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1. 发明授权

US09037238B2 Method for efficient delivery of dual site pacing 有权
标题翻译：双位置起搏有效运送的方法
公开(公告)号：US09037238B2
公开(公告)日：2015-05-19
申请号：US13301084
申请日：2011-11-21
申请人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
IPC分类号： A61N1/00 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3684 , A61N1/368 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses to a first pacing site along a heart chamber and a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the electrodes. A sensing module measures an activation time at multiple pacing electrode sites along the heart chamber in response to delivering pacing pulses at the first pacing site. A controller is configured to identify a second pacing site from the plurality of pacing electrode sites in response to the activation times measured during pacing at the first site.
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号并将心脏起搏脉冲输送到沿着心脏室的第一起搏部位的电极和用于经由心脏起搏器将心脏起搏脉冲输送到患者心脏的治疗递送模块电极。响应于在第一起搏部位输送起搏脉冲，感测模块测量沿着心室的多个起搏电极部位的激活时间。控制器被配置为响应于在第一站点的起搏期间测量的激活时间，从多个起搏电极位置识别第二起搏部位。

2. 发明授权

US08682433B2 Method for efficient delivery of dual site pacing 有权
标题翻译：双位置起搏有效运送的方法
公开(公告)号：US08682433B2
公开(公告)日：2014-03-25
申请号：US13301113
申请日：2011-11-21
申请人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
发明人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3686 , A61N1/371
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses. Electrodes positioned at first and second selected pacing sites are used to deliver pacing pulses to a first heart chamber using a bipole comprising the first electrode and the second electrode. A controller is configured to determine if anodal and cathodal capture can be achieved during pacing using the bipole. Responsive to anodal and cathodal capture being achieved, the controller selects a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites.
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号和递送心脏起搏脉冲的电极。使用位于第一和第二选定的起搏部位的电极，使用包括第一电极和第二电极的双极将起搏脉冲输送到第一心室。控制器被配置为确定在使用双极的起搏期间是否可以实现阳极和阴极捕获。响应于实现阳极和阴极捕获，控制器选择包括用于单步起搏第一和第二起搏部位的双极的多位置起搏配置。

3. 发明授权

US08626291B2 Method for discriminating anodal and cathodal capture 有权
标题翻译：鉴别阳极和阴极捕获的方法
公开(公告)号：US08626291B2
公开(公告)日：2014-01-07
申请号：US13192713
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
IPC分类号： A61N1/365
CPC分类号： A61N1/371 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method detect anodal capture during electrical stimulation. A first pacing pulse is delivered using a first cathode and a first anode. A second pacing pulse is delivered using the first cathode and a second anode. A first response to the first pacing pulse and a second response to the second pacing pulse are measured. Anodal capture of the first pacing pulse at the first anode is detected in response to a first difference between the first response and the second response.
摘要翻译：可植入装置和相关方法在电刺激期间检测阳极捕获。使用第一阴极和第一阳极传送第一起搏脉冲。使用第一阴极和第二阳极传送第二起搏脉冲。测量对第一起搏脉冲的第一响应和对第二起搏脉冲的第二响应。响应于第一响应和第二响应之间的第一差异来检测在第一阳极处的第一起搏脉冲的阳极捕获。

4. 发明申请

US20130131749A1 METHOD FOR EFFICIENT DELIVERY OF DUAL SITE PACING 有权
标题翻译：双层高效交付方法
公开(公告)号：US20130131749A1
公开(公告)日：2013-05-23
申请号：US13301113
申请日：2011-11-21
申请人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
发明人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/3686 , A61N1/371
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses. Electrodes positioned at first and second selected pacing sites are used to deliver pacing pulses to a first heart chamber using a bipole comprising the first electrode and the second electrode. A controller is configured to determine if anodal and cathodal capture can be achieved during pacing using the bipole. Responsive to anodal and cathodal capture being achieved, the controller selects a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号和递送心脏起搏脉冲的电极。使用位于第一和第二选定的起搏部位的电极，使用包括第一电极和第二电极的双极将起搏脉冲输送到第一心室。控制器被配置为确定在使用双极的起搏期间是否可以实现阳极和阴极捕获。响应于实现阳极和阴极捕获，控制器选择包括用于单步起搏第一和第二起搏部位的双极的多位置起搏配置

