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1. 发明授权

US5558640A System for infusion of medicine into the body of a patient 失效
标题翻译：将药物输入患者体内的系统
公开(公告)号：US5558640A
公开(公告)日：1996-09-24
申请号：US400953
申请日：1995-03-08
申请人： Manfred Pfeiler , Konrad Mund , Walter Preidel , Goesta Sjoeholm
发明人： Manfred Pfeiler , Konrad Mund , Walter Preidel , Goesta Sjoeholm
IPC分类号： A61M5/00 , A61M1/36 , A61M5/142 , A61M5/172 , A61M31/00 , A61K9/22 , A61N1/18
CPC分类号： A61M5/14276 , A61M5/1723
摘要： A system for infusing medicine into the body of a patient includes an implantable infusion apparatus containing a dosing unit with a reservoir for the medicine and a medicine delivery pump for pumping doses of the medicine from the reservoir into the patient. The infusion apparatus also includes a sensor for sensing a parameter of the patient for controlling the dosing of medicine according to the sensed parameter. The dosing unit and the sensor are galvanically separable and are each provided with separate telemetry communication units for communication with an external programmer/controller. The external programmer/controller includes telemetry communication units for selectable communication with the dosing unit or the sensor or both simultaneously. The telemetry communication units of the external programmer/controller, the dosing unit and the sensor are constructed for bi-directional communication between the external controller and each one of the dosing unit and the sensor.
摘要翻译：用于将药物注入患者体内的系统包括可植入输注装置，其包含具有用于药物的储存器的计量单元和用于将药物的剂量从储存器泵送到患者中的药物输送泵。输注装置还包括传感器，用于感测患者的参数，以根据所感测的参数来控制药物的给药。配量单元和传感器是电流可分离的，并且每个都具有用于与外部编程器/控制器通信的单独的遥测通信单元。外部编程器/控制器包括用于与计量单元或传感器或两者同时选择通信的遥测通信单元。外部编程器/控制器，计量单元和传感器的遥测通信单元被构造用于在外部控制器和每个配量单元和传感器之间进行双向通信。

2. 发明授权

US4853091A Method and apparatus for the electrochemical determination of oxygen concentration 失效
标题翻译：用于电化学测定氧浓度的方法和装置
公开(公告)号：US4853091A
公开(公告)日：1989-08-01
申请号：US186755
申请日：1988-04-26
申请人： Konrad Mund , Walter Preidel , J. Raghavendra Rao , Gerhard Richter
发明人： Konrad Mund , Walter Preidel , J. Raghavendra Rao , Gerhard Richter
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1473 , A61B5/15 , A61N1/365 , G01N27/27 , G01N27/416 , G01N27/49
CPC分类号： A61B5/14542 , A61B5/1473 , G01N33/4925 , G01N27/404
摘要： The electrochemical determination of the oxygen concentration, particularly in biological matter, is possible by means of an oxygen sensor with a measuring electrode and a counter electrode over long periods of time, even if the sensor is implanted, by taking the following measures; two potentials are cyclically impressed on the measuring electrode, with one potential (measuring potential) in the range -1.4 V.ltoreq..rho.Ag/AgCl.ltoreq.-0.4 V, and the other potential (recovery potential) in the range -0.2 V.ltoreq..rho.Ag/AgCl.ltoreq.+0.2 V; the dwelling time at the measuring potential is small as compared to the duration of the cycle; and the current flowing during the measuring period is evaluated as the measuring signal.
摘要翻译：通过采取以下措施，即使传感器被植入，氧浓度的电化学测定，特别是生物物质的电化学测定也可以通过具有测量电极和对电极长时间的氧传感器来实现。在测量电极上周期性地施加两个电势，其中一个电位（测量电位）在-1.4V Ag / AgCl

