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1. 发明申请

WO2012148793A1 FITTING ASSEMBLIES 审中-公开
标题翻译：配件组合
公开(公告)号：WO2012148793A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/034342
申请日：2012-04-20
申请人： WATERS TECHNOLOGIES CORPORATION , DELLAROVERE, Dennis , MURPHY, James P.
发明人： DELLAROVERE, Dennis , MURPHY, James P.
IPC分类号： B01D15/08
CPC分类号： G01N30/02 , F16L17/02 , F16L19/065 , F16L37/084 , G01N30/6026 , G01N30/6034
摘要： A fitting assembly includes a first fitting that is configured to receive a first fluid tube and a second fitting that is configured to receive a second fluid tube. The first fitting defines a first groove. The second fitting includes a spring that is configured to engage the first groove to connect the first and second fittings such that the first and second fluid tubes are placed in fluid communication and a fluid tight seal is established between the first and second sealing fittings.
摘要翻译：配件组件包括构造成接收第一流体管的第一配件和被配置为接收第二流体管的第二配件。第一配件限定第一凹槽。第二配件包括弹簧，其构造成接合第一槽以连接第一和第二配件，使得第一和第二流体管被放置成流体连通并且在第一和第二密封配件之间建立流体密封。

2. 发明申请

WO2013028765A1 MICROFLUIDIC DEVICE WITH DRIED BLOOD SPOTS (DBS) CARD INTERFACE 审中-公开
标题翻译：具有DRIED BLOOD SPOTS（DBS）卡接口的微流体装置
公开(公告)号：WO2013028765A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051876
申请日：2012-08-22
申请人： WATERS TECHNOLOGIES CORPORATION , MICHIENZI, Joseph D. , MURPHY, James P. , KEENE, Russell L.
发明人： MICHIENZI, Joseph D. , MURPHY, James P. , KEENE, Russell L.
IPC分类号： B01D15/08
CPC分类号： G01N30/06 , B01L3/502715 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , G01N30/16 , G01N30/6095 , G01N30/88 , G01N33/49 , G01N2001/383 , G01N2030/009 , G01N2030/062
摘要： An apparatus for use in a chromatography system includes a first microfluidic substrate having a first fluidic channel. One end of the first fluidic channel terminates at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first fluidic channel terminates at a second fluidic port on a second side of the first microfluidic substrate. A second microfluidic substrate has a second fluidic channel. One end of the second fluidic channel terminates at a first fluidic port on a first side of the second microfluidic substrate. The first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the fluidic port of the second microfluidic substrate aligns with one of the fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second fluidic channels.
摘要翻译：用于色谱系统的装置包括具有第一流体通道的第一微流体衬底。第一流体通道的一端终止在第一微流体衬底的第一侧上的第一流体端口处，并且第一流体通道的相对端终止于第一微流体衬底的第二侧上的第二流体端口。第二微流体衬底具有第二流体通道。第二流体通道的一端终止在第二微流体衬底的第一侧上的第一流体端口处。第二微流体衬底的第一侧邻接第一微流体衬底的第二侧，使得第二微流体衬底的流体端口与第一微流体衬底的流体端口中的一个对准，并且对准产生流体路径，其包括第一微流体衬底和第二流体通道。

