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1. 发明申请

US20080300183A1 Gastrointestinal proliferative factor and uses thereof 审中-公开
标题翻译：胃肠增生因子及其用途
公开(公告)号：US20080300183A1
公开(公告)日：2008-12-04
申请号：US11805883
申请日：2007-05-24
申请人： Bryan J. Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Y. Tom Tang , Mikio Yagi , Kazuma Tomizuka
发明人： Bryan J. Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Y. Tom Tang , Mikio Yagi , Kazuma Tomizuka
IPC分类号： A61K38/16 , A61P1/00
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译：本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。

2. 发明申请

US20100137210A1 Gastrointestinal proliferative foctor and uses thereof 有权
标题翻译：胃肠道增生症及其用途
公开(公告)号：US20100137210A1
公开(公告)日：2010-06-03
申请号：US12589727
申请日：2009-10-27
申请人： Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Mikio Yagi , Kazuma Tomizuka
发明人： Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Mikio Yagi , Kazuma Tomizuka
IPC分类号： A61K38/17 , A61P1/00
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译：本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。

3. 发明授权

US07951381B2 Method of stimulating epithelial cell proliferation by administration of gastrointestinal proliferative factor 有权
标题翻译：通过施用胃肠增生因子刺激上皮细胞增殖的方法
公开(公告)号：US07951381B2
公开(公告)日：2011-05-31
申请号：US12589727
申请日：2009-10-27
申请人： Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Mikio Yagi , Kazuma Tomizuka
发明人： Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Mikio Yagi , Kazuma Tomizuka
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译：本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。

4. 发明申请

US20050256036A1 Gastrointestinal proliferative factor and uses thereof 审中-公开
标题翻译：胃肠增生因子及其用途
公开(公告)号：US20050256036A1
公开(公告)日：2005-11-17
申请号：US11046644
申请日：2005-01-27
申请人： Bryan Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Park , Y. Tang , Mikio Yagi , Kazuma Tomizuka
发明人： Bryan Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Park , Y. Tang , Mikio Yagi , Kazuma Tomizuka
IPC分类号： A01K67/027 , A61K38/18 , A61K48/00 , C07K14/475 , C12N15/85 , G01N33/50
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译：本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。

5. 发明申请

US20050256044A1 Gastrointestinal proliferative factor and uses thereof 审中-公开
公开(公告)号：US20050256044A1
公开(公告)日：2005-11-17
申请号：US11046456
申请日：2005-01-27
申请人： Bryan Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Park , Y. Tang , Mikio Yagi , Kazuma Tomizuka
发明人： Bryan Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Park , Y. Tang , Mikio Yagi , Kazuma Tomizuka
IPC分类号： A01K67/027 , A61K38/18 , A61K48/00 , C07K14/475 , C12N15/85 , G01N33/50
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.

6. 发明申请

US20090036369A1 ANTI-TUMOR AGENTS COMPRISING R-SPONDINS 审中-公开
标题翻译：包含R-SPONDINS的抗肿瘤药物
公开(公告)号：US20090036369A1
公开(公告)日：2009-02-05
申请号：US11996684
申请日：2006-07-26
申请人： Makoto Kakitani , Takeshi Oshima , Kazuma Tomizuka , Kazumasa Hasegawa
发明人： Makoto Kakitani , Takeshi Oshima , Kazuma Tomizuka , Kazumasa Hasegawa
IPC分类号： A61K38/16 , A61K31/7052 , A61P35/00
CPC分类号： A61K38/17
摘要： The present invention provides an anti-tumor agent comprising a human R-spondin including R-spondin1 (GIPF), R-spondin2, R-spondin3 or R-spondin4, or a fragment thereof which has human R-spondin activity as an active ingredient.
摘要翻译：本发明提供包含人R-螺旋蛋白的抗肿瘤剂，其包含具有人R-螺旋蛋白活性的活性成分的R-螺旋菌素（GIPF），R-螺环素2，R-螺环素3或R-螺环素4或其片段。

