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1. 发明申请

WO2008036239A3 USE OF LXR AGONISTS FOR THE TREATMENT OF OSTEOARTHRITIS 审中-公开
公开(公告)号：WO2008036239A3
公开(公告)日：2008-03-27
申请号：PCT/US2007/020150
申请日：2007-09-18
申请人： WYETH , NAGPAL, Sunil , YANG, Zhiyong , MORRIS, Elisabeth , LAVALLIE, Edward , COLLINS-RACIE, Lisa
发明人： NAGPAL, Sunil , YANG, Zhiyong , MORRIS, Elisabeth , LAVALLIE, Edward , COLLINS-RACIE, Lisa
IPC分类号： A61K31/00 , A61K31/18 , A61K31/195 , A61K31/404 , A61K31/42 , A61K31/513 , A61K31/575 , A61K31/58 , G01N33/68 , G01N33/74 , G01N33/92
摘要： Disclosed herein is the use of LXR agonists for preventing and treating osteoarthritis as well as methods of detecting an osteoarthritic phenotype in a subject and methods of identifying an LXR ligand capable of reducing an osteoarthritic effect in cartilage.

2. 发明申请

WO2009102789A3 USE OF RXR AGONISTS FOR THE TREATMENT OF OSTEROARTHRITIS 审中-公开
公开(公告)号：WO2009102789A3
公开(公告)日：2009-08-20
申请号：PCT/US2009/033795
申请日：2009-02-11
申请人： WYETH , NAGPAL, Sunil , YANG, Zhiyong , MORRIS, Elisabeth , LAVALLIE, Edward , COLLINS-RACIE, Lisa, A.
发明人： NAGPAL, Sunil , YANG, Zhiyong , MORRIS, Elisabeth , LAVALLIE, Edward , COLLINS-RACIE, Lisa, A.
IPC分类号： A61K31/20 , A61K31/203 , A61K31/202 , A61K31/192 , A61K31/435 , A61P19/02 , G01N33/00
摘要： Disclosed herein are methods of preventing and treating osteoarthritis through the use of RXR agonists.

3. 发明申请

WO2021255509A1 A FLOATING PLATFORM WITH CANTED COLUMNS 审中-公开
公开(公告)号：WO2021255509A1
公开(公告)日：2021-12-23
申请号：PCT/IB2020/056394
申请日：2020-07-08
申请人： YANG, Zhiyong , LI, Tingting , FENG, Nan , YANG, Yumin
发明人： YANG, Zhiyong , LI, Tingting , FENG, Nan , YANG, Yumin
IPC分类号： B63B35/44 , F03D13/25 , F03D9/30
摘要： A floating platform comprises: a. at least 3 columns (23), wherein each of said at least 3 columns (23) comprises an upper end and a lower end; b. at least 3 pontoons (24), wherein each of said at least 3 pontoons (24) comprises a left end and a right end; wherein, each of said at least 3 columns (23) is connected to two adjacent columns (23) of said at least 3 columns (23) at said upper end to converge and form a surface for supporting of a topside, each of said at least 3 pontoons (24) is horizontally disposed with said left end and right end separately connected to the lower ends of two adjacent columns (23) of said at least 3 columns (23) to form a closed hull structure whereby one or more of said at least 3 columns (23) are canted or inclined inward.

4. 发明申请

WO2008011766A1 PRECISE POSITIONING SYSTEM FOR DUAL STAGE SWITCHING EXPOSURE 审中-公开
标题翻译：精密定位系统，用于双级开关接触
公开(公告)号：WO2008011766A1
公开(公告)日：2008-01-31
申请号：PCT/CN2006/003126
申请日：2006-11-20
申请人： SHANGHAI MICRO ELECTRONICS EQUIPMENT CO., LTD. , LI, Yingsheng , LI, Xiaoping , YANG, Zhiyong , GUAN, Jun , GAO, Shaowen , SUN, Wenfeng , LI, Gang , CAI, Yanmin
发明人： LI, Yingsheng , LI, Xiaoping , YANG, Zhiyong , GUAN, Jun , GAO, Shaowen , SUN, Wenfeng , LI, Gang , CAI, Yanmin
IPC分类号： G03F7/20 , H01L21/027
CPC分类号： G03F7/70733
摘要： A precise positioning system for dual stage switching exposure comprises at least a base, a first wafer stage positioning unit disposed on the base for a pre-processing workstation, and a second wafer stage positioning unit for an exposure workstation. Each of the wafer stage positioning units comprises at least a wafer stage, a motion positioning detector, an X-direction guide bar, and a Y-direction guide bar. The pre-processing workstation and the exposure workstation of the system both have two X-direction guide bars positioned on and movable along the Y-direction guide bars. The X-direction guide bars of adjacent workstations can be connected each other.
摘要翻译：用于双级切换曝光的精确定位系统包括至少一个基座，设置在用于预处理工作站的基座上的第一晶片台定位单元和用于曝光工作站的第二晶片台定位单元。每个晶片台定位单元至少包括晶片台，运动定位检测器，X方向导向杆和Y方向导向杆。系统的预处理工作站和曝光工作站都具有位于Y方向导杆上并可沿Y方向导杆移动的两个X方向导杆。相邻工作站的X方向导杆可以互相连接。

