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1. 发明申请

WO1994000186A1 A PATCH ELECTRODE 审中-公开
标题翻译： PATCH电极
公开(公告)号：WO1994000186A1
公开(公告)日：1994-01-06
申请号：PCT/US1992005725
申请日：1992-07-07
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： W.L. GORE & ASSOCIATES, INC. , HULL, John, R. , LACK, Craig, D. , MORTIMER, William, P. , STALEY, Richard, A.
IPC分类号： A61N01/05
CPC分类号： A61N1/0587 , A61N1/04
摘要： A flexible patch electrode for use with living tissue, comprising, in sequential laminar form, a layer of electrically conductive porous polytetrafluoroethylene, a layer of polymeric adhesive, a layer of electrically conductive sheet material having lower resistivity than the layer of porous polytetrafluoroethylene, and an insulating layer. The layer of electrically conductive sheet material is of less length and width than the adjacent layers and is placed so that its edges are not exposed at the edges of the flexible patch electrode.
摘要翻译：一种与活组织一起使用的柔性贴片电极，包括以顺序层叠形式的导电多孔聚四氟乙烯层，聚合物粘合剂层，具有比多孔聚四氟乙烯层低的电阻率的导电片材层，以及绝缘层。导电片材层的长度和宽度比邻近的层薄，并且被放置成使其边缘不露出在柔性贴片电极的边缘处。

2. 发明申请

WO1994007565A1 AN IMPLANTABLE LEAD 审中-公开
标题翻译：可塑性领先
公开(公告)号：WO1994007565A1
公开(公告)日：1994-04-14
申请号：PCT/US1992010675
申请日：1992-12-14
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： W.L. GORE & ASSOCIATES, INC. , SOUKUP, Thomas, M. , STALEY, Richard, A.
IPC分类号： A61N01/05
CPC分类号： A61N1/05
摘要： An implantable lead (10) for use with cardiac pacemakers, defibrillators and other long term implantable electrical devices intended for sensing or tissue stimulation, having a helically wound conductor (12) with a surrounding tubular insulating layer of elastomeric material (14) such as silicone or polyurethane and an additional coaxial tubular exterior biocompatible layer of porous PTFE (16) having a microstructure of nodes (24) interconnected by fibrils (22). The exterior tubular layer of porous PTFE may be fitted coaxially over the elastomeric tubular layer whereby the porous PTFE tubular layer is in longitudinal compression and the fibrils within the microstructure have a bent and wavy appearance. Any portion of the length of the porous PTFE tubing in longitudinal compression allows that portion of the length of the lead wire to be extensible to a controlled extent limited by the straightening of the bent fibrils within the porous PTFE microstructure.
摘要翻译：一种用于心脏起搏器，除颤器和旨在用于感测或组织刺激的其它长期可植入电气设备的可植入引线（10），具有螺旋缠绕的导体（12），其具有弹性体材料（14）的周围管状绝缘层，例如硅树脂或聚氨酯和具有通过原纤维（22）互连的节点（24）的微结构的多孔PTFE（16）的另外的同轴管状外部生物相容性层。多孔PTFE的外部管状层可以同轴地装配在弹性体管层上，由此多孔PTFE管层处于纵向压缩状态，并且微结构体内的原纤维具有弯曲和波浪形的外观。多孔PTFE管的纵向压缩长度的任何部分允许引线长度的那部分可延伸到受多孔PTFE微结构内弯曲原纤维矫正所限制的受限程度。

3. 发明申请

WO1994017852A1 AN IMPLANTABLE ELECTRODE 审中-公开
标题翻译：可植入电极
公开(公告)号：WO1994017852A1
公开(公告)日：1994-08-18
申请号：PCT/US1993005777
申请日：1993-06-16
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： W.L. GORE & ASSOCIATES, INC. , SOUKUP, Thomas, M. , STALEY, Richard, A.
IPC分类号： A61N01/05
CPC分类号： A61N1/056 , A61N1/0565
摘要： An implantable electrode in the form a helically wound conductor having an electrically conductive polymeric layer coaxially surrounding and contacting the helically wound conductor, wherein the electrically conductive polymeric layer is electrically conductive in a dry state prior to implantation. Preferably, the electrode has two conductive portions, the additional second conductive portion being preferably located at the distal tip. The implantable electrode preferably incorporates an insulating portion wherein an additional length of the helically wound conductor is continuous with the remaining length of helically wound conductor coaxially covered by the electrically conductive polymeric layer. The insulating portion has a coaxial covering of impermeable polymeric electrically insulating material which is preferably silicone tubing. More preferably the coaxial covering of impermeably polymeric electrically insulating material has an additional exterior coaxial covering of porous PTFE for improved biocompatibility and flexibility. The porous PTFE is preferably porous expanded PTFE having a fibril length of less than 10 microns in order to substantially preclude tissue ingrowth and tissue attachment. The electrically conductive polymeric layer of the electrode is preferably made of porous expanded PTFE containing an electrically conductive filler, the porous expanded PTFE again having a fibril length of less than 10 microns.
摘要翻译：形成螺旋缠绕导体的可植入电极，其具有同轴地围绕并接触螺旋缠绕的导体的导电聚合物层，其中导电聚合物层在植入之前处于干燥状态下导电。优选地，电极具有两个导电部分，附加的第二导电部分优选位于远端。可植入电极优选地包括绝缘部分，其中螺旋缠绕的导体的额外长度与由导电聚合物层同轴地覆盖的螺旋缠绕导体的剩余长度连续。绝缘部分具有不可渗透的聚合物电绝缘材料的同轴覆盖物，其优选为硅胶管。更优选地，不透水聚合物电绝缘材料的同轴覆盖物具有用于改善生物相容性和柔韧性的多孔PTFE的另外的外部同轴覆盖。多孔PTFE优选是原纤维长度小于10微米的多孔膨体PTFE，以便基本上排除组织向内生长和组织附着。电极的导电聚合物层优选由含有导电填料的多孔膨体PTFE制成，多孔膨体PTFE再次具有小于10微米的原纤维长度。

