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1. 发明申请

WO2005032513A3 PANTOPRAZOLE MULTIPARTICULATE FORMULATIONS 审中-公开
标题翻译：潘多拉唑多颗粒制剂
公开(公告)号：WO2005032513A3
公开(公告)日：2005-08-18
申请号：PCT/US2004033058
申请日：2004-09-30
申请人： WYETH CORP , VENKATA RAMANA RAO SRIPRIYA , SHAH SYED M , TATAPUDY HANUMANTHARAO , SAUNDERS RICHARD WILLIAM , FAWZI MAHDI , NAGI ARWINDER , SINGH SHAILESH , HASAN SUMON A
发明人： VENKATA RAMANA RAO SRIPRIYA , SHAH SYED M , TATAPUDY HANUMANTHARAO , SAUNDERS RICHARD WILLIAM , FAWZI MAHDI , NAGI ARWINDER , SINGH SHAILESH , HASAN SUMON A
IPC分类号： A61K9/16 , A61K9/26 , A61K9/28 , A61K9/50 , A61K31/4439 , A61K47/14 , A61K47/32 , A61K47/38
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a distintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.
摘要翻译：描述了泮托拉唑钠多颗粒避免粘附到鼻胃管和美食管。泮托拉唑多颗粒具有泮托拉唑或其对映体的球体核或其盐，表面活性剂和崩解剂; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底衣，底衣上的肠溶衣，以及由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠衣上的最终密封包衣。

2. 发明公开

EP2651443A4 ANTI-CCL25 AND ANTI-CCR9 ANTIBODIES FOR THE PREVENTION AND TREATMENT OF CANCER AND CANCER CELL MIGRATION 审中-公开
标题翻译： ANTI-CCL25-和抗CCR9抗体的预防与治疗癌症与肿瘤细胞的迁移
公开(公告)号：EP2651443A4
公开(公告)日：2015-03-25
申请号：EP11849820
申请日：2011-12-13
申请人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
发明人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
IPC分类号： G01N33/574 , C07K16/24 , C07K16/28 , G01N33/53 , G01N33/68
CPC分类号： C07K16/24 , C07K16/2866 , C07K2317/73

3. 发明公开

EP2652507A4 DETECTING CANCER WITH ANTI-CCL25 AND ANTI-CCR9 ANTIBODIES 审中-公开
标题翻译： NACHWEIS VON KREBS MIT ANTI-CCL25- UND ANTI-CCR9-ANTIKÖRPERN
公开(公告)号：EP2652507A4
公开(公告)日：2015-04-22
申请号：EP11848773
申请日：2011-12-13
申请人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
发明人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
IPC分类号： G01N33/574 , G01N33/53 , G01N33/68
CPC分类号： G01N33/57496 , C07K16/24 , C07K16/2866 , C07K2317/73 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/574 , G01N33/57407 , G01N33/57426 , G01N33/5743 , G01N33/57488 , G01N33/57492 , G01N2333/521 , G01N2333/522 , G01N2333/7158 , G01N2800/52
摘要： Methods for diagnosing cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprises CXCL13 or CXCR5 or both CXCL13 and CXCR5. Also disclosed is a kit for detecting cancer or monitoring cancer progression.
摘要翻译：公开了用于诊断受试者中的癌症的方法。该方法包括检测从受试者获得的生物样品中一种或多种癌症标志物的表达水平; 并将生物样品中的一种或多种癌症标志物的表达水平与一种或多种癌症标志物的正常表达水平进行比较。一种或多种癌症标志物包括CXCL13或CXCR5或CXCL13和CXCR5。还公开了用于检测癌症或监测癌症进展的试剂盒。

4. 发明公开

EP2652508A4 THE USE OF ANTI-CXCL13 AND ANTI-CXCR5 ANTIBODIES FOR THE TREATMENT OR DETECTION OF CANCER 有权
标题翻译： ANTI-CXCL13-和抗CXCR5抗体的治疗或用于癌症的检测中使用
公开(公告)号：EP2652508A4
公开(公告)日：2015-07-15
申请号：EP11849217
申请日：2011-12-07
申请人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
发明人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
IPC分类号： G01N33/574 , G01N33/53 , G01N33/68
CPC分类号： G01N33/57407 , G01N2333/7158
摘要： The use of anti-CXCL13 and anti-CXCR5 antiboies for the treatment or dectection of in a subject is disclosed.

