请人： Warren P. Williamson, IV , Craig B. Berky , Stephen P. Whitlatch , Thomas J. Ward
发明人： Warren P. Williamson, IV , Craig B. Berky , Stephen P. Whitlatch , Thomas J. Ward
IPC分类号： G01N1/28
CPC分类号： G01N1/36 , B01L3/508 , B01L9/52 , B01L2300/043 , G01N2001/315 , G01N2001/366 , Y10T436/25
摘要： The disclosure relates to a cassette, frame and mold for holding a tissue sample during an embedding and mircotoming process, and related methods. The cassette is sectionable in a microtome and includes a body with a bottom wall and a plurality of side walls. First and second side walls are generally V-shaped to present an apex of the “V” to the microtome blade. A lid of the cassette is stiffer than the bottom wall of the cassette to assist with positioning the tissue sample. The side walls of the cassette are perforated so as to significantly reduce the amount of cassette material that must be cut by the microtome blade. In one embodiment, to additionally reduce blade wear the ribs on one side wall are offset lengthwise relative to the ribs on an opposite side wall. An upper flange of the cassette includes depressions configured to register with detents in the frame.
摘要翻译：本公开涉及一种用于在嵌入和微型切割过程期间保持组织样本的盒，框架和模具及相关方法。盒子可在切片机中切片，并且包括具有底壁和多个侧壁的主体。第一侧壁和第二侧壁通常为V形以呈现与切片机叶片“V”的顶点。盒的盖比盒的底壁更硬，以帮助定位组织样品。盒的侧壁是穿孔的，以便显着减少必须由切片机刀片切割的盒材料的量。在一个实施例中，为了额外地减少刀片磨损，一个侧壁上的肋相对于相对侧壁上的肋纵向偏移。盒的上凸缘包括配置成与框架中的棘爪对准的凹陷。

6. 发明申请

US20110182783A1 TISSUE CASSETTE FOR AUTOMATED HANDLING AND EMBEDDING OF TISSUE SAMPLES 有权
标题翻译：用于组织样品的自动处理和嵌入的组织样品盒
公开(公告)号：US20110182783A1
公开(公告)日：2011-07-28
申请号：US13047044
申请日：2011-03-14
申请人： Warren P. Williamson, IV , Thomas J. Ward , Stephen P. Whitlatch
发明人： Warren P. Williamson, IV , Thomas J. Ward , Stephen P. Whitlatch
IPC分类号： B01L3/00
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

7. 发明申请

US20100278627A1 CASSETTE AND EMBEDDING ASSEMBLY FOR HANDLING AND HOLDING TISSUE SAMPLES DURING PROCESSING, EMBEDDING AND MICROTOME PROCEDURES, STAGING DEVICES THEREFOR, AND METHODS THEREFOR 有权
标题翻译：用于处理，嵌入和微阵列程序的处理和保存组织样本的CASSETTE和嵌入式组件，其分类设备及其方法
公开(公告)号：US20100278627A1
公开(公告)日：2010-11-04
申请号：US12836102
申请日：2010-07-14
申请人： Warren P. Williamson, IV , Craig B. Berky , Stephen P. Whitlatch , Thomas J. Ward
发明人： Warren P. Williamson, IV , Craig B. Berky , Stephen P. Whitlatch , Thomas J. Ward
IPC分类号： C12M1/00 , B25J1/00
CPC分类号： G01N1/36 , B01L3/508 , B01L9/52 , B01L2300/043 , G01N2001/315 , G01N2001/366 , Y10T436/25
摘要： The disclosure relates to a cassette, frame and mold for holding a tissue sample during an embedding and mircotoming process, and related methods. The cassette is sectionable in a microtome and includes a body with a bottom wall and a plurality of side walls. First and second side walls are generally V-shaped to present an apex of the “V” to the microtome blade. A lid of the cassette is stiffer than the bottom wall of the cassette to assist with positioning the tissue sample. The side walls of the cassette are perforated so as to significantly reduce the amount of cassette material that must be cut by the microtome blade. In one embodiment, to additionally reduce blade wear the ribs on one side wall are offset lengthwise relative to the ribs on an opposite side wall. An upper flange of the cassette includes depressions configured to register with detents in the frame.
摘要翻译：本公开涉及一种用于在嵌入和微型切割过程期间保持组织样本的盒，框架和模具及相关方法。盒子可在切片机中切片，并且包括具有底壁和多个侧壁的主体。第一侧壁和第二侧壁通常为V形以呈现与切片机叶片“V”的顶点。盒的盖比盒的底壁更硬，以帮助定位组织样品。盒的侧壁是穿孔的，以便显着减少必须由切片机刀片切割的盒材料的量。在一个实施例中，为了额外地减少刀片磨损，一个侧壁上的肋相对于相对侧壁上的肋纵向偏移。盒的上凸缘包括配置成与框架中的棘爪对准的凹陷。