4. 发明公开

EP0662853A1 AN IMPLANTABLE LEAD 有权
标题翻译：植入引线。
公开(公告)号：EP0662853A1
公开(公告)日：1995-07-19
申请号：EP93901387.0
申请日：1992-12-14
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： SOUKUP, Thomas M. , STALEY, Richard, A.
IPC分类号： A61N1
CPC分类号： A61N1/05
摘要： An implantable lead (10) for use with cardiac pacemakers, defibrillators and other long term implantable electrical devices intended for sensing or tissue stimulation, having a helically wound conductor (12) with a surrounding tubular insulating layer of elastomeric material (14) such as silicone or polyurethane and an additional coaxial tubular exterior biocompatible layer of porous PTFE (16) having a microstructure of nodes (24) interconnected by fibrils (22). The exterior tubular layer of porous PTFE may be fitted coaxially over the elastomeric tubular layer whereby the porous PTFE tubular layer is in longitudinal compression and the fibrils within the microstructure have a bent and wavy appearance. Any portion of the length of the porous PTFE tubing in longitudinal compression allows that portion of the length of the lead wire to be extensible to a controlled extent limited by the straightening of the bent fibrils within the porous PTFE microstructure.

5. 发明授权

EP0662853B1 AN IMPLANTABLE LEAD 有权
标题翻译：植入引线，
公开(公告)号：EP0662853B1
公开(公告)日：1997-11-19
申请号：EP93901387.6
申请日：1992-12-14
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： SOUKUP, Thomas M. , STALEY, Richard, A.
IPC分类号： A61N1/05
CPC分类号： A61N1/05
摘要： An implantable lead (10) for use with cardiac pacemakers, defibrillators and other long term implantable electrical devices intended for sensing or tissue stimulation, having a helically wound conductor (12) with a surrounding tubular insulating layer of elastomeric material (14) such as silicone or polyurethane and an additional coaxial tubular exterior biocompatible layer of porous PTFE (16) having a microstructure of nodes (24) interconnected by fibrils (22). The exterior tubular layer of porous PTFE may be fitted coaxially over the elastomeric tubular layer whereby the porous PTFE tubular layer is in longitudinal compression and the fibrils within the microstructure have a bent and wavy appearance. Any portion of the length of the porous PTFE tubing in longitudinal compression allows that portion of the length of the lead wire to be extensible to a controlled extent limited by the straightening of the bent fibrils within the porous PTFE microstructure.

6. 发明授权

EP0681494B1 AN IMPLANTABLE ELECTRODE 有权
标题翻译：植入电极
公开(公告)号：EP0681494B1
公开(公告)日：1999-08-18
申请号：EP93916575.9
申请日：1993-06-16
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： SOUKUP, Thomas, M. , STALEY, Richard, A.
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0565
摘要： An implantable electrode in the form a helically wound conductor having an electrically conductive polymeric layer coaxially surrounding and contacting the helically wound conductor, wherein the electrically conductive polymeric layer is electrically conductive in a dry state prior to implantation. Preferably, the electrode has two conductive portions, the additional second conductive portion being preferably located at the distal tip. The implantable electrode preferably incorporates an insulating portion wherein an additional length of the helically wound conductor is continuous with the remaining length of helically wound conductor coaxially covered by the electrically conductive polymeric layer. The insulating portion has a coaxial covering of impermeable polymeric electrically insulating material which is preferably silicone tubing. More preferably the coaxial covering of impermeably polymeric electrically insulating material has an additional exterior coaxial covering of porous PTFE for improved biocompatibility and flexibility. The porous PTFE is preferably porous expanded PTFE having a fibril length of less than 10 microns in order to substantially preclude tissue ingrowth and tissue attachment. The electrically conductive polymeric layer of the electrode is preferably made of porous expanded PTFE containing an electrically conductive filler, the porous expanded PTFE again having a fibril length of less than 10 microns.

7. 发明公开

EP0681494A1 AN IMPLANTABLE ELECTRODE 有权
标题翻译：植入电极。
公开(公告)号：EP0681494A1
公开(公告)日：1995-11-15
申请号：EP93916575.0
申请日：1993-06-16
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： SOUKUP, Thomas, M. , STALEY, Richard, A.
IPC分类号： A61N1
CPC分类号： A61N1/056 , A61N1/0565
摘要： An implantable electrode in the form a helically wound conductor having an electrically conductive polymeric layer coaxially surrounding and contacting the helically wound conductor, wherein the electrically conductive polymeric layer is electrically conductive in a dry state prior to implantation. Preferably, the electrode has two conductive portions, the additional second conductive portion being preferably located at the distal tip. The implantable electrode preferably incorporates an insulating portion wherein an additional length of the helically wound conductor is continuous with the remaining length of helically wound conductor coaxially covered by the electrically conductive polymeric layer. The insulating portion has a coaxial covering of impermeable polymeric electrically insulating material which is preferably silicone tubing. More preferably the coaxial covering of impermeably polymeric electrically insulating material has an additional exterior coaxial covering of porous PTFE for improved biocompatibility and flexibility. The porous PTFE is preferably porous expanded PTFE having a fibril length of less than 10 microns in order to substantially preclude tissue ingrowth and tissue attachment. The electrically conductive polymeric layer of the electrode is preferably made of porous expanded PTFE containing an electrically conductive filler, the porous expanded PTFE again having a fibril length of less than 10 microns.

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