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1. 发明授权

US4906666A Hydroxamic acids and pharmaceutical compositions containing them, and anti-allergic use thereof 失效
标题翻译：羟肟酸和含有它们的药物组合物及其抗过敏应用
公开(公告)号：US4906666A
公开(公告)日：1990-03-06
申请号：US11096
申请日：1987-02-05
申请人： Erhard Reinholz , Walter-Gunar Friebe , Wolfgang Kampe , Jurgen Mertin , Otto-Henning Wilhelms
发明人： Erhard Reinholz , Walter-Gunar Friebe , Wolfgang Kampe , Jurgen Mertin , Otto-Henning Wilhelms
IPC分类号： A61K31/10 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/235 , A61K31/26 , A61K31/275 , A61K31/41 , A61P11/00 , A61P29/00 , A61P37/08 , C07C67/00 , C07C313/00 , C07C315/02 , C07C317/18 , C07C317/44 , C07C323/12 , C07C323/14 , C07C323/20 , C07C323/52 , C07C323/54 , C07C323/60 , C07C325/00 , C07C331/04 , C07D257/04 , C07D257/06
CPC分类号： C07D257/04 , A61K31/10 , A61K31/26 , A61K31/275 , C07C323/12 , C07C323/52 , C07C323/60 , C07C331/04 , C07D257/06
摘要： The present invention provides compounds of the general formula: ##STR1## wherein Ar is a phenyl radical optionally substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, A is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 aliphatic hydrocarbon radical which is optionally substituted by a hydroxyl group, n is 0, 1 or 2, B is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 -aliphatic hydrocarbon radical and R is 5-(1H)-tetrazolyl, --CO--NH-tetrazolyl, ##STR2## CN, SCN, OH, halogen, 5-(1H)-tetrazolylthio, ##STR3## or CO--O--NH--R.sub.1, wherein R.sub.1 is a hydrogen atom, an alkyl radical optionally substituted by cycloalkyl or an alkenyl, cycloalkyl, aralkyl or aryl radical, wherein the aromatic moiety can be substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen; and the pharmacologically acceptable salts thereof. The present invention also provides processes for preparing these compounds and pharmaceutical compositions containing them for combating allergic diseases.
摘要翻译：本发明提供以下通式的化合物：其中Ar是任选被烷基，烯基，烷氧基，烷硫基，烷酰基，羟基，羟基烷基，羧基，烷氧基羰基，氨基甲酰基，硝基，氨基或卤素取代的苯基 A是直链或支链，饱和或不饱和的C1-C8脂族烃基，其任选被羟基取代，n是0,1或2，B是直链或支链的饱和或不饱和的C1- C8-脂族烃基，R是5-（1H） - 四唑基，-CO-NH-四唑基，CN，SCN，OH，卤素，5-（1H） - 四唑基硫代， NH-R1，其中R1是氢原子，任选被环烷基或烯基，环烷基，芳烷基或芳基取代的烷基，其中芳族部分可以被烷基，烯基，烷氧基，烷硫基，烷酰基，羟基，羟烷基，羧基，烷氧基羰基，氨基甲酰基，硝基，氨基或卤素; 及其药理学上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的用于防治过敏性疾病的药物组合物。

2. 发明授权

US4348401A N-Phenoxyalkylpiperidine derivatives 失效
标题翻译： N-苯氧基烷基哌啶衍生物
公开(公告)号：US4348401A
公开(公告)日：1982-09-07
申请号：US185839
申请日：1980-09-10
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Max Thiel , Wolfgang Schaumann , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Max Thiel , Wolfgang Schaumann , Otto-Henning Wilhelms
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61P11/14 , A61P37/00 , C07D211/22 , C07D211/58 , C07D401/12 , C07D409/12 , C07D409/14 , A61K31/455 , C07D403/12 , C07D407/12
CPC分类号： C07D211/58 , C07D211/22 , Y10S514/87
摘要： An N-phenoxyalkylpiperidine derivative of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, an acyl radical or an optionally substituted aryl radical, R.sub.2 is a hydroxymethyl radical, a cyano group, an amidino group, an amidino group substituted by hydroxyl, a 1H tetrazol-5-yl radical or a --CO--R.sub.3 radical, R.sub.3 is a hydroxyl group, a lower alkoxy radical, an amino group, or an amino group substituted by a 1H-tetrazol-5-yl radical, X is an imino group or an oxymethyl radical, A is an alkylene radical containing 2 to 4 carbon atoms, and B is a valency bond or a 4-hydroxypyrimidin-2,5-diyl radical; or a pharmacologically acceptable salt thereof. The compounds exhibit anti-histaminic, anti-oedematous and anti-phlogistic activity.
摘要翻译：其中R 1是氢原子，酰基或任意取代的芳基，R 2是羟甲基，氰基，脒基，被羟基取代的脒基， 1H-四唑-5-基或-CO-R 3基团，R 3是羟基，低级烷氧基，氨基或被1H-四唑-5-基取代的氨基，X是亚氨基基团或氧甲基，A是含有2至4个碳原子的亚烷基，B是价键或4-羟基嘧啶-2,5-二基; 或其药理学上可接受的盐。该化合物表现出抗组胺，抗氧化和抗病毒活性。

