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1. 发明申请

WO2005111246A1 OLIGONUCLEOTIDE ARRAYS TO MONITOR GENE EXPRESSION AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：寡核苷酸阵列监测基因表达及其制备和使用方法
公开(公告)号：WO2005111246A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/016880
申请日：2005-05-11
申请人： WYETH , MELVILLE, Mark, W. , CHARLEBOIS, Timothy, S. , MOUNTS, William, M. , HANN, Louane, E. , SINACORE, Martin, S. , LEONARD, Mark, W. , BROWN, Eugene, L. , MILLER, Christopher, P. , LEE, Gene, W.
发明人： MELVILLE, Mark, W. , CHARLEBOIS, Timothy, S. , MOUNTS, William, M. , HANN, Louane, E. , SINACORE, Martin, S. , LEONARD, Mark, W. , BROWN, Eugene, L. , MILLER, Christopher, P. , LEE, Gene, W.
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention.
摘要翻译：本发明提供了能够鉴定涉及通过细胞系诱导特定表型的基因和相关途径的寡核苷酸阵列，例如涉及通过细胞系诱导转基因表达的基因和相关途径。当关于正在研究的细胞系的基因组的信息很少或没有信息时，本发明是特别有用的，因为它提供了用于鉴定已知和先前未被发现的基因的共有序列的方法，以及为所识别的共有序列设计寡核苷酸探针。另外，当该阵列用于确定由细胞系表达转基因的最佳条件时，本发明教导了将寡核苷酸探针包括在阵列中的转基因序列的方法。本发明还提供了使用该阵列鉴定涉及诱导特定细胞系表型的基因和相关途径的方法。本发明还提供未被发现的基因的新型多核苷酸（即，未被测序和/或显示由CHO细胞表达的基因）和参与诱导特定细胞表型的新型多核苷酸，例如当在下面生长时增加的存活压力培养条件，转基因表达增加，抗原产生减少等。这些新型多核苷酸分别被称为新的CHO序列和差异CHO序列。本发明还提供基因工程表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。本发明还向本发明的核酸分子提供反义和RNAi分子。本发明还提供使用本发明的多核苷酸的方法。

2. 发明申请

WO2006014755A3 METHODS OF IDENTIFYING PATIENTS AT RISK OF DEVELOPING ENCEPHALITIS FOLLOWING IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE 审中-公开
公开(公告)号：WO2006014755A3
公开(公告)日：2006-02-09
申请号：PCT/US2005/025771
申请日：2005-07-20
申请人： WYETH , O'TOOLE, Margot , DORNER, Andrew, J. , JANSZEN, Derek, B. , SLONIM, Donna, K. , MOUNTS, William, M. , REDDY, Padmalatha, S. , HILL, Andrew, A.
发明人： O'TOOLE, Margot , DORNER, Andrew, J. , JANSZEN, Derek, B. , SLONIM, Donna, K. , MOUNTS, William, M. , REDDY, Padmalatha, S. , HILL, Andrew, A.
IPC分类号： G01N33/50 , G01N33/68
摘要： The present invention generally relates to a method for an improved treatment for Alzheimer’s disease (AD) using immunotherapy, e.g., immunotherapy targeting β amyloid (Aβ), e.g. immunotherapy based on AN1792. In one embodiment, the method allows for predicting an adverse clinical response, and therefore allows for an improved safety profile of AN1792. In another embodiment, the method allows for predicting a favorable clinical response, and therefore allows for an improved efficacy profile of AN1792. The methods of the present invention may be combined to predict a favorable clinical response and the lack of an adverse clinical response.

3. 发明申请

WO2005116265A3 PROBE ARRAYS FOR EXPRESSION PROFILING OF RAT GENES 审中-公开
公开(公告)号：WO2005116265A3
公开(公告)日：2005-12-08
申请号：PCT/US2005/018251
申请日：2005-05-25
申请人： WYETH , MOUNTS, William, M.
发明人： MOUNTS, William, M.
IPC分类号： C12Q1/68
摘要： The present invention provides probe arrays for expression profiling of rat genes. Each probe array comprises a plurality of probes, each of which is directed to a rat gene that encodes a sequence selected from SEQ ID NOs: 1 - 8,192. Suitable probes for the present invention include polynucleotides that can hybridize under stringent or nucleic acid array hybridization conditions to the RNA transcripts, or the complements thereof, of the corresponding rat genes. Suitable probes also include antibodies or other protein-binding molecules that can bind to the protein products of the corresponding rat genes. In one embodiment, a probe array of the present invention includes one or more probes, each of which is directed to a rat gene that encodes a sequence selected from SEQ ID NOs: 7622 and 8084 - 8124.

