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1. 发明授权

US5786164A Method for separating non-high density lipoproteins from lipoprotein containing body fluid samples 失效
标题翻译：从含有脂蛋白的体液样品中分离非高密度脂蛋白的方法
公开(公告)号：US5786164A
公开(公告)日：1998-07-28
申请号：US661833
申请日：1996-06-11
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12Q1/60 , G01N33/52 , G01N33/92
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The invention relates to a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDL-s are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
摘要翻译：本发明涉及从含有它们的生物液体中分离非高密度脂蛋白（称为“非HDL”）的方法。提供含有非HDL沉淀剂的多孔载体。只需要将感兴趣的样品与载体接触一分钟或更短时间，之后沉淀的非HDL-不再存在于待测样品中。该方法的应用包括测定样品中高密度脂蛋白而不受非HDL干扰的能力。

2. 发明授权

US06171849B2 Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step 有权
$Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step$
标题翻译：通过具有综合分馏步骤的快速诊断剂测定HDL胆固醇的方法
公开(公告)号：US06171849B2
公开(公告)日：2001-01-09
申请号：US09481664
申请日：2000-01-12
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12M100
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein (non-HDL) from a lipoprotein in a body sample and for determining high density lipoprotein (HDL) cholesterol in a HDL and non high density lipoprotein (non-HDL) in a body sample.
摘要翻译：公开了一种包括用于评估生物流体样品的第一多孔载体和第二多孔载体的装置。该装置用于从身体样品中的脂蛋白分离非高密度脂蛋白（非HDL），并用于测定身体样品中HDL和非高密度脂蛋白（非HDL）中的高密度脂蛋白（HDL）胆固醇。

3. 发明授权

US5426030A Apparatus for determination of HDL cholesterol 失效
标题翻译：用于测定HDL胆固醇的装置
公开(公告)号：US5426030A
公开(公告)日：1995-06-20
申请号：US572875
申请日：1990-08-24
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12Q1/60 , G01N33/52 , G01N33/92 , G01N21/00
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The invention relates to an apparatus and a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDLs are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
摘要翻译：本发明涉及一种用于从含有它们的生物液体中分离非高密度脂蛋白（被称为“非HDL”）的装置和方法。提供含有非HDL沉淀剂的多孔载体。仅需要将感兴趣的样品与载体接触一分钟或更短时间，之后沉淀的非HDL不再存在于待测样品中。该方法的应用包括测定样品中高密度脂蛋白而不受非HDL干扰的能力。

4. 再颁专利

USRE39915E1 Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step 失效
$Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step$
标题翻译：通过具有综合分馏步骤的快速诊断剂测定HDL胆固醇的方法
公开(公告)号：USRE39915E1
公开(公告)日：2007-11-06
申请号：US10644617
申请日：2003-08-20
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12M1/00 , C12M1/36 , C12M1/34
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92
摘要： An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein (non-HDL) from a lipoprotein in a body sample and for determining high density lipoprotein (HDL) cholesterol in a HDL and non high density lipoprotein (non-HDL) in a body sample.
摘要翻译：公开了一种包括用于评估生物流体样品的第一多孔载体和第二多孔载体的装置。该装置用于从身体样品中的脂蛋白分离非高密度脂蛋白（非HDL），并用于测定身体样品中HDL和非高密度脂蛋白（非HDL）中的高密度脂蛋白（HDL）胆固醇。

5. 发明授权

US06214570B1 Method for separating non-HDLs from HDLs, and determining, HDL cholesterol 失效
标题翻译：从HDL中分离非HDL和测定HDL胆固醇的方法
公开(公告)号：US06214570B1
公开(公告)日：2001-04-10
申请号：US09114361
申请日：1998-07-14
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12Q160
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The subject matter of the application is a method for the separation of non-HDL lipoproteins from biological fluids in a carrier through which liquids can flow. The carrier contains a precipitating agent for non-high density lipoproteins (non-HDLs).
摘要翻译：本申请的主题是用于从液体可以流过的载体中的生物流体分离非HDL脂蛋白的方法。载体含有用于非高密度脂蛋白（非HDL）的沉淀剂。

