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1. 发明授权

US07838261B2 Method for preventing chemical crosstalk in enzyme-linked reactions, and associated system 有权
标题翻译：防止酶联反应中化学串扰的方法及相关系统
公开(公告)号：US07838261B2
公开(公告)日：2010-11-23
申请号：US10432782
申请日：2001-11-26
申请人： Walter Gumbrecht , Rainer Hintsche , Konrad Mund , Manfred Stanzel
发明人： Walter Gumbrecht , Rainer Hintsche , Konrad Mund , Manfred Stanzel
IPC分类号： G01N33/58
CPC分类号： B01J19/0093 , B01J19/0046 , B01J2219/00317 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00644 , B01J2219/00659 , B01J2219/00783 , B01J2219/00828 , B01J2219/0086 , B01J2219/00867 , B01L3/502 , B01L3/50853 , B01L2200/0642 , B01L2200/0673 , B01L2300/0819 , B01L2300/0829 , C40B60/14 , G01N27/3277
摘要： A method for biochemical analysis uses a micro-reaction array with at least two reaction chambers for materials which react together chemically or biochemically. The reaction chambers are smaller than 1 μl, the reaction chambers are filled together by throughflow, the chemical or biochemical reactions of the substances retained therein then occurs in the individual isolated reaction chambers, thus preventing an interference between the reactions in the individual reaction chambers and the reaction products remain enclosed in the relevant reaction chambers. In the system the planar array has at least two reaction chambers for substances, whereby the reaction chambers are closed with the goal of preventing an exchange of substances.
摘要翻译：用于生化分析的方法使用具有至少两个反应室的微反应阵列用于化学或生化反应的材料。反应室小于1μl，反应室通过通流填充在一起，其中保留的物质的化学或生物化学反应发生在各个分离的反应室中，从而防止各反应室中的反应与反应产物保持封闭在相关反应室中。在系统中，平面阵列具有至少两个用于物质的反应室，由此反应室被封闭，目的是防止物质交换。

2. 发明授权

US08105478B2 Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device 有权
标题翻译：用于测量氧化还原活性物质浓度或浓度变化的方法及相应的装置
公开(公告)号：US08105478B2
公开(公告)日：2012-01-31
申请号：US10587837
申请日：2005-01-26
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N27/26 , G01N33/53 , G01N33/487
CPC分类号： G01N27/3277 , G01N2333/916 , Y10T436/143333
摘要： In order to follow the change in concentration of a redox-active substance, potential suitable for a reducing process or oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of the measuring phase and relaxation phase being predetermined in a suitable manner. In this manner, a rapid relaxation of the concentration gradient is forced electrochemically so that the measurement can be carried out on simple transducer arrays. The device includes a transducer array in addition to a suitable potentiostat. The transducer array may include a planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is located. The array is generated by suitably structuring the substrate.
摘要翻译：为了跟踪氧化还原活性物质的浓度变化，适用于还原过程或氧化过程的电位被施加到测量装置的工作电极。工作电极的电位是脉冲的，交替地产生测量相位和弛豫阶段，测量相位和弛豫阶段的脉冲长度以合适的方式被预先确定。以这种方式，电化学强迫浓缩梯度的快速松弛，使得可以在简单的换能器阵列上进行测量。除了合适的恒电位仪之外，该装置还包括一个换能器阵列。换能器阵列可以包括平面金属基底，其上定位有在金属表面和绝缘体表面之间具有牢固连接的至少一个柔性绝缘体。该阵列通过适当地构造基底而产生。

