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1. 发明专利

CA3116032A1 WATER SPRAYING DEVICE 未知
公开(公告)号：CA3116032A1
公开(公告)日：2021-11-04
申请号：CA3116032
申请日：2021-04-23
申请人： WILLIAMS MARK , PRYCE JACQUELINE
发明人： WILLIAMS MARK , PRYCE JACQUELINE
IPC分类号： A63B63/08 , A47K3/28 , B05B15/60 , F16K31/44
摘要： A water spraying device is disclosed. The water spraying device includes a main housing, an actuator arm, and a sprayer assembly. The main housing is to be mounted to a basketball net. The actuator arm includes a proximal end pivotally mounted to the main housing and a distal end extending outwards from the main housing. The actuator arm is biased to a neutral position and pivotable to a depressed position responsive to downward force applied to the distal end of the actuator arm by a basketball. The sprayer assembly is mounted to the main housing, and includes a valve having a hose adapter on an inlet and a nozzle on an outlet of the valve. The valve is triggered to open responsive to the actuator arm pivoting to the depressed position.

2. 发明专利

AU2018201056A1 A DISPOSABLE SERVING ARRANGEMENT 未知
公开(公告)号：AU2018201056A1
公开(公告)日：2018-10-25
申请号：AU2018201056
申请日：2018-02-13
申请人： WILLIAMS MARK
发明人： WILLIAMS MARK
IPC分类号： A47G23/06 , A47G19/03
摘要： Abstract There is provided a disposable serving arrangement. The disposable serving arrangement comprises a disposable tray having a base and a periphery extending upwards from the base, defining a compartment; and a serviette attached to the periphery; wherein the serviette has a skirt adapted for use by a user.

3. 发明专利

IL296215A Purine compounds for treating disorders 未知
公开(公告)号：IL296215A
公开(公告)日：2022-11-01
申请号：IL29621522
申请日：2022-09-05
申请人： MARVEL BIOTECHNOLOGY , WILLIAMS MARK
发明人： WILLIAMS MARK
IPC分类号： A61P25/00 , A61K31/522 , A61P25/24
摘要： Substituted purine compounds of formula (I)-(III) and salts thereof act as adenosine A2a receptor (A2aR) antagonists for cancer immunotherapy, depression, anxiety, multiple sclerosis, NASH, scleroderma, ADHD, Alzheimer's 5 and Parkinsons. Pharmaceutical compositions comprising such compounds, and methods of their use in treating depression are also taught.

4. 发明专利

CA2684667A1 VERTICAL CURVE SYSTEM FOR SURFACE GRADING 未知
公开(公告)号：CA2684667A1
公开(公告)日：2008-10-30
申请号：CA2684667
申请日：2008-04-18
申请人： WILLIAMS ALAN , WILLIAMS MARK
发明人： WILLIAMS ALAN , WILLIAMS MARK
IPC分类号： E02F3/76
摘要： A method is disclosed that generates design profiles and a surface theref rom that promote water drainage from soil in an area of interest. Topographi cal data describing an initial surface of the area of interest are used to f orm initial profiles. The method generates the design profiles using the ini tial profiles and desired design parameters such as minimum slope, maximum s lope, optimal slope, maximum depth, optimal depth, starting elevation, endin g elevation, rules of curvature, and rules of earth balancing. The method ge nerates design surface profiles so that the cut volumes and fill volumes of the soil are at or near balance as much as possible from the available soil in the area of interest.

5. 发明专利

AU2002350322A1 INHIBITORS OF HEPATITIS C VIRUS PROTEASE 未知
公开(公告)号：AU2002350322A1
公开(公告)日：2003-06-30
申请号：AU2002350322
申请日：2002-12-13
申请人： TYRREL D LORNE , JOYCE MICHAEL , WILLIAMS MARK , HINDSGAUL OLE
发明人： TYRREL D LORNE , JOYCE MICHAEL , WILLIAMS MARK , HINDSGAUL OLE
IPC分类号： A61K38/00 , A61K38/04 , A61K38/08 , C07H21/04 , C07K5/00 , C07K7/00 , C07K7/06 , C07K14/18 , C07K14/81 , C07K16/00 , C07K17/00 , C07K7/04
摘要： The present invention features HCV protease inhibitors, which act by affecting the activity of the HCV protease NS3, or by preventing its activation by NS4A. The invention also features methods of use of the inhibitors of the invention in the treatment of HCV infection in a subject.

