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    • 7. 发明申请
    • FISTULA PLUGS INCLUDING A HYDRATION RESISTANT COMPONENT
    • FISTULA包括耐水性组分
    • WO2009035779A1
    • 2009-03-19
    • PCT/US2008/071530
    • 2008-07-30
    • COOK BIOTECH INCORPORATEDAGNEW, Charles, W.
    • AGNEW, Charles, W.
    • A61B17/00
    • A61B17/0057A61B17/12022A61B17/12159A61B17/12163A61B17/1219A61B2017/00641A61B2017/00654A61L27/3633A61L27/3641A61L31/005
    • Described, in certain aspects, are devices and methods for treating fistulae. In one embodiment, a fistula plug includes a hydratable component and hydration resistant component incorporated on or in the hydratable component. Illustratively, an inventive plug can include a first component and a second component, wherein the first component is hydratable, and the second component is less receptive to hydration than the first component (or is essentially non- hydratable). Either of these components may be formed with one or more of a variety of biocompatible materials including some that are naturally derived and some that are non-naturally derived. In one embodiment, the first component and the second component, while dissimilar in their receptivity to hydration, are both comprised of a remodelable, angiogenic material, for example, a remodelable extracellular matrix material such as submucosa.
    • 在某些方面描述了用于治疗瘘的装置和方法。 在一个实施方案中,瘘塞包括结合在可水合组分上或其中的可水合组分和耐水化组分。 示例性地,本发明的塞子可以包括第一组分和第二组分,其中第一组分是可水合的,并且第二组分比第一组分(或基本上不可水合)更不容易接受水合。 这些成分中的任何一种可以由多种生物相容性材料中的一种或多种形成,包括天然衍生的一些或非天然衍生的一些。 在一个实施方案中,第一组分和第二组分尽管不同于水合的接受性,但都包含可重塑的血管生成材料,例如可重塑的细胞外基质材料如粘膜下层。