7. 发明申请

US20100011452A1 CHIMERIC NON-HUMAN ANIMAL 审中-公开
标题翻译： CHIMERIC非人类动物
公开(公告)号：US20100011452A1
公开(公告)日：2010-01-14
申请号：US12481476
申请日：2009-06-09
申请人： Kazuma TOMIZUKA , Makoto Kakitani , Takashi Yoneya , Isao Ishida
发明人： Kazuma TOMIZUKA , Makoto Kakitani , Takashi Yoneya , Isao Ishida
IPC分类号： G01N33/00 , A01K67/00
CPC分类号： C07K14/50 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , C07K14/524 , C07K14/70596 , C07K16/00 , C07K2317/50 , C12N2800/30 , C12N2830/008
摘要： The present invention relates to a method for producing a chimeric non-human animal expressing a desired protein, and a chimeric non-human animal or an offspring thereof expressing a desired protein.The present invention also relates to a method for analyzing the functions of a desired protein or a gene encoding the protein by comparing the phenotype of the above chimeric non-human animal with that of a corresponding wild-type animal.
摘要翻译：本发明涉及一种表达所需蛋白质的嵌合非人动物的方法，以及表达所需蛋白质的嵌合非人动物或其后代。本发明还涉及通过将上述嵌合非人动物的表型与相应野生型动物的表型进行比较来分析所需蛋白质或编码该蛋白质的基因的功能的方法。

8. 发明申请

US20090151011A1 Chimeric Non-Human Animal and Use Thereof 审中-公开
标题翻译：嵌合非人类动物及其用途
公开(公告)号：US20090151011A1
公开(公告)日：2009-06-11
申请号：US11795693
申请日：2006-01-23
申请人： Makoto Kakitani , Kazuma Tomizuka
发明人： Makoto Kakitani , Kazuma Tomizuka
IPC分类号： A01K67/027 , C12N15/02 , C12P21/00 , C12N5/06
CPC分类号： C12P21/02 , A01K67/0271 , A01K2217/05 , A01K2267/03 , C07K14/515 , C07K2319/02 , C12N15/8509 , C12N2517/02 , C12N2800/30 , C12N2830/008
摘要： This invention provides: a pluripotent cell derived from a non-human animal comprising foreign DNA that encodes a desired protein in such a manner that the expression of the desired protein is regulated by the control region of a gene expressed in certain cells and/or tissue, wherein the foreign DNA is bound to a nucleic acid fragment comprising a promoter/the whole or part of 5′ non-translational region/a leader sequence coding region derived from a gene expressed in certain cells and/or tissue, and wherein in said cell one or more drug resistant marker genes used for introducing the foreign DNA into the genome have been removed; a chimeric non-human animal that is prepared from the pluripotent cell and highly expresses the desired protein, or a progeny thereof; a method for producing a desired protein using the chimeric animal; and a method for analyzing in vivo function of a desired gene using the chimeric animal.
摘要翻译：本发明提供：源自非人动物的多潜能细胞，其包含编码所需蛋白质的外源DNA，使得所需蛋白质的表达受到在某些细胞和/或组织中表达的基因的对照区域的调节其中所述外来DNA与包含启动子/全部或部分5'非翻译区的核酸片段/衍生自在某些细胞和/或组织中表达的基因的前导序列编码区结合，并且其中在所述已经去除了用于将外源DNA引入基因组的细胞一个或多个耐药性标记基因; 由多能细胞制备并高度表达所需蛋白质或其后代的嵌合非人动物; 使用该嵌合动物产生所需蛋白质的方法; 以及使用嵌合动物分析所需基因的体内功能的方法。

