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1. 发明申请

WO2008121453A2 DEVICE, APPARATUS AND METHOD FOR PERFORMING SEPARATIONS 审中-公开
标题翻译：用于执行分离的装置，装置和方法
公开(公告)号：WO2008121453A2
公开(公告)日：2008-10-09
申请号：PCT/US2008054237
申请日：2008-02-19
申请人： WATERS INVESTMENTS LTD , BELANGER JONATHAN , WATT MICAH INGLIS , SHINER STEPHEN J , FISK RAYMOND P
发明人： BELANGER JONATHAN , WATT MICAH INGLIS , SHINER STEPHEN J , FISK RAYMOND P
IPC分类号： B01D63/08
CPC分类号： B01D15/22 , B01D15/12 , G01N30/08 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N2030/085 , Y10T29/49826 , G01N30/6039
摘要： Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.
摘要翻译：本发明的实施例的特征在于具有主体，分离介质和玻璃料元件的装置。主体的外表面具有围绕介质室和玻璃料部分中的至少一个径向放置的第一附接装置，以形成紧凑的组件。

2. 发明专利

GB2428393B Frit for high pressure liquid chromotography 未知
公开(公告)号：GB2428393B
公开(公告)日：2008-10-01
申请号：GB0619685
申请日：2005-03-04
申请人： WATERS INVESTMENTS LTD
发明人： IRANETA PAMELA C , BELANGER JONATHAN , FISK RAYMOND P
IPC分类号： B01D15/08 , G01N30/60

3. 发明专利

GB2408469B A chromatographic column and methods for controlling sorbent density 未知
公开(公告)号：GB2408469B
公开(公告)日：2007-04-18
申请号：GB0502761
申请日：2003-09-08
申请人： WATERS INVESTMENTS LTD
发明人： IZZO GARY S , FISK RAYMOND P , BELANGER JONATHAN , TUVIM YURI , ZINITI DONALD E
IPC分类号： B01D15/20 , B01D15/08 , B01D15/22 , B01D15/32 , B01D15/34 , B01D15/36 , B01D15/38 , B01J20/281 , B01J20/283 , G01N30/16 , G01N30/52 , G01N30/56 , G01N30/60 , G01N30/62 , G01N30/72 , G01N30/74 , G01N30/88
摘要： Disclosed herein are apparatus and methods for mitigating column bed compression over time. This invention provides for an improved column design and method of controlling bed density in a chromatographic column using a protruding portion of a filter assembly. The invention results in a higher sorbent bed density than can normally be achieved using a fixed length column of conventional design. The invention may be implemented as a unique filter assembly or as a column tailored for the application and a matching filter assembly.

4. 发明专利

GB2428393A Frit for high pressure liquid chromotography 未知
公开(公告)号：GB2428393A
公开(公告)日：2007-01-31
申请号：GB0619685
申请日：2005-03-04
申请人： WATERS INVESTMENTS LTD
发明人： IRANETA PAMELA C , BELANGER JONATHAN , FISK RAYMOND P
IPC分类号： B01D15/08 , G01N30/60
摘要： A frit (44) includes a porous support structure having a plurality of void spaces, where a plurality of secondary particles (46) are filled in the void spaces, the secondary particles (46) being dimensioned with respect to the void spaces such that the frit (44) retains packing materials with diameters of less than about 2.5 microns. Preferably one or more frits (44) are received in a high pressure liquid chromatography (HPLC) chromatographic column, where the column includes fittings and filter assemblies for receiving frits (44) at its inlet and outlet The frit (44) can be constructed from a porous support structure with void spaces or pores that are filled with secondary particles (46) smaller those used to manufacture the support. The particles (46) contained in the void spaces are large enough to be retained by the support, but small enough to create a finer network of interconnected channels within the support's void spaces that are capable of retaining sub-2.5 micrometer particles.

5. 发明专利

DE10393207T5 未知
公开(公告)号：DE10393207T5
公开(公告)日：2005-08-25
申请号：DE10393207
申请日：2003-09-08
申请人： WATERS INVESTMENTS LTD
发明人： IZZO GARY S , FISK RAYMOND P , BELANGER JONATHAN , TUVIM YURI , ZINITI DONALD E
IPC分类号： B01D15/08 , B01D15/20 , B01D15/22 , B01D15/32 , B01D15/34 , B01D15/36 , B01D15/38 , B01J20/281 , B01J20/283 , G01N30/16 , G01N30/52 , G01N30/56 , G01N30/60 , G01N30/62 , G01N30/72 , G01N30/74 , G01N30/88
摘要： Disclosed herein are apparatus and methods for mitigating column bed compression over time. This invention provides for an improved column design and method of controlling bed density in a chromatographic column using a protruding portion of a filter assembly. The invention results in a higher sorbent bed density than can normally be achieved using a fixed length column of conventional design. The invention may be implemented as a unique filter assembly or as a column tailored for the application and a matching filter assembly.

