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1. 发明申请

WO2009036241A1 LIVE ATTENUATED MYCOPLASMA STRAINS 审中-公开
标题翻译：活跃的MYCOPLASMA菌株
公开(公告)号：WO2009036241A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076119
申请日：2008-09-12
申请人： WYETH , KUMAR, Mahesh , KHAN, Muhammad Ayub
发明人： KUMAR, Mahesh , KHAN, Muhammad Ayub
IPC分类号： A61K39/02 , C12Q1/68 , G01N33/569
CPC分类号： A61K39/0241 , A61K2039/522 , G01N33/56933 , G01N33/6803 , G01N2333/30
摘要： The present invention provides live, attenuated Mycoplasma bacteria that exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type Mycoplasma bacterium of the same species. Also provided are vaccines and vaccination methods involving the use of the live, attenuated Mycoplasma bacteria, and methods for making live attenuated Mycoplasma bacteria.
摘要翻译：本发明提供了活的减毒支原体细菌，相对于野生型，表现出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质的表达相同物种的支原体细菌还提供了涉及使用活的，减毒的支原体细菌的疫苗和疫苗接种方法，以及用于制造活的减毒支原体细菌的方法。

2. 发明申请

WO2009035644A1 ATTENUATED MYCOPLASMA GALLISEPTICUM STRAINS 审中-公开
标题翻译：衰老的MYCOPLASMA GALLISEPTICUM菌株
公开(公告)号：WO2009035644A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/010630
申请日：2008-09-10
申请人： WYETH , KUMAR, Mahesh , KHAN, Muhammad, Ayub
发明人： KUMAR, Mahesh , KHAN, Muhammad, Ayub
IPC分类号： A61K39/02 , C12N1/36 , C12R1/35
CPC分类号： C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12R1/35
摘要： The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.
摘要翻译：本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。在某些实施方案中，相对于野生型M，减毒细菌可另外显示出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质的表达降低胆汁败霉菌还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的在鸡中

3. 发明申请

WO2008118902A1 VACCINATION AGAINST MULTIPLE SEROTYPES OF PASTEURELLA MULTOCIDA 审中-公开
标题翻译：针对多发性葡萄球菌的多个菌株进行疫苗接种
公开(公告)号：WO2008118902A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/058109
申请日：2008-03-25
申请人： WYETH , KUMAR, Mahesh , ANSCHUTZ, Christine , TIAN, Jean Q.
发明人： KUMAR, Mahesh , ANSCHUTZ, Christine , TIAN, Jean Q.
IPC分类号： A61K39/102
CPC分类号： A61K39/102 , A61K2039/522 , A61K2039/542 , A61K2039/545 , A61K2039/552
摘要： The present invention provides methods for inducing cross-protective immunity against virulent strains of P. multocida in animals such as cattle and poultry. The methods of the invention include administering to an animal a mutant P. multocida strain, whereby the mutant P. multocida strain induces cross-protective immunity against one or more virulent P. multocida strains having serotypes that are different from the serotype of the mutant P. multocida strain. The mutant P. multocida strain will preferably contain one or more mutations that cause the cells to be acapsular and/or attenuated. Exemplary mutations include, e.g., mutations that impair the expression of one or more genes in the P. multocida capsule biosynthetic operon (e.g., phyB, phyA, hyaE, hyaD, hyaC, hyaB, hexD, hexC, hexB, and/or hexA).
摘要翻译：本发明提供了在动物如牛和家禽中诱导针对多杀巴斯德氏体毒性毒株的交叉保护性免疫的方法。本发明的方法包括对动物施用突变体多杀巴斯氏杆菌菌株，其中突变体多杀巴斯德氏杆菌菌株对具有不同于突变体P的血清型的血清型的一种或多种毒力多杀巴氏杆菌菌株诱导交叉保护性免疫多毛菌株。突变体多杀巴斯德氏菌菌株将优选含有一种或多种导致细胞被囊泡和/或减毒的突变。示例性的突变包括例如损害多球梭菌（Multocida）胶囊生物合成操纵子中一个或多个基因表达的突变（例如phyB，phyA，hyaE，hyaD，hyaC，hyaB，hexD，hexC，hexB和/或hexA）。

