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1. 发明申请

WO2003076417A3 OXO-AZABICYCLIC COMPOUNDS 审中-公开
公开(公告)号：WO2003076417A3
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002277
申请日：2003-03-06
申请人： WARNER-LAMBERT COMPANY LLC , GAUDILLIERE, Bernard , JACOBELLI, Henry , KOSTLAN, Catherine , LI, Jack , YUE, Wen-Song
发明人： GAUDILLIERE, Bernard , JACOBELLI, Henry , KOSTLAN, Catherine , LI, Jack , YUE, Wen-Song
IPC分类号： C07D239/91
摘要： A compound selected from those of formula (I) wherein: X 1 , X 2 , and X 3 , represent N or -CR 3 in which R 3 is as described in the description, G 1 represents a group selected from those of formulae (i/a) and (i/b) in which R 4 , R 5 , and R 6 are as defined in the description, G 2 represents a group selected from carbon-carbon triple bond, -CH=C=CH-, C=O, C=S, S(O) n1 in which nl represents an integer from 0 to 2 inclusive, or a group of formula (i/c) in which Y 1 represents O, S, -NH or -Nalkyl, and Y 2 represents O, S, -NH or -Nalkyl, n is an integer from 0 to 6 inclusive, and m is an integer from 0 to 7 inclusive, Z 1 represents -CR 9 R 10 ,wherein R 9 and R 10 are as defined in the description, A represents a ring system, R 1 represents a group selected from H, alkyl, alkenyl, alkynyl, optionally substituted and the group of formula (i/d) in which p, Z 2 , B, q and G 3 are as defined in the description and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix mettaloprotease.

2. 发明申请

WO2003076417A2 OXO-AZABICYCLIC COMPOUNDS 审中-公开
标题翻译： OXO-AZABICYCLIC化合物
公开(公告)号：WO2003076417A2
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002277
申请日：2003-03-06
申请人： WARNER-LAMBERT COMPANY LLC , GAUDILLIERE, Bernard , JACOBELLI, Henry , KOSTLAN, Catherine , LI, Jack , YUE, Wen-Song
发明人： GAUDILLIERE, Bernard , JACOBELLI, Henry , KOSTLAN, Catherine , LI, Jack , YUE, Wen-Song
IPC分类号： C07D239/91
CPC分类号： C07D471/04 , C07D239/91
摘要： A compound selected from those of formula (1): ~',Xi Gi X 2 (7l) I ,N - R 1 (I) 11 - G 2 X3 wherein: 5 • X,, X2, and X3, represent N or -CR3 in which R3 is as described in the description, • G, represents a group selected from those of formulae (i/a) and (i/b): R4 R6 \ R4 N (i/a) (i/b) in which R4, R5, and R6 are as defined in the description, • G2 represents a group selected from carbon-carbon triple bond, -CH=C=CH-, C=O, 10 C=S, S(O) n , in which nl represents an integer from 0 to 2 inclusive, or a group of formula (i/c): 11-1y -r ( i/c ) Y 1 in which Y1 represents O, S, -NH or -Nalkyl, and Y2 represents O, S, -NH or -Nalkyl, • n is an integer from 0 to 6 inclusive, and m is an integer from 0 to 7 inclusive, 15 • Z, represents -CRgR,o, wherein R9 and R I O areas defined in the description, • A represents a ring system, • R, represents a group selected from H, alkyl, alkenyl, alkynyl, optionally substituted and the group of formula (i/d) (G3)q~(Z2 )~ (i/d) 20 in which p, Z2, B, q and G3 are as defined in the description and optionally, its optical isomers , N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix mettaloprotease.
摘要翻译：选自式（I）的化合物的化合物，其中：X 1，X 2和X 3表示N或-CR 3，其中R 3如描述中所述，G 1表示选自式（i / a）和（其中R 4，R 5和R 6如说明书中所定义，R 2表示选自碳 - 碳三键，-CH = C = CH-，C = O，C = S，S（O ）n1，其中n1表示0〜2的整数，或其中Y1表示O，S，-NH或-N烷基的式（i / c）基团，Y2表示O，S，-NH或-N烷基 n为0以上6以下的整数，m为0以上7以下的整数，Z1为-CR9R10，其中，R9和R10如说明书中所定义，A表示环系，R1表示选自 H，烷基，烯基，炔基，任选被取代的基团和其中p，Z2，B，q和G3如说明书中所定义的任选的其光学异构体，N-氧化物和加成其盐与药学上可接受的 le酸或碱，含有它们的药物可用作13型基质金属蛋白酶的特异性抑制剂。