3. 发明授权

US4919770A Method for determining the concentration of electro-chemically convertible substances 失效
标题翻译：确定电化学可转换物质浓度的方法
公开(公告)号：US4919770A
公开(公告)日：1990-04-24
申请号：US945065
申请日：1986-12-19
申请人： Walter Preidel , Konrad Mund
发明人： Walter Preidel , Konrad Mund
IPC分类号： G01N33/487
CPC分类号： G01N33/48714
摘要： The invention involves a method for determining the concentration of electro-chemically convertible substances in a solution by means of an analyzer equipped with a test electrode, so that a precise determination of the concentration, dependable over extended periods, is possible. The invention provides for a potential varying with time within a potential interval to be impressed on the test electrode, for an ac voltage of a predetermined amplitude and frequency to be superimposed on this potential, and for the real and/or imaginary portions of the impedance to be determined for at least one potential step, thus determining the concentration. The method is particularly suited for determining the concentration of glucose in body fluids.
摘要翻译：本发明涉及一种通过配备有测试电极的分析仪测定溶液中的电化学可转换物质的浓度的方法，从而可以在长时间内可靠地确定浓度的精确测定。本发明提供了在电势间隔内随时间变化的电位，以施加在测试电极上，对于要叠加在该电位上的预定幅度和频率的交流电压，以及阻抗的实部和/或虚部确定至少一个潜在步骤，从而确定浓度。该方法特别适用于测定体液中葡萄糖的浓度。

4. 发明授权

US06306533B1 Cooling system for a fuel cell battery 有权
标题翻译：燃料电池电池的冷却系统
公开(公告)号：US06306533B1
公开(公告)日：2001-10-23
申请号：US09319891
申请日：1999-06-14
申请人： Konrad Mund , Rittmar von Helmolt
发明人： Konrad Mund , Rittmar von Helmolt
IPC分类号： H01O804
CPC分类号： F28F3/12 , H01M8/0202 , H01M8/0228 , H01M8/0258 , H01M8/0267 , H01M8/0297 , H01M8/04007 , H01M8/04029 , H01M8/04074 , H01M8/2404 , H01M8/241 , H01M8/247 , H01M2300/0082
摘要： A cooling system for a battery of fuel cells that contains at least two fuel cells, each of which comprises a membrane-electrode unit and two collector plates is disclosed. Cooling cards supplied with coolant and that are connected to one another via lines are thereby arranged between the individual fuel cell units.
摘要翻译：公开了一种用于燃料电池的电池的冷却系统，其包含至少两个燃料电池，每个燃料电池包括膜电极单元和两个集电板。因此，在各个燃料电池单元之间配置有冷却液供给并通过管线彼此连接的冷却卡。

5. 发明授权

US5658318A Method and apparatus for detecting a state of imminent cardiac arrhythmia in response to a nerve signal from the autonomic nerve system to the heart, and for administrating anti-arrhythmia therapy in response thereto 失效
标题翻译：用于响应于自主神经系统到心脏的神经信号检测即将发生的心律失常状态的方法和装置，以及响应于其施用抗心律失常疗法
公开(公告)号：US5658318A
公开(公告)日：1997-08-19
申请号：US534933
申请日：1995-09-28
申请人： Brigitte Stroetmann , Konrad Mund , Siegfried Kallert
发明人： Brigitte Stroetmann , Konrad Mund , Siegfried Kallert
IPC分类号： A61B5/022 , A61B5/0402 , A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36114 , A61N1/36135 , A61N1/362 , A61N1/3962 , A61B5/04001 , A61B5/4035 , A61B5/4836
摘要： A device for detecting a state of imminent cardiac arrhythmia, relative to a normal state for a heart, in response to activity in nerve signals conveying information from the autonomic nerve system to the heart, contains a sensor body for sensing neural activity, a comparator with a threshold value forming a condition for the presence of an arrhythmia, the comparator emitting an arrhythmia-indicating output signal depending on whether neural activity meets the condition, and the sensor body being placeable in an extracardiac position for at least one of the sympathetic and vagus nerves. The sensor body directly senses activity in the nerve at that location in direct contact with the nerve. An implanted blood pressure sensing cuff also can be provided which generates signals indicative of blood pressure which can be evaluated in combination with the nerve signals for identifying the state of imminent cardiac arrhythmia.
摘要翻译：用于检测相对于心脏正常状态的紧急心律失常状态的装置，其响应于将信息从自主神经系统传递到心脏的神经信号的活动，包含用于感测神经活动的传感器体，具有形成用于存在心律失常的条件的阈值，所述比较器根据神经活动是否满足条件而发出心律失常指示输出信号，并且所述传感器体可放置在心外部位置以用于至少一种交感神经和迷走神经神经传感器体直接感知与该神经直接接触的位置处的神经中的活动。还可以提供植入式血压感测袖带，其产生指示血压的信号，其可以与用于识别即将发生的心律失常状态的神经信号结合进行评估。