4. 发明申请

WO2008157659A1 EMULSION VACCINE COMPOSITIONS COMPRISING ANTIGEN AND ADJUVANT IN THE AQUEOUS PHASE 审中-公开
标题翻译：包含抗原和补体在乳酸阶段的乳化剂组合物
公开(公告)号：WO2008157659A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/067433
申请日：2008-06-19
申请人： WYETH , LUTZ, David Leon , RODENBERG, Jeffrey Harold , DIEHL, Evan James , KUMAR, Mahesh
发明人： LUTZ, David Leon , RODENBERG, Jeffrey Harold , DIEHL, Evan James , KUMAR, Mahesh
IPC分类号： A61K39/00 , A61K39/145
CPC分类号： A61K39/145 , A61K9/107 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , C12N7/00 , C12N2760/16134 , C12N2760/16171
摘要： Emulsion vaccine formulations containing an antigen and an adjuvant in the aqueous phase are used for the vaccination of animals wherein the adjuvant is an acrylic polymer and/or dimethyl dioctadecyl ammonium bromide (DDA). These formulations can be prepared by mixing an aqueous phase containing the antigen and adjuvant with an oil phase in the presence of an emulsifier.
摘要翻译：在水相中含有抗原和佐剂的乳剂疫苗制剂用于疫苗接种动物，其中佐剂是丙烯酸聚合物和/或二甲基双十八烷基溴化铵（DDA）。这些制剂可以通过在乳化剂存在下将含有抗原和佐剂的水相与油相混合来制备。

5. 发明申请

WO2007019128A1 STABILIZERS FOR VETERINARY VACCINES 审中-公开
标题翻译：维生素V的稳定剂
公开(公告)号：WO2007019128A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/029849
申请日：2006-07-31
申请人： WYETH , KUMAR, Mahesh , RODENBERG, Jeff, H. , HANSEN, Jason, M. , CHU, Andrew, D.
发明人： KUMAR, Mahesh , RODENBERG, Jeff, H. , HANSEN, Jason, M. , CHU, Andrew, D.
IPC分类号： A61K47/18 , A61K47/42
CPC分类号： A61K9/19 , A61K9/0019 , A61K39/12 , A61K39/125 , A61K39/15 , A61K39/17 , A61K39/215 , A61K39/245 , A61K39/275 , A61K47/183 , A61K47/42 , A61K47/46 , A61K2039/5254 , A61K2039/552 , A61K2039/55516 , A61K2039/70 , C12N7/00 , C12N2710/16034 , C12N2710/24034 , C12N2720/10034 , C12N2720/12034 , C12N2760/18134 , C12N2770/20034 , C12N2770/32434
摘要： A formulation for a animal vaccines is provided. The vaccine formulation contains a stabilizer component and a viral immunogen. The stabilizer component includes a substantially TSE/BSE-safe animal-based protein and a vegetable-based protein. The stabilizer component provides for the stabilization of a vaccine throughout its storage and administration.
摘要翻译：提供动物疫苗的制剂。疫苗制剂含有稳定剂组分和病毒免疫原。稳定剂组分包括基本上基于TSE / BSE的基于动物的蛋白质和基于植物的蛋白质。稳定剂组分提供疫苗在整个储存和给药过程中的稳定化。

6. 发明申请

WO2008115785A2 MULTIVALENT AVIAN INFLUENZA VACCINES AND METHODS 审中-公开
标题翻译：多发性流行性感冒疫苗和方法
公开(公告)号：WO2008115785A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/056982
申请日：2008-03-14
申请人： WYETH , PLANA DURAN, Joan , KUMAR, Mahesh
发明人： PLANA DURAN, Joan , KUMAR, Mahesh
IPC分类号： A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/55566 , A61K2039/70 , C12N2760/16134
摘要： The present invention provides vaccine compositions comprising at least two strains of avian influenza virus, wherein one of the strains has an H5 hemagglutinin subtype and the other strain has an H7 hemagglutinin subtype, and wherein at least one of the strains has an N4 neuraminidase subtype and neither strain has an N1 subtype. Also provided are vaccination methods that utilize the novel vaccine compositions of the invention. The compositions and methods of the present invention provide protection against infection with H5 and H7 influenza strains (e.g., H5N1 and H7N1) while at the same time facilitating the distinction between infected and vaccinated animals.
摘要翻译：本发明提供了包含至少两种禽流感病毒菌株的疫苗组合物，其中一种菌株具有H5血凝素亚型，另一种菌株具有H7血凝素亚型，并且其中至少一种菌株具有N4神经氨酸酶亚型和两个菌株都没有N1亚型。还提供了利用本发明的新型疫苗组合物的疫苗接种方法。本发明的组合物和方法提供了针对H5和H7流感病毒株（例如H5N1和H7N1）感染的保护，同时有利于感染和接种疫苗的动物之间的区别。