3. 发明授权

US4234585A 1,2-Dihydroquinoline-2-one derivatives 失效
标题翻译： 1,2-二氢喹啉-2-酮衍生物
公开(公告)号：US4234585A
公开(公告)日：1980-11-18
申请号：US45472
申请日：1979-06-04
申请人： Werner Winter , Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch , Otto-Henning Wilhelms
发明人： Werner Winter , Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch , Otto-Henning Wilhelms
IPC分类号： C07D215/22 , A61K31/4704 , A61K31/495 , A61P37/08 , C07D215/227 , C07D215/26 , C07D401/12
CPC分类号： C07D215/227 , C07D215/26
摘要： A (4-substituted-piperazin-1-yl)-alkoxy-2-oxo-1,2-dihydroquinoline of the formula: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 each independently is hydrogen or a lower alkyl radical,R.sub.4 is hydrogen, halogen, or a lower alkyl or lower alkoxy radical,n is 2, 3, 4 or 5 andA is a valency bond or a methylene radical optionally substituted by a phenyl radical,or a salt thereof, which exhibits anti-allergic and anti-hypertensive activity.
摘要翻译：下式的（4-取代 - 哌嗪-1-基） - 烷氧基-2-氧代-1,2-二氢喹啉：其中R 1，R 2和R 3各自独立地是氢或低级烷基，R 4是氢，卤素或低级烷基或低级烷氧基，n为2,3,4或5，A为任选被苯基或其盐取代的价键或亚甲基，其表现出抗过敏和抗高血压活动。

4. 发明授权

US4904666A Pyrazolo(3,4-d)pyrimidine compounds, compositions and method of use 失效
标题翻译：吡唑并（3,4-d）嘧啶化合物，组合物和使用方法
公开(公告)号：US4904666A
公开(公告)日：1990-02-27
申请号：US181729
申请日：1988-04-14
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Otto-Henning Wilhelms
IPC分类号： A61K31/505 , A61K31/519 , A61P11/08 , A61P11/16 , A61P29/00 , A61P37/08 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides pyrazolo[3,4-d]-pyrimidines of the general formula: ##STR1## wherein R.sub.1 is a C.sub.1 to C.sub.6 -alkyl radical, a C.sub.2 to C.sub.6 -alkenyl radical, a C.sub.3 to C.sub.7 -cycloalkyl radical or an aryl radical, R.sub.2 is a C.sub.2 to C.sub.6 -alkenyl radical, a C.sub.3 to C.sub.7 -cycloalkyl radical or an aralkyl or hetaralkyl radical with 1 to 6 carbon atoms in the alkyl moiety and substituted, if desired, one or more times by halogen, C.sub.1 to C.sub.6 -alkyl, hydroxyl, C.sub.1 to C.sub.6 -alkoxy, C.sub.1 to C.sub.3 -haloalkyl, C.sub.3 to C.sub.7 -alkoxy carbonyl, aminocarbonyl, C.sub.2 to C.sub.7 -alkylaminocarbonyl, C.sub.3 to C.sub.13 -dialkylaminocarbonyl, cyano or C.sub.1 to C.sub.6 -alkylthio and R.sub.3 is a hydrogen atom or a C.sub.2 to C.sub.6 -alkyl radical substituted, if desired, one or more times by hydroxyl or is a tetrahydrofuranyl or tetrahydropyranyl radical, with the proviso that R.sub.2 cannot be an unsubstituted benzyl radical when R.sub.1 is a methyl radical, and the physiologically acceptable salts thereof with inorganic and organic acids.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.
摘要翻译：本发明提供通式如下的吡唑并[3,4-d] - 嘧啶：其中R 1为C 1至C 6 - 烷基，C 2至C 6链烯基，C 3至C 7环烷基基团或芳基，R 2是C 2至C 6 - 烯基，C 3至C 7 - 环烷基或在烷基部分具有1至6个碳原子的芳烷基或杂烷基，如果需要，卤素，C1至C6烷基，羟基，C1至C6烷氧基，C1至C3-卤代烷基，C3至C7-烷氧基羰基，氨基羰基，C2至C7-烷基氨基羰基，C3至C13-二烷基氨基羰基，氰基或C1至C6-烷硫基并且R 3是氢原子或C 2至C 6烷基如果需要，被羟基取代一次或多次，或者是四氢呋喃基或四氢吡喃基，条件是当R 1是甲基时，R 2不能是未被取代的苄基，以及其与无机和有机酸的生理上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。