6. 发明专利

AU2003218134A1 DEVICE FOR SOLID PHASE EXTRACTION AND METHOD FOR PURIFYING SAMPLES PRIOR TO ANALYSIS 未知
公开(公告)号：AU2003218134A1
公开(公告)日：2003-10-08
申请号：AU2003218134
申请日：2003-03-12
申请人： WATERS INVESTMENTS LTD
发明人： FISK RAYMOND P , IRANETA PAMELA C , TUVIM YURI , BOUVIER EDOUARD S P , BELANGER JONATHAN , GILAR MARTIN
IPC分类号： B01D15/08 , B01J20/281 , B01L3/00 , G01N1/40 , G01N30/00 , G01N30/06 , G01N30/26 , G01N30/60 , G01N30/80 , G01N30/88

7. 发明专利

GB2467031B8 Analytical column for use in hplc separations. 未知
公开(公告)号：GB2467031B8
公开(公告)日：2010-12-22
申请号：GB0922387
申请日：2005-08-17
申请人： WATERS INVESTMENTS LTD
发明人： BENEVIDES CHRISTOPHER C , BELANGER JONATHAN , KELE MARIANNA , WALTER THOMAS H , FISK RAYMOND P
IPC分类号： B01D15/08 , B01D15/12 , B01D15/22 , G01N30/14 , G01N30/60
摘要： Embodiments of the present invention are directed to devices, methods and apparatus for performing separations in which particulates are separated or removed from a fluid stream flowing to a column. In one embodiment directed to a device, the invention includes a body (13) having a first surface (17) and a second surface (19) and at least one wall (23). At least one of the first surface (17) and second surface (19) is for receiving in sealing engagement a first conduit means. The remaining first surface (17) or second surface (19) is for engaging a column or a second conduit (19). The at least one wall (23) extends between the first surface (17) and the second surface (19). The body (13) has at least one opening (25) extending from the first surface (17) to the second surface (19) defining a chamber for receiving a solid phase separation media assembly (15). The device further includes a solid phase separation media assembly (15) within the chamber formed in the opening of the body between the first surface (17) and the second surface (19). The solid phase separation media assembly (15) is for removing particulates and undesired materials of a fluid flowing through the chamber. The body is constructed and arranged to fit in a body fitting to be attached to a column or which body fitting is part of an assembly for communicating with an column or a detector.

8. 发明专利

GB2467031A8 Analytical column for use in hplc separations 未知
公开(公告)号：GB2467031A8
公开(公告)日：2010-12-22
申请号：GB0922387
申请日：2005-08-17
申请人： WATERS INVESTMENTS LTD
发明人： BENEVIDES CHRISTOPHER C , BELANGER JONATHAN , KELE MARIANNA , WALTER THOMAS H , FISK RAYMOND P
摘要： Embodiments of the present invention are directed to devices, methods and apparatus for performing separations in which particulates are separated or removed from a fluid stream flowing to a column. In one embodiment directed to a device, the invention includes a body (13) having a first surface (17) and a second surface (19) and at least one wall (23). At least one of the first surface (17) and second surface (19) is for receiving in sealing engagement a first conduit means. The remaining first surface (17) or second surface (19) is for engaging a column or a second conduit (19). The at least one wall (23) extends between the first surface (17) and the second surface (19). The body (13) has at least one opening (25) extending from the first surface (17) to the second surface (19) defining a chamber for receiving a solid phase separation media assembly (15). The device further includes a solid phase separation media assembly (15) within the chamber formed in the opening of the body between the first surface (17) and the second surface (19). The solid phase separation media assembly (15) is for removing particulates and undesired materials of a fluid flowing through the chamber. The body is constructed and arranged to fit in a body fitting to be attached to a column or which body fitting is part of an assembly for communicating with an column or a detector.

9. 发明专利

GB2467031B Analytical column for use in hplc separations 未知
公开(公告)号：GB2467031B
公开(公告)日：2010-09-01
申请号：GB0922387
申请日：2005-08-17
申请人： WATERS INVESTMENTS LTD
发明人： BENEVIDES CHRISTOPHER C , BELANGER JONATHAN , KELE MARIANNA , WALTER THOMAS H , FISK RAYMOND P
IPC分类号： B01D15/08 , B01D15/12 , B01D15/22 , G01N30/14 , G01N30/60
摘要： Embodiments of the present invention are directed to devices, methods and apparatus for performing separations in which particulates are separated or removed from a fluid stream flowing to a column. In one embodiment directed to a device, the invention includes a body (13) having a first surface (17) and a second surface (19) and at least one wall (23). At least one of the first surface (17) and second surface (19) is for receiving in sealing engagement a first conduit means. The remaining first surface (17) or second surface (19) is for engaging a column or a second conduit (19). The at least one wall (23) extends between the first surface (17) and the second surface (19). The body (13) has at least one opening (25) extending from the first surface (17) to the second surface (19) defining a chamber for receiving a solid phase separation media assembly (15). The device further includes a solid phase separation media assembly (15) within the chamber formed in the opening of the body between the first surface (17) and the second surface (19). The solid phase separation media assembly (15) is for removing particulates and undesired materials of a fluid flowing through the chamber. The body is constructed and arranged to fit in a body fitting to be attached to a column or which body fitting is part of an assembly for communicating with an column or a detector.

10. 发明专利

GB2467031A Analytical column for use in hplc separations 未知
公开(公告)号：GB2467031A
公开(公告)日：2010-07-21
申请号：GB0922387
申请日：2005-08-17
申请人： WATERS INVESTMENTS LTD
发明人： BENEVIDES CHRISTOPHER C , BELANGER JONATHAN , KELE MARIANNA , WALTER THOMAS H , FISK RAYMOND P
IPC分类号： B01D15/08 , B01D15/12 , B01D15/22 , G01N30/14 , G01N30/60
摘要： The present invention relates to an analytical column for use in HPLC systems for performing separations in which particulates are separated or removed from a fluid stream flowing to a column. The column includes a filter device 11 which comprises a body 13 received in a recess 121 provided in the column. The body has a pair of opposed sealing faces 17, 19 and an opening 25 extending between the opposed sealing faces. The opening defines a chamber containing a solid phase separation media 15 assembly. Preferably the solid phase separation media is a typical monolith or a stack of porous frits or a packing of particles 36 of separation material disposed between a first and second fait. Advantageously the filter device functions to protect against the effects of particulates and pressure pulsations in a high pressure environment.

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