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    • 2. 发明申请
    • Method of inducing memory B cell development and terminal differentiation
    • 诱导记忆B细胞发育和终末分化的方法
    • US20060057123A1
    • 2006-03-16
    • US11197221
    • 2005-08-03
    • Catherine EttingerPeter LipskyWarren LeonardRosanne SpolskiHerbert Morse
    • Catherine EttingerPeter LipskyWarren LeonardRosanne SpolskiHerbert Morse
    • A61K35/14C12N5/08
    • G01N33/5052A61K35/17A61K38/20A61K2035/124A61K2039/5158C12N5/0635C12N2501/052C12N2501/23C12N2501/50C12N2501/52G01N2333/54
    • A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. In one embodiment, the B cell progenitor is an immature B cell. A method is also disclosed for enhancing an immune response. The method includes contacting a population of cells including a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. The memory B cells and/or the plasma cell are then introduced into the subject to enhance the immune response. A method is also disclosed for treating a subject with a condition comprising a specific deficiency of at least one of memory B cells and plasma cells. A method is disclosed for identifying an agent with a physiological effect on one or more of a memory B cell and a plasma cell differentiation. A method is also disclosed for identifying agents that inhibit an activity of IL-21. Methods are also disclosed for inducing apoptosis of a B cell and for decreasing the number of B cells. A method is also described for producing a B cell hybridoma.
    • 本文公开了一种用于诱导B细胞祖细胞分化为记忆B细胞和/或浆细胞的方法。 该方法包括使包含成熟B细胞或B细胞祖细胞的细胞群与有效量的IL-21接触,并分离记忆B细胞或浆细胞。 在一个实施方案中,B细胞祖细胞是未成熟B细胞。 还公开了一种用于增强免疫应答的方法。 该方法包括使包含B细胞祖细胞的细胞群与有效量的IL-21接触,并分离记忆B细胞或浆细胞。 然后将记忆B细胞和/或浆细胞引入受试者以增强免疫应答。 还公开了一种用于治疗患有包含存储B细胞和浆细胞中的至少一种的特定缺陷的病症的受试者的方法。 公开了用于鉴定对存储B细胞和浆细胞分化中的一种或多种具有生理作用的药剂的方法。 还公开了用于鉴定抑制IL-21活性的试剂的方法。 还公开了诱导B细胞凋亡和减少B细胞数量的方法。 还描述了用于产生B细胞杂交瘤的方法。
    • 3. 发明申请
    • Method of inducing memory b cell development and terminal differentiation
    • 诱导记忆b细胞发育和终末分化的方法
    • US20070003515A1
    • 2007-01-04
    • US10579988
    • 2004-11-18
    • Warren LeonardPeter LipskyHerbert MorseCatherine EttingerRosanne Spolski
    • Warren LeonardPeter LipskyHerbert MorseCatherine EttingerRosanne Spolski
    • A61K38/20A61K35/14G01N33/567
    • G01N33/5052A61K35/17A61K38/20A61K2035/124A61K2039/5158C12N5/0635C12N2501/052C12N2501/23C12N2501/50C12N2501/52G01N2333/54
    • A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. In one embodiment, the B cell progenitor is an immature B cell. A method is also disclosed for enhancing an immune response. The method includes contacting a population of cells including a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. The memory B cells arid/or the plasma cell are then introduced into the subject to enhance the immune response. A method is also disclosed for treating a subject with a condition comprising a specific deficiency of at least one of memory B cells and plasma cells. A method is disclosed for identifying an agent with a physiological effect on one or more of a memory B cell and a plasma cell differentiation. A method is also disclosed for identifying agents that inhibit an activity of IL-21.
    • 本文公开了一种用于诱导B细胞祖细胞分化为记忆B细胞和/或浆细胞的方法。 该方法包括使包含成熟B细胞或B细胞祖细胞的细胞群与有效量的IL-21接触,并分离记忆B细胞或浆细胞。 在一个实施方案中,B细胞祖细胞是未成熟B细胞。 还公开了一种用于增强免疫应答的方法。 该方法包括使包含B细胞祖细胞的细胞群与有效量的IL-21接触,并分离记忆B细胞或浆细胞。 然后将记忆B细胞和/或浆细胞引入受试者以增强免疫应答。 还公开了一种用于治疗患有包含存储B细胞和浆细胞中的至少一种的特定缺陷的病症的受试者的方法。 公开了用于鉴定对存储B细胞和浆细胞分化中的一种或多种具有生理作用的药剂的方法。 还公开了用于鉴定抑制IL-21活性的试剂的方法。
    • 5. 发明授权
    • Compositions and methods for treating thermal injury
    • 治疗热损伤的组合物和方法
    • US06203793B1
    • 2001-03-20
    • US08832464
    • 1997-04-02
    • Peter LipskyWilliam Mileski
    • Peter LipskyWilliam Mileski
    • A61K39345
    • C07K16/2845A61K38/00C07K16/2821C07K16/2854C07K16/2884
    • Disclosed is a method for treating tissue necrosis (loss) in an animal. Tissue necrosis is treated by providing the subject with an anti-adhesion cell agent capable of binding an ICAM-1 antigen, a CD18 antigen, an L-selectin agent, a CD44 antigen, a P-selectin antigen, a VCAM-1 antigen, an ICAM-2 antigen, or a fragment thereof. Also provided is a method for preventing thermal-related tissue loss or necrosis, particularly the thermal injury and progressive tissue necrosis which results from a burn injury. Thermal-related tissue injury surrounding a thermal injury site is inhibited or prevented by providing an animal with an anti-adhesion agent, such as an anti-CD18 antibody, an anti-ICAM-1 antibody, or a mixture or fragment thereof. A method for inhibiting/preventing scarring attendant healing of a thermal injury is also disclosed.
    • 公开了一种治疗动物组织坏死(损失)的方法。 通过向受试者提供能够结合ICAM-1抗原,CD18抗原,L-选择素试剂,CD44抗原,P-选择蛋白抗原,VCAM-1抗原的抗粘附细胞试剂来治疗组织坏死, ICAM-2抗原或其片段。 还提供了防止热相关组织损失或坏死的方法,特别是由烧伤引起的热损伤和进行性组织坏死。 通过向动物提供抗粘连剂,例如抗CD18抗体,抗ICAM-1抗体或其混合物或片段,可以抑制或预防围绕热损伤部位的热相关组织损伤。 还公开了用于抑制/预防热损伤的瘢痕形成伴随愈合的方法。