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1. 发明专利

AU2015205914B2 1,6- DIAZABICYCLO [3,2,1] OCTAN- 7- ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS 未知
公开(公告)号：AU2015205914B2
公开(公告)日：2016-07-28
申请号：AU2015205914
申请日：2015-07-23
申请人： WOCKHARDT LTD
发明人： PATIL VIJAYKUMAR JAGDISHWAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , KALE AMOL , VELUPILLAI LOGANATHAN , DEKHANE DEEPAK , BIRAJDAR SATISH SHRIMANT , SHAIKH MOHAMMAD USMAN , MAURYA SUSHILKUMAR , PATEL PIYUSH AMBALAL , DIXIT PRASAD , PAWAR MANGESH , PATEL MAHESH VITHALBHAI , BHAGWAT SACHIN
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Compounds of Formula (I), their preparation and use in preventing or treating 5 bacterial infections are disclosed. N Formula (I) o o

2. 发明专利

AU2013308127A1 1,6- Diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections 未知
公开(公告)号：AU2013308127A1
公开(公告)日：2014-07-10
申请号：AU2013308127
申请日：2013-04-19
申请人： WOCKHARDT LTD
发明人： PATIL VIJAYKUMAR JAGDISHWAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , KALE AMOL , VELUPILLAI LOGANATHAN , DEKHANE DEEPAK , BIRAJDAR SATISH SHRIMANT , SHAIKH MOHAMMAD USMAN , MAURYA SUSHILKUMAR , PATEL PIYUSH AMBALAL , DIXIT PRASAD , PAWAR MANGESH , PATEL MAHESH VITHALBHAI , BHAGWAT SACHIN
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

3. 发明专利

NZ626314A 1,6-diazabicyclo[3,2,1]octan-7-one derivatives and their use in the treatment of bacterial infections 未知
公开(公告)号：NZ626314A
公开(公告)日：2017-02-24
申请号：NZ62631413
申请日：2013-04-19
申请人： WOCKHARDT LTD
发明人： PATIL VIJAYKUMAR JAGDISHWAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , KALE AMOL , VELUPILLAI LOGANATHAN , DEKHANE DEEPAK , BIRAJDAR SATISH SHRIMANT , SHAIKH MOHAMMAD USMAN , MAURYA SUSHILKUMAR , PATEL PIYUSH AMBALAL , DIXIT PRASAD , PAWAR MANGESH , PATEL MAHESH VITHALBHAI , BHAGWAT SACHIN
IPC分类号： A61K31/439 , A61K31/4166 , A61K31/4188 , A61K31/551 , A61P31/04 , C07D471/18
摘要： Disclosed are 7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide derivatives and prodrugs of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof; wherein: R1 is: SO3M, SO2NH2, PO3M, CH2COOM, CF2COOM, CHFCOOM, or CF3; M is hydrogen or a cation; R2 is: hydrogen, (CH2)n-R3, or COOR3; R3 is: hydrogen, optionally substituted alkyl, CN, NR6R7, CONR6R7, NHCONR6R7, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, or OR8; and wherein the remaining substituents are as defined herein, and wherein said alkyl is a branched or unbranched saturated acyclic hydrocarbon radical with 1 to 6 carbon atoms; said cycloalkyl is a three to seven member saturated or unsaturated cyclic hydrocarbon radical; said heterocyclyl is a four to seven member cycloalkyl group containing one or more heteroatoms selected from nitrogen, oxygen or sulfur; said aryl is a monocyclic or polycyclic aromatic hydrocarbon containing six to fourteen ring atoms; and said heteroaryl is a monocyclic or polycyclic aromatic hydrocarbon wherein one or more carbon atoms have been replaced with heteroatoms selected from nitrogen, oxygen, or sulfur. Representative compounds include (2S,5R)-N-{ [(2S,4R)-4-trifluoroacetylamino-pyrrolidin-2-yl]methyloxy} -7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, (2S,5R)-N-{ [(2S)-1-carbamimidoyl-pyrrolidin-2-yl]methyloxy} -7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, (2S,5R)-7-oxo-N-{ [(2S)-5-oxopyrrolidin-2-yl]methyloxy} -6-(sulfooxy)-1,6-diazabicyclo [3.2.1]octane-2-carboxamide, (2S,5R)-7-oxo-N-{ [(4S)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]methyloxy} -6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, (2S,5R)-7-oxo-N-[(2S)-pyrrolidin-2-ylmethyloxy]-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, (2S,5R)-N-{ [(2S,4R)-4-hydroxyl-pyrrolidin-2-yl]methyloxy} -7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, (2S,5R)-N-[(2R)-azetidin-2-ylmethyloxy]-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, and (2S,5R)-N-hydroxy-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide sodium salt. Also disclosed is a pharmaceutical composition comprising a compound as defined above, and optionally further comprising at least one antibacterial agent and/or beta-lactamase inhibitor (such as sulbactam, tazobactam and/or clavulanic acid), for the prevention or treatment of a bacterial infection in a subject, including for the treatment of infection caused by bacteria producing one or more beta-lactamase enzymes.