3. 发明申请

WO2012148699A1 CARTRIDGE WITH MULTIPLE ELECTROSPRAY EMITTERS 审中-公开
标题翻译：带多个电喷雾器的墨盒
公开(公告)号：WO2012148699A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/033431
申请日：2012-04-13
申请人： WATERS TECHNOLOGIES CORPORATION , MURPHY, James P. , MICHIENZI, Joseph P.
发明人： MURPHY, James P. , MICHIENZI, Joseph P.
IPC分类号： B01L3/00
CPC分类号： G01N30/24 , B01L3/0268 , B01L3/50273 , B01L2200/0631 , B01L2400/0415 , G01N30/6091 , G01N30/7233 , H01J49/0431 , H01J49/167
摘要： An apparatus includes a portable housing and a plurality of separately operable microfluidic emitters disposed within the housing. Each microfluidic emitter has an inlet for receiving a liquid and an outlet for emitting a spray. Each microfluidic emitter is movable within the portable housing between a first position in which the outlet of that microfluidic emitter is fully retracted within the portable housing and a second position in which the outlet of that microfluidic emitter projects out of the portable housing. The portable housing with the multiple emitters is adapted to be detachably coupled to another housing portion. This housing portion includes a microfluidic substrate with a channel for transporting an eluent and an outlet aperture for emitting the eluent. The inlet of one of the emitters is detachably coupled to the outlet aperture of the microfluidic substrate.
摘要翻译：一种装置包括便携式外壳和设置在外壳内的多个单独可操作的微流体发射器。每个微流体发射器具有用于接收液体的入口和用于发射喷雾的出口。每个微流体发射器可在便携式外壳内在第一位置和第二位置之间移动，在第一位置，该微流体发射器的出口完全缩回到便携式外壳内，而第二位置中该微流体发射器的出口突出到便携式外壳之外。具有多个发射器的便携式壳体适于可拆卸地联接到另一壳体部分。该壳体部分包括具有用于输送洗脱液的通道的微流体衬底和用于发射洗脱液的出口孔。一个发射器的入口可拆卸地联接到微流体衬底的出口孔。

4. 发明申请

WO2010138678A1 TEMPERATURE CONTROL OF ENRICHMENT AND SEPARATION COLUMNS IN CHROMATOGRAPHY 审中-公开
标题翻译：色谱条件下分离柱的温度控制
公开(公告)号：WO2010138678A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036335
申请日：2010-05-27
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： MURPHY, James P. , FADGEN, Keith , GERHARDT, Geoff C. , DONEANU, Angela , STAPELS, Martha, Degen
IPC分类号： B01D35/18 , C02F1/02
CPC分类号： G01N30/6095 , B01D15/22 , B01D15/424 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2400/0487 , G01N30/461 , G01N30/606 , G01N30/6091 , G01N30/7233 , G01N30/7266 , G01N2030/027 , G01N2030/085 , G01N2030/8881 , Y10T29/49826
摘要： A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.
摘要翻译：分析样品的方法包括将足够量的样品加载到陷阱柱上以使捕获柱过载; 将分析柱和捕集柱加热至比分析柱更大的温度; 并将溶剂泵送到捕集塔，其具有溶剂组成分布，其与温差相配合使至少一些组分从捕集塔顺序洗脱至分析柱，并在分离柱之前聚焦在分析柱上从分析柱洗脱; 或任选地：将小分子样品加载到分析柱的冷却部分上; 加热分析柱; 并将溶剂泵入加热的分析柱，以从分析柱中洗脱组分。色谱分离包括：陷阱柱; 分离柱; 一个陷阱加热器; 分离柱加热器; 溶剂泵单元; 并且可以使用控制单元。

5. 发明申请

WO2019073442A1 MATCHING OF RESTRICTORS AND SEPARATION COLUMNS 审中-公开
公开(公告)号：WO2019073442A1
公开(公告)日：2019-04-18
申请号：PCT/IB2018/057905
申请日：2018-10-11
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： FOGWILL, Michael O. , MURPHY, James P. , GERHARDT, Geoff C.
IPC分类号： B01D15/16 , B01D15/40 , G01N30/86 , G01N30/32 , G01N30/60
CPC分类号： B01D53/025 , B01D15/163 , B01D15/40 , G01N30/32 , G01N30/6095 , G01N30/8658
摘要： The present disclosure relates to a method of configuring a chromatography system (500) whereby a separation column (515) having an operative flow rate is matched to an appropriate restrictor (521), which is capable of maintaining the post-column pressure at a target pressure. A kit comprising the matched column-restrictor pair and a processing unit is disclosed as is an integrated microfluidic chromatography system comprising such a matched column-restrictor pair.