5. 发明申请

WO2011119777A2 COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASE 审中-公开
标题翻译：用于治疗神经病变疾病的组合物和方法
公开(公告)号：WO2011119777A2
公开(公告)日：2011-09-29
申请号：PCT/US2011/029689
申请日：2011-03-23
申请人： THE JOHNS HOPKINS UNIVERSITY , THE SCRIPPS RESEARCH INSTITUTE , ZACK, Donald, Jeffrey , BANNISTER, Thomas , VOJKOVSKY, Tomas , YANG, Zhiyong , BERLINICKE, Cynthia
发明人： ZACK, Donald, Jeffrey , BANNISTER, Thomas , VOJKOVSKY, Tomas , YANG, Zhiyong , BERLINICKE, Cynthia
IPC分类号： C07D403/06 , C07D403/14 , A61K31/404 , A61P25/28
CPC分类号： A61K31/404 , A61K31/439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D209/34 , C07D403/06 , C07D403/14 , C07D453/02 , C07D495/04 , A61K2300/00
摘要： Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
摘要翻译：公开了用于治疗与神经变性或眼部疾病相关的病症的化合物，组合物，试剂盒和方法。

6. 发明申请

WO2010017541A3 COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASE 审中-公开
公开(公告)号：WO2010017541A3
公开(公告)日：2010-02-11
申请号：PCT/US2009/053241
申请日：2009-08-08
申请人： THE JOHNS HOPKINS UNIVERSITY , ZACK, Donald, J. , YANG, Zhiyong , BERLINICKE, Cynthia , QUIGLEY, Harry
发明人： ZACK, Donald, J. , YANG, Zhiyong , BERLINICKE, Cynthia , QUIGLEY, Harry
IPC分类号： A61K31/404 , A61P27/06 , A61P25/28
摘要： Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.

7. 发明申请

WO2020247500A1 HUMANIZED TETRA-SPECIFIC OCTAVALENT ANTIBODY AGAINST CLOSTRIDIUM DIFFICILE TOXIN A AND B 审中-公开
公开(公告)号：WO2020247500A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/035925
申请日：2020-06-03
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , FZATA, INC. , FENG, Hanping , ZHANG, Yongrong , YANG, Zhiyong , YU, Hua , ZHANG, Yinfan
发明人： FENG, Hanping , ZHANG, Yongrong , YANG, Zhiyong , YU, Hua , ZHANG, Yinfan
IPC分类号： A61K39/08 , A61K39/40 , C07K14/33 , C07K16/12 , C07K16/46 , C07K19/00
摘要： Novel, antibody-based binding agents derived from camelid V H H and human immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include humanized V H H peptide monomers, linked groups of humanized V H H peptide monomers, humanized V H H peptide monomers joined to antibody Fc domains, and humanized V H H peptide monomers joined to IgG antibodies.

