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1. 发明专利

DE19954934A1 未知
公开(公告)号：DE19954934A1
公开(公告)日：2001-05-17
申请号：DE19954934
申请日：1999-11-16
申请人： WOLFBEIS OTTO S , LEHMANN FRANK
发明人： WOLFBEIS OTTO S , ARBTER MICHAELA , LEHMANN FRANK
IPC分类号： A61K31/66 , C07B47/00 , C07F9/09 , C07F9/6561 , C09B23/16 , C09B69/00 , G01N33/532 , G01N33/533 , G01N33/58
摘要： The invention relates to a method for improving the aqueous solubility of optical markers. Said optical markers serve to mark bio-molecules, polymers and medicaments. According to the invention, aqueous solubility of optical markers is achieved through a method, whereby a phosphoric or phosphonic acid group, or the salt or monoester thereof is introduced into the marker.

2. 发明专利

DE19856152A1 New heterocyclylalkene substituted quinolinium and pyridinium derivatives useful for labelling of biomolecules, particles and pharmaceuticals 未知
公开(公告)号：DE19856152A1
公开(公告)日：2000-06-08
申请号：DE19856152
申请日：1998-12-05
申请人： WOLFBEIS OTTO S , LEHMANN FRANK
发明人： WOLFBEIS OTTO S , PROBST MARIO , LEHMANN FRANK
IPC分类号： C09B23/02 , G01N27/447 , G01N33/533 , G01N33/58 , C09B23/00 , C09B62/002 , C09K11/06 , G01N21/64 , G01N30/02 , G01N33/52 , G01N33/53 , G01N33/68
摘要： Heterocyclylalkene-substituted quinolinium and pyridinium derivatives are new. The substituted quinolinium derivatives are compounds (Ia) and (Ib) and the substituted pyridinium derivatives are compounds (IIa) and (IIb). Z = group of formula (i)-(iii): X = O; S; Se; NR; C(CH3)2; or CH=CH; R1-R15: at least one is an isothiocyanate, isocyanate, mono- or dichlorotriazine, aziridine, sulfonyl halide, N-hydroxysuccinimide ester, imido ester, glyoxal, maleimide, iodoacetamide or phosphoramidite group capable of covalent bonding to a chromophore and optionally bonded via a spacer -(CH2)m- and at least one can be an ionizable or ionized group, e.g. SO3 , PO3 , COO or NR ; m = 1-18; n (not shown in formulae, but assumed to define the unit in square brackets) = 1-3; or R11 and R12 are bridged to form formula (iv) or (v) when n = 2 and formula (vi) or (vii) when n = 3: A-G = R1-R15 or A, B and C = O; S; C(CN)2; or N(R); R = aliphatic or aromatic group (optionally reactive), e.g. (CH2)nCOOH or (CH2)NH 2; or D = Cl; or an aromatic or aliphatic ring optionally substituted with R -R15; or R1-R10 = higher condensed aromatic or heterocyclic rings. Independent claims are also included for: (A) the preparation of compounds (Ia)-(IIb); and (B) a system for the qualitative or quantitative determination of proteins, nucleic acids, oligomers, DNA, RNA, biological cells, lipids, polymers, pharmaceuticals and polymer particles by the covalent coupling of compounds (Ia)-(IIb) to these substances via OH, NH2 or SH groups carried by the latter.

3. 发明申请

WO2011098575A3 DRESSING MATERIAL FOR MONITORING A WOUND HEALING 审中-公开
标题翻译：用于监测伤口愈合的组装材料
公开(公告)号：WO2011098575A3
公开(公告)日：2011-10-13
申请号：PCT/EP2011052057
申请日：2011-02-11
申请人： FRAUNHOFER GES FORSCHUNG , WOLFBEIS OTTO S , MOHR GERHARD J , SZEIMIES MARKUS , TRUPP SABINE , STICH MATTHIAS
发明人： WOLFBEIS OTTO S , MOHR GERHARD J , SZEIMIES MARKUS , TRUPP SABINE , STICH MATTHIAS
IPC分类号： A61F13/02
CPC分类号： A61F13/00051 , A61F13/0226 , A61F13/0273 , A61F2013/00846
摘要： A dressing material for monitoring a wound healing comprises a dressing base material and a control element. The control element lies in or on the dressing base material such that a control surface of the control element is visible and a liquid or gaseous secretion of a wound is in contact with the control element when the dressing material is applied onto the wound. Furthermore, the control element is designed to cause a visible change of the control surface on the basis of a chemical reaction when a property of the wound changes in order to enable the monitoring of the wound healing, said control element having at least one receptor that is designed to selectively respond to one or more analytes. The analyte(s) are selected from the group that contains reactive oxygen species, amines, alcohols, thiols, aldehydes, ketones, diols, hydrogen peroxide, nitrogen oxide, amino acids, hydrogen sulfide, carboxylic acids, and mercaptans.
摘要翻译：用于监测伤口愈合的敷料包括敷料基座和控制元件。所述控制元件被布置在上或敷料基材，使得控制元件的控制区域是可见的，并与控制元件伤口的液体或气体的分泌是在接触时，敷料材料施加到伤口上。此外，它的设计，以产生在基于化学反应的伤口的性质的变化，控制元件使所述控制表面的可见的变化，以允许伤口愈合的监控，其特征在于，所述控制元件具有至少一个受体，其适合于选择性地一种或多种分析物接触，所述一个或选自活性氧，胺，醇，硫醇，醛，酮，二醇的组中选择的，含有过氧化氢的氮氧化物，氨基酸，硫化氢，羧酸，以及硫醇。

4. 发明申请

WO2005095926A3 LUMINESCENCE OPTICAL METHOD FOR AUTHENTICATING PRODUCTS 审中-公开
标题翻译： EMITTING进行认证的产品系列光学方法
公开(公告)号：WO2005095926A3
公开(公告)日：2005-11-24
申请号：PCT/EP2005003522
申请日：2005-04-04
申请人： CHROMEON GMBH , WOLFBEIS OTTO S , GRUBER MICHAELA , BASTIAN PETRA
发明人： WOLFBEIS OTTO S , GRUBER MICHAELA , BASTIAN PETRA
IPC分类号： G01N21/64 , G06K19/14
CPC分类号： G01N21/6408
摘要： The invention relates to a method for carrying out luminescence optical authentication during which a product is provided with at least one luminescent marker, and the authentication ensues by determining the decay time of the luminescence of the marker.
摘要翻译：本发明涉及一种用于发光光学认证的方法，其中，与至少一个发光标记物的产物被提供并且所述认证是通过确定标记的发光的衰减时间进行。

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