9. 发明申请

US20060123490A1 Pluripotent cells with improved efficiency of homologous recombination and use of the same 审中-公开
标题翻译：具有改善同源重组效率并使用其的多能细胞
公开(公告)号：US20060123490A1
公开(公告)日：2006-06-08
申请号：US11212101
申请日：2005-08-26
申请人： Makoto Kakitani , Kazuma Tomizuka
发明人： Makoto Kakitani , Kazuma Tomizuka
IPC分类号： A01K67/00 , C12N5/06
CPC分类号： A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C12N2830/30
摘要： The present invention provides a method of enhancing an efficiency of homologous recombination when a gene encoding a desired protein known or unknown in terms of function is introduced into a genome of a pluripotent cell such as ES cell. More particularly, the present invention relates to: a non-human animal-derived pluripotent cell comprising a foreign enhancer at a site downstream of an immunoglobulin gene on chromosome; a non-human animal pluripotent cell comprising a gene, which encodes a desired protein at a site downstream of the immunoglobulin gene and upstream of the foreign enhancer on the chromosome, said gene being in an overexpressible state; a method of establishing said pluripotent cell; and a chimeric non-human animal and its progeny produced by use of the pluripotent cells and a method of producing the same. The present invention further relates to a method of analyzing the function of a desired protein or a gene encoding the protein by comparing a phenotype of the chimeric non-human animal or its progeny with that of a control animal, and/or to a method of producing a useful protein by use of the chimeric non-human animal or its progeny.
摘要翻译：本发明提供了当将编码功能方面已知或未知的所需蛋白质的基因导入多能细胞如ES细胞的基因组时，提高同源重组效率的方法。更具体地说，本发明涉及：在人染色体上的免疫球蛋白基因下游的位置上含有外源增强子的非人动物来源的多能细胞; 一种非人动物多能细胞，其包含编码所述免疫球蛋白基因下游位点和染色体上外源增强子上游位点的所需蛋白质的基因，所述基因处于过表达状态; 建立所述多能细胞的方法; 和嵌合非人动物及其通过使用多能细胞产生的后代及其制备方法。本发明还涉及通过将嵌合非人动物或其后代的表型与对照动物的表型进行比较来分析所需蛋白质或编码该蛋白质的基因的功能的方法，和/或通过使用嵌合非人动物或其后代产生有用的蛋白质。

10. 发明申请

US20110237514A1 PHARMACEUTICAL COMPOSITION FOR TREATING BONE DISEASES WHICH COMPRISES PROTEIN COMPRISING Frizzled1, Frizzled2 OR Frizzled7 EXTRACELLULAR CYSTEINE-RICH DOMAIN 审中-公开
标题翻译：用于治疗骨质疏松症的药物组合物，其包含卷曲1，卷曲2或卷曲7蛋白质的细胞蛋白
公开(公告)号：US20110237514A1
公开(公告)日：2011-09-29
申请号：US13121637
申请日：2009-09-30
申请人： Makoto Kakitani , Kazuma Tomizuka
发明人： Makoto Kakitani , Kazuma Tomizuka
IPC分类号： A61K38/17 , A61K31/7088 , A61P19/08 , A61P19/10 , C12N15/63 , C07K16/28
CPC分类号： A61K38/177 , A01K67/027 , A01K67/0271 , A01K2207/12 , A01K2207/30 , A01K2217/072 , A01K2227/105 , A01K2267/035 , A61K31/7088 , A61K38/1709 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K47/6835 , A61K48/00 , C07K14/723 , C07K2319/30
摘要： This invention relates to a pharmaceutical composition for treatment of a bone disease comprising, as an active ingredient, a protein comprising an extracellular cysteine-rich domain, which is from the Frizzled receptor selected from the group consisting of mammalian animal-derived Frizzled 1, Frizzled 2, and Frizzled 7 and has activity of increasing bone mass, bone density, and/or bone strength, or a mutant of such domain having sequence identity of 85% or higher to the amino acid sequence of the domain and having activity of increasing bone mass, bone density, and/or bone strength, or a vector comprising a nucleic acid encoding the protein.
摘要翻译：本发明涉及一种用于治疗骨疾病的药物组合物，其包含作为活性成分的蛋白质，所述蛋白质包含富含细胞外富含半胱氨酸的结构域，所述结构域来自所述卷曲状受体，所述卷曲受体选自哺乳动物来源的卷曲1，卷曲的 2和卷曲7，并且具有增加骨量，骨密度和/或骨强度的活性，或具有与结构域的氨基酸序列具有85％或更高的序列同一性并具有增加骨活性的这种结构域的突变体质量，骨密度和/或骨强度，或包含编码该蛋白质的核酸的载体。

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