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1. 发明公开

EP1582869A3 Interrupted flow testing device and method for immunological confirmatory tests 失效转让
标题翻译：中断流动试验设备和方法，用于免疫学确认试验
公开(公告)号：EP1582869A3
公开(公告)日：2006-11-15
申请号：EP05001804.3
申请日：2005-01-28
申请人： Wang, Naishu , Zhou, David F.
发明人： Wang, Naishu , Zhou, David F.
IPC分类号： G01N33/558 , G01N33/543
CPC分类号： G01N33/558 , G01N2333/16
摘要： A self-contained device using a gravitationally encouraged, interrupted downward and programmed flow of fluid to provide for rapid confirmatory immunological testing ("RCIT") in a point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber and premixed with a first measured, reactive mix buffer solution carried within an openable tank. The mix buffer carries a colloidal conjugate of antigens and/or antibodies pathogenically specific to the condition being tested. The premixture flows out of the first chamber toward chromatographic test strips having a single layer of uniformly dispersed porous matrix material such as polyethylene and inclined in a downward flow orientation. The flow is interrupted by a holding reservoir which is drained by siphoning, gravity and capillary forces. The delayed and regulated flow provides an incubation time for a better affinity binding of the specimen. In one embodiment, after a waiting period a bladder containing a stop-wash buffer solution is opened to flow into the reservoir and onto the strips. An absorbant pad collects excess fluid at the bottom end of the strips. It is a rapid confirmatory immunological test device having an analytical panel which can provide profile diagnostic results.

2. 发明公开

EP1582869A2 Interrupted flow testing device and method for immunological confirmatory tests 失效转让
标题翻译： Unterbrochene Durchfluss-Testvorrichtung und MethodefürimmunologischeBestätigungstests
公开(公告)号：EP1582869A2
公开(公告)日：2005-10-05
申请号：EP05001804.3
申请日：2005-01-28
申请人： Wang, Naishu , Zhou, David F.
发明人： Wang, Naishu , Zhou, David F.
IPC分类号： G01N33/53 , G01N33/558
CPC分类号： G01N33/558 , G01N2333/16
摘要： A self-contained device using a gravitationally encouraged, interrupted downward and programmed flow of fluid to provide for rapid confirmatory immunological testing ("RCIT") in a point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber and premixed with a first measured, reactive mix buffer solution carried within an openable tank. The mix buffer carries a colloidal conjugate of antigens and/or antibodies pathogenically specific to the condition being tested. The premixture flows out of the first chamber toward chromatographic test strips having a single layer of uniformly dispersed porous matrix material such as polyethylene and inclined in a downward flow orientation. The flow is interrupted by a holding reservoir which is drained by siphoning, gravity and capillary forces. The delayed and regulated flow provides an incubation time for a better affinity binding of the specimen. In one embodiment, after a waiting period a bladder containing a stop-wash buffer solution is opened to flow into the reservoir and onto the strips. An absorbant pad collects excess fluid at the bottom end of the strips. It is a rapid confirmatory immunological test device having an analytical panel which can provide profile diagnostic results.
摘要翻译：一个独立的设备，使用重力鼓励，中断向下和编程的流体流动，以便在护理环境中提供快速确认的免疫测试（“RCIT”）。流体样品如血液，唾液或尿液沉积到第一室中，并与在可开启的罐内携带的第一测量的反应性混合缓冲溶液预混合。混合缓冲液携带针对被测试病症病原特异性的抗原和/或抗体的胶体缀合物。预混合物从第一室流出到具有单层均匀分散的多孔基质材料如聚乙烯并且以向下流动方向倾斜的色谱测试条。流动被一个通过虹吸，重力和毛细管力排出的储液槽中断。延迟和调节的流动提供了对样品更好的亲和性结合的孵育时间。在一个实施方案中，在等待时间之后，打开包含停止洗涤缓冲溶液的气囊以流入储存器和条上。吸收垫在条的底端收集多余的流体。它是具有可提供轮廓诊断结果的分析面板的快速确认免疫测试装置。

3. 发明公开

EP1686378A3 Fluid flow diffuser for immunological testing devices and method 有权
标题翻译：流扩散免疫学测试的装置和方法
公开(公告)号：EP1686378A3
公开(公告)日：2006-08-30
申请号：EP06001758.9
申请日：2006-01-27
申请人： Wang, Naishu , Zhou, David F.
发明人： Wang, Naishu , Zhou, David F.
IPC分类号： G01N33/558 , G01N33/543
CPC分类号： G01N33/558 , G01N33/54366
摘要： A porous fluid flow-diffusing structure for enhancing rapid confirmatory immunological testing ("RCIT") in, for example, a clinical, point-of-care setting using flow-based devices such as non-lateral flow RCIT devices containing releasable amounts of buffer solution or devices containing lateral flow chromatographic immunoassay test strips. The flow-diffusive structure is located on a fluid path between a conjugate source and a reaction membrane. Flow through the diffusive structure causes a delay and additional mixing of the fluid so that it exhibits a more uniformly high degree of first affinity binding before flowing onto the reaction membrane. Various exemplary embodiments provide one or more diffusive structures that can be pretreated with mixture enhancing chemicals such as surfactants.

4. 发明公开

EP1686378A2 Fluid flow diffuser for immunological testing devices and method 有权
标题翻译：用于免疫学检测装置和方法的流体流动扩散器
公开(公告)号：EP1686378A2
公开(公告)日：2006-08-02
申请号：EP06001758.9
申请日：2006-01-27
申请人： Wang, Naishu , Zhou, David F.
发明人： Wang, Naishu , Zhou, David F.
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , G01N33/54366
摘要： A porous fluid flow-diffusing structure for enhancing rapid confirmatory immunological testing ("RCIT") in, for example, a clinical, point-of-care setting using flow-based devices such as non-lateral flow RCIT devices containing releasable amounts of buffer solution or devices containing lateral flow chromatographic immunoassay test strips. The flow-diffusive structure is located on a fluid path between a conjugate source and a reaction membrane. Flow through the diffusive structure causes a delay and additional mixing of the fluid so that it exhibits a more uniformly high degree of first affinity binding before flowing onto the reaction membrane. Various exemplary embodiments provide one or more diffusive structures that can be pretreated with mixture enhancing chemicals such as surfactants.
摘要翻译：多孔流体流动扩散结构用于在例如使用基于流动的装置（例如含有可释放量的缓冲液的非侧向流动RCIT装置）的临床即时护理设置中增强快速确认性免疫测试（“RCIT”）溶液或含有侧流色谱免疫分析测试条的设备。流动扩散结构位于共轭源和反应膜之间的流体路径上。通过扩散结构的流动导致流体的延迟和附加混合，使得其在流到反应膜上之前呈现出更均匀的高度的第一亲和力结合。各种示例性实施方式提供了一种或多种扩散结构，其可以用混合物增强化学品如表面活性剂进行预处理。

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