5. 发明授权

US4428955A Benzopyran compounds, pharmaceutical compositions containing them and methods of use 失效
标题翻译：苯并吡喃化合物，含有它们的药物组合物和使用方法
公开(公告)号：US4428955A
公开(公告)日：1984-01-31
申请号：US372415
申请日：1982-04-27
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Egon Roesch , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Egon Roesch , Otto-Henning Wilhelms
IPC分类号： C07D409/14 , A61K31/35 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P37/08 , A61P43/00 , C07D311/22 , C07D405/06 , C07D405/12 , C07D405/14
CPC分类号： C07D405/12 , Y10S514/87
摘要： The present invention provides benzopyranyl ethers of the general formula: ##STR1## wherein A is an alkylene radical containing 2 to 4 carbon atoms and R is a hydrogen atom or an acyl radical; as well as the salts thereof with pharmacologically acceptable acids.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. Furthermore, the present invention is concerned with the use of these compounds for treating allergic diseases.
摘要翻译：本发明提供以下通式的苯并吡喃基醚：其中A是含有2至4个碳原子的烷基，R是氢原子或酰基; 以及其与药理学上可接受的酸的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。此外，本发明涉及这些化合物用于治疗过敏性疾病的用途。

6. 发明授权

US5399575A Pyridine compounds which have useful pharmaceutical activity 失效
标题翻译：具有有用药物活性的吡啶化合物
公开(公告)号：US5399575A
公开(公告)日：1995-03-21
申请号：US66058
申请日：1993-06-14
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Marcel Linssen , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Marcel Linssen , Otto-Henning Wilhelms
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61P37/08 , C07D213/30 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/89 , C07D401/04 , C07D401/10 , C07D401/12 , C07D213/54
CPC分类号： C07D213/30 , C07D213/55 , C07D213/56 , C07D213/57 , C07D401/12
摘要： Compounds of the formula I ##STR1## in which A signifies an alkylene radical with 1 to 3 carbon atoms or a group --CH.dbd.CH--, B an oxygen atom or a valency bond, m a whole number from 0 to 5, n the number 0 or 1, X a valency bond, an oxygen atom or a sulphur atom, Y a valency bond or a phenylene radical substituted, if desired, one or more times by C.sub.1 - to C.sub.6 -alkyl, C.sub.1 - to C.sub.6 -alkoxy, halogen, hydroxyl or aminocarbonyl, Z hydrogen, halogen, C.sub.1 - to C.sub.6 -alkyl or cyano and R a group CN, COOH, COOC.sub.1 - to C.sub.6 -alkyl, CONH-tetrazolyl, CON(OH)(C.sub.1 -C.sub.6 -alkyl) or 5-(1H)-tetrazolyl, as well as, for the case that Y represents a phenylene radical, also hydrogen, with the exception of the compound 4-[2-(4)-pyridinovinyl]-carboxymethoxybenzene, their physiologically compatible salts and processes for their preparation, as well as medicaments containing these compounds for the treatment of allergic diseases.
摘要翻译： PCT No.PCT / EP91 / 02249 Sec。 371日期：1993年6月14日 102（e）日期1993年6月14日PCT 1991年11月28日PCT PCT。第WO92 / 09598号公报日期：1992年6月11日。式I的化合物（I）其中A表示具有1至3个碳原子的亚烷基或基团-CH = CH-，B为氧原子或价键， 0至5的整数，n为0或1，X为价键，氧原子或硫原子，Y为化合键或亚苯基，如果需要，可以被C 1 -C 6 - 烷基，C 1至C 6 - 烷氧基，卤素，羟基或氨基羰基，Z氢，卤素，C 1至C 6 - 烷基或氰基，R a基团CN，COOH，COOC 1 -C 6烷基，CONH-四唑基，CON ）（C 1 -C 6 - 烷基）或5-（1H） - 四唑基，以及对于Y代表亚苯基的情况，也是氢，除了化合物4- [2-（4） - 吡啶基乙烯基 ] - 羧甲氧基苯，它们的生理上相容的盐及其制备方法，以及含有这些化合物用于治疗过敏性疾病的药物。