4. 发明申请

WO2004048521A2 COMPOSITION AND METHOD FOR TREATING LUPUS NEPHRITIS 审中-公开
标题翻译：用于治疗红斑狼疮的组合物和方法
公开(公告)号：WO2004048521A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/037339
申请日：2003-11-21
申请人： WYETH , O'TOOLE, Margot , MOUNTS, William, M. , SHOJAEE, Negin
发明人： O'TOOLE, Margot , MOUNTS, William, M. , SHOJAEE, Negin
IPC分类号： C12N
CPC分类号： C07K14/4713
摘要： The present invention provides novel isolated BFLP0169 polynucleotides and polypeptides encoded by the BFLP0169 polynucleotides. Also provided are the antibodies that immunospecifically bind to a BFLP0 169 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the BFLP0169 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the BFLP0169 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译：本发明提供新的分离的BFLP0169多核苷酸和由BFLP0169多核苷酸编码的多肽。还提供了免疫特异性结合BFLP0 169多肽或BFLP0169多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段的抗体。本发明还提供了BFLP0169多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

5. 发明申请

WO2006025879A2 NOVEL POLYNUCLEOTIDES RELATED TO OLIGONUCLEOTIDE ARRAYS TO MONITOR GENE EXPRESSION 审中-公开
标题翻译：与寡核苷酸阵列相关的新型多核苷酸监测基因表达
公开(公告)号：WO2006025879A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/016425
申请日：2005-05-11
申请人： WYETH , MELVILLE, Mark, W. , CHARLEBOIS, Timothy, S. , MOUNTS, William, M. , HANN, Louane, E. , SINACORE, Martin, S. , LEONARD, Mark, W. , BROWN, Eugene, L. , MILLER, Christopher, P. , LEE, Gene, W.
发明人： MELVILLE, Mark, W. , CHARLEBOIS, Timothy, S. , MOUNTS, William, M. , HANN, Louane, E. , SINACORE, Martin, S. , LEONARD, Mark, W. , BROWN, Eugene, L. , MILLER, Christopher, P. , LEE, Gene, W.
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is a little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention.
摘要翻译：本发明提供了能够鉴定涉及通过细胞系诱导特定表型的基因和相关途径的寡核苷酸阵列，例如涉及通过细胞系诱导转基因表达的基因和相关途径。当有关于正在研究的细胞系的基因组的信息很少或没有信息时，本发明是特别有用的，因为它提供了用于鉴定已知和先前未被发现的基因的共有序列的方法，以及为所识别的共有序列设计寡核苷酸探针。另外，当该阵列用于确定由细胞系表达转基因的最佳条件时，本发明教导了将寡核苷酸探针包括在阵列中的转基因序列的方法。本发明还提供了使用该阵列鉴定涉及诱导特定细胞系表型的基因和相关途径的方法。本发明还提供未被发现的基因（即，未被测序和/或显示由CHO细胞表达的基因）的新型多核苷酸以及参与特定细胞表型诱导的新型多核苷酸，例如当在下压力培养条件，转基因表达增加，抗原产生减少等。这些新型多核苷酸分别被称为新的CHO序列和差异CHO序列。本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。本发明还向本发明的核酸分子提供反义和RNAi分子。本发明还提供使用本发明的多核苷酸的方法。

6. 发明申请

WO2004047740A2 COMPOSITION AND METHOD FOR TREATING LUPUS NEPHRITIS 审中-公开
标题翻译：用于治疗红斑狼疮的组合物和方法
公开(公告)号：WO2004047740A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/037317
申请日：2003-11-21
申请人： WYETH , O'TOOLE, Margot , MOUNTS, William, M. , SHOJAEE, Negin
发明人： O'TOOLE, Margot , MOUNTS, William, M. , SHOJAEE, Negin
IPC分类号： A61K
CPC分类号： C07K14/705
摘要： The present invention provides novel isolated BFLP1698 polynucleotides and polypeptides encoded by the BFLP1698 polynucleotides. Also provided are the antibodies that immunospecifically bind to a BFLP1698 polypeptide or any derivative (including fusion derivative), variant, mutant, or fragment of the BFLP1698 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the BFLP1968 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译：本发明提供新的分离的BFLP1698多核苷酸和由BFLP1698多核苷酸编码的多肽。还提供了免疫特异性结合BFLP1698多肽或BFLP1698多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段的抗体。本发明另外提供了BFLP1968多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