3. 发明申请

WO2003076416A1 OXO AZABICYCLIC COMPOUNDS 审中-公开
标题翻译： OXO AZABICYCLIC化合物
公开(公告)号：WO2003076416A1
公开(公告)日：2003-09-18
申请号：PCT/EP2002/003240
申请日：2002-03-08
申请人： WARNER-LAMBERT COMPANY LLC , GAUDILLIERE, Bernard , JACOBELLI, Henry , KOSTLAN, Catherine , LI, Jack , YUE, Wen-Song
发明人： GAUDILLIERE, Bernard , JACOBELLI, Henry , KOSTLAN, Catherine , LI, Jack , YUE, Wen-Song
IPC分类号： C07D239/91
CPC分类号： C07D471/04 , C07D239/91
摘要： A compound selected from those of formula (I): formula (I) wherein: - X 1 , X 2 , and X 3 , represent N or CR 3 in which R 3 is as described in the description, - G 1 represents a group selected from those of formulae (i/a) and (i/b): formula (II) in which R 4 , R 5 , and R 6 are as defined in the description, - G 2 represents a group selected from carbon-carbon triple bond, -CH=C=CH-, C=O, C=S, S(O) nt in which n1 represents an integer from 0 to 2 inclusive, or a group of formula (i/c): formula (III) in which Y 1 represents O, S, -NH or Nalkyl, and Y 2 represents O, S, -NH or Nalkyl, - n is an integer from 0 to 6 inclusive, and m is an integer from 0 to 7 inclusive, Z 1 represents CR 9 R 10 , wherein R 9 and R 10 are as defined in the description, - A represents a ring system, - R 1 represents a group selected from H, alkyl, alkenyl, alkynyl, optionally substituted and the group of formula (i/d): formula (IV) in which p, Z 2 , B, q and G 3 are as defined in the description and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix mettaloprotease.
摘要翻译：选自式（I）的化合物：式（I）其中：-X 1，X 2和X 3表示其中R 3如描述中所述的N或CR 3，-G1表示选自式 I / a）和（i / b）：其中R 4，R 5和R 6如说明书中所定义的式（II），-G2表示选自碳 - 碳三键，-CH = C = CH- ，C = O，C = S，S（O）nt，其中n1表示0〜2的整数，或式（i / c）：式（III）的基团，其中Y1表示O，S， NH或N烷基，Y2表示O，S，-NH或N烷基，-n为0〜6的整数，m为0〜7的整数，Z1表示CR9R10，其中R9和R10如描述，-A表示环系，-R 1表示选自H，烷基，烯基，炔基，任选取代的基团和式（I / d）的基团：式（IV）其中p，Z2，B， q和G3如说明书中所定义，并且任选地，其光学异构体，和其药学上可接受的酸或碱的加成盐和含有它们的药物可用作13型基质金属蛋白酶的特异性抑制剂。

4. 发明公开

EP1492775A2 OXO-AZABICYCLIC COMPOUNDS 审中-公开
标题翻译： OXO-氮杂双环CONNECTIONS
公开(公告)号：EP1492775A2
公开(公告)日：2005-01-05
申请号：EP03708181.7
申请日：2003-03-06
申请人： Warner-Lambert Company LLC
发明人： GAUDILLIERE, Bernard , JACOBELLI, Henry , KOSTLAN, Catherine , LI, Jack , YUE, Wen-Song
IPC分类号： C07D239/91
CPC分类号： C07D471/04 , C07D239/91
摘要： A compound selected from those of formula (I) wherein: X1, X2, and X3, represent N or -CR3 in which R3 is as described in the description, G1 represents a group selected from those of formulae (i/a) and (i/b) in which R4, R5, and R6 are as defined in the description, G2 represents a group selected from carbon-carbon triple bond, -CH=C=CH-, C=O, C=S, S(O)n1 in which nl represents an integer from 0 to 2 inclusive, or a group of formula (i/c) in which Y1 represents O, S, -NH or -Nalkyl, and Y2 represents O, S, -NH or -Nalkyl, n is an integer from 0 to 6 inclusive, and m is an integer from 0 to 7 inclusive, Z1 represents -CR9R10,wherein R9 and R10 are as defined in the description, A represents a ring system, R1 represents a group selected from H, alkyl, alkenyl, alkynyl, optionally substituted and the group of formula (i/d) in which p, Z2, B, q and G3 are as defined in the description and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix mettaloprotease.

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