6. 发明授权

US5614246A Method for manufacturing a sensor electrode 失效
标题翻译：传感器电极的制造方法
公开(公告)号：US5614246A
公开(公告)日：1997-03-25
申请号：US554767
申请日：1995-11-07
申请人： Konrad Mund , J. Raghavendra Rao , Armin Datz
发明人： Konrad Mund , J. Raghavendra Rao , Armin Datz
IPC分类号： G01N27/30 , A61B5/00 , A61B5/0408 , A61B5/145 , A61B5/1473 , A61N1/365 , B05D3/12 , B05D5/12
CPC分类号： A61B5/14542 , A61B5/0408 , A61B5/1473
摘要： In a method for manufacturing a working electrode for an implantable, electrochemical oxygen sensor a thin layer of a uniform mixture composed of an epoxy-based resin, a hardener and powdered vitreous carbon is applied onto a ring or hollow cylinder of biocompatible, inert, electrically conductive material, and the resin is hardened.
摘要翻译：在用于制造植入式工作电极的方法中，电化学氧传感器将由环氧树脂，硬化剂和粉状玻璃碳组成的均匀混合物的薄层施加到生物相容的，惰性的，电的导电材料，树脂硬化。

7. 发明授权

US4609508A Method for the manufacture of implantable electrodes of vitreous carbon 失效
标题翻译：玻璃碳植入式电极的制造方法
公开(公告)号：US4609508A
公开(公告)日：1986-09-02
申请号：US659442
申请日：1984-10-10
申请人： Martin Edeling , Konrad Mund , Raghavendra Rao , Erhard Weidlich
发明人： Martin Edeling , Konrad Mund , Raghavendra Rao , Erhard Weidlich
IPC分类号： A61N1/04 , A61N1/05 , C04B35/524 , B29C39/10
CPC分类号： C04B35/524 , A61N1/05
摘要： The invention relates to a method for the manufacture of implantable electrodes of vitreous carbon with an electrode head and an electrode stem, by pyrolysis of cross-linked synthetic resins. Electrodes manufactured in accordance with such a method exhibit high surface quality. In accordance with embodiments of the disclosure, the electrode stem is manufactured in the form of a blank by hardening a resin precondensate, then the electrode head is cast onto the blank in a casting mold, using a resin precondensate, and is cross-linked. Subsequently hardening takes place and then the synthetic resin is converted into vitreous carbon by pyrolysis, and the electrode obtained in this manner may, if desired, be activated to provide the electrode with a microporous surface structure.
摘要翻译：本发明涉及通过交联合成树脂的热解制造具有电极头和电极杆的玻璃碳可植入电极的方法。根据这种方法制造的电极表现出高的表面质量。根据本公开的实施例，电极杆通过硬化树脂预缩合物而以坯料的形式制造，然后使用树脂预缩合物将电极头在铸模中铸造到坯件上，并且是交联的。随后发生硬化，然后通过热解将合成树脂转化成玻璃碳，如果需要，可以将这样获得的电极活化，以提供具有微孔表面结构的电极。