5. 发明申请

US20130131748A1 METHOD FOR EFFICIENT DELIVERY OF DUAL SITE PACING 有权
标题翻译：双层高效交付方法
公开(公告)号：US20130131748A1
公开(公告)日：2013-05-23
申请号：US13301084
申请日：2011-11-21
申请人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/3684 , A61N1/368 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses to a first pacing site along a heart chamber and a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the electrodes. A sensing module measures an activation time at multiple pacing electrode sites along the heart chamber in response to delivering pacing pulses at the first pacing site. A controller is configured to identify a second pacing site from the plurality of pacing electrode sites in response to the activation times measured during pacing at the first site.
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号并将心脏起搏脉冲输送到沿着心脏室的第一起搏部位的电极和用于经由心脏起搏器将心脏起搏脉冲输送到患者心脏的治疗递送模块电极。响应于在第一起搏部位输送起搏脉冲，感测模块测量沿着心室的多个起搏电极部位的激活时间。控制器被配置为响应于在第一站点的起搏期间测量的激活时间，从多个起搏电极位置识别第二起搏部位。

6. 发明授权

US08401646B2 Method and apparatus to determine the relative energy expenditure for a plurality of pacing vectors 有权
标题翻译：确定多个起搏向量的相对能量消耗的方法和装置
公开(公告)号：US08401646B2
公开(公告)日：2013-03-19
申请号：US13194100
申请日：2011-07-29
申请人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
IPC分类号： A61B1/00
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3686 , A61N1/3708
摘要： A medical device system determines and displays relative energy expenditure information for programmable parameter values. The system establishes a programmable parameter and multiple values of the parameter to be compared. A module performs a measurements for each of the multiple values and related to energy expenditure of a battery of an implantable medical device when operating according to each of the multiple parameter values. An energy expenditure for each of the values is computed using the measurements, and a graphical user interface is generated for displaying information corresponding to the computed energy expenditure for multiple parameter values.
摘要翻译：医疗设备系统确定并显示可编程参数值的相对能量消耗信息。系统建立可编程参数和要比较的参数的多个值。当根据多个参数值中的每个参数值进行操作时，模块对可植入医疗装置的电池的能量消耗进行测量。使用测量来计算每个值的能量消耗，并且生成用于显示与多个参数值的计算能量消耗相对应的信息的图形用户界面。

7. 发明授权

US08718770B2 Capture threshold measurement for selection of pacing vector 有权
标题翻译：拍摄阈值测量用于选择起搏矢量
公开(公告)号：US08718770B2
公开(公告)日：2014-05-06
申请号：US12909057
申请日：2010-10-21
申请人： Wade M. Demmer , Todd J. Sheldon
发明人： Wade M. Demmer , Todd J. Sheldon
IPC分类号： A61N1/08
CPC分类号： A61N1/3712 , A61N1/3686
摘要： Various techniques for selecting a pacing vector based on pacing capture thresholds are described. One example method described includes for each of a plurality of vectors, iteratively delivering at least one pacing stimulus at each of a plurality of magnitudes within a predetermined range of magnitudes to a first chamber, determining if a depolarization occurred in a second chamber of the heart within a predetermined threshold time interval after the pacing stimulus that is less than an interval, identifying a pacing stimulus for which a depolarization in the second chamber does not occur within the predetermined threshold time interval, determining a capture threshold magnitude for the vector based on the magnitude of the pacing pulse for which a depolarization in the second chamber does not occur within the predetermined threshold time interval, and recording the capture threshold magnitudes.
摘要翻译：描述了基于起搏捕获阈值来选择起搏向量的各种技术。所描述的一个示例性方法包括针对多个向量中的每一个，在预定范围内的多个量级中的每一个向第一室迭代递送至少一个起搏刺激，确定是否在心脏的第二腔室中发生去极化在所述起搏刺激小于间隔之后的预定阈值时间间隔内，识别在所述预定阈值时间间隔内不发生所述第二腔室中去极化的起搏刺激，基于所述步骤确定所述矢量的捕获阈值量值在预定的阈值时间间隔内在第二腔室中去极化的起搏脉冲的幅值，并记录捕获阈值量值。