6. 发明授权

US5580743A Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step 失效
$Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step$
标题翻译：通过具有综合分馏步骤的快速诊断剂测定HDL胆固醇的方法
公开(公告)号：US5580743A
公开(公告)日：1996-12-03
申请号：US384046
申请日：1995-02-06
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12Q1/60 , G01N33/52 , G01N33/92 , G01N31/22
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The invention relates to a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDLs are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
摘要翻译：本发明涉及从含有它们的生物液体中分离非高密度脂蛋白（称为“非HDL”）的方法。提供含有非HDL沉淀剂的多孔载体。仅需要将感兴趣的样品与载体接触一分钟或更短时间，之后沉淀的非HDL不再存在于待测样品中。该方法的应用包括测定样品中高密度脂蛋白而不受非HDL干扰的能力。

7. 发明授权

US4665023A Imidazole derivatives as redox indicators 失效
标题翻译：咪唑衍生物作为氧化还原指标
公开(公告)号：US4665023A
公开(公告)日：1987-05-12
申请号：US717511
申请日：1985-03-29
申请人： Ulfert Deneke , Werner Guthlein , Manfred Kuhr , Hartmut Merdes , Hans-Rudiger Murawski , Hans Wielinger
发明人： Ulfert Deneke , Werner Guthlein , Manfred Kuhr , Hartmut Merdes , Hans-Rudiger Murawski , Hans Wielinger
IPC分类号： C07D233/60 , A61K49/00 , C07D233/54 , C07D233/61 , C07D233/64 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D455/04 , C07F9/6506 , C12Q1/28 , G01N33/50 , G01N33/68
CPC分类号： C07D233/64 , C07D403/04 , C07D405/04 , C07D455/04 , C12Q1/28 , C12Q2326/00 , Y10T436/206664
摘要： The present invention provides imidazole derivatives of the general formula: ##STR1## wherein R, R.sub.1 and R.sub.2 are defined hereinbelow. The present invention is also concerned with processes for the preparation of these imidazole derivatives and with the use thereof as redox indicators.
摘要翻译：本发明提供以下通式的咪唑衍生物：其中R，R 1和R 2定义如下。本发明还涉及制备这些咪唑衍生物的方法，并将其用作氧化还原指示剂。

8. 发明授权

US4563422A Method and composition for the removal of ascorbic acid from aqueous liquids 失效
标题翻译：从含水液体中除去抗坏血酸的方法和组合物
公开(公告)号：US4563422A
公开(公告)日：1986-01-07
申请号：US380804
申请日：1982-05-21
申请人： Ulfert Deneke , Hans Lange , Walter Rittersdorf
发明人： Ulfert Deneke , Hans Lange , Walter Rittersdorf
IPC分类号： C02F3/34 , A23L2/70 , C02F3/00 , C12P1/00 , C12Q1/26 , C12Q1/54 , G01N33/493 , C12Q1/30 , C12Q1/28
CPC分类号： C12Q1/54 , C12Q1/26 , Y10S435/805 , Y10S435/81 , Y10T436/142222 , Y10T436/25125
摘要： The present invention provides a process for removing ascorbic acid from aqueous solutions by the addition of ascorbate oxidase, wherein catalase and hydrogen peroxide are also added to the solution.The present invention also provides an agent for the removal of ascorbic acid from aqueous solutions, based on a solid carrier material impregnated with ascorbate oxidase, wherein the carrier material also contains catalase and hydrogen peroxide and optionally also a stabilizer and/or buffer substance.
摘要翻译：本发明提供了通过加入抗坏血酸氧化酶从水溶液中除去抗坏血酸的方法，其中还向溶液中加入过氧化氢酶和过氧化氢。本发明还提供了一种基于浸渍有抗坏血酸氧化酶的固体载体材料从水溶液中除去抗坏血酸的试剂，其中载体材料还含有过氧化氢酶和过氧化氢以及任选的稳定剂和/或缓冲物质。