8. 发明授权

US08105478B2 Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device 有权
标题翻译：用于测量氧化还原活性物质浓度或浓度变化的方法及相应的装置
公开(公告)号：US08105478B2
公开(公告)日：2012-01-31
申请号：US10587837
申请日：2005-01-26
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N27/26 , G01N33/53 , G01N33/487
CPC分类号： G01N27/3277 , G01N2333/916 , Y10T436/143333
摘要： In order to follow the change in concentration of a redox-active substance, potential suitable for a reducing process or oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of the measuring phase and relaxation phase being predetermined in a suitable manner. In this manner, a rapid relaxation of the concentration gradient is forced electrochemically so that the measurement can be carried out on simple transducer arrays. The device includes a transducer array in addition to a suitable potentiostat. The transducer array may include a planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is located. The array is generated by suitably structuring the substrate.
摘要翻译：为了跟踪氧化还原活性物质的浓度变化，适用于还原过程或氧化过程的电位被施加到测量装置的工作电极。工作电极的电位是脉冲的，交替地产生测量相位和弛豫阶段，测量相位和弛豫阶段的脉冲长度以合适的方式被预先确定。以这种方式，电化学强迫浓缩梯度的快速松弛，使得可以在简单的换能器阵列上进行测量。除了合适的恒电位仪之外，该装置还包括一个换能器阵列。换能器阵列可以包括平面金属基底，其上定位有在金属表面和绝缘体表面之间具有牢固连接的至少一个柔性绝缘体。该阵列通过适当地构造基底而产生。

9. 发明申请

US20100155263A1 METHOD AND SYTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE/ENZUME COMPLEX OR OF AN ANALYTE/ENZYME CONJUGATE, ESPECIALLY FOR THE ELECTROCHEMICAL DETECTION OF THE ANALYTE, AND CORRESPONDING MEASURING DEVICE 有权
标题翻译：用于确定分析物/酶复合物浓度或分析物/酶合成浓度的方法和系统，特别是用于分析仪的电化学检测和相应的测量装置
公开(公告)号：US20100155263A1
公开(公告)日：2010-06-24
申请号：US11989938
申请日：2006-07-31
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N33/543
CPC分类号： C12Q1/001 , G01N27/3271 , Y10S435/817
摘要： A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of measuring phase and relaxation phase being determined in a suitable manner. A rapid relaxation of the concentration gradient is electrochemically forced so that the measurement can be carried out on simple transducer arrays. A device for carrying out the method includes a transducer array in addition to a suitable potentiostat. The transducer array can be formed of a planar metal substrate on which at least one flexible insulator is disposed, the metal surface and the insulator surface being firmly linked. The transducer array can also be formed of silicone-based CMOS structures.
摘要翻译：一种遵循氧化还原活性物质浓度变化的方法，由此将适当的还原过程或氧化过程的电位施加到测量装置的工作电极上。工作电极的电位是脉冲的，并且交替地产生测量相位和松弛相位，测量相位和弛豫阶段的脉冲长度以适当的方式确定。浓度梯度的快速弛豫是电化学强制的，以便可以在简单的换能器阵列上进行测量。用于执行该方法的装置包括除合适的恒电位仪之外的换能器阵列。换能器阵列可以由其上设置有至少一个柔性绝缘体的平面金属基板形成，金属表面和绝缘体表面牢固地连接。换能器阵列也可以由硅基CMOS结构形成。

10. 发明申请

US20080099347A1 Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device 有权
标题翻译：用于测量氧化还原活性物质浓度或浓度变化的方法及相应的装置
公开(公告)号：US20080099347A1
公开(公告)日：2008-05-01
申请号：US10587837
申请日：2005-01-26
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N27/26 , G01N27/28
CPC分类号： G01N27/3277 , G01N2333/916 , Y10T436/143333
摘要： In order to follow the change in concentration of a redox-active substance, potential suitable for a reducing process or oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of the measuring phase and relaxation phase being predetermined in a suitable manner. In this manner, a rapid relaxation of the concentration gradient is forced electrochemically so that the measurement can be carried out on simple transducer arrays. The device includes a transducer array in addition to a suitable potentiostat. The transducer array may include a planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is located. The array is generated by suitably structuring the substrate.
摘要翻译：为了跟踪氧化还原活性物质的浓度变化，适用于还原过程或氧化过程的电位被施加到测量装置的工作电极。工作电极的电位是脉冲的，交替地产生测量相位和弛豫阶段，测量相位和弛豫阶段的脉冲长度以合适的方式被预先确定。以这种方式，电化学强迫浓缩梯度的快速松弛，使得可以在简单的换能器阵列上进行测量。除了合适的恒电位仪之外，该装置还包括一个换能器阵列。换能器阵列可以包括平面金属基底，其上定位有在金属表面和绝缘体表面之间具有牢固连接的至少一个柔性绝缘体。该阵列通过适当地构造基底而产生。

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