6. 发明专利

CA2506374A1 MONITORING COMPRESSION OF SUCCESSIVE LAYERS OF LANDFILL MATERIAL AND MEASUREMENT OF LAYER DENSITY 未知
公开(公告)号：CA2506374A1
公开(公告)日：2005-11-06
申请号：CA2506374
申请日：2005-05-05
申请人： WILLIAMS ALAN , WILLIAMS MARK , JULIAN CHARLES
发明人： WILLIAMS ALAN , WILLIAMS MARK , JULIAN CHARLES
IPC分类号： B09B5/00 , G01C7/04
摘要： A method and system and the use of a 3-D positioning system for monitoring a landfill and landfill material added thereto and undergoing compaction and measures in real time the relative density of the compressed landfill material. The method and system calculates thickness, volume, densi ty during the landfill operation to ensure that the landfill is comprised of compacted layers of substantially optimized density.

7. 发明申请

WO2010065863A3 ASSAYS FOR IDENTIFYING GENES ENCODING SALTY TASTE RECEPTORS AND MODULATORS 审中-公开
标题翻译：用于识别编码盐类受体和调节剂的基因的测定
公开(公告)号：WO2010065863A3
公开(公告)日：2010-10-14
申请号：PCT/US2009066788
申请日：2009-12-04
申请人： SENOMYX INC , MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SAGANICH MICHAEL , DAHAN MICHAEL , LAITA BIANCA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK
发明人： MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SAGANICH MICHAEL , DAHAN MICHAEL , LAITA BIANCA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK
IPC分类号： C07K14/705
CPC分类号： G01N33/5008 , A01K2267/03 , C07K14/705 , G01N2333/705
摘要： The present invention relates to rationales for selecting salty taste receptors from a discrete set of taste specific genes disclosed infra by use of methods including electrophysiology, bioiirformatics, and quantitative gene expression assays using transgenic animals as well as functional assays wherein these salty taste receptors may be expressed alone or in association with other taste specific polypeptides such as TRPML3, PKD2L1 or GPRl 13. In addition the invention relates to the use of the identified salty taste receptors in assays, preferably high- throughput, in order to identify modulators which maybe used as flavor additives to modulate salty taste. Preferably, the invention provides high- throughput mammalian and medium- throughput oocyte- based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds maybe used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels. This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion.
摘要翻译：本发明涉及通过使用包括电生理学，生物信息学和使用转基因动物的定量基因表达测定的方法以及其中这些咸味受体可能的功能测定法从下文所公开的离散的味道特异性基因组中选择咸味受体的理由单独表达或与其它味道特异性多肽如TRPML3，PKD2L1或GPR113共同表达。此外，本发明涉及鉴定的咸味受体在测定中的应用，优选高通量，以便鉴定可用作风味添加剂调味咸味。优选地，本发明提供用于鉴定人类TRPML3调节剂（优选TRPML3增强子）的高通量哺乳动物和中等通量的基于卵母细胞的电生理测定。在测定中调节TRPML3功能的化合物预期会影响人体的咸味。本发明的电生理测定，例如双电极电压钳技术，有助于鉴定特异性调节人TRPML3的化合物。本发明的测定法提供了一种可用于检测促进（增强）或抑制TRPML3功能的化合物的稳健筛选。增强或阻断TRPML3通道活性的化合物应该调节咸味。此外，这些化合物也可用于调节与钠水平相关的钠排泄，泌尿生产和其他生物学功能。本发明涉及TRPML3涉及包括人和可能的其他哺乳动物在内的灵长类动物的咸味感知（给出钠和其它离子对生理功能和条件的重要性，该表型可能在不同动物中强烈保守）。 TRPML3基因还调节钠代谢，钠排泄，血压，流体保留，心脏功能和尿液功能如尿液产生和排泄中的一种或多种。