6. 发明申请

WO2014143419A1 THERMALLY MODULATED VARIABLE RESTRICTOR 审中-公开
标题翻译：热调制变量限制器
公开(公告)号：WO2014143419A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/013153
申请日：2014-01-27
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： FOGWILL, Michael O. , MICHIENZI, Joseph D. , MURPHY, James P.
IPC分类号： G01N30/32
CPC分类号： G01N30/30 , B01D15/163 , B01D15/40 , G01N30/32 , G01N30/6004 , G01N2030/3038 , G01N2030/324 , G01N2030/6008
摘要： Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatographic column. The restrictors include a restrictor body having a fluidic channel with an inlet that receives the mobile phase from the column and an outlet through which the mobile phase leaves the fluidic channel. A restrictor tip, disposed adjacent the outlet of the fluidic channel, has an egress opening that is smaller than an internal diameter of the fluidic channel. A heating element, thermally coupled to a subsection of the fluidic channel between its inlet and outlet, heats the mobile phase passing through that subsection of the fluidic channel. The restriction produced by the restrictor tip in response to the heating of the mobile phase enables independent control of system pressure and linear velocity of the mobile phase within the column.
摘要翻译：色谱系统中使用的热调制可变限制器可独立控制通过色谱柱的可压缩流动相的系统压力和线速度。限流器包括具有流体通道的限流器主体，其具有从柱接收流动相的入口和流动相离开流体通道的出口。设置在流体通道出口附近的限制器尖端具有小于流体通道的内径的出口开口。热连接到流体通道在其入口和出口之间的子部分的加热元件加热通过流体通道的该部分的流动相。限制器尖端响应于流动相的加热而产生的限制使得能够独立地控制柱内的流动相的系统压力和线性速度。

7. 发明申请

WO2015020963A1 APPARATUS AND METHODS FOR CREATING A STATIC AND TRAVERSING THERMAL GRADIENT ON A MICROFLUIDIC DEVICE 审中-公开
标题翻译：用于在微流体装置上形成静态和阻挡热梯度的装置和方法
公开(公告)号：WO2015020963A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049616
申请日：2014-08-04
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： MICHIENZI, Joseph D. , MURPHY, James P. , FOGWILL, Michael O. , FADGEN, Keith , GERHARDT, Geoff , BERTONE, Gary W.
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L3/50273 , B01L3/502761 , B01L7/54 , B01L2200/0652 , B01L2200/12 , B01L2300/0883 , B01L2300/1805 , B01L2300/1811 , B01L2300/1894
摘要： A microfluidic device, for use in separation systems, includes a substrate having a fluidic channel. One or more heaters made of a thick film material are integrated with the substrate and in thermal communication with the fluidic channel of the substrate. The one or more heaters produce a thermal gradient within the fluidic channel in response to a current flowing through the one or more heaters. A plurality of electrically conductive taps can be in electrically conductive contact with the one or more heaters. The plurality of electrically conductive taps provides an electrically conductive path to the one or more heaters by which an electrical supply can produce the current flowing through the one or more heaters. Alternatively, the thick film material can be ferromagnetic, and the electrical supply can use induction to cause the current to flow through the one or more heaters.
摘要翻译：用于分离系统的微流体装置包括具有流体通道的基板。由厚膜材料制成的一个或多个加热器与基板一体化并且与衬底的流体通道热连通。响应于流过一个或多个加热器的电流，一个或多个加热器在流体通道内产生热梯度。多个导电抽头可以与一个或多个加热器导电接触。多个导电抽头提供到一个或多个加热器的导电路径，电源可以通过该导电路径产生流过一个或多个加热器的电流。或者，厚膜材料可以是铁磁性的，并且电源可以使用感应来使电流流过一个或多个加热器。

