专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008150848A1 ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS 审中-公开
标题翻译：杂交聚苯乙烯的抗逆异构体衍生物
公开(公告)号：WO2008150848A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065058
申请日：2008-05-29
申请人： WYETH , FAILLI, Amedeo, A. , EVRARD, Deborah , LI, Yanfang , HATZENBUHLER, Nicole, T. , MOGISH, Juliann , GUNAWAN, Iwan, S. , NIKITENKO, Antonina , ZHOU, Ping
发明人： FAILLI, Amedeo, A. , EVRARD, Deborah , LI, Yanfang , HATZENBUHLER, Nicole, T. , MOGISH, Juliann , GUNAWAN, Iwan, S. , NIKITENKO, Antonina , ZHOU, Ping
IPC分类号： C07D491/04 , A61K31/36 , A61P25/00
CPC分类号： C07D491/12
摘要： The invention provides compounds of the Formula: (I) that are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre- menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses. The compounds are able to block the recptake of serotonin and are modulators at brain 5HT 1A serotonin receptors.
摘要翻译：本发明提供了可用于治疗抑郁症（包括但不限于重度抑郁障碍，儿童抑郁症和心境恶化），焦虑症，恐慌症，创伤后应激障碍，经前焦虑障碍（I）的化合物（I）也称为月经前综合征），注意力缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症，神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。这些化合物能够阻断5-羟色胺的摄入，并且是脑5HT1A 5-羟色胺受体的调节剂。

2. 发明申请

WO2006089053A2 CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES 审中-公开
标题翻译：环丙基吲哚，苯并苯，苯并呋喃和茚三酮衍生物
公开(公告)号：WO2006089053A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005521
申请日：2006-02-16
申请人： WYETH , SABB, Annmarie, Louise , VOGEL, Robert, Lewis , STACK, Gary, Paul , EVRARD, Deborah, Ann , FAILLI, Amedeo, Arturo , KRISHNAN, Lalitha , CHAN, Anita Wai-Yin , REN, Jianxin , GUINOSSO, Charles , BAUDY, Reinhardt, Bernahrd , SZE, Jean Yi-ching , LI, Yanfang , STANTON, Charles, John, III , NIKITENKO, Antonia
发明人： SABB, Annmarie, Louise , VOGEL, Robert, Lewis , STACK, Gary, Paul , EVRARD, Deborah, Ann , FAILLI, Amedeo, Arturo , KRISHNAN, Lalitha , CHAN, Anita Wai-Yin , REN, Jianxin , GUINOSSO, Charles , BAUDY, Reinhardt, Bernahrd , SZE, Jean Yi-ching , LI, Yanfang , STANTON, Charles, John, III , NIKITENKO, Antonia
IPC分类号： C07D493/04 , C07D233/76 , C07D209/88 , A61K31/4741 , A61K31/381 , A61K31/407 , A61P25/24
CPC分类号： C07D209/88 , C07D233/76 , C07D491/04 , C07D493/04
摘要： The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and modulating serotonin levels.
摘要翻译：本发明提供环烷基稠合吲哚，苯并噻吩，苯并呋喃和茚衍生物，以及使用它们例如通过拮抗5-HT 1A受体和调节5-羟色胺水平来治疗，预防和/或改善中枢神经系统疾病的方法。

3. 发明申请

WO2003101962A1 1-(AMINOALKYL)-3-SULFONYLINDOLE AND -INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基木聚糖-6配位体的1-（氨基甲酰基）-3-磺酰基吲哚衍生物
公开(公告)号：WO2003101962A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/017472
申请日：2003-06-03
申请人： WYETH , BERNOTAS, Ronald, Charles , LENICEK, Steven, Edward , ANTANE, Schuyler, A. , ZHOU, Ping , LI, Yanfang
发明人： BERNOTAS, Ronald, Charles , LENICEK, Steven, Edward , ANTANE, Schuyler, A. , ZHOU, Ping , LI, Yanfang
IPC分类号： C07D209/30
CPC分类号： C07D209/48 , C07D209/08 , C07D209/30 , C07D231/56 , C07D403/12 , C07D409/12 , C07D513/04
摘要： The present invention provides compounds of formula (I) and the use thereof for the treatment of central nervous system disorders related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