8. 发明申请

WO0175605A3 MULTI-CHANNEL, MULTI-SERVICE DEBUG ON A PIPELINED CPU ARCHITECTURE 审中-公开
标题翻译：多通道，多管理CPU架构的多服务调试
公开(公告)号：WO0175605A3
公开(公告)日：2002-03-14
申请号：PCT/US0110251
申请日：2001-03-30
申请人： BROADCOM CORP , JOHNSON KELLY GENE , WILLIAMS MARK
发明人： JOHNSON KELLY GENE , WILLIAMS MARK
IPC分类号： G06F11/36
CPC分类号： G06F11/3628 , G06F11/3648
摘要： A method and system for debugging an executing service on a pipelined CPU architecture are described. In one embodiment, a breakpoint within an executing service is set and a minimum state of the executing service is saved. In addition, a program counter of the executing service is altered. The program counter is restored and the state of the executing service is restored.
摘要翻译：描述了用于在流水线CPU架构上调试执行服务的方法和系统。在一个实施例中，设置执行服务内的断点，并且保存执行服务的最小状态。此外，更改执行服务的程序计数器。程序计数器被恢复，执行服务的状态恢复。

9. 发明专利

CA2684667C VERTICAL CURVE SYSTEM FOR SURFACE GRADING 未知
公开(公告)号：CA2684667C
公开(公告)日：2014-02-25
申请号：CA2684667
申请日：2008-04-18
申请人： WILLIAMS MARK , WILLIAMS ALAN
发明人： WILLIAMS MARK , WILLIAMS ALAN
IPC分类号： G06F17/50 , A01G25/00 , G06N3/12
摘要： A method is disclosed that generates design profiles and a surface therefrom that promote water drainage from soil in an area of interest. Topographical data describing an initial surface of the area of interest are used to form initial profiles. The method generates the design profiles using the initial profiles and desired design parameters such as minimum slope, maximum slope, optimal slope, maximum depth, optimal depth, starting elevation, ending elevation, rules of curvature, and rules of earth balancing. The method generates design surface profiles so that the cut volumes and fill volumes of the soil are at or near balance as much as possible from the available soil in the area of interest.

10. 发明申请

WO2012178028A2 PORTABLE TOBACCO VAPORIZER 审中-公开
标题翻译：便携式烟草挥发器
公开(公告)号：WO2012178028A2
公开(公告)日：2012-12-27
申请号：PCT/US2012043776
申请日：2012-06-22
申请人： NWT HOLDING LLC , ALEXANDER ROBINSON , TAYLOR JOSEPH , WILLIAMS MARK
发明人： ALEXANDER ROBINSON , TAYLOR JOSEPH , WILLIAMS MARK
IPC分类号： A24F47/00 , A24D1/14 , A61M15/06
CPC分类号： A61M15/06 , A61M11/042 , A61M16/108 , A61M2205/3368 , A61M2205/3653 , A61M2205/8206
摘要： A vaporizer and method of vaporizing a botanical material, such as tobacco, is described. Embodiments of the apparatus include a self-contained, fully enclosed, battery operated vaporizer having an air inlet and a mouthpiece. The vaporizer includes a window for viewing a botanical material contained therein and a heating element that is also visible through the window and through an air inlet. The vaporizer also includes a push-button switch that rapidly provides power to heat air, which is then drawn through the botanical material by inhaling. Embodiments of the method include utilizing a push-button switch for heating vaporizer air and viewing the glow of the heating element as a signal that the vaporizer is ready for use.
摘要翻译：描述蒸发器和蒸发植物材料如烟草的方法。该装置的实施例包括具有空气入口和吹口的独立的，完全封闭的电池操作的蒸发器。蒸发器包括用于观察容纳在其中的植物材料的窗口和也可通过窗口并通过空气入口可见的加热元件。蒸发器还包括按钮开关，其快速地提供加热空气的功率，然后通过吸入将其吸入植物材料。该方法的实施例包括利用按钮开关来加热蒸发器空气并观察加热元件的辉光，作为蒸发器准备使用的信号。

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