3. 发明申请

US20100155263A1 METHOD AND SYTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE/ENZUME COMPLEX OR OF AN ANALYTE/ENZYME CONJUGATE, ESPECIALLY FOR THE ELECTROCHEMICAL DETECTION OF THE ANALYTE, AND CORRESPONDING MEASURING DEVICE 有权
标题翻译：用于确定分析物/酶复合物浓度或分析物/酶合成浓度的方法和系统，特别是用于分析仪的电化学检测和相应的测量装置
公开(公告)号：US20100155263A1
公开(公告)日：2010-06-24
申请号：US11989938
申请日：2006-07-31
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N33/543
CPC分类号： C12Q1/001 , G01N27/3271 , Y10S435/817
摘要： A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of measuring phase and relaxation phase being determined in a suitable manner. A rapid relaxation of the concentration gradient is electrochemically forced so that the measurement can be carried out on simple transducer arrays. A device for carrying out the method includes a transducer array in addition to a suitable potentiostat. The transducer array can be formed of a planar metal substrate on which at least one flexible insulator is disposed, the metal surface and the insulator surface being firmly linked. The transducer array can also be formed of silicone-based CMOS structures.
摘要翻译：一种遵循氧化还原活性物质浓度变化的方法，由此将适当的还原过程或氧化过程的电位施加到测量装置的工作电极上。工作电极的电位是脉冲的，并且交替地产生测量相位和松弛相位，测量相位和弛豫阶段的脉冲长度以适当的方式确定。浓度梯度的快速弛豫是电化学强制的，以便可以在简单的换能器阵列上进行测量。用于执行该方法的装置包括除合适的恒电位仪之外的换能器阵列。换能器阵列可以由其上设置有至少一个柔性绝缘体的平面金属基板形成，金属表面和绝缘体表面牢固地连接。换能器阵列也可以由硅基CMOS结构形成。

4. 发明申请

US20080099347A1 Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device 有权
标题翻译：用于测量氧化还原活性物质浓度或浓度变化的方法及相应的装置
公开(公告)号：US20080099347A1
公开(公告)日：2008-05-01
申请号：US10587837
申请日：2005-01-26
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N27/26 , G01N27/28
CPC分类号： G01N27/3277 , G01N2333/916 , Y10T436/143333
摘要： In order to follow the change in concentration of a redox-active substance, potential suitable for a reducing process or oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of the measuring phase and relaxation phase being predetermined in a suitable manner. In this manner, a rapid relaxation of the concentration gradient is forced electrochemically so that the measurement can be carried out on simple transducer arrays. The device includes a transducer array in addition to a suitable potentiostat. The transducer array may include a planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is located. The array is generated by suitably structuring the substrate.
摘要翻译：为了跟踪氧化还原活性物质的浓度变化，适用于还原过程或氧化过程的电位被施加到测量装置的工作电极。工作电极的电位是脉冲的，交替地产生测量相位和弛豫阶段，测量相位和弛豫阶段的脉冲长度以合适的方式被预先确定。以这种方式，电化学强迫浓缩梯度的快速松弛，使得可以在简单的换能器阵列上进行测量。除了合适的恒电位仪之外，该装置还包括一个换能器阵列。换能器阵列可以包括平面金属基底，其上定位有在金属表面和绝缘体表面之间具有牢固连接的至少一个柔性绝缘体。该阵列通过适当地构造基底而产生。

5. 发明申请

US20060216813A1 Dna chip comprising a microarray made of an microelectrode system 有权
标题翻译： Dna芯片包括由微电极系统制成的微阵列
公开(公告)号：US20060216813A1
公开(公告)日：2006-09-28
申请号：US10539817
申请日：2003-12-15
申请人： Walter Gumbrecht , Konrad Mund , Meinrad Schienle , Roland Thewes
发明人： Walter Gumbrecht , Konrad Mund , Meinrad Schienle , Roland Thewes
IPC分类号： C12M1/34
CPC分类号： G01N33/5438 , C12Q1/6825
摘要： A DNA chip includes a carrier and a microarray of spots containing immobilised catcher molecules which are arranged on the carrier. Each spot contains a microelectrode system for the impedance spectroscopic detection of binding events occurring between the catcher molecules and target molecules of an analyte solution applied to the spots. The microelectrode system has a pair of polarisation electrodes in order to produce an alternating electromagnetic field and a pair of sensor electrodes for measuring a voltage drop in the analyte.
摘要翻译： DNA芯片包括布置在载体上的载体和含有固定捕获剂分子的斑点的微阵列。每个斑点包含用于阻抗光谱检测在施加到斑点的分析物溶液的捕获剂分子和靶分子之间发生的结合事件的微电极系统。微电极系统具有一对极化电极以产生交变电磁场和一对传感器电极，用于测量分析物中的电压降。