5. 发明公开

EP2652506A4 THE USE ANTI-CXCL16 AND ANTI-CXCR6 ANTIBODIES FOR THE TREATMENT OR DETECTING CANCER 审中-公开
标题翻译：抗体CXCL16和CXCR6用于治疗或使用用于癌症的检测
公开(公告)号：EP2652506A4
公开(公告)日：2015-03-25
申请号：EP11848243
申请日：2011-12-06
申请人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
发明人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
IPC分类号： G01N33/574 , A61K31/7088 , A61K39/395 , A61K48/00 , A61P35/00 , C07K16/24 , C07K16/28 , G01N33/68
CPC分类号： A61K39/395 , C07K16/24 , C07K16/2866 , C07K2317/73

6. 发明申请

WO2012082494A3 THE USE OF ANTI-CXCL13 AND ANTI-CXCR5 ANTIBODIES FOR THE TREATMENT OR DETECTION OF CANCER 审中-公开
标题翻译：使用抗CXCL13和抗CXCR5抗体治疗或检测癌症
公开(公告)号：WO2012082494A3
公开(公告)日：2012-12-13
申请号：PCT/US2011063761
申请日：2011-12-07
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
发明人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
IPC分类号： G01N33/574 , G01N33/53 , G01N33/68
CPC分类号： G01N33/57407 , G01N2333/7158
摘要： The use of anti-CXCL13 and anti-CXCR5 antiboies for the treatment or dectection of in a subject is disclosed.
摘要翻译：公开了用于治疗或检测受试者的抗CXCL13和抗CXCR5抗体的用途。

7. 发明申请

WO2007027540A3 DISTRIBUTED FIBER OPTIC SENSOR WITH LOCATION CAPABILITY 审中-公开
标题翻译：具有位置能力的分布式光纤传感器
公开(公告)号：WO2007027540A3
公开(公告)日：2007-07-26
申请号：PCT/US2006033363
申请日：2006-08-25
申请人： COMPUDYNE CORP , ANDERSON DUWAYNE , SINGH SHAILESH
发明人： ANDERSON DUWAYNE , SINGH SHAILESH
IPC分类号： G02B6/00
CPC分类号： G08B13/186 , G01D5/35303 , G01D5/35383 , G08B13/2497
摘要： A spatially distributed sensor system (100) has an optical transmitter (102), an optical conduit (104) optically coupled to the optical transmitter (102) at an input position, and a sensing element (106) optically coupled to the optical conduit (104) at a position along th optical conduit (104) spatially separated from the input position. The sensing element (106) is structured to split off a fraction of light from the optical transmitter (102) upon being coupled into the optical conduit (104) and to return light to the optical conduit (104) in amount responsive to an effect being sensed. The spatially distributed sensor system (100) also has an optical receiver (108) coupled t the optical conduit (104) to receive at least a portion of light from the optical conduit (104) that includes light returned to the optical conduit (104) from the sensing element (106). An analysis of light received by the optical receiver (108) provides information to determine a position of the sensing element (106).
摘要翻译：空间分布式传感器系统（100）具有光学发射器（102），在输入位置处光耦合到光发射器（102）的光学导管（104）和光学耦合到光导管（106）的感测元件（106） 104）沿着与输入位置空间分离的光导管（104）的位置。感测元件（106）被构造成在被耦合到光导管（104）中时从光发射器（102）中分离出一部分光，并且响应于效果而将光返回到光导管（104）检测。空间分布式传感器系统（100）还具有耦合到光导管（104）的光接收器（108），以接收来自光导管（104）的至少一部分光，其包括返回到光导管（104）的光，从传感元件（106）。由光接收器（108）接收的光的分析提供用于确定感测元件（106）的位置的信息。

