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1. 发明申请

WO2007120596A1 DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：二氢[1,4]二氧杂环[2,3-e]吲哚衍生物，为5-羟基木聚糖-6配体
公开(公告)号：WO2007120596A1
公开(公告)日：2007-10-25
申请号：PCT/US2007/008713
申请日：2007-04-09
申请人： WYETH , GREENFIELD, Alexander, Alexei , GROSANU, Cristina , ELOKDAH, Hassan, Mahmoud , ROBICHAUD, Albert Jean
发明人： GREENFIELD, Alexander, Alexei , GROSANU, Cristina , ELOKDAH, Hassan, Mahmoud , ROBICHAUD, Albert Jean
IPC分类号： C07D491/04 , A61K31/4162 , A61P25/00
CPC分类号： C07D491/056 , C07D491/04
摘要： The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

2. 发明申请

WO2007120594A1 SUBSTITUTED-DIHYDRO[1,4]OXAZINO[2,3,4-HI]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：取代的二氢[1,4]氧杂吖啉[2,3,4-HI]吲哚衍生物作为5-羟基木聚糖-6配体
公开(公告)号：WO2007120594A1
公开(公告)日：2007-10-25
申请号：PCT/US2007/008710
申请日：2007-04-09
申请人： WYETH , ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , GROSANU, Cristina , ROBICHAUD, Albert Jean
发明人： ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , GROSANU, Cristina , ROBICHAUD, Albert Jean
IPC分类号： C07D498/06 , A61K31/5383 , A61P25/00
CPC分类号： C07D498/06
摘要： The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor (I) .
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体（I）相关或受其影响的中枢神经系统疾病的用途。

3. 发明申请

WO2007032833A1 AZINYL-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基木聚糖-6配位体的亚氨基-3-磺酰基吖啶衍生物
公开(公告)号：WO2007032833A1
公开(公告)日：2007-03-22
申请号：PCT/US2006/030837
申请日：2006-08-08
申请人： WYETH , GROSANU, Cristina , ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCFARLANE, Geraldine, Ruth , LO, Jennifer, Rebecca , ROBICHAUD, Albert, Jean
发明人： GROSANU, Cristina , ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCFARLANE, Geraldine, Ruth , LO, Jennifer, Rebecca , ROBICHAUD, Albert, Jean
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , A61P25/00
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统病症的用途。

4. 发明申请

WO2007120599A2 DIHYDRO[1,4]OXAZINO[2,3,4-HI]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基硝胺-6配体的二氢[1,4]恶嗪并[2,3,4-H]吲唑衍生物
公开(公告)号：WO2007120599A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008717
申请日：2007-04-09
申请人： WYETH , GREENFIELD, Alexander, Alexei , GROSANU, Cristina , ELOKDAH, Hassan, Mahmoud , ROBICHAUD, Albert, Jean
发明人： GREENFIELD, Alexander, Alexei , GROSANU, Cristina , ELOKDAH, Hassan, Mahmoud , ROBICHAUD, Albert, Jean
IPC分类号： C07D491/06 , A61K31/536 , A61P25/00
CPC分类号： C07D491/06
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供了式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

5. 发明申请

WO2007021711A3 SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
公开(公告)号：WO2007021711A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/030965
申请日：2006-08-08
申请人： WYETH , ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCDEVITT, Robert, Emmett , MCFARLANE, Geraldine, Ruth , GROSANU, Cristina , LO, Jennifer, Rebecca , LI, Yanfang , ROBICHAUD, Albert, Jean , BERNOTAS, Ronald, Charles
发明人： ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCDEVITT, Robert, Emmett , MCFARLANE, Geraldine, Ruth , GROSANU, Cristina , LO, Jennifer, Rebecca , LI, Yanfang , ROBICHAUD, Albert, Jean , BERNOTAS, Ronald, Charles
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D413/12 , C07D403/06 , A61K31/40 , A61P25/00
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