8. 发明申请

WO2016127104A2 TETRA-SPECIFIC, OCTAMERIC BINDING AGENTS AND ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXIN A AND TOXIN B FOR TREATMENT OF C. DIFFICILE INFECTION 审中-公开
标题翻译： TETRA特异性，OCTAMERIC结合剂和针对治疗C感染的角叉菜胶毒素A和毒素B的抗体
公开(公告)号：WO2016127104A2
公开(公告)日：2016-08-11
申请号：PCT/US2016/016852
申请日：2016-02-05
申请人： FENG, Hanping , GUAN, Yongjun , ZHANG, Yongrong , YANG, Zhiyong , SHI, Lianfa , UNIVERSITY OF MARYLAND, BALTIMORE
发明人： FENG, Hanping , GUAN, Yongjun , ZHANG, Yongrong , YANG, Zhiyong , SHI, Lianfa
IPC分类号： A61K39/40 , C07K16/12
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/30 , C07K2317/35 , C07K2317/52 , C07K2317/569 , C07K2317/60 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： Novel, antibody-based binding agents derived from human and camelid immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include camelid V H H peptide monomers, linked groups of V H H peptide monomers, V H H peptide monomers joined to antibody Fc domains, and V H H peptide monomers joined to IgG antibodies.
摘要翻译：描述了衍生自人和骆驼类免疫球蛋白的新型基于抗体的结合剂。这些结合剂识别并且对艰难梭菌毒素A和/或毒素B具有特异性并且在一些情况下表现出毒素中和活性。这些结合剂可用于治疗或预防原发性和复发性CDI。结合剂包括骆驼VHH肽单体，VHH肽单体的连接基团，连接到抗体Fc结构域的VHH肽单体，以及与IgG抗体连接的VHH肽单体。

9. 发明申请

WO2012112674A3 COMPOUNDS AND METHODS OF USE THEREOF FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开
公开(公告)号：WO2012112674A3
公开(公告)日：2012-08-23
申请号：PCT/US2012/025228
申请日：2012-02-15
申请人： THE JOHNS HOPKINS UNIVERSITY , ZACK, Donald J. , BERLINICKE, Cynthia , HACKLER, Laszlo , YANG, Zhiyong , STEINER, Joseph P. , VOJKOVSKY, Tomas , FERRARIS, Dana , SLUSHER, Barbara S. , INGLESE, James
发明人： ZACK, Donald J. , BERLINICKE, Cynthia , HACKLER, Laszlo , YANG, Zhiyong , STEINER, Joseph P. , VOJKOVSKY, Tomas , FERRARIS, Dana , SLUSHER, Barbara S. , INGLESE, James
IPC分类号： C07D403/12 , C07D403/14 , A61K31/506 , A61P25/00
摘要： Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.

10. 发明申请

WO2007147304A1 IMMERSION FLOW FIELD MAINTENANCE SYSTEM FOR IMMERSION LITHOGRAPHY MACHINE 审中-公开
标题翻译：灌注流平面机维护流场维护系统
公开(公告)号：WO2007147304A1
公开(公告)日：2007-12-27
申请号：PCT/CN2006/003592
申请日：2006-12-25
申请人： SHANGHAI MICRO ELECTRONICS EQUIPMENT CO., LTD. , YANG, Zhiyong
发明人： YANG, Zhiyong
IPC分类号： G03F7/20 , H01L21/027
CPC分类号： G03F7/70341 , G03F7/70733
摘要： An immersion flow field maintenance system is used in an immersion lithography machine which includes a projection objective lens, at least a wafer stage for supporting a wafer, and an immersion supplying system distributed around the projection objective lens for producing an immersion flow field under the projection objective lens. The immersion flow field maintenance system includes a horizontal guideway, a flat board connected with the horizontal guideway through the cantilever, and plural drivers for driving the flat board to move. When the wafer is unloaded and the wafer stage is moved out of the exposure area under the projection objective lens, the flat board connects to and moves synchronously with the wafer stage to transfer the immersion flow field from above the wafer stage to above the flat board. When the wafer is loaded and the wafer stage is moved into the exposure area, the flat board connects to and moves synchronously with the wafer stage to transfer the immersion flow field from above the flat board to above the wafer stage.
摘要翻译：浸没式流场维护系统用于浸没式光刻机中，浸没式光刻机包括投影物镜，至少用于支撑晶片的晶片台和分布在投影物镜周围的浸没供应系统，用于在投影下产生浸没流场物镜。浸没流场维护系统包括水平导轨，通过悬臂与水平导轨连接的平板以及用于驱动平板移动的多个驱动器。当晶片卸载并且晶片台从投影物镜下方的曝光区域移出时，平板与晶片台连接并与晶片台同步移动，以将浸没流场从晶片台上方传递到平板上方。当晶片被加载并且晶片台移动到曝光区域中时，平板与晶片台连接并与晶片台同步地移动，以将浸没流场从平板上方转移到晶片台上方。

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