8. 发明授权

US08527050B2 Method for discriminating anodal and cathodal capture 有权
标题翻译：鉴别阳极和阴极捕获的方法
公开(公告)号：US08527050B2
公开(公告)日：2013-09-03
申请号：US13192697
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
IPC分类号： A61N1/368
CPC分类号： A61N1/3712
摘要： An implantable device and associated method discriminate between cathodal and anodal capture during electrical stimulation. A control response to a pacing pulse delivered using a candidate cathode electrode and a universal anode and responses to bipolar pacing pulses delivered using candidate bipoles including the candidate cathode are measured. Responsive to the control response meeting a threshold response, the control response is classified as normal and each of the responses for the candidate bipoles are compared to the control response. The responses for the candidate bipoles are each classified based on the comparison.
摘要翻译：可植入装置和相关方法在电刺激期间区分阴极和阳极捕获。测量使用候选阴极电极和通用阳极传送的起搏脉冲的控制响应以及使用包括候选阴极的候选双极传送的双极起搏脉冲的响应。响应于满足阈值响应的控制响应，将控制响应分类为正常，并将候选双极的每个响应与控制响应进行比较。根据比较对候选双极的响应进行分类。

9. 发明申请

US20130030493A1 METHODS FOR SETTING CARDIAC PACING PARAMETERS IN RELATIVELY HIGH EFFICIENCY PACING SYSTEMS 有权
标题翻译：在相对高效率的PACING系统中设置心脏参数的方法
公开(公告)号：US20130030493A1
公开(公告)日：2013-01-31
申请号：US13193783
申请日：2011-07-29
申请人： Todd J. Sheldon , Wade M. Demmer
发明人： Todd J. Sheldon , Wade M. Demmer
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/3708 , A61N1/37205 , A61N1/3756
摘要： According to some methods, for example, preprogrammed in a microprocessor element of an implantable cardiac pacing system, at least one of a number of periodic pacing threshold searches includes steps to reduce an evoked response amplitude threshold for evoked response signal detection. The reduction may be to a minimum value measurable above zero, for example, as determined by establishing a ‘noise floor’. Alternately, amplitudes of test pacing pulses and corresponding post pulse signals are collected and reviewed to search for a break, to determine a lower value to which the evoked response threshold may be adjusted without detecting noise. Subsequent to reducing the threshold, if no evoked response signal is detected for a test pulse applied at or above a predetermined maximum desirable pulse energy, an operational pacing pulse energy is set to greater than or equal to the maximum desirable in conjunction with a reduction in pacing rate.
摘要翻译：根据一些方法，例如，在可植入心脏起搏系统的微处理器元件中预编程，多个周期性起搏阈值搜索中的至少一个包括减少诱发响应信号检测的诱发响应振幅阈值的步骤。该减小可以是在零以上可测量的最小值，例如通过建立噪声本底来确定。或者，收集和检查测试起搏脉冲和对应的后脉冲信号的振幅以搜索中断，以确定可以在不检测噪声的情况下调整诱发响应阈值的较低值。在降低阈值之后，如果对于在预定的最大期望脉冲能量之上或之上施加的测试脉冲没有检测到诱发响应信号，则可以将运行起搏脉冲能量设置为大于或等于期望的最大值，起搏率

10. 发明申请

US20120101546A1 METHOD AND APPARATUS TO DETERMINE THE RELATIVE ENERGY EXPENDITURE FOR A PLURALITY OF PACING VECTORS 有权
标题翻译：确定多边形矢量相对能源支出的方法和装置
公开(公告)号：US20120101546A1
公开(公告)日：2012-04-26
申请号：US13194100
申请日：2011-07-29
申请人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
IPC分类号： A61N1/08 , A61N1/37
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3686 , A61N1/3708
摘要： A medical device system determines and displays relative energy expenditure information for programmable parameter values. The system establishes a programmable parameter and multiple values of the parameter to be compared. A module performs a measurements for each of the multiple values and related to energy expenditure of a battery of an implantable medical device when operating according to each of the multiple parameter values. An energy expenditure for each of the values is computed using the measurements, and a graphical user interface is generated for displaying information corresponding to the computed energy expenditure for multiple parameter values.
摘要翻译：医疗设备系统确定并显示可编程参数值的相对能量消耗信息。系统建立可编程参数和要比较的参数的多个值。当根据多个参数值中的每个参数值进行操作时，模块对可植入医疗装置的电池的能量消耗进行测量。使用测量来计算每个值的能量消耗，并且生成用于显示与多个参数值的计算能量消耗相对应的信息的图形用户界面。

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