7. 发明申请

WO2007124479A2 AVIAN INFLUENZA VIRUSES, VACCINES, COMPOSITIONS, FORMULATIONS, AND METHODS 审中-公开
标题翻译：禽流感病毒，疫苗，组合物，制剂和方法
公开(公告)号：WO2007124479A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/067205
申请日：2007-04-23
申请人： WYETH , ST. JUDE CHILDREN'S RESEARCH HOSPITAL , KRAUSS, Scott, L. , WEBBY, Richard, J. , HOFFMANN, Erich , WEBSTER, Robert, G. , KUMAR, Mahesh
发明人： KRAUSS, Scott, L. , WEBBY, Richard, J. , HOFFMANN, Erich , WEBSTER, Robert, G. , KUMAR, Mahesh
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K35/12 , A61K39/12 , A61K39/39 , A61K49/0004 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N2760/16134
摘要： A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined hemagglutinin (HA) total is at least about 200 HA/dose of the vaccine composition, and wherein each of the strains presents at least about 128 HA/dose, and further wherein one of the strains has the same HA subtype as that of a challenge virus, and wherein at least one of the strains has a different NA subtype than the challenge virus.
摘要翻译：本文阐述了有效预防或改善禽流感病毒感染的疫苗组合物和方法。疫苗含有至少两种灭活的禽流感病毒株，其中组合的血凝素（HA）总量为至少约200HA /剂量的疫苗组合物，并且其中每种毒株呈现至少约128HA /剂量，和进一步其中一种菌株具有与攻击病毒相同的HA亚型，并且其中至少一种菌株具有与攻击病毒不同的NA亚型。

8. 发明申请

WO2004103402A1 AVIAN E. COLI VACCINE FOR THE PROTECTION AGAINST COLIBACILLOSIS 审中-公开
标题翻译： AVIAN E. COLI疫苗用于防止结肠炎
公开(公告)号：WO2004103402A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/014835
申请日：2004-05-12
申请人： WYETH , FAN, Henry, H. , KUMAR, Mahesh , LA RAGIONE, Roberto, Marcello , WOODWARD, Martin, John
发明人： FAN, Henry, H. , KUMAR, Mahesh , LA RAGIONE, Roberto, Marcello , WOODWARD, Martin, John
IPC分类号： A61K39/108
CPC分类号： A61K39/0258 , A61K2039/522 , A61K2039/55 , A61K2039/552 , Y02A50/474
摘要： A genetic deletion mutant live E. coli vaccine suitable for mass application to poultry, including chickens, is provided. Also provided is a safe and effective method to protect poultry against the ravages of Escherichia coli bacillosis infection and disease in which a live mutant aroA- gene deleted E. coli immunogen is administered to chickens, turkeys and the like via mass application routes such as coarse sprays and drinking water.
摘要翻译：提供了适合大规模应用于家禽，包括鸡的遗传缺失突变型活大肠杆菌疫苗。还提供了一种安全有效的方法来保护家禽免受大肠杆菌杆菌感染和其中活的突变体aroA-基因缺失的大肠杆菌免疫原通过大量施用途径（例如粗的）施用于鸡，火鸡等的疾病喷水和饮用水。

9. 发明申请

WO2004103401A3 AVIAN COMBINATION-VACCINE AGAINST E.COLI AND SALMONELLA 审中-公开
公开(公告)号：WO2004103401A3
公开(公告)日：2004-12-02
申请号：PCT/US2004/014836
申请日：2004-05-12
申请人： WYETH , FAN, Henry, H. , KUMAR, Mahesh
发明人： FAN, Henry, H. , KUMAR, Mahesh
IPC分类号： A61K39/112
摘要： There is provided a vaccine composition comprising a combination of a genetic deletion mutant S. typhimurium microorganism and a genetic deletion mutant E. coli microorganism, suitable for mass application to poultry. Also provided is a safe and effective method to protect poultry against the ravages of E coli and Salmonella infection and disease.

10. 发明申请

WO2009099869A3 SWINE VACCINATION SYSTEM 审中-公开
公开(公告)号：WO2009099869A3
公开(公告)日：2009-08-13
申请号：PCT/US2009/032363
申请日：2009-01-29
申请人： WYETH LLC , KUMAR, Mahesh
发明人： KUMAR, Mahesh
IPC分类号： A61D7/00
摘要： A system for vaccinating swine according to one embodiment includes a housing having an open first end and an open opposite second end. The housing has a pair of side walls that are angled and non-parallel to one another such that at the second end only a single piglet can exit at one time. The system also includes a vaccination station for individually vaccinating piglets. The vaccination station is located between the pair of side walls in a region thereof that is sized to only permit one piglet to stand between the side walls. The vaccination station includes at least one sensor that detects the presence of the one piglet within the vaccination station and at least one spray nozzle positioned within the vaccination station such that a vaccine dose discharged therefrom is directed upwardly into facial areas of the piglet effectively.

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