6. 发明授权

US08128803B2 Method and system for determining the concentration of an analyte/enzyme complex or of an analyte/enzyme conjugate, especially for the electrochemical detection of the analyte, and corresponding measuring device 有权
标题翻译：用于确定分析物/酶复合物或分析物/酶缀合物的浓度的方法和系统，特别是用于分析物的电化学检测，以及对应的测量装置
公开(公告)号：US08128803B2
公开(公告)日：2012-03-06
申请号：US11989938
申请日：2006-07-31
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N33/543 , G01N27/26 , G01N27/49
CPC分类号： C12Q1/001 , G01N27/3271 , Y10S435/817
摘要： A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of measuring phase and relaxation phase being determined in a suitable manner. A rapid relaxation of the concentration gradient is electrochemically forced so that the measurement can be carried out on simple transducer arrays. A device for carrying out the method includes a transducer array in addition to a suitable potentiostat. The transducer array can be formed of a planar metal substrate on which at least one flexible insulator is disposed, the metal surface and the insulator surface being firmly linked. The transducer array can also be formed of silicone-based CMOS structures.
摘要翻译：一种遵循氧化还原活性物质浓度变化的方法，由此将适当的还原过程或氧化过程的电位施加到测量装置的工作电极上。工作电极的电位是脉冲的，并且交替地产生测量相位和松弛相位，测量相位和弛豫阶段的脉冲长度以适当的方式确定。浓度梯度的快速弛豫是电化学强制的，以便可以在简单的换能器阵列上进行测量。用于执行该方法的装置包括除合适的恒电位仪之外的换能器阵列。换能器阵列可以由其上设置有至少一个柔性绝缘体的平面金属基板形成，金属表面和绝缘体表面牢固地连接。换能器阵列也可以由硅基CMOS结构形成。

7. 发明授权

US07572624B2 DNA chip comprising a microarray made of an microelectrode system 有权
标题翻译： DNA芯片包括由微电极系统制成的微阵列
公开(公告)号：US07572624B2
公开(公告)日：2009-08-11
申请号：US10539817
申请日：2003-12-15
申请人： Walter Gumbrecht , Konrad Mund , Meinrad Schienle , Roland Thewes
发明人： Walter Gumbrecht , Konrad Mund , Meinrad Schienle , Roland Thewes
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/5438 , C12Q1/6825
摘要： A DNA chip includes a carrier and a microarray of spots containing immobilised catcher molecules which are arranged on the carrier. Each spot contains a microelectrode system for the impedance spectroscopic detection of binding events occurring between the catcher molecules and target molecules of an analyte solution applied to the spots. The microelectrode system has a pair of polarisation electrodes in order to produce an alternating electromagnetic field and a pair of sensor electrodes for measuring a voltage drop in the analyte.
摘要翻译： DNA芯片包括布置在载体上的载体和含有固定捕获剂分子的斑点的微阵列。每个斑点包含用于阻抗光谱检测在施加到斑点的分析物溶液的捕获剂分子和靶分子之间发生的结合事件的微电极系统。微电极系统具有一对极化电极以产生交变电磁场和一对传感器电极，用于测量分析物中的电压降。

8. 发明授权

US06306533B1 Cooling system for a fuel cell battery 有权
标题翻译：燃料电池电池的冷却系统
公开(公告)号：US06306533B1
公开(公告)日：2001-10-23
申请号：US09319891
申请日：1999-06-14
申请人： Konrad Mund , Rittmar von Helmolt
发明人： Konrad Mund , Rittmar von Helmolt
IPC分类号： H01O804
CPC分类号： F28F3/12 , H01M8/0202 , H01M8/0228 , H01M8/0258 , H01M8/0267 , H01M8/0297 , H01M8/04007 , H01M8/04029 , H01M8/04074 , H01M8/2404 , H01M8/241 , H01M8/247 , H01M2300/0082
摘要： A cooling system for a battery of fuel cells that contains at least two fuel cells, each of which comprises a membrane-electrode unit and two collector plates is disclosed. Cooling cards supplied with coolant and that are connected to one another via lines are thereby arranged between the individual fuel cell units.
摘要翻译：公开了一种用于燃料电池的电池的冷却系统，其包含至少两个燃料电池，每个燃料电池包括膜电极单元和两个集电板。因此，在各个燃料电池单元之间配置有冷却液供给并通过管线彼此连接的冷却卡。