4. 发明申请

WO2007078813A3 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION 审中-公开
公开(公告)号：WO2007078813A3
公开(公告)日：2007-07-12
申请号：PCT/US2006/047673
申请日：2006-12-14
申请人： WYETH , ZHOU, Ping , BERNOTAS, Ronald, Charles , LI, Yanfang , NOWAK, Pawel, Wojciech , COLE, Derek, Cecil , MANAS, Eric, Steven , FAN, Yi , YAN, Yinfa
发明人： ZHOU, Ping , BERNOTAS, Ronald, Charles , LI, Yanfang , NOWAK, Pawel, Wojciech , COLE, Derek, Cecil , MANAS, Eric, Steven , FAN, Yi , YAN, Yinfa
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/454 , A61K31/506 , A61P25/28
摘要： The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula (I) The present invention also provides methods and compositions for the inhibition of ß-secretase (BACE) and the treatment of ß-amyloid deposits and neurofibrillary tangles.

5. 发明申请

WO2007005404A1 AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION 审中-公开
标题翻译： AMINO-5-（6-MEMBERED）异环糊精化合物及其用于β-分泌酶调节
公开(公告)号：WO2007005404A1
公开(公告)日：2007-01-11
申请号：PCT/US2006/024912
申请日：2006-06-26
申请人： WYETH , ZHOU, Ping , MALAMAS, Michael Sotirios , LI, Yanfang , ROBICHAUD, Albert Jean , QUAGLIATO, Dominick Anthony
发明人： ZHOU, Ping , MALAMAS, Michael Sotirios , LI, Yanfang , ROBICHAUD, Albert Jean , QUAGLIATO, Dominick Anthony
IPC分类号： C07D401/04 , C07D401/14 , C07D409/14 , C07D405/14 , C07D403/04 , C07D403/14 , A61K31/4439 , A61K31/506 , A61P25/28
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I. The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物。本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法

6. 发明申请

WO2007053353A2 PYRROLO[2,3-F] AND [3,2-F]ISOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基硝胺-6配体的吡咯并[2,3-F]和[3,2-F]异喹啉酮衍生物
公开(公告)号：WO2007053353A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/041333
申请日：2006-10-23
申请人： WYETH , ZHOU, Ping , LI, Yanfang
发明人： ZHOU, Ping , LI, Yanfang
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P25/22 , A61P25/28 , A61P25/18 , A61P25/24
CPC分类号： C07D209/08 , C07D471/04
摘要： The present invention provides a compound of formula I or II and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供了式I或II化合物及其在治疗性治疗与5-HT 6受体有关或受5-HT 6受体影响的中枢神经系统疾病中的用途。

7. 发明申请

WO2007084841A2 SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS 审中-公开
标题翻译：磺酰基取代的1H-吲哚作为5-羟基苯丙胺受体的配体
公开(公告)号：WO2007084841A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/060454
申请日：2007-01-12
申请人： WYETH , MCDEVITT, Robert, E. , LI, Yanfang , ROBICHAUD, Albert, J. , HEFFERNAN, Gavin, D. , COGHLAN, Richard, D. , BERNOTAS, Ronald, C.
发明人： MCDEVITT, Robert, E. , LI, Yanfang , ROBICHAUD, Albert, J. , HEFFERNAN, Gavin, D. , COGHLAN, Richard, D. , BERNOTAS, Ronald, C.
IPC分类号： C07D209/30 , A61K31/404 , A61P25/28
CPC分类号： C07D209/30 , C07D405/12
摘要： The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment of disorders related to or associated with the 5-hydroxytryptamine-6 and 5- hydroxtryptamine-2A receptors or with norepinephrine reuptake inhibition.
摘要翻译：本发明涉及式I的化合物：其是5-羟色胺-6和5-羟色胺-2A受体的调节剂并且是去甲肾上腺素再摄取的抑制剂。本发明化合物及其药物组合物可用于治疗与5-羟色胺-6和5-羟色胺-2A受体有关或与5-羟色胺-6和5-羟色胺-2A受体有关的病症，或用于去甲肾上腺素再摄取抑制。