8. 发明授权

US08329120B2 Microtome sectionable biopsy support for orienting tissue samples 有权
标题翻译：用于定向组织样本的切片机可切片活检支架
公开(公告)号：US08329120B2
公开(公告)日：2012-12-11
申请号：US12692208
申请日：2010-01-22
申请人： Warren P. Williamson, IV , Stephen P. Whitlatch , Carlos A. Saez
发明人： Warren P. Williamson, IV , Stephen P. Whitlatch , Carlos A. Saez
IPC分类号： A61B10/00
CPC分类号： B01L9/52 , G01N1/06 , G01N1/312 , G01N1/36 , G01N33/4833 , Y10T436/25
摘要： Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for holding one or more biopsy tissue samples therebetween. Associated methods include using the cassettes and orientation devices to hold and orient tissue samples for processing, embedding and microtome sectioning.
摘要翻译：组织取向装置包括具有至少一个用于接收组织样本的穿孔通道的穿孔组织支撑件，以及多个突出部，其被构造成沿着和延伸通道以在加工和嵌入期间保持组织样本。组织取向装置包括连接在一起的细长腿以在其间保持一个或多个活检组织样本。相关方法包括使用盒和取向装置来保持和定向组织样品进行加工，嵌入和切片机切片。

9. 发明申请

US20100184127A1 MICROTOME SECTIONABLE BIOPSY SUPPORT FOR ORIENTING TISSUE SAMPLES 有权
标题翻译：用于面向组织样品的MICROTOME部分生物支持
公开(公告)号：US20100184127A1
公开(公告)日：2010-07-22
申请号：US12692208
申请日：2010-01-22
申请人： Warren P. Williamson, IV , Stephen P. Whitlatch , Carlos A. Saez
发明人： Warren P. Williamson, IV , Stephen P. Whitlatch , Carlos A. Saez
IPC分类号： G01N1/28 , C12M1/00
CPC分类号： B01L9/52 , G01N1/06 , G01N1/312 , G01N1/36 , G01N33/4833 , Y10T436/25
摘要： Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for holding one or more biopsy tissue samples therebetween. Associated methods include using the cassettes and orientation devices to hold and orient tissue samples for processing, embedding and microtome sectioning.
摘要翻译：组织取向装置包括具有至少一个用于接收组织样本的穿孔通道的穿孔组织支撑件，以及多个突出部，其被构造成沿着和延伸通道以在加工和嵌入期间保持组织样本。组织取向装置包括连接在一起的细长腿以在其间保持一个或多个活检组织样本。相关方法包括使用盒和取向装置来保持和定向组织样品进行加工，嵌入和切片机切片。

10. 发明申请

US20110165615A1 APPARATUS AND METHODS FOR AUTOMATED HANDLING AND EMBEDDING OF TISSUE SAMPLES 有权
标题翻译：装置和组织样品的自动处理和嵌入方法
公开(公告)号：US20110165615A1
公开(公告)日：2011-07-07
申请号：US13047053
申请日：2011-03-14
申请人： Douglas P. Allen , Dominic P. DiNovo , George A. Keller , Rebeccah P. Quam , Thomas J. Ward , Warren P. Williamson, IV
发明人： Douglas P. Allen , Dominic P. DiNovo , George A. Keller , Rebeccah P. Quam , Thomas J. Ward , Warren P. Williamson, IV
IPC分类号： G01N1/30 , C12M1/34
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

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