9. 发明授权

US4603107A Reagent and process for the determination of the activity of the enzyme gamma-glutamyl transferase 失效
标题翻译：用于测定γ-谷氨酰转移酶酶活性的试剂和方法
公开(公告)号：US4603107A
公开(公告)日：1986-07-29
申请号：US532907
申请日：1983-09-16
申请人： Ulfert Deneke , Rolf Nagel , Walter Rittersdorf
发明人： Ulfert Deneke , Rolf Nagel , Walter Rittersdorf
IPC分类号： G01N33/50 , C12Q1/28 , C12Q1/48 , C12Q1/00 , C12Q1/36
CPC分类号： C12Q1/48 , Y10S435/805 , Y10S435/81
摘要： The present invention provides a process for the kinetic determination of .gamma.-glutamyl transferase activity by the reaction of a .gamma.-glutamylarylamide with the formation of an arylamine at a pH value of from 6 to 10, wherein the arylamine is simultaneously reacted with an aromatic amine or phenol appropriate as a coupling component and an appropriate oxidation agent to give a colored compound with an absorption maximum above 565 nm, the rate of formation of which is monitored photometrically and is used as a measure for the .gamma.-glutamyl transferase activity.The present invention also provides a reagent for the kinetic determination of .gamma.-GT activity, wherein it contains the following reagents:.gamma.-GT-arylamide:1-100 mmol/l..gamma.-glutamyl acceptor (glycylglycine):10-500 mmol/l.coupling component:1-500 mmol/l.oxidation agent:0.1-500 mmol/l.buffer:10-1000 mmol/l.
摘要翻译：本发明提供了一种通过γ-谷氨酰基芳基酰胺与pH6至10的芳胺形成反应来动态测定γ-谷氨酰转移酶活性的方法，其中芳胺与芳族胺同时反应或苯酚作为偶联组分和适当的氧化剂，得到最大吸收峰值高于565nm的着色化合物，其形成速率通过光度法监测并用作γ-谷氨酰转移酶活性的量度。本发明还提供用于γ-GT活性的动力学测定的试剂，其中它含有以下试剂：γ-GT-芳基酰胺：1-100mmol / l。 γ-谷氨酰受体（甘氨酰甘氨酸）：10-500mmol / l。偶联组分：1-500 mmol / l。氧化剂：0.1-500mmol / l。缓冲液：10-1000mmol / l。

10. 发明授权

US5162200A Method for determination of a peroxidate-acting substance with a diarylimidazole compound 失效
标题翻译：用二胺咪唑化合物测定过氧化物作用物质的方法
公开(公告)号：US5162200A
公开(公告)日：1992-11-10
申请号：US530661
申请日：1990-05-30
申请人： Hans-Peter Braun , Ulfert Deneke , Werner Guethlein , Rolf Nagel
发明人： Hans-Peter Braun , Ulfert Deneke , Werner Guethlein , Rolf Nagel
IPC分类号： G01N31/22 , C07D233/54 , C07D233/64 , C07D455/04 , C12Q1/26 , C12Q1/28 , C12Q1/50
CPC分类号： C07D233/64 , C12Q1/28 , C12Q1/50 , C12Q2326/00
摘要： Diarylimidazoles of the general formula: ##STR1## wherein R.sup.1 is a radical of the general formula: ##STR2## in which R.sup.3 and R.sup.6 are hydrogen atoms, R.sup.4 and R.sup.5, which can be the same or different, are lower alkyl radicals or R.sup.3 /R.sup.4 and/or R.sup.5 /R.sup.6 in each case together represent a lower alkylene radical and R.sup.2 is a lower alkyl radical, and/or of a salt thereof, are used as redox indicators in the colorimetric diarylimidazoles are not influenced by the presence of a SH group-containing substance. The peroxidate-acting substance can be used to determine the presence of creatine kinase.
摘要翻译：具有以下通式的二芳基咪唑：其中R 1是具有以下通式的基团：其中R 3和R 6是氢原子，R 4和R 5可以相同或不同，在各种情况下，低级烷基或R 3 / R 4和/或R 5 / R 6一起代表低级亚烷基，R 2为低级烷基，和/或其盐用作比色二芳基咪唑中的氧化还原指示剂不受影响通过存在含SH基团的物质。过氧化物作用物质可用于测定肌酸激酶的存在。

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