7. 发明公开

EP1563056A2 COMPOSITION AND METHOD FOR TREATING LUPUS NEPHRITIS 审中-公开
标题翻译：治疗狼疮性肾炎的组合物和方法
公开(公告)号：EP1563056A2
公开(公告)日：2005-08-17
申请号：EP03786989.8
申请日：2003-11-21
申请人： Wyeth
发明人： O'TOOLE, Margot , MOUNTS, William, M. , SHOJAEE, Negin
IPC分类号： C12N1/19 , C12N1/21 , C12N15/11 , C12N15/85 , C12N15/86 , C07K5/00 , C07K14/00 , C07H21/04
CPC分类号： C07K14/705
摘要： The present invention provides novel isolated BFLP1698 polynucleotides and polypeptides encoded by the BFLP1698 polynucleotides. Also provided are the antibodies that immunospecifically bind to a BFLP1698 polypeptide or any derivative (including fusion derivative), variant, mutant, or fragment of the BFLP1698 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the BFLP1968 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译：本发明提供了由BFLP1698多核苷酸编码的新的分离的BFLP1698多核苷酸和多肽。还提供了免疫特异性结合BFLP1698多肽或BFLP1698多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段的抗体。本发明另外提供了其中BFLP1968多肽，多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及用于其它用途的方法。

8. 发明公开

EP1784509A2 METHODS OF IDENTIFYING PATIENTS AT RISK OF DEVELOPING ENCEPHALITIS FOLLOWING IMMUNOTHERAPY FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译：方法患者的风险后免疫治疗抗阿尔茨海默氏病脑炎开发鉴定
公开(公告)号：EP1784509A2
公开(公告)日：2007-05-16
申请号：EP05795582.5
申请日：2005-07-20
申请人： Wyeth , Neuralab, Ltd.
发明人： O'TOOLE, Margot , DORNER, Andrew, J. , JANSZEN, Derek, B. , SLONIM, Donna, K. , MOUNTS, William, M. , REDDY, Padmalatha, S. , HILL, Andrew, A.
IPC分类号： C12Q1/68
CPC分类号： G01N33/5023 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/5008 , G01N33/5044 , G01N33/6896 , G06F19/00 , G06F19/20 , G06F19/24 , G06F19/28 , G06Q50/24 , Y02A90/22 , Y02A90/26
摘要： The present invention generally relates to a method for an improved treatment for Alzheimer's disease (AD) using immunotherapy, e.g., immunotherapy targeting beta amyloid (Abeta), e.g., immunotherapy based on AN1792. In one embodiment, the method allows for predicting an adverse clinical response, and therefore allows for an improved safety profile of AN1792. In another embodiment, the method allows for predicting a favorable clinical response, and therefore allows for an improved efficacy profile of AN1792. The methods of the present invention may be combined to predict a favorable clinical response and the lack of an adverse clinical response.

9. 发明公开

EP1747294A2 NOVEL POLYNUCLEOTIDES RELATED TO OLIGONUCLEOTIDE ARRAYS TO MONITOR GENE EXPRESSION 审中-公开
标题翻译：与寡核苷酸阵列用于监测基因表达的新的相关的多核苷酸
公开(公告)号：EP1747294A2
公开(公告)日：2007-01-31
申请号：EP05812713.5
申请日：2005-05-11
申请人： Wyeth
发明人： MELVILLE, Mark, W. , CHARLEBOIS, Timothy, S. , MOUNTS, William, M. , HANN, Louane, E. , SINACORE, Martin, S. , LEONARD, Mark, W. , BROWN, Eugene, L. , MILLER, Christopher, P. , LEE, Gene, W.
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is a little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention.

10. 发明公开

EP1747289A1 OLIGONUCLEOTIDE ARRAYS TO MONITOR GENE EXPRESSION AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：为了确定基因表达寡核苷酸阵列以及生产这种阵列的方法
公开(公告)号：EP1747289A1
公开(公告)日：2007-01-31
申请号：EP05757217.4
申请日：2005-05-11
申请人： Wyeth
发明人： MELVILLE, Mark, W. , CHARLEBOIS, Timothy, S. , MOUNTS, William, M. , HANN, Louane, E. , SINACORE, Martin, S. , LEONARD, Mark, W. , BROWN, Eugene, L. , MILLER, Christopher, P. , LEE, Gene, W.
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention.

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