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1. 发明授权

US6002066A H2-M modified transgenic mice 失效
标题翻译： H2-M修饰的转基因小鼠
公开(公告)号：US6002066A
公开(公告)日：1999-12-14
申请号：US780949
申请日：1997-01-10
申请人： Wai-Ping Leung , Lars Karlsson , Lubing Zhou , Per A. Peterson
发明人： Wai-Ping Leung , Lars Karlsson , Lubing Zhou , Per A. Peterson
IPC分类号： A01K67/027 , C07K14/74 , C12N5/10 , C12N15/09 , C12N15/85 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/70539 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0368 , A01K2267/0381
摘要： A transgenic mouse with alterations in the H2-Ma gene is prepared by introduction of an altered H2-Ma gene into a host mouse. The resulting transgenic mice do not produce functional H2-M molecules.
摘要翻译：通过将改变的H2-Ma基因引入宿主小鼠中制备具有H2-Ma基因改变的转基因小鼠。所得转基因小鼠不产生功能性H2-M分子。

2. 发明授权

US06372955B1 Methods for Producing B cells and antibodies from H2-O modified transgenic mice 有权
标题翻译：从H2-O修饰的转基因小鼠产生B细胞和抗体的方法
公开(公告)号：US06372955B1
公开(公告)日：2002-04-16
申请号：US09516390
申请日：2000-03-01
申请人： Lars Karlsson , Wai-Ping Leung , Per A. Peterson , Christopher Alfonso
发明人： Lars Karlsson , Wai-Ping Leung , Per A. Peterson , Christopher Alfonso
IPC分类号： A01K6700
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/4703
摘要： A transgenic animal with alterations in an H2-O gene is prepared by introduction of an altered H2-O gene into a host animal. The resulting transgenic animals produce a substantially greater frequency of high affinity antibodies compared to H2-O wild type animals. A method for the production of high affinity antibodies is disclosed.
摘要翻译：通过将改变的H 2 -O基因引入宿主动物来制备具有H2-O基因改变的转基因动物。与H2-O野生型动物相比，所得到的转基因动物产生显着更高的高亲和力抗体频率。公开了生产高亲和力抗体的方法。

3. 发明申请

US20080102476A1 Analyzing Histamine H4 Receptor-Mediated Effects In Whole Blood 审中-公开
标题翻译：分析组胺H4受体介导的全血中的作用
公开(公告)号：US20080102476A1
公开(公告)日：2008-05-01
申请号：US10572985
申请日：2004-09-24
申请人： Lars Karlsson , Wai-Ping Leung , Ping Ling , Robin Thurmond
发明人： Lars Karlsson , Wai-Ping Leung , Ping Ling , Robin Thurmond
IPC分类号： G01N33/53
CPC分类号： G01N33/566 , G01N2500/04
摘要： Assay methods for analyzing whole blood to detect histamine H4 receptor-mediated effects, such as eosinophil shape change, cytoskeletal change, adhesion molecule up-regulation, or calcium flux are described. Such methods are useful in clinical and diagnostic applications.
摘要翻译：描述了用于分析全血以检测组胺H 4受体介导的作用的测定方法，例如嗜酸性粒细胞形状变化，细胞骨架变化，粘附分子上调或钙通量。这些方法在临床和诊断应用中是有用的。

4. 发明授权

US07439335B2 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US07439335B2
公开(公告)日：2008-10-21
申请号：US10822173
申请日：2004-04-08
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N5/00 , C07K14/74
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，以及将正在进行的激活状态转移到Th1或Th2细胞的优选的分化群体中。

5. 发明授权

US07402430B2 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
公开(公告)号：US07402430B2
公开(公告)日：2008-07-22
申请号：US10903213
申请日：2004-07-29
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N5/16 , G01N33/53 , A01N63/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.

6. 发明授权

US06355479B1 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US06355479B1
公开(公告)日：2002-03-12
申请号：US09194285
申请日：1999-04-12
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N510
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，并将正在进行的激活状态转移到Th1或Th2细胞的优选分化群体中。

7. 发明授权

US07074617B1 MHC class II antigen-presenting systems and methods for activatind CD4+T cells 失效
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US07074617B1
公开(公告)日：2006-07-11
申请号：US09715891
申请日：2000-11-17
申请人： Susan R. Webb , Ola Wingvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Wingvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N15/12 , C12N5/06 , C12N15/63 , C07H21/04
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，以及将正在进行的激活状态转移到Th1或Th2细胞的优选的分化群体中。