8. 发明申请

WO2014189738A2 THERMALLY MODULATED VARIABLE RESTRICTOR FOR NORMALIZATION OF DYNAMIC SPLIT RATIOS 审中-公开
标题翻译：用于动态分割比例正常化的热调制变量限制器
公开(公告)号：WO2014189738A2
公开(公告)日：2014-11-27
申请号：PCT/US2014/038027
申请日：2014-05-15
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： FOGWILL, Michael O. , MICHIENZI, Joseph D. , MURPHY, James P.
IPC分类号： G01N30/38
CPC分类号： G01N30/30 , B01D15/161 , B01D15/40 , G01N30/16 , G01N30/32 , G01N30/34 , G01N30/7213 , G01N30/84 , G01N2030/3038
摘要： A chromatography system includes a separation column that separates a sample carried by a compressible mobile phase flow into analytes and a splitter in fluidic communication with the separation column to receive and divide the compressible mobile phase flow into first and second mobile phase streams in accordance with a split ratio. A thermally modulated variable restrictor is coupled between the splitter and a detector. The restrictor receives the first mobile phase stream from the splitter and has a temperature element in thermal communication with the first mobile phase stream to exchange heat therewith. A controller, in communication with the restrictor, dynamically adjusts a temperature setting of the temperature element of the restrictor to adjust the heat exchange between the thermally modulated variable restrictor and the first mobile phase stream in order to keep the split ratio constant throughout a chromatographic run.
摘要翻译：色谱系统包括分离柱，其将由可压缩流动相流携带的样品分离成分析物，以及与分离塔流体连通的分离器，以将可压缩流动相流接收并分成第一和第二流动相流，根据分流比。热调制变量限制器耦合在分路器和检测器之间。限流器从分流器接收第一流动相流，并且具有与第一流动相流热连通的温度元件以与其进行热量交换。与节流器连通的控制器动态地调节限流器的温度元件的温度设置，以调节热调节的可变节流器和第一流动相流之间的热交换，以便在整个色谱运行期间保持分流比恒定。

9. 发明申请

WO2018134750A1 DEVICES PROVIDING SOLVENT CONTAINER IDENTIFICATION 审中-公开
公开(公告)号：WO2018134750A1
公开(公告)日：2018-07-26
申请号：PCT/IB2018/050293
申请日：2018-01-17
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： SONG, Xiangjin , MURPHY, James P. , FADGEN, Keith , LEVEILLE, Wade P., Sr. , MICHIENZI, Joseph D. , BELANGER, Jonathan L. , JUNG, Moon Chul , TARAFDER, Abhijit
IPC分类号： G01N30/26 , G01N35/10 , G01N30/80
摘要： Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.

10. 发明公开

EP2972291A1 THERMALLY MODULATED VARIABLE RESTRICTOR 审中-公开
标题翻译：热调制式可变限制器
公开(公告)号：EP2972291A1
公开(公告)日：2016-01-20
申请号：EP14764098.1
申请日：2014-01-27
申请人： Waters Technologies Corporation
发明人： FOGWILL, Michael O. , MICHIENZI, Joseph D. , MURPHY, James P.
IPC分类号： G01N30/32
CPC分类号： G01N30/30 , B01D15/163 , B01D15/40 , G01N30/32 , G01N30/6004 , G01N2030/3038 , G01N2030/324 , G01N2030/6008
摘要： Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatographic column. The restrictors include a restrictor body having a fluidic channel with an inlet that receives the mobile phase from the column and an outlet through which the mobile phase leaves the fluidic channel. A restrictor tip, disposed adjacent the outlet of the fluidic channel, has an egress opening that is smaller than an internal diameter of the fluidic channel. A heating element, thermally coupled to a subsection of the fluidic channel between its inlet and outlet, heats the mobile phase passing through that subsection of the fluidic channel. The restriction produced by the restrictor tip in response to the heating of the mobile phase enables independent control of system pressure and linear velocity of the mobile phase within the column.

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