9. 发明授权

US5658318A Method and apparatus for detecting a state of imminent cardiac arrhythmia in response to a nerve signal from the autonomic nerve system to the heart, and for administrating anti-arrhythmia therapy in response thereto 失效
标题翻译：用于响应于自主神经系统到心脏的神经信号检测即将发生的心律失常状态的方法和装置，以及响应于其施用抗心律失常疗法
公开(公告)号：US5658318A
公开(公告)日：1997-08-19
申请号：US534933
申请日：1995-09-28
申请人： Brigitte Stroetmann , Konrad Mund , Siegfried Kallert
发明人： Brigitte Stroetmann , Konrad Mund , Siegfried Kallert
IPC分类号： A61B5/022 , A61B5/0402 , A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36114 , A61N1/36135 , A61N1/362 , A61N1/3962 , A61B5/04001 , A61B5/4035 , A61B5/4836
摘要： A device for detecting a state of imminent cardiac arrhythmia, relative to a normal state for a heart, in response to activity in nerve signals conveying information from the autonomic nerve system to the heart, contains a sensor body for sensing neural activity, a comparator with a threshold value forming a condition for the presence of an arrhythmia, the comparator emitting an arrhythmia-indicating output signal depending on whether neural activity meets the condition, and the sensor body being placeable in an extracardiac position for at least one of the sympathetic and vagus nerves. The sensor body directly senses activity in the nerve at that location in direct contact with the nerve. An implanted blood pressure sensing cuff also can be provided which generates signals indicative of blood pressure which can be evaluated in combination with the nerve signals for identifying the state of imminent cardiac arrhythmia.
摘要翻译：用于检测相对于心脏正常状态的紧急心律失常状态的装置，其响应于将信息从自主神经系统传递到心脏的神经信号的活动，包含用于感测神经活动的传感器体，具有形成用于存在心律失常的条件的阈值，所述比较器根据神经活动是否满足条件而发出心律失常指示输出信号，并且所述传感器体可放置在心外部位置以用于至少一种交感神经和迷走神经神经传感器体直接感知与该神经直接接触的位置处的神经中的活动。还可以提供植入式血压感测袖带，其产生指示血压的信号，其可以与用于识别即将发生的心律失常状态的神经信号结合进行评估。

10. 发明授权

US5614246A Method for manufacturing a sensor electrode 失效
标题翻译：传感器电极的制造方法
公开(公告)号：US5614246A
公开(公告)日：1997-03-25
申请号：US554767
申请日：1995-11-07
申请人： Konrad Mund , J. Raghavendra Rao , Armin Datz
发明人： Konrad Mund , J. Raghavendra Rao , Armin Datz
IPC分类号： G01N27/30 , A61B5/00 , A61B5/0408 , A61B5/145 , A61B5/1473 , A61N1/365 , B05D3/12 , B05D5/12
CPC分类号： A61B5/14542 , A61B5/0408 , A61B5/1473
摘要： In a method for manufacturing a working electrode for an implantable, electrochemical oxygen sensor a thin layer of a uniform mixture composed of an epoxy-based resin, a hardener and powdered vitreous carbon is applied onto a ring or hollow cylinder of biocompatible, inert, electrically conductive material, and the resin is hardened.
摘要翻译：在用于制造植入式工作电极的方法中，电化学氧传感器将由环氧树脂，硬化剂和粉状玻璃碳组成的均匀混合物的薄层施加到生物相容的，惰性的，电的导电材料，树脂硬化。

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