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    • 1. 发明申请
    • DEVICE AND METHOD FOR SIMULTANEOUS MULTIPLE CHEMICAL SYNTHESES
    • 用于同时多元化学合成的装置和方法
    • WO1998014277A1
    • 1998-04-09
    • PCT/US1997018046
    • 1997-10-03
    • WHATMAN, INC.SCARMOUTZOS, Louis, M.MANNS, Roy, L.BOLESSA, Evon, A.ROBBINS, James, C.
    • WHATMAN, INC.
    • B01L11/00
    • B01L3/50255B01J19/0046B01J2219/00313B01J2219/00315B01J2219/00319B01J2219/00416B01J2219/00421B01J2219/00423B01J2219/00495C40B60/14
    • The device of the present invention is comprised of a multi-well filter bottom plate (10) with a selectively permeable barrier (14) comprised of a porous substrate having an oleophobic chemical surface. The filter plate (10) is used to contain multiple simultaneous chemical reactions. The selectively permeable barrier (14) holds the reaction mixtures in the wells until such time that it is desirable to remove some or all of the well contents. The selectively permeable barrier (14) is designed or selected to have a lower effective critical surface energy than the surface energy of the reaction mixture. The reaction wells can be drained by lowering the effective surface tension of the reaction mixture; this can be accomplished by altering the surface tension of the reaction mixture with the addition of a surface tension lowering composition. Alternatively, the reaction wells can be drained by the application of a pressure differential across the selectively permeable barrier, or by the application of centrifugal force.
    • 本发明的装置包括具有选择性渗透阻挡层(14)的多孔过滤器底板(10),所述选择性渗透屏障(14)由具有疏油化学表面的多孔基材组成。 过滤板(10)用于包含多次同时化学反应。 选择性可渗透屏障(14)将反应混合物保持在孔中,直到期望除去部分或全部井内容物为止。 选择性渗透屏障(14)被设计或选择为具有比反应混合物的表面能更低的有效临界表面能。 可以通过降低反应混合物的有效表面张力来排出反应孔; 这可以通过添加表面张力降低组合物来改变反应混合物的表面张力来实现。 或者,可以通过在选择性渗透屏障上施加压力差,或通过施加离心力来排出反应孔。