7. 发明授权

US5025028A Tetrazolyl substituted thioethers, pharmaceutical compositions and anti-allergic use thereof 失效
标题翻译：四唑基取代的硫醚，药物组合物和抗过敏应用
公开(公告)号：US5025028A
公开(公告)日：1991-06-18
申请号：US466197
申请日：1990-01-17
申请人： Erhard Reinholz , Walter-Gunar Friebe , Wolfgang Kampe , Jurgen Mertin , Otto-Henning Wilhelms
发明人： Erhard Reinholz , Walter-Gunar Friebe , Wolfgang Kampe , Jurgen Mertin , Otto-Henning Wilhelms
IPC分类号： A61K31/10 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/235 , A61K31/26 , A61K31/275 , A61K31/41 , A61P11/00 , A61P29/00 , A61P37/08 , C07C67/00 , C07C313/00 , C07C315/02 , C07C317/18 , C07C317/44 , C07C323/12 , C07C323/14 , C07C323/20 , C07C323/52 , C07C323/54 , C07C323/60 , C07C325/00 , C07C331/04 , C07D257/04 , C07D257/06
CPC分类号： C07D257/04 , A61K31/10 , A61K31/26 , A61K31/275 , C07C323/12 , C07C323/52 , C07C323/60 , C07C331/04 , C07D257/06
摘要： The present invention provides compounds of the general formula: ##STR1## wherein Ar is a phenyl radical optionally substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, A is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 aliphatic hydrocarbon radical which is optionally substituted by a hydroxyl group, n is 0, 1 or 2, B is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 -aliphatic hydrocarbon radical and R is 5-(1H)-tetrazolyl, --CO--NH-tetrazolyl, ##STR2## Cn, SCN, OH, halogen, 5-(1H)-tetrazolylthio, ##STR3## or CO--O--NH--R.sub.1, wherein R.sub.1 is a hydrogen atom, an alkyl radical optionally substituted by cycloalkyl or an alkenyl, cycloalkyl, aralkyl or aryl radical, wherein the aromatic moiety can be substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen; and the pharmacologically acceptable salts thereof. The present invention also provides processes for preparing these compounds and pharmaceutical compositions containing them for combating allergic diseases.

8. 发明授权

US4621098A Thioethers and pharmaceutical compositions containing them 失效
标题翻译：硫醚和含有它们的药物组合物
公开(公告)号：US4621098A
公开(公告)日：1986-11-04
申请号：US626690
申请日：1984-07-02
申请人： Robert Umminger , Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch , Otto-Henning Wilhelms
发明人： Robert Umminger , Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch , Otto-Henning Wilhelms
IPC分类号： C07D295/12 , A61K31/04 , A61K31/10 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/22 , A61K31/535 , A61K31/5375 , A61P37/08 , C07C67/00 , C07C313/00 , C07C315/02 , C07C317/00 , C07C317/04 , C07C317/18 , C07C319/14 , C07C321/28 , C07C323/07 , C07C323/12 , C07C323/14 , C07C323/20 , C07C323/22 , C07C323/25 , C07C323/36 , C07C323/52 , C07C323/58 , C07C323/62 , C07C323/65 , C07D295/18 , C07D295/185 , C07C147/107
CPC分类号： C07D295/185 , C07C317/00 , C07C321/00 , C07C323/00 , C07C323/25
摘要： The present invention provides thioethers of the general formula: ##STR1## wherein Ar is a phenyl radical which is optionally substituted one, two or three times by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, Q is an oxygen or sulphur atom or an NH group, A is a straight-chained or branched C.sub.2 -C.sub.8 alkylene radical which is optionally substituted by a hydroxyl group or can be interrupted by an ethenylene or ethynylene group, n is 0, 1 or 2, and R is a hydrogen atom or a straight-chained or branched alkyl radical which is optionally substituted one or more times by the same or different radicals selected from alkoxycarbonyl, alkoxy, hydroxyl, carboxyl or optionally substituted carbamoyl or amino; as well as the pharmacologically acceptable salts thereof, with the proviso that A cannot be ethylene when Ar is a phenyl radical, Q is an oxygen atom and R is the group --CH.sub.2 COOH.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.
摘要翻译：本发明提供以下通式的硫醚：其中Ar是任选被烷基，烯基，烷氧基，烷硫基，烷酰基，羟基，羟基烷基，羧基，烷氧基羰基任选取代一至两次的苯基，氨基甲酰基，硝基，氨基或卤素，Q是氧或硫原子或NH基团，A是任选被羟基取代的直链或支链C 2 -C 8亚烷基，或可被亚乙烯或亚乙炔基，n为0,1或2，R为氢原子或直链或支链烷基，其任选被相同或不同的选自烷氧基羰基，烷氧基，羟基，羧基或基团的基团取代一次或多次任选取代的氨基甲酰基或氨基; 以及其药理学上可接受的盐，条件是当Ar为苯基时A不能为乙烯，Q为氧原子，R为基团-CH 2 COOH。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。