8. 发明申请

WO2004086226A1 A DEVICE FOR RESTORING AT LEAST ONE OF FILES, DIRECTORIES AND APPLICATION ORIENTED FILES IN A COMPUTER TO A PREVIOUS STATE 审中-公开
标题翻译：用于将计算机中的至少一个文件，目录和应用程序文件恢复到以前的状态的设备
公开(公告)号：WO2004086226A1
公开(公告)日：2004-10-07
申请号：PCT/SE2004/000453
申请日：2004-03-25
申请人： SYSTEMOK AB , Alexander Hars , Lars Karlsson
发明人： Alexander Hars , Lars Karlsson
IPC分类号： G06F11/16
CPC分类号： G06F11/1451 , G06F11/1469 , G06F11/1471
摘要： A device (1) for restoring items such as files, directories and application-oriented files in a computer to a previous state is disclosed. The device comprises a processor (3), a memory (5), input/output means (7). The memory (5) comprises a storage area (9), backup area (11), an attribute area (13), an activity log file (15), and a state content area (17). The backup area (11) comprises originals of the items. The storage area (9), comprises changes to items. The attribute area (13) comprises copies of attributes to files and directories. The activity log file (15) comprises events that have occurred after the time of the previous state. The state content area (17) comprises content in relation to items at the time corresponding to the previous state. The device (1) is configured for managing the process of the restoring.
摘要翻译：公开了一种用于将诸如计算机中的文件，目录和面向应用文件的项目恢复到先前状态的设备（1）。该装置包括处理器（3），存储器（5），输入/输出装置（7）。存储器（5）包括存储区域（9），备份区域（11），属性区域（13），活动日志文件（15）和状态内容区域（17）。备用区域（11）包括项目的原件。存储区域（9）包括对项目的改变。属性区域（13）包括属性到文件和目录的副本。活动日志文件（15）包括在先前状态之后发生的事件。状态内容区域（17）包括与在先前状态对应的时间项目相关的内容。设备（1）被配置为管理恢复过程。

9. 发明申请

US20140104110A1 Method for Real-time, Automatic, Wideband, High Accuracy RF Direction Finding 有权
标题翻译：实时，自动，宽带，高精度RF方向寻找方法
公开(公告)号：US20140104110A1
公开(公告)日：2014-04-17
申请号：US13653476
申请日：2012-10-17
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： G01S3/02
CPC分类号： G01S3/74
摘要： This system and method provides a direction finding system that enables modern RF DF systems to analyze short duration signals in the entire instantaneous bandwidth. By providing a method to process wideband data, the invention drastically improves throughput and probability of intercept (POI). The invention is unique in that it does not require separate narrowband channels for analysis, and can simultaneously calculate azimuth and elevation estimates for every frequency in the bandwidth of an incident signal. It is also well-suited for fixed point, FPGA implementations making it a perfect match for modern state-of-the-art processing systems. The system and method capitalizes on the ability of Fourier Frequency Transform operations to accurately resolve incident wave phase at discrete frequencies. The system then uses the phase information from the individual elements in the array to arrive at an emitter azimuth angle. The azimuth angle is nearly simultaneously used in concert with lookup tables of all possible elevation angles to compare the arrival time delay between the array elements to determine emitter elevation angle.
摘要翻译：该系统和方法提供了一种方向发现系统，其使得现代RF DF系统能够在整个瞬时带宽中分析短持续时间信号。通过提供处理宽带数据的方法，本发明大大提高了吞吐量和拦截概率（POI）。本发明是独特的，因为它不需要单独的窄带信道用于分析，并且可以同时计算入射信号带宽中每个频率的方位角和高程估计。它也非常适合固定点，FPGA实现使其成为现代最先进的处理系统的完美匹配。该系统和方法利用傅里叶频率变换操作精确地解决离散频率入射波相位的能力。然后，系统使用来自阵列中的各个元件的相位信息来达到发射器方位角。方位角几乎同时用于所有可能仰角的查找表，以比较阵列元件之间的到达时间延迟，以确定发射器仰角。

10. 发明申请

US20120137843A1 TUBE CUTTING 审中-公开
标题翻译：管切割
公开(公告)号：US20120137843A1
公开(公告)日：2012-06-07
申请号：US13145160
申请日：2010-02-25
申请人： Carina Petersson , Sandra Philipsson , Niklas Svensson , Lars Karlsson
发明人： Carina Petersson , Sandra Philipsson , Niklas Svensson , Lars Karlsson
IPC分类号： B23D21/14 , B23D21/00
CPC分类号： B23D21/14 , B23D21/00 , B23D35/005 , B23D35/007 , Y10T82/16 , Y10T82/16147
摘要： A knife holder (402) for a tube cutting unit is adapted to receiving a rotating tube fed out from a tube manufacturing device in a feed direction (316). The feed direction is parallel with the tube's longitudinal direction and the rotation takes place about an axis in the tube's longitudinal direction. The knife holder is adapted to following the rotating tube in the latter's longitudinal direction and to bringing a knife element into contact with the tube in a cutting direction and thereby creating in the rotating tube a cut at right angles to the longitudinal direction of the tube. The knife holder is further provided with at least a first bearing element (414) and a second bearing element (415) configured to engage in respective brackets (416, 417) in the tube cutting unit. The bearing elements are so disposed relative to one another that the perpendicular direction (464) to a plane (462), which plane runs in the cutting direction through the bearing elements, and the longitudinal direction of the tube deviate from being parallel.
摘要翻译：用于管切割单元的刀保持器（402）适于接收沿进给方向（316）从管制造装置送出的旋转管。进给方向与管的纵向平行，并且围绕管的纵向方向的轴线进行旋转。刀架适于在后者的纵向方向上跟随旋转管，并使刀元件沿切割方向与管接触，从而在旋转管中产生与管的纵向方向成直角的切口。刀架还设置有至少第一轴承元件（414）和第二轴承元件（415），该第二轴承元件构造成与管切割单元中的相应托架（416,417）啮合。轴承元件相对于彼此设置成使得垂直方向（464）到平面（462），该平面（462），该平面在切割方向上通过轴承元件延伸，并且管的纵向方向偏离平行。

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