8. 发明申请

WO2007021711A3 SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
公开(公告)号：WO2007021711A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/030965
申请日：2006-08-08
申请人： WYETH , ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCDEVITT, Robert, Emmett , MCFARLANE, Geraldine, Ruth , GROSANU, Cristina , LO, Jennifer, Rebecca , LI, Yanfang , ROBICHAUD, Albert, Jean , BERNOTAS, Ronald, Charles
发明人： ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCDEVITT, Robert, Emmett , MCFARLANE, Geraldine, Ruth , GROSANU, Cristina , LO, Jennifer, Rebecca , LI, Yanfang , ROBICHAUD, Albert, Jean , BERNOTAS, Ronald, Charles
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D413/12 , C07D403/06 , A61K31/40 , A61P25/00
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

9. 发明公开

EP1679040A1 EASILY RETRIEVED BIOLOGICAL SPECIMEN POUCH 审中-公开
标题翻译： LEICHTZURÜCKHOLBARER生物学家PROBENBEUTEL
公开(公告)号：EP1679040A1
公开(公告)日：2006-07-12
申请号：EP04789836.6
申请日：2004-10-15
申请人： Zhou, Xing , Li, Yanfang
发明人： ZHOU, Xing , LI, Yanfang , GUO, Aijun
IPC分类号： A61B17/00
CPC分类号： A61B10/00 , A61B17/221 , A61B2017/00287 , A61B2017/00867
摘要： The invention relates to an easily retrieved biological specimen pouch. The easily retrieved biological specimen pouch of the invention comprises flexible wall, open end and closed end, and the specimen pouch can receive a biological specimen; A) The flexible wall of the open end of the specimen pouch has discontinuous serration; B) On the serration, there are slots through which an open and retrieval string or an open spring or a retrieval noose can pass. As the open end of the specimen pouch is provided with a flexible wall of discontinuous serration, and the open and retrieval string or the retrieval noose passes through the slots on the discontinuous serration of the flexible wall of the open end of the specimen pouch, when the open and retrieval string is pulled towards an outer sheath to retrieve the specimen pouch of the invention, the bulk of contracted open end is reduced due to the discontinuous serration of the flexible wall of the open end. It is easy to close the open end of the specimen pouch, and convenient to retrieve the specimen pouch into the outer sheath or extract it through a small incision. The specimen pouch of the invention is simple, convenient, safe and efficient.
摘要翻译：本发明涉及容易回收的生物样本袋。本发明容易回收的生物样本袋包括柔性壁，开口端和封闭端，试样袋可以容纳生物样本; A）样品袋开口端的柔性壁具有不连续的锯齿状; B）在锯齿处，有一个槽，一个开放的和取出的绳子或一个开放的弹簧或一个检索的索引可以通过。由于试样袋的开放端设置有不连续锯齿的柔性壁，开放和取出的绳索或取回的索糖通过样品袋开放端的柔性壁的不连续锯齿上的槽，当打开和取出的绳子被拉向外护套以取回本发明的样品袋，由于开口端的柔性壁的不连续的锯齿，收缩的开口端的大部分被减小。容易关闭样品袋的开口端，方便将样本袋取回外护套或通过小切口提取。本发明样品袋简单，方便，安全，高效。

10. 发明公开

EP1973876A2 SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS 审中-公开
标题翻译：磺酰基-1H-吲哚作为配体对5-羟色胺受体
公开(公告)号：EP1973876A2
公开(公告)日：2008-10-01
申请号：EP07710091.5
申请日：2007-01-12
申请人： Wyeth
发明人： MCDEVITT, Robert, E. , LI, Yanfang , ROBICHAUD, Albert, J. , HEFFERNAN, Gavin, D. , COGHLAN, Richard, D. , BERNOTAS, Ronald, C.
IPC分类号： C07D209/30 , A61K31/404 , A61P25/28
CPC分类号： C07D209/30 , C07D405/12
摘要： The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment of disorders related to or associated with the 5-hydroxytryptamine-6 and 5- hydroxtryptamine-2A receptors or with norepinephrine reuptake inhibition.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式