6. 发明申请

WO2007142904A3 BENZOXAZOLE AND BENZOTHIAZOLE DERIVATIVES AS 5-HYDROXYTRYTAMINE-6 LIGANDS 审中-公开
公开(公告)号：WO2007142904A3
公开(公告)日：2007-12-13
申请号：PCT/US2007/012569
申请日：2007-05-25
申请人： WYETH , LIU, Kevin , ROBICHAUD, Albert Jean , ELOKDAH, Hassan, Mahmoud
发明人： LIU, Kevin , ROBICHAUD, Albert Jean , ELOKDAH, Hassan, Mahmoud
IPC分类号： C07D263/58 , C07D277/82 , A61K31/423 , A61K31/428
摘要： The present invention provides a compound of Formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

7. 发明申请

WO2007117413A1 SULFONYL-3-HETEROCYCLYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基木聚糖-6配位体的三氟甲磺酰基-3-喹唑啉衍生物
公开(公告)号：WO2007117413A1
公开(公告)日：2007-10-18
申请号：PCT/US2007/008234
申请日：2007-03-30
申请人： WYETH , LIU, Kevin , ROBICHAUD, Albert Jean , LO, Jennifer, Rebecca , ELOKDAH, Hassan, Mahmoud
发明人： LIU, Kevin , ROBICHAUD, Albert Jean , LO, Jennifer, Rebecca , ELOKDAH, Hassan, Mahmoud
IPC分类号： C07D401/04 , A61K31/416 , A61P25/28
CPC分类号： C07D401/04
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

8. 发明申请

WO2005030192A1 4- (1H-INDOL-3-YL-METHYLIDENEAMINOXY-PROPOXY) -BENZIOC ACID DERIVATIVES AND RELATED COMPOUNDS AS PAI-1 INHIBITORS FOR THE TREATMENT OF IMPAIRMENT OF THE FIBRINOLYTIC SYSTEM AND OF THROMBISIS 审中-公开
标题翻译： 4-（1H-吲哚-3-基-L-甲基氨基甲酰氧基 - 丙氧基） - 苯甲酸衍生物及相关化合物作为PAI-1抑制剂治疗纤维蛋白溶解系统和血栓形成的影响
公开(公告)号：WO2005030192A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031456
申请日：2004-09-24
申请人： WYETH , HAVRAN, Lisa, Marie , BUTERA, John, Anthony , ELOKDAH, Hassan, Mahmoud , JENKINS, Douglas, John , GUNDERSEN, Eric, Gould
发明人： HAVRAN, Lisa, Marie , BUTERA, John, Anthony , ELOKDAH, Hassan, Mahmoud , JENKINS, Douglas, John , GUNDERSEN, Eric, Gould
IPC分类号： A61K31/15
CPC分类号： C07D209/14
摘要： The present invention relates to substituted indole oximes and methods of using them.
摘要翻译：本发明涉及取代的吲哚肟及其使用方法。

9. 发明申请

WO2005030750A1 SUBSTITUTED NAPHTHYL BENZOTHIOPHENE ACIDS 审中-公开
标题翻译：取代的苄基苯并噻唑酸
公开(公告)号：WO2005030750A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031397
申请日：2004-09-24
申请人： WYETH , ELOKDAH, Hassan, Mahmoud , MCFARLANE, Geradline, Ruth
发明人： ELOKDAH, Hassan, Mahmoud , MCFARLANE, Geradline, Ruth
IPC分类号： C07D333/56
CPC分类号： C07D409/12 , C07D333/56
摘要： The present invention relates generally to substituted naphthyl benzothiophene acids and methods of using them.
摘要翻译：本发明一般涉及取代的萘基苯并噻吩酸及其使用方法。

