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1. 发明授权

KR870000742B1 5-옥소-2-피롤리딘프로판산 및 유도체의 제조방법 失效
公开(公告)号：KR870000742B1
公开(公告)日：1987-04-13
申请号：KR830002256
申请日：1983-05-23
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E
IPC分类号： C07D207/26 , C07D401/12 , C07D207/267

2. 发明专利

JPS6242966A SATURATED CYCLOALKYL(C)PYRROLE-2(1H)-ACETIC ACID AMIDE AND DERIVATIVES THEREOF 失效
公开(公告)号：JPS6242966A
公开(公告)日：1987-02-24
申请号：JP19068186
申请日：1986-08-15
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E , TOPLISS JOHN G
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61P25/28 , A61P43/00 , C07D209/46 , C07D209/52 , C07D401/12

3. 发明专利

CA1285939C SUBSTITUTED TETRAHYDRO-3-PYRIDINE-CARBOXYLIC ACID, ESTER AND AMIDE CHOLINERGIC AGENTS 未知
公开(公告)号：CA1285939C
公开(公告)日：1991-07-09
申请号：CA528411
申请日：1987-01-28
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E , DODD JOHN H , MOOS WALTER H , TECLE HAILE
IPC分类号： A61K31/445 , A61K31/4433 , A61K31/4465 , A61K31/451 , A61K31/455 , A61P25/28 , C07D211/78 , C07D333/00 , C07D401/06 , C07D409/04 , C07D413/06 , C07D413/12
摘要： Certain substituted 1,2,3,6-tetrahydro- and 1,2,5,6-tetrahydropyridine-3-carboxylic acids, esters, and amides possessing muscarinic binding activity, having utility for the treatment of the symptoms of senile cognitive decline disclosed. Pharmaceutical compositions and a pharmaceutical method of treatment are also disclosed.

4. 发明专利

DE3763863D1 未知
公开(公告)号：DE3763863D1
公开(公告)日：1990-08-30
申请号：DE3763863
申请日：1987-02-17
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E , MOOS WALTER H , DODD JOHN H , TECLE HAILE
IPC分类号： A61K31/445 , A61K31/4433 , A61K31/4465 , A61K31/451 , A61K31/455 , A61P25/28 , C07D211/78 , C07D333/00 , C07D401/06 , C07D409/04 , C07D413/06 , C07D413/12
摘要： 1,2,3,6-Tetrahydro- and 1,2,5,6-tetrahydropyridine-3-car-boxylic acids, esters, and amides having structural formula I … … wherein the dashed lines indicate the presence of only one carbon-carbon double bond either between carbon atoms numbers 3 and 4 or between carbon atoms numbers 4 and 5; R1 = hydrogen: C1-C6-alkyl, C2-C6 alkenyl, alkoxycarbonyl of from 2 to 5 C, C4-C8-cycloalkyl or phenyl-(C1-C6)-alkyl, wherein the phenyl ring may be substituted; R3 = -COOR, wherein R = hydrogen, C1-C6-alkyl, C2-C6-alkenyl; C3-C8-cycloalkyl or phenyl, which may be substituted; -CONR min R sec , wherein R min and R sec are independently hydrogen or cycloalkyl, benzyloxy or phenyl-(C1-C6)-alkyl, wherein the phenyl ring may be substituted, or R min and R sec when taken together with the nitrogen atom to which they are attached from a 5 to 7 membered heterocyclic ring which may contain another heteroatom selected from N,0 or S; R4 = C1-C6-alkyl, C2-C6-alkenyl,C3-C8-cycloalkyl, 2- or 3-thienyl, phenyl, which may be substituted or phenyl-(C1-C6)-alkyl, wherein the phenyl group may be substituted, and the pharmaceutically acceptable salts thereof, possessing muscarinic binding activity, having utility for the treatment of the symptoms of senile cognitive decline are disclosed. Pharmaceutical compositions and pharmaceuticals are also disclosed.

5. 发明专利

AT54910T 未知
公开(公告)号：AT54910T
公开(公告)日：1990-08-15
申请号：AT87102216
申请日：1987-02-17
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E , MOOS WALTER H , DODD JOHN H , TECLE HAILE
IPC分类号： A61K31/445 , A61K31/4433 , A61K31/4465 , A61K31/451 , A61K31/455 , A61P25/28 , C07D211/78 , C07D333/00 , C07D401/06 , C07D409/04 , C07D413/06 , C07D413/12
摘要： 1,2,3,6-Tetrahydro- and 1,2,5,6-tetrahydropyridine-3-car-boxylic acids, esters, and amides having structural formula I … … wherein the dashed lines indicate the presence of only one carbon-carbon double bond either between carbon atoms numbers 3 and 4 or between carbon atoms numbers 4 and 5; R1 = hydrogen: C1-C6-alkyl, C2-C6 alkenyl, alkoxycarbonyl of from 2 to 5 C, C4-C8-cycloalkyl or phenyl-(C1-C6)-alkyl, wherein the phenyl ring may be substituted; R3 = -COOR, wherein R = hydrogen, C1-C6-alkyl, C2-C6-alkenyl; C3-C8-cycloalkyl or phenyl, which may be substituted; -CONR min R sec , wherein R min and R sec are independently hydrogen or cycloalkyl, benzyloxy or phenyl-(C1-C6)-alkyl, wherein the phenyl ring may be substituted, or R min and R sec when taken together with the nitrogen atom to which they are attached from a 5 to 7 membered heterocyclic ring which may contain another heteroatom selected from N,0 or S; R4 = C1-C6-alkyl, C2-C6-alkenyl,C3-C8-cycloalkyl, 2- or 3-thienyl, phenyl, which may be substituted or phenyl-(C1-C6)-alkyl, wherein the phenyl group may be substituted, and the pharmaceutically acceptable salts thereof, possessing muscarinic binding activity, having utility for the treatment of the symptoms of senile cognitive decline are disclosed. Pharmaceutical compositions and pharmaceuticals are also disclosed.