9. 发明授权

US4284633A Derivatives of xanthine 失效
标题翻译：黄嘌呤衍生物
公开(公告)号：US4284633A
公开(公告)日：1981-08-18
申请号：US148870
申请日：1980-05-12
申请人： Walter-Gunar Friebe , Max Thiel , Wolfgang Kampe , Otto-Henning Wilhelms , Androniki Roesch
发明人： Walter-Gunar Friebe , Max Thiel , Wolfgang Kampe , Otto-Henning Wilhelms , Androniki Roesch
IPC分类号： A61K31/52 , A61K31/522 , A61P11/08 , A61P37/08 , C07D473/08 , C07D473/10 , C07D473/06
CPC分类号： C07D473/08 , C07D473/10 , Y10S514/826
摘要： The present invention provides xanthine derivatives of the general formula: ##STR1## wherein one of the symbols R.sub.1 and R.sub.2 stands for a methyl radical and the other for a radical of the general formula: ##STR2## wherein R.sub.3 is a hydrogen atom or an acyl radical; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them and is also concerned with the use thereof for the preparation of pharmaceutical compositions for the treatment of allergies.
摘要翻译：本发明提供了以下通式的黄嘌呤衍生物：其中符号R1和R2之一代表甲基，另一个代表下列通式的基团：其中R3是氢原子或酰基激进; 及其药理学上可接受的盐。本发明还提供了制备这些化合物和含有它们的药物组合物的方法，并且还涉及其用于制备用于治疗过敏症的药物组合物的用途。

10. 发明授权

US4086347A 9-[3-(4-Phenoxymethylpiperidino)-propyl]-adenines 失效
标题翻译： 9- {8- 3-（4-苯氧基甲基哌啶子基） - 丙基{9-腺嘌呤
公开(公告)号：US4086347A
公开(公告)日：1978-04-25
申请号：US737507
申请日：1976-11-02
申请人： Walter-Gunar Friebe , Max Thiel , Kurt Stach, deceased , by Werner Plattner, administrator , Otto-Henning Wilhelms , Erika VON Mullendorff , Gisbert Sponer
发明人： Walter-Gunar Friebe , Max Thiel , Kurt Stach, deceased , by Werner Plattner, administrator , Otto-Henning Wilhelms , Erika VON Mullendorff , Gisbert Sponer
IPC分类号： A61K31/52 , A61P3/00 , A61P9/12 , A61P29/00 , A61P37/08 , C07D401/06 , C07D401/14 , C07D473/34
CPC分类号： C07D473/34 , Y10S514/826 , Y10S514/87
摘要： 9-[3-(4-Phenoxymethylpiperidino)-propyl]-adenines of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom, a ower alkyl radical optionally substituted by hydroxyl, or a cycloalkyl radical, orR.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a heterocyclic ring, andR.sub.3 is a hydrogen atom, a halogen atom, a lower alkyl radical or a lower alkoxy radical,In the form of the free base or a salt thereof, exhibit anti-allergic, anti-inflammatory, anti-oedematous and anti-hypertensive activity.
摘要翻译：式[IMAGE]的9- [3-（4-苯氧基甲基哌啶子基） - 丙基] - 腺嘌呤，其中R 1为氢原子或低级烷基，R 2为氢原子，任选被羟基取代的烷基，或环烷基或R 1和R 2与它们所连接的氮原子一起形成杂环，并且R 3是氢原子，卤素原子，低级烷基或低级烷氧基，在自由基的形式或其盐，展示抗过敏，抗炎，抗氧化和抗高血压活性。

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