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1. 发明申请

WO2005056112A1 PORTABLE THERAPEUTIC DEVICE AND METHOD FOR PAIN RELIEF 审中-公开
标题翻译：便携式治疗装置和疼痛缓解方法
公开(公告)号：WO2005056112A1
公开(公告)日：2005-06-23
申请号：PCT/US2004/015422
申请日：2004-05-18
申请人： WANG, Tianxin , ZOU, Shazhou , WANG, Victor
发明人： WANG, Tianxin , ZOU, Shazhou , WANG, Victor
IPC分类号： A61N01/18
CPC分类号： A61N1/36021
摘要： The invention relates to a method and device of reducing pain and other symptoms in a patient utilizing a non-invasive electrical stimulation device applied over acupuncture points and adjacent nerves of a patient. The non-invasive electrical stimulation device is a portable electrical therapeutic device. The device includes electronic circuitry for imparting electrical impulses to the desired acupuncture points and areas. Batteries within the device power the electric circuitry, and an operable switch on the device controls on/off and pulse frequency and amplitude.
摘要翻译：本发明涉及一种利用应用于患者的穴位和相邻神经的非侵入性电刺激装置来减轻患者的疼痛和其它症状的方法和装置。非侵入性电刺激装置是便携式电疗治疗装置。该装置包括用于将电脉冲施加到期望的针灸点和区域的电子电路。设备内的电池为电路供电，设备上的可操作开关控制开/关以及脉冲频率和幅度。

2. 发明申请

WO2007146197A1 METHODS AND REAGENTS FOR VIRUS ISOLATION AND DETECTION 审中-公开
标题翻译：用于病毒分离和检测的方法和试剂
公开(公告)号：WO2007146197A1
公开(公告)日：2007-12-21
申请号：PCT/US2007/013636
申请日：2007-06-11
申请人： LI, Xing-Xiang , WANG, Tianxin
发明人： LI, Xing-Xiang , WANG, Tianxin
IPC分类号： C12N7/00 , C12N7/02
CPC分类号： C12N7/00 , C12N2730/10151 , C12N2740/15051 , C12N2770/24251 , C12N2770/32451 , G01N33/56983 , G01N2333/02 , G01N2333/16 , Y02A50/54
摘要： The present invention relates to reagents and methods used in virus isolation and analysis.
摘要翻译：本发明涉及用于病毒分离和分析的试剂和方法。

3. 发明申请

WO2022093658A1 IN SITU VACCINE FOR CANCER CELL AND TUMOR TREATMENT 审中-公开
公开(公告)号：WO2022093658A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/056391
申请日：2021-10-24
申请人： WANG, Tianxin
发明人： WANG, Tianxin
IPC分类号： A61K9/06 , A61K47/36 , A61K45/08 , A61P35/00
摘要： This disclosure provides agents, compositions and methods for treating cancer by treating tumor in a subject. The composition comprises cancer cell inactivating agent and immune activity enhancing agent in a sustained release formulation, which can be used as intratumoral injection to convert the treated tumor into an in situ vaccine for cancer. Suitable immune activity enhancing agents include TLR agonist and STING agonist.

4. 发明申请

WO2016200645A1 METHODS FOR PROTEIN MODIFICATION IN PHARMACEUTICAL APPLICATIONS 审中-公开
标题翻译：药物应用蛋白质修饰方法
公开(公告)号：WO2016200645A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/035111
申请日：2016-05-31
申请人： WANG, Tianxin
发明人： WANG, Tianxin
IPC分类号： C07K1/04 , C07K1/06 , A61K47/48 , A61K31/08 , A61K31/7084 , A61K38/27
CPC分类号： C07K14/61 , C07K16/00 , C07K16/1063 , C07K16/32 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/61 , C07K2319/70 , C12N9/00
摘要： The current invention discloses methods to modify protein for pharmaceutical applications and reagents to treat disease such as pathogen infection and cancer. The method involves increasing the molecular weight of the protein by connecting multiple protein units with site specific conjugation to extend the in vivo half life. The current invention also discloses methods to construct affinity ligand in protein or aptamer form, which becomes active when they reach the treatment target, therefore provide higher specificity for treatment.
摘要翻译：本发明公开了用于改变用于药物应用的蛋白质和用于治疗疾病如病原体感染和癌症的试剂的方法。该方法包括通过连接具有位点特异性缀合的多个蛋白质单位来增加蛋白质的分子量以延长体内半衰期。本发明还公开了构建蛋白质或适体形式的亲和配体的方法，当它们到达治疗靶时变得有活性，因此提供更高的治疗特异性。

5. 发明申请

WO2017100725A1 METHODS TO TREAT DISEASES WITH PROTEIN, PEPTIDE, ANTIGEN MODIFICATION AND HEMOPURIFICATION 审中-公开
标题翻译：用蛋白质，肽，抗原修饰和血液透析治疗疾病的方法
公开(公告)号：WO2017100725A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/066040
申请日：2016-12-11
申请人： WANG, Tianxin
发明人： WANG, Tianxin
IPC分类号： C07K1/06 , A61K47/55 , A61K47/64 , A61K39/39 , A61P37/00
CPC分类号： A61K39/0008 , A61K39/00 , A61K39/385 , A61K47/6889 , A61K2039/6031 , A61K2039/6087 , C07K14/47 , C07K14/575 , C07K14/58 , C07K14/605
摘要： The current invention discloses methods to modify protein and peptide and antigen to treat disease such as pathogen infection, autoimmune diseases and cancer. The method involves increasing the molecular weight of the protein by connecting multiple peptide units with site specific conjugation to extend the in vivo half life. The current invention also discloses methods to construct activatable enzyme, which becomes active when they reach the treatment target, therefore provide higher specificity for treatment. The current invention also relates to methods to treat disease with hemopurification.
摘要翻译：本发明公开了修饰蛋白质，肽和抗原以治疗诸如病原体感染，自身免疫疾病和癌症等疾病的方法。该方法涉及通过连接具有位点特异性缀合的多个肽单元来延长蛋白质的分子量以延长体内半衰期。本发明还公开了构建可激活酶的方法，其在到达治疗目标时变得有活性，因此提供更高的治疗特异性。本发明还涉及用血液纯化治疗疾病的方法。