6. 发明专利

DE3664044D1 未知
公开(公告)号：DE3664044D1
公开(公告)日：1989-07-27
申请号：DE3664044
申请日：1986-09-23
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E
IPC分类号： A61K31/40 , A61P25/00 , C07D207/34 , C07D487/04
摘要： A unique series of N,N-dialkylaminoalkyl-hexahydro-5-oxo-1H-pyrrolizine-3-carboxamides are disclosed. These compounds are useful as agents for the reversal of amnesia. Intermediates for preparing the compounds, pharmaceutical compositions containing them, and methods for using the pharmaceutical compositions for treating senility and for the reversal of amnesia are described.

7. 发明专利

DE3569926D1 未知
公开(公告)号：DE3569926D1
公开(公告)日：1989-06-08
申请号：DE3569926
申请日：1985-07-15
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E , LEONARD JAMES D
IPC分类号： A61K31/40 , C07D487/04
摘要： A compound having the following general formula I: wherein A is the radical -NR1R2 in which R1 and R2 are independently hydrogen, lower alkyl, or lower alkenyl; or wherein A is the radical -NHR3 in which R3 is phenyl, phenylmethyl, N,N-bis (1-methylethyl)- aminoethyl or 4-pyridyl; or wherein A is the radical -OR4 in which R4 is lower alkyl, phenyl (optionally substituted in the 2-, 3-, or 4-position with one or more of a chlorine, fluorine, lower alkoxy or phenylmethoxy), or phenylmethyl (optionally substituted in the 2-,3-, or 4- position with one or more of a chlorine, fluorine, lower alkoxy or phenyl (methoxy); and the pharmaceutically acceptable salts of those compounds of formula I having a basic nitrogen atom. The compounds are effective as cognition activators for treating senility or for reversing the effects of electroshock induced amnesia. A process for producing the compounds, a useful intermediate in their preparation and pharmaceutical compositions are also disclosed.

8. 发明专利

AT38837T 未知
公开(公告)号：AT38837T
公开(公告)日：1988-12-15
申请号：AT85300664
申请日：1985-01-31
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E , L ITALIEN YVON J
IPC分类号： C07D455/00 , A61K31/40 , A61K31/435 , A61K31/47 , A61P25/28 , A61P43/00 , C07D209/34 , C07D209/52 , C07D215/22 , C07D215/227 , C07D455/03 , C07D455/04 , C07D457/06 , C07D471/06 , C07D487/06
摘要： Compounds of formula wherein x is zero, one, two or three and y and z are independently zero or one are disclosed. A method of preparing the compounds and pharmaceutical compositions including the compounds are also disclosed. The compounds are useful as agents in treating senility and amnesia.

9. 发明专利

DE3563621D1 (SUBSTITUTED-PHENYL)-5-OXO-2-PYRROLIDINEPROPANOIC ACIDS, A PROCESS FOR PRODUCING THE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS 未知
公开(公告)号：DE3563621D1
公开(公告)日：1988-08-11
申请号：DE3563621
申请日：1985-04-26
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E , THOMAS ANTHONY J
IPC分类号： A61K31/40 , A61K31/4015 , A61P25/28 , C07D207/26 , C07D207/267
摘要： Compounds of formula I or II … … wherein R is a hydrogen, a pharmaceutically acceptable metal or amine cation, an alkyl radical of from one to six carbon atoms, a phenyl radical, or a phenylmethyl radical; and wherein X and Y are independently a hydrogen, an alkyl radical of from one to six carbon atoms, an alkoxy radical of from one to six carbon atoms, a chlorine or a trifluoromethyl radical. A process for preparing the compounds and pharmaceutical compositions comprising the compounds are also disclosed, The compounds are useful in the treatment of senility and for reversing amnesia.

10. 发明专利

AT35546T 未知
公开(公告)号：AT35546T
公开(公告)日：1988-07-15
申请号：AT85302948
申请日：1985-04-26
申请人： WARNER LAMBERT CO
发明人： BUTLER DONALD E , THOMAS ANTHONY J
IPC分类号： A61K31/40 , A61P25/28 , C07C205/53 , C07D207/26 , C07D487/04
摘要： 1-(Substituted-aryl)-dihydro-1H-pyrrolizine-3, 5-[2H, 6H]-diones having the structural formulawherein X and Y are independently hydrogen, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, chlorine or trifluoromethyl. Pharmaceutical compositions containing these compound and a process for preparing the compounds are also disclosed. The compounds are effective cognition activating agents for the treatment of senility and for reversing amnesia.

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