10. 发明申请

WO2005030199A1 4-(1-BENZOFURAN-3-YL-METHYLIDENEAMINOXY.PROPOXY))-BENZOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS PAI-1 INHIBITORS FOR THE TREATMENT OF IMPAIRMENT OF THE FIBRINOLYTIC SYSTEM AND OF THROMBOSIS 审中-公开
标题翻译： 4-（1-苯并呋喃-3-基-L-甲氧基苯氧基氧基）） - 苯甲酸衍生物及相关化合物作为PAI-1抑制剂治疗纤维蛋白溶解系统和血栓形成的影响
公开(公告)号：WO2005030199A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031361
申请日：2004-09-24
申请人： WYETH , HAVRAN, Lisa, Marie , BUTERA, John, Anthony , ELOKDAH, Hassan, Mahmoud , JENKINS, Douglas, John , GUNDERSEN, Eric, Gould
发明人： HAVRAN, Lisa, Marie , BUTERA, John, Anthony , ELOKDAH, Hassan, Mahmoud , JENKINS, Douglas, John , GUNDERSEN, Eric, Gould
IPC分类号： A61K31/343
CPC分类号： C07D307/81
摘要： The present invention relates to benzofuryl-oximes of formula (I) or a pharmaceutically acceptable salt or ester form thereof wherein R 1 is a direct bond to A, C 1 -C 4 alkylene, or -O-C 1 -C 4 alkylene; R 2 and R 3 are, independently hydrogen, halogen, C 1 -C 4 alkyl, C 1 -C 3 perfluoroalkyl, -O-C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, -OH, -NH 2 , -NO 2 , -O(CH 2 ) p -aryl, -O(CH 2 ) P -heteroaryl, aryl, heteroaryl, -NH(CH 2 ) P -aryl, -NH(CH 2 ) P -heteroaryl, -NH(CO)-aryl, NH(CO)-heteroaryl, -O(CO)-aryl, O(CO)-heteroaryl, -NH(CO)-CH=CH-aryl, or -NH(CO)-CH=CH-heteroaryl; p is an integer from 0-6; R 4 is hydrogen, C 1 -C 8 alkyl, or C 3 -C 6 cycloalkyl; A is -COOH or an acid mimic; X is C 1 -C 8 alkylène, C 3 -C 6 cycloalkylene, -(CH 2 ) m O-, or -(CH 2 ) m NH-; m is an integer from 1-6; and R 5 is hydrogen, C 1 -C 8 alkyl, C 3 -C 6 alkyl, C 3 -C 6 cycloalkyl, -CH 2 -C 3 -C 6 cycloalkyl, heteroaryl, -CH 2 -heteroaryl, aryl or benzyl; R 6 and R 7 are independently, hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 perfluoroalkyl, -O-C 1 -C 6 perfluoroalkyl, C 1 -C 6 alkoxy, _OH, -NH 2 , -NO 2 , -O(CH 2 ) n -aryl, -O(CH 2 ) n -heteroaryl, aryl, or heteroaryl; and n is an integer from 0-6, wherein the alkyl, cycloalkyl, aryl and heteroaryl groups are each optionally substituted by one or more substituents. The present compounds are PAI-1 inhibitors for the treatment e.g of impairment of the fibrinolytic system, thrombosis or cardiovascular diseases.
摘要翻译：本发明涉及式（I）的苯并呋喃基 - 肟或其药学上可接受的盐或酯形式，其中R1是与A，C1-C4亚烷基或-O-C1-C4亚烷基的直接键合; R2和R3独立地是氢，卤素，C1-C4烷基，C1-C3全氟烷基，-O-C1-C3全氟烷基，C1-C3烷氧基，-OH，-NH2，-NO2，-O（CH2），-O（CH 2）p - 杂芳基，芳基，杂芳基，-NH（CH 2）P - 芳基，-NH（CH 2）P - 杂芳基，-NH（CO） - 芳基，NH（CO） CO） - 芳基，O（CO） - 杂芳基，-NH（CO）-CH = CH-芳基或-NH（CO）-CH = CH-杂芳基; p是0-6的整数; R4是氢，C1-C8烷基或C3-C6环烷基; A是-COOH或酸模拟物; X是C1-C8烷基，C3-C6亚环烷基， - （CH2）mO-或 - （CH2）mNH-; m是1-6的整数; R 5是氢，C 1 -C 8烷基，C 3 -C 6烷基，C 3 -C 6环烷基，-CH 2 -C 3 -C 6环烷基，杂芳基，-CH 2 - 杂芳基，芳基或苄基; R6和R7独立地为氢，卤素，C1-C6烷基，C1-C6全氟烷基，-O-C1-C6全氟烷基，C1-C6烷氧基，_OH，-NH2，-NO2，-O（CH2）n - 芳基， - 杂芳基， - （CH 2）n - 杂芳基，芳基或杂芳基; 且n为0-6的整数，其中烷基，环烷基，芳基和杂芳基各自任选被一个或多个取代基取代。本发明化合物是用于治疗例如纤维蛋白溶解系统，血栓形成或心血管疾病的损伤的PAI-1抑制剂。

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