6. 发明申请

WO2016025541A1 THERAPEUTICAL METHODS, FORMULATIONS AND NUTRACEUTICAL FORMULATIONS 审中-公开
标题翻译：治疗方法，制剂和营养制剂
公开(公告)号：WO2016025541A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/044746
申请日：2015-08-12
申请人： WANG, Tianxin
发明人： WANG, Tianxin , ZOU, Shazhou
IPC分类号： A61K36/9066 , A61K31/655 , A61K36/38 , A61K31/443 , A61K31/135 , A61P15/00
CPC分类号： A61K31/12 , A61K31/122 , A61K31/7028 , A61K36/38 , A61K36/9066 , A61K45/06 , A61K2300/00
摘要： The invention provides compositions and methods for the prevention, treatment, or management of sexual dysfunction, such as premature ejaculation. The method comprises administering an effective amount of curcuminoid containing composition to a human male on an as-needed basis shortly before sexual activity to delay ejaculation.
摘要翻译：本发明提供了用于预防，治疗或管理性功能障碍（例如早泄）的组合物和方法。该方法包括在性活动之前在需要的基础上向男性男性施用有效量的含姜黄素的组合物以延迟射精。

7. 发明申请

WO2009139811A2 CHEMILUMINESCENT METHODS AND REAGENTS FOR ANALYTE DETECTION 审中-公开
标题翻译：用于分析物检测的CHEMILUMINESCENT方法和试剂
公开(公告)号：WO2009139811A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/002137
申请日：2009-04-06
申请人： WANG, Tianxin
发明人： WANG, Tianxin , XINGXIANG, Li
IPC分类号： G01N21/76 , C07D277/62 , C12Q1/66 , C12Q1/70
CPC分类号： C12Q1/66
摘要： The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current invention relates to use chemiluminescent enzyme coupled with analyte binding molecules to detect specific analyte molecules in a homogenous phase.
摘要翻译：本发明涉及化学发光方法和检测分析物的方法。本发明的一个方面涉及使用酶底物，其可被靶酶切割以释放化学发光化合物，给出用于检测各种目标酶的光信号。本发明的另一方面涉及使用化学发光酶与分析物结合分子偶联以检测均匀相中的特异性分析物分子。

8. 发明申请

WO2005085850A1 METHODS FOR MULTIPLEXED ANALYTE DETECTION 审中-公开
标题翻译：多重分析检测方法
公开(公告)号：WO2005085850A1
公开(公告)日：2005-09-15
申请号：PCT/US2005/005904
申请日：2005-02-26
申请人： WANG, Tianxin , LI, XingXiang
发明人： WANG, Tianxin , LI, XingXiang
IPC分类号： G01N33/53
CPC分类号： C12Q1/682
摘要： The methods and compositions provided herein are based on use of reporter system to detect multiple analyte in a sample. The reporter system can be a signal amplification system that includes a carrier, typically a particle containing an analyte binding moiety, and multiple copies of a signaling moiety. Different reporter system can bind with different analyte. Different reporter system or their signaling moiety can be distinguished and detected. In various embodiments, the signaling moiety is physically released from its carrier after the carrier has been bound to the analyte and distinguished and detected after the release (Figure 5).
摘要翻译：本文提供的方法和组合物基于报道系统的用途来检测样品中的多种分析物。报告系统可以是包括载体，通常是含有分析物结合部分的颗粒和信号传导部分的多个拷贝的信号放大系统。不同的报告系统可以与不同的分析物结合。可以区分和检测不同的报道系统或其信号传导部分。在各种实施方案中，在载体结合到分析物之后，信号传导部分从其载体物理释放，并在释放后被区分并检测（图5）。

9. 发明申请

WO2020198085A1 METHOD AND DEVICE FOR IMPROVING BRAIN FUNCTION 审中-公开
公开(公告)号：WO2020198085A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/024084
申请日：2020-03-21
申请人： WANG, Tianxin
发明人： WANG, Tianxin
IPC分类号： A61N1/36 , A61N5/06 , A61F7/00
摘要： Methods and therapeutic devices with noninvasive means for improving brain function and treating senile dementia including Alzheimer's disease are described. The non-invasive means is selected from electrical stimulation, heat stimulation, IR (infrared) radiation or their combinations. In some embodiments, the method and device utilize electrical current passed through acupuncture sites on the human head to achieve desired therapeutical effects.

10. 发明申请

WO2018187636A1 CELL SURFACE ANCHORING ANTIGEN CONJUGATES TO TREAT CANCER 审中-公开
公开(公告)号：WO2018187636A1
公开(公告)日：2018-10-11
申请号：PCT/US2018/026346
申请日：2018-04-06
申请人： WANG, Tianxin
发明人： WANG, Tianxin
IPC分类号： A61K31/04 , A61K31/7004 , A61K31/7016 , A61K31/14 , A61K39/00 , A61K47/28 , A61K38/16 , A61P35/00
摘要： This disclosure provides cell surface anchoring antigen conjugates, formulations comprising cell surface anchoring antigen conjugates, and methods of using the same for treating cancer.

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