8. 发明申请

WO2012082742A3 DETECTING CANCER WITH ANTI-CCL25 AND ANTI-CCR9 ANTIBODIES 审中-公开
标题翻译：用抗CCL25和抗CCR9抗体检测癌症
公开(公告)号：WO2012082742A3
公开(公告)日：2013-01-24
申请号：PCT/US2011064653
申请日：2011-12-13
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
发明人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
IPC分类号： G01N33/574 , G01N33/53 , G01N33/68
CPC分类号： G01N33/57496 , C07K16/24 , C07K16/2866 , C07K2317/73 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/574 , G01N33/57407 , G01N33/57426 , G01N33/5743 , G01N33/57488 , G01N33/57492 , G01N2333/521 , G01N2333/522 , G01N2333/7158 , G01N2800/52
摘要： Methods for detecting cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprise CCL25 or CCR9 or both CCL25 and CCR9.
摘要翻译：公开了用于检测受试者中癌症的方法。该方法包括检测从受试者获得的生物样品中一种或多种癌症标志物的表达水平; 以及将生物样品中的一种或多种癌症标志物的表达水平与一种或多种癌症标志物的正常表达水平进行比较。一种或多种癌症标志物包括CCL25或CCR9或CCL25和CCR9两者。

9. 发明申请

WO2007109244A3 NOVEL NANOPARTICLES FOR DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：用于交付活性剂的新型纳米颗粒
公开(公告)号：WO2007109244A3
公开(公告)日：2008-07-31
申请号：PCT/US2007006844
申请日：2007-03-20
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD JAMES W , SINGH RAJESH , SINGH SHAILESH
发明人： LILLARD JAMES W , SINGH RAJESH , SINGH SHAILESH
IPC分类号： A61K9/14 , A61K31/235 , A61K31/282 , A61K38/00 , A61K45/00 , A61K47/30 , A61K47/36 , A61K47/38
CPC分类号： A61K31/337 , A61K9/146 , A61K9/1641 , A61K9/1652 , A61K9/5031 , A61K9/5146 , A61K9/5161 , A61K33/24 , A61K38/00 , A61K47/593 , A61K47/62 , A61K47/6939
摘要： Milled nanoparticles comprising a biolgically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications
摘要翻译：包含生物活性剂，至少一种生物聚合物和含有至少一种作为聚合物或配体涂层的涂层的研磨纳米粒子是使用以前未用于这些应用的研磨和涂覆技术制备的

10. 发明申请

WO2012082470A8 THE USE ANTI-CXCL16 AND ANTI-CXCR6 ANTIBODIES FOR THE TREATMENT OR DETECTING CANCER 审中-公开
标题翻译：使用抗CXCL16和抗CXCR6抗体治疗或检测癌症
公开(公告)号：WO2012082470A8
公开(公告)日：2013-11-14
申请号：PCT/US2011063532
申请日：2011-12-06
申请人： MORE HOUSE SCHOOL OF MEDICINE , LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
发明人： LILLARD JAMES W , SINGH SHAILESH , SINGH RAJESH
IPC分类号： G01N33/574 , A61K31/7088 , A61K39/395 , A61K48/00 , A61P35/00 , G01N33/68
CPC分类号： A61K39/395 , C07K16/24 , C07K16/2866 , C07K2317/73
摘要： Methods for prevention or inhibition of the growth or metastasis of cancer cells using CXCL16 or CXCR6 or both CXCL16 and CXCR6 in a subject are disclosed. Methods for detecting cancer or monitoring cancer progression in a subject are also disclosed.
摘要翻译：公开了在受试者中使用CXCL16或CXCR6或CXCL16和CXCR6两者预防或抑制癌细胞生长或转移的方法。还公开了用于检测受试者中癌症或监测癌症进展的方法。

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