4. 发明专利

CA2881169C 1,6-DIAZABICYCLO [3,2,1]OCTAN - 7 - ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS 未知
公开(公告)号：CA2881169C
公开(公告)日：2020-06-16
申请号：CA2881169
申请日：2013-04-19
申请人： WOCKHARDT LTD
发明人： PATIL VIJAYKUMAR JAGDISHWAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , KALE AMOL , VELUPILLAI LOGANATHAN , DEKHANE DEEPAK , BIRAJDAR SATISH SHRIMANT , SHAIKH MOHAMMAD USMAN , MAURYA SUSHILKUMAR , PATEL PIYUSH AMBALAL , DIXIT PRASAD , PAWAR MANGESH , PATEL MAHESH VITHALBHAI , BHAGWAT SACHIN
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

5. 发明专利

ES2672100T3 Derivados de 1,6-diazabiciclo[3,2,1]octano-7-ona y su uso en el tratamiento de infecciones bacterianas 未知
公开(公告)号：ES2672100T3
公开(公告)日：2018-06-12
申请号：ES13726298
申请日：2013-04-19
申请人： WOCKHARDT LTD
发明人： PATIL VIJAYKUMAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , KALE AMOL , VELUPILLAI LOGANATHAN , DEKHANE DEEPAK , BIRAJDAR SATISH , SHAIKH MOHAMMAD , MAURYA SUSHILKUMAR , PATEL PIYUSH , DIXIT PRASAD , PAWAR MANGESH , PATEL MAHESH , BHAGWAT SACHIN
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Compuesto de Fórmula (I)**Fórmula** o un estereoisómero o una sal farmacéuticamente aceptable del mismo; donde: R1 es SO3M; M es hidrógeno o un catión; R2 es: (a) hidrógeno, (CH2)n-R3, o COOR3, n es 0, 1 o 2; R3 es: (a) hidrógeno, (b) alquilo C1-C6 sustituido con heterociclilo, estando dicho heterociclilo sustituido con uno o más sustituyentes elegidos del grupo que consiste en alquilo C1-C6, halógeno, CN, COOH, CONH2, OH, NH2 y NHCOCH3.

6. 发明专利

AU2015205914A1 1,6- DIAZABICYCLO [3,2,1] OCTAN- 7- ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS 未知
公开(公告)号：AU2015205914A1
公开(公告)日：2015-08-20
申请号：AU2015205914
申请日：2015-07-23
申请人： WOCKHARDT LTD
发明人： PATIL VIJAYKUMAR JAGDISHWAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , KALE AMOL , VELUPILLAI LOGANATHAN , DEKHANE DEEPAK , BIRAJDAR SATISH SHRIMANT , SHAIKH MOHAMMAD USMAN , MAURYA SUSHILKUMAR , PATEL PIYUSH AMBALAL , DIXIT PRASAD , PAWAR MANGESH , PATEL MAHESH VITHALBHAI , BHAGWAT SACHIN
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Compounds of Formula (I), their preparation and use in preventing or treating 5 bacterial infections are disclosed. N Formula (I) o o

7. 发明专利

AU2013308127B2 1,6- Diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections 未知
公开(公告)号：AU2013308127B2
公开(公告)日：2015-08-13
申请号：AU2013308127
申请日：2013-04-19
申请人： WOCKHARDT LTD
发明人： PATIL VIJAYKUMAR JAGDISHWAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , KALE AMOL , VELUPILLAI LOGANATHAN , DEKHANE DEEPAK , BIRAJDAR SATISH SHRIMANT , SHAIKH MOHAMMAD USMAN , MAURYA SUSHILKUMAR , PATEL PIYUSH AMBALAL , DIXIT PRASAD , PAWAR MANGESH , PATEL MAHESH VITHALBHAI , BHAGWAT SACHIN
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

8. 发明专利

MX2015002177A DERIVADOS DE 1,6- DIAZABICICLO [3.2,1] OCTANO-7-ONA Y SU USO EN EL TRATAMIENTO DE LAS INFECCIONES BACTERIANAS. 未知
公开(公告)号：MX2015002177A
公开(公告)日：2015-04-10
申请号：MX2015002177
申请日：2013-04-19
申请人： WOCKHARDT LTD
发明人： PATEL MAHESH VITHALBHAI , BHAGWAT SACHIN , PATIL VIJAYKUMAR JAGDISHWAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , SHAIKH MOHAMMAD USMAN , DEKHANE DEEPAK , PATEL PIYUSH AMBALAL , KALE AMOL , VELUPILLAI LOGANATHAN , BIRAJDAR SATISH SHRIMANT , MAURYA SUSHILKUMAR , DIXIT PRASAD , PAWAR MANGESH
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Los compuestos de Fórmula (I), su preparación y uso en la prevención o tratamiento de infecciones bacterianas se dan a conocer. (ver Fórmula).

9. 发明专利

CA2881169A1 1,6-DIAZABICYCLO [3,2,1]OCTAN - 7 - ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS 未知
公开(公告)号：CA2881169A1
公开(公告)日：2014-03-06
申请号：CA2881169
申请日：2013-04-19
申请人： WOCKHARDT LTD
发明人： PATIL VIJAYKUMAR JAGDISHWAR , TADIPARTHI RAVIKUMAR , DOND BHARAT , KALE AMOL , VELUPILLAI LOGANATHAN , DEKHANE DEEPAK , BIRAJDAR SATISH SHRIMANT , SHAIKH MOHAMMAD USMAN , MAURYA SUSHILKUMAR , PATEL PIYUSH AMBALAL , DIXIT PRASAD , PAWAR MANGESH , PATEL MAHESH VITHALBHAI , BHAGWAT SACHIN
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

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