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1. 发明授权

EP1490368B1 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS 有权转让
标题翻译： 2,2-双（羟甲基）亚环丙基甲基嘌呤和嘧啶作为抗病毒剂
公开(公告)号：EP1490368B1
公开(公告)日：2011-08-03
申请号：EP03748894.7
申请日：2003-03-14
申请人： WAYNE STATE UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： ZEMLICKA, Jiri , DRACH,John, C. , ZHOU, Shaoman
IPC分类号： C07D473/16 , C07D473/18 , C07D239/32 , C07D239/48 , C07D239/52 , A61K31/52 , A61K31/522 , A61K31/505 , A61P31/22
CPC分类号： C07D239/36 , C07D239/54 , C07D473/18 , C07D473/30 , C07D473/34 , C07D473/40
摘要： Compounds which are active against viruses have the following formulas: Formula (I), Formula (II), wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.

2. 发明公开

EP1490368A2 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS 有权转让
标题翻译： 2,2-双（羟甲基）亚环丙基甲基嘌呤和嘧啶作为抗病毒剂
公开(公告)号：EP1490368A2
公开(公告)日：2004-12-29
申请号：EP03748894.7
申请日：2003-03-14
申请人： Wayne State University , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： ZEMLICKA, Jiri , DRACH,John, C.
IPC分类号： C07D473/16 , C07D473/18 , C07D239/32 , C07D239/48 , C07D239/52 , A61K31/52 , A61K31/522 , A61K31/505 , A61P31/22
CPC分类号： C07D239/36 , C07D239/54 , C07D473/18 , C07D473/30 , C07D473/34 , C07D473/40
摘要： Compounds which are active against viruses have the following formulas: Formula (I), Formula (II), wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.

3. 发明申请

WO2003104440A3 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS 审中-公开
公开(公告)号：WO2003104440A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/007916
申请日：2003-03-14
申请人： WAYNE STATE UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ZEMLICKA, Jiri , ZHOU, Shaoman , DRACH,John, C.
发明人： ZEMLICKA, Jiri , ZHOU, Shaoman , DRACH,John, C.
IPC分类号： C07D473/16
摘要： Compounds which are active against viruses have the following formulas: Formula (I), Formula (II), wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.

4. 发明申请

WO2003104440A2 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS 审中-公开
标题翻译： 2,2-BIS（羟甲基）环丙基二乙烯基 - 嘌呤和嘧啶类作为抗病毒剂
公开(公告)号：WO2003104440A2
公开(公告)日：2003-12-18
申请号：PCT/US2003/007916
申请日：2003-03-14
申请人： WAYNE STATE UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ZEMLICKA, Jiri , ZHOU, Shaoman , DRACH,John, C.
发明人： ZEMLICKA, Jiri , ZHOU, Shaoman , DRACH,John, C.
IPC分类号： C12N
CPC分类号： C07D239/36 , C07D239/54 , C07D473/18 , C07D473/30 , C07D473/34 , C07D473/40
摘要： Compounds which are active against viruses have the following formulas: Formula (I), Formula (II), wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.
摘要翻译：对病毒有活性的化合物具有下式：式（I），式（II），其中B是嘌呤或嘧啶杂环或碱基。在优选的实施方案中，嘌呤包括6-氨基嘌呤（腺嘌呤），6-羟基嘌呤（次黄嘌呤），2-氨基-6-羟基嘌呤（鸟嘌呤），2,6-二氨基嘌呤，2-氨基-6-叠氮基嘌呤，2 2-氨基-6-氯嘌呤，2-氨基-6-氟嘌呤，2-氨基-6-氟代嘌呤，2-氨基-6-甲氧基嘌呤，2-氨基-6-环丙基氨基嘌呤，2 2-氨基-6-烷基氨基或2-氨基-6-二烷基氨基取代的嘌呤，2-氨基-6-硫嘌呤，2-氨基-6-烷硫基取代的嘌呤，3-脱氮嘌呤，7-脱氮嘌呤和8-氮杂嘌呤。嘧啶含有胞嘧啶，尿嘧啶和胸腺嘧啶，5-卤素取代的胞嘧啶和尿嘧啶，5-烷基取代的胞嘧啶和尿嘧啶，包括具有饱和或不饱和烷基的